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GOA - Genome Organisation Australia

@genome-org-aus.bsky.social
30 followers 80 following 14 posts

A monthly seminar series about everything genome organisation. Conveners: Hannah Coughlan (WEHI) and Zoe Grant (Gladstone Institutes) Next speaker: A.Prof. Aleksandra Pękowska 4 pm (AEST) 25th of September

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GOA - Genome Organisation Australia @genome-org-aus.bsky.social · 15/09/2026
Our September GOA speaker is Aleksandra Pękowska aleksandrapekowska.bsky.social. Join us to hear her talk titled: RNA-dependent regulation of CTCF-anchored chromatin topology during differentiation. Registration link: unimelb.zoom.us/webinar/regi... #3Dgenome #CTCF #Chromatin
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GOA - Genome Organisation Australia @genome-org-aus.bsky.social · 29/07/2026
Amazing work by GOA convener Dr Zoe Grant! Her study on the impact of the 3D genome in heart disease was just published in Science! Read about it here: www.science.org/doi/abs/10.1...
science.org
Dose-dependent sensitivity of human three-dimensional chromatin to a heart disease–linked transcription factor
Dosage-sensitive transcription factors (TFs) underlie altered gene regulation in human developmental disorders, and cell type–specific gene regulation is linked to the reorganization of three-dimensio...
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Gladstone Institutes @gladstoneinst.bsky.social · 28/07/2026
Congenital heart disease is the most common birth defect. In a new study published in @science.org researchers investigated why losing just one functional copy of the gene TBX5—a genetic cause of congenital heart disease—can have such devastating effects on heart development.
youtube.com
Discovery Spotlight│Misfolded DNA Blueprint: A New Origin for Genetic Disease
YouTube video by Gladstone Institutes
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GOA - Genome Organisation Australia @genome-org-aus.bsky.social · 23/07/2026
Want to learn about rewiring of the 3D genome in cancer? Join us next week for GOA!
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GOA - Genome Organisation Australia @genome-org-aus.bsky.social · 12/07/2026
Our July GOA speaker is @aachinger.bsky.social. Join us to hear her talk titled: 3D chromatin rewiring governs lineage identity in prostate cancer. Registration: unimelb.zoom.us/webinar/regi...
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Anders Sejr Hansen @andersshansen.bsky.social · 14/07/2026
@mileshuseyin.bsky.social and the lab have put together a comprehensive protocol for genome-wide Micro-C and for Region-Capture Micro-C in @natprot.nature.com : www.nature.com/articles/s41... See also the GitHub for a user-friendly end-to-end computational pipeline: github.com/ahansenlab/M...
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GOA - Genome Organisation Australia @genome-org-aus.bsky.social · 12/07/2026
Our July GOA speaker is @aachinger.bsky.social. Join us to hear her talk titled: 3D chromatin rewiring governs lineage identity in prostate cancer. Registration: unimelb.zoom.us/webinar/regi...
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bioRxiv Genomics @biorxiv-genomic.bsky.social · 18/06/2026
Haplotype-resolved genome architecture mapping uncovers pervasive structural heterogeneity between human homologous chromosomes www.biorxiv.org/content/10.64898/20…
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Vijay Ramani @vram142.bsky.social · 18/06/2026
JIT 4 summer, the latest preprint from our lab, brilliantly led by @kaitezhang.bsky.social w/ support from Collepardo lab (@juliamaristany.bsky.social / @janhuemar.bsky.social). www.biorxiv.org/content/10.6... describes a new single-molecule epigenomic method, & discoveries it enables ... (1/n)
biorxiv.org
Single-molecule nucleosome spacing coordinates chromatin fiber interactions
Nucleosome spacing influences higher-order chromatin fiber organization in vitro but how this relates to cellular chromosome structure remains contentious. To address this, we developed Ligation Analy...
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Elphege Nora Lab at UCSF @elphegenoralab.bsky.social · 16/06/2026
Interested in hearing about mechanisms of cohesin-dependent vs. -independent enhancer regulation? @karissalhansen.bsky.social will be presenting her work **Tues June 23rd 8am CET** www.biorxiv.org/content/10.6... www.science.org/doi/10.1126/... Thank you @genome-org-aus.bsky.social ! 👇
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GOA - Genome Organisation Australia @genome-org-aus.bsky.social · 16/06/2026
Only one week to go until our next GOA seminar! @karissalhansen.bsky.social will present here work on the mechanisms of long-range enhancer-promoter communication. Registration link: unimelb.zoom.us/webinar/regi...
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Anders Sejr Hansen @andersshansen.bsky.social · 27/05/2026
Going from the discovery of epigenetic silencing of CTCF insulators www.nature.com/articles/s41... to aberrