iiinova — where your digital self keeps evolving

Mark Hedglin @hedglinlab.bsky.social · 09/09/2026

This work is a culmination of years of monumental efforts from @pennstatechemistry.bsky.social PhD student Samuel Perreault & another successful collaboration w/@professorantony.bsky.social lab. Thank you to NIGMS for support.

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Mark Hedglin @hedglinlab.bsky.social · 09/09/2026

After years of focusing on human PCNA monoubiquitination, we swam upstream in this ubiquitin cascade & discovered a novel mechanism of ubiquitin-charging a bivalent E2:RING E3 complex. Check it out in our new pre-print! www.biorxiv.org/content/10.6...

biorxiv.org

A novel mechanism of ubiquitin-charging a bivalent E2:RING E3 complex

Protein ubiquitination results from a cascade of enzyme interactions that transfer ubiquitin from one covalent bond to another. First, an E1 is activated by attaching ubiquitin to itself through a thi...

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Sarah Keane @keanelab.bsky.social · 08/06/2026

My lab is currently recruiting 2(!!) postdocs in RNA structural biology/biochemistry! Full details can be found below and on our website (sites.lsa.umich.edu/keane-lab/op...).

Job posting. Details available at https://sites.lsa.umich.edu/keane-lab/openings/.

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GL Moldovan Laboratory @moldovanlab.bsky.social · 05/03/2026

Happy to share our new work on the nuclease EXO1, published in Nature Communications. We show that EXO1 is overexpressed in cancers. This promotes nascent DNA degradation, even in BRCA-proficient cells, resulting in genomic instability and chemotherapy sensitization. www.nature.com/articles/s41...

nature.com

The nuclease EXO1 promotes genomic instability by degrading nascent DNA in BRCA-proficient cells - Nature Communications

DNA repair genes are generally considered tumor suppressors, as they maintain genomic stability. Here, the authors show that the exonuclease EXO1 is overexpressed in a significant proportion of tumors...

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Agnel Sfeir @agnelsfeir.bsky.social · 02/03/2026

The Sfeir Lab at MSKCC is hiring a Research Assistant! We are looking for a motivated scientist with at least 2 years of research experience and a two-year commitment. Learn more about our work here www.sfeirlab.com, and message me your CV and cover letter if interested

sfeirlab.com

Sfeir Lab

The official website of the Sfeir Lab at the Skirball Institute of Biomolecular Medicine of New York University Langone Medical Center.

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Environmental Mutagenesis and Genomics Society @emgsus.bsky.social · 11/02/2026

Get ready for a new #EMGS webinar: "Understanding molecular mechanisms of mutagenesis with implications in human health and disease" presented by the Mutagenic Mechanisms and Assessments SIG! Read More and Register Now! emgs-us.org/event/MolMec...

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Mark Hedglin @hedglinlab.bsky.social · 04/02/2026

This 👇is such a great opportunity for young scientists in the field. I “grew up” on this conference & still hold so many meaningful relationships to this day that I made at these conferences.

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Bret Freudenthal @freudlab.bsky.social · 27/01/2026

🎉Kicking off 2026 with our first paper from the Freudenthal lab in NAR. Ribonucleotides reshape telomeric G4s and are resistant to RNase H2 repair. Congrats to the authors and huge thanks to our collaborator Hui-Ting Lee! academic.oup.com/nar/article/...

academic.oup.com

Effects of ribonucleotides on telomeric G4 formation, dynamics, and initiation of ribonucleotide excision repair by RNase H2

Abstract. Human telomeres are composed of TTAGGG repeats that can fold into G-quadruplexes (G4s). G4s can form several different conformations, including p

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Mark Hedglin @hedglinlab.bsky.social · 07/01/2026

Great start to 2026! Another successful collaboration with @professorantony.bsky.social lab & final to piece to Dr. Jessica L. Norris's Chemistry PhD thesis with new additions by current Chemistry PhD graduate student Grace Young. Thanks to NIGMS for funding our groups. doi.org/10.1093/nar/gkaf1478

academic.oup.com

Validate User

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Edwin Antony @professorantony.bsky.social · 10/12/2025

What does phosphorylation do to RPA? This has been a long-standing question in the field of genome integrity. In our newest publication in Nature Communications rdcu.be/eT4z3 with @proforiganti.bsky.social , we reveal the answer. Thanks to funding from NIGMS to our groups.

media.tenor.com

a man is sitting on a couch with his arms outstretched and making a funny face .

