In eukaryotes, ribosome biogenesis initiates within the nucleolus, a hallmark multilayered compartment of the nucleus. Structures of pre-ribosomes have been characterized ex situ, but their assembly p...

The move came after the NIH director refused Trump’s request to cut Harvard grants in an Oval Office meeting.

The Trump administration’s deep cuts to health and public health and assaults on science-based policy are already being felt across the country—from Medicaid, research and staffing cuts to attacks on ...

ALT: Sesame Street's Cookie Monster: 'So Share It Maybe'

It’s far too early to declare a discovery, physicists with the LZ detector say

Authored by anonymous current and former NIH workers with experience in peer review

Letter to the Editor

A June 2026 Nature report revealed that mandatory reviews by top officials, checking for a list of 235 disfavored terms, have left hundreds of meritorious NIH applications in administrative limbo (Koz...

Proteome-wide prediction and structural modeling of disordered protein interaction interfaces advance characterization of disease-associated variants in disordered protein regions.

Brandon, Robinson-Thiewes, Kaulage et al. report that targeted BRD4 recruitment enables transcription through H3K9me3/HP1-marked heterochromatin without erasing repressive marks, identifying condensat...

Macroautophagy/autophagy is a process that degrades intracellular components and is strongly triggered by nitrogen starvation (-N). Some ATG (autophagy related) genes are activated at the transcriptio...

In Schizosaccharomyces pombe , the conserved CHD remodeler Mit1 function within the SHREC remodeler-deacetylase complex (a homolog of the metazoan Mi-2/NuRD complex), which is essential for H3K9 methy...