ALT: a man is sitting on a couch with his arms outstretched and making a funny face .

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Edwin Antony @professorantony.bsky.social · 18/11/2025

POSTDOCTORAL POSITION IN STRUCTURAL BIOLOGY We need a structural biologist to work on several CryoEM datasets. For more information, please visit: www.antonylab.org Expertise in structure refinement and model-building are required. Please share.

antonylab.org

ANTONY LAB SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE

Edwin Antony Lab Website

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Mark Hedglin @hedglinlab.bsky.social · 31/10/2025

Members of @acsbiol.bsky.social, the Fall 2025 Election is occurring now & will run until 11/28. To ensure you receive your ballot, be sure that your ACS membership is up to date & your email filters are set to receive from elections@vote-now.com.

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Mark Hedglin @hedglinlab.bsky.social · 19/09/2025

Had such an exceptional seminar visit to the Dept. of Biochemistry & Molecular Genetics @ the University of Virginia School of Medicine. Beautiful campus & outstanding scientific community. Thank you @tmweaver.bsky.social for the invitation & all staff, students & faculty for the hospitality.

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Mark Hedglin @hedglinlab.bsky.social · 17/09/2025

We ARE…HIRING POSTDOCS!! The Hedglin Lab at PSU is looking for PhD graduates interested in biophysical & kinetic investigations of human DNA replication pathways. Further details of the position are below. Please spread the word & DM with any questions. psu.wd1.myworkdayjobs.com/PSU_Academic...

psu.wd1.myworkdayjobs.com

Postdoctoral Scholar (Chemistry Department)

APPLICATION INSTRUCTIONS: CURRENT PENN STATE EMPLOYEE (faculty, staff, technical service, or student), please login to Workday to complete the internal application process. Please do not apply here, a...

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Kara Bernstein @karabernstein.bsky.social · 03/09/2025

Co-organizing a one day FREE conference on Genome Instability- Discovery to Personalized Medicine 11/1/25. Please join us! Short talks available. https//noncredit.t...

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Duxin lab @duxinlab.bsky.social · 22/08/2025

It is not always safe to repair DNA Damage. Sometimes, cells "just bypass it". During DNA replication, repair of lesions on DNA can be dangerous. Cells instead "tolerate" DNA damage and focus on finishing replication. Read our review and find out why and how: doi.org/10.1016/j.ti...

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JStark lab @jstarklab.bsky.social · 19/08/2025

We have openings for a postdoctoral training program on DNA Damage and Oncogenic Signaling. Our past trainees have been very successful. Apply by Aug 31 for full consideration. See link for details. www.imgs-coh.edu/postdoctoral...

imgs-coh.edu

Postdoctoral Training Programs

Funded by the National Cancer Institute (T32CA186895), the program at City of Hope provides exceptionally motivated, recent (2 years or less) postdoctoral fellows with scientific knowledge, researc

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Mark Hedglin @hedglinlab.bsky.social · 17/07/2025

So happy & excited to see this out. An honest & sincere thank you to the editor & reviewers for their constructive criticism & feedback that helped bring the best version of this story to life! doi.org/10.1093/nar/...

doi.org

A human high-fidelity DNA polymerase holoenzyme has a wide range of lesion bypass activities

Abstract. During replication, lagging strand lesions are initially encountered by high-fidelity DNA polymerase (pol) holoenzymes comprised of pol δ and the

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Mark Hedglin @hedglinlab.bsky.social · 11/06/2025

#3 Chemistry PhD defense from the lab was a success. Congratulations Dr. Rachel Dannenberg, PhD!! We are so very proud of you & excited for your future. Thank you for your unwavering dedication, determination, grit & everlasting footprint on the lab.

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Environmental Mutagenesis and Genomics Society @emgsus.bsky.social · 03/06/2025

Join us NEXT WEEK for the #EMGS webinar "Oxidative DNA Damage and Repair: Impacts and Methods of Detection," featuring a workshop lead by Drs. Laurie Sanders and Tobias Dansen, a keynote talk by Dr. Karlene Cimprich, and more! Register Today: emgs-us.org/event/OxiDNA...

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Mark Hedglin @hedglinlab.bsky.social · 29/05/2025

Research mentors, "unofficial" mentors within the PSU & greater scientific community, colleagues, former lab mates. Thank you all so much.

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Mark Hedglin @hedglinlab.bsky.social · 29/05/2025

This is a credit to all past & present lab members whose hard work, dedication, & scientific intrigue made this dream a reality. Also, a credit to SO many along the way (too many to mention by name) that provided unwavering support, motivation, & inspiration.

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Mark Hedglin @hedglinlab.bsky.social · 29/05/2025

It's official: Promoted to Associate Professor of Chemistry with Tenure. Beyond proud & excited for the lab to continue our journey in the genome stability field & charter new territories from within such an amazing community.

psu.edu

Penn State announces tenure-line faculty promotions, effective July 1, 2025 | Penn State University

The following is a list of academic promotions for tenured and tenure-line faculty members at Penn State, effective July 1, 2025.

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Environmental Mutagenesis and Genomics Society @emgsus.bsky.social · 06/05/2025

Don't miss the next #EMGS webinar "Oxidative DNA Damage and Repair: Impacts and Methods of Detection," presented by the EMGS DNA Repair SIG. 🧬 Register Today: emgs-us.org/event/OxiDNAWEB

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Edwin Antony @professorantony.bsky.social · 24/04/2025

Our story detailing how asymmetry in nitrogenase-like proteins regulate electron transfer reactions is finally out! rdcu.be/ejaeK Congratulations to postdoc @rajnandani.bsky.social and fantastic collaborators. Thanks to funding from the Department of Energy and the NIH.

rdcu.be

Cryo-EM captures the coordination of asymmetric electron transfer through a di-copper site in DPOR

Nature Communications - CryoEM snapshots of the nitrogenase-like DPOR protein complex captured during turnover reveal that asymmetric conformational changes, substrate recognition, and an interplay...

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Nucleic Acids Research @narjournal.bsky.social · 15/04/2025

🧬 Don't miss the fourth and final session of NAR Cancer's 5th Anniversary Virtual Symposium! 🕛 Thursday 17 April at 12pm US Eastern time 👥 Speakers include Dr Elise Fouquerel and Dr Robert W. Sobol Register here: lnkd.in/eRxxSxeu #NARCancer #PARPInhibitors #DNARepair #GenomicStability

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Mark Hedglin @hedglinlab.bsky.social · 02/04/2025

Sorry to hear that. Any luck yet? DM if there is still a problem.

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Mark Hedglin @hedglinlab.bsky.social · 01/04/2025

Excited to share our new pre-print. Direct, ensemble FRET assays developed by our lab reveal that assembly of Rad51 filaments at stalled replication sites via RPA/Rad51 exchange causes complete & irreversible PCNA unloading. Big implications for interplay between human DNA damage tolerance pathways

biorxiv.org

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Tyler Weaver @tmweaver.bsky.social · 24/03/2025

The final piece of my postdoctoral work in the @freudlab.bsky.social was recently published! Quite amazing what this small little repair polymerase can do to fill 1-nt gaps in chromatin. www.nature.com/articles/s41...

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The EMBO Journal @embojournal.org · 03/03/2025

Why does yeast replication require two alternative clamp loaders? Joe Yeeles and coworkers show that RFC can only load PCNA on lagging strands, while leading strand polymerases necessitate the involvement of CMG-interaction Ctf18-RFC www.embopress.org/doi/full/10....

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Bill Dynan - NAR Cancer Editor @nar-cancer-editor.bsky.social · 11/02/2025

NAR Cancer 5th anniversary symposium on manipulating DNA repair and the DDR - Session 2 this Thursday, Feb 13, noon US Eastern time. Kara Bernstein and Joanna Loizou speaking. In collaboration with Social DNAing. Information and free registration link at academic.oup.com/narcancer/pa...

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Tyler Weaver @tmweaver.bsky.social · 10/02/2025

We are still accepting application for the Postdoc position in my lab! We have some exciting projects at the interface of DNA repair and chromatin biology. If interested, please get in touch or apply for the position through the link below! jobs.virginia.edu/us/en/job/R0...

jobs.virginia.edu

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keithcaldecott.bsky.social @keithcaldecott.bsky.social · 10/02/2025

Dear all, Postdoc positions are available to work on (1) the role of DNA strand break repair proteins during DNA replication and (2) the molecular/structural biology of XRCC1 protein complexes, as part of our work on genetic diseases & cancer. Contact me if interested: k.w.caldecott@sussex.ac.uk

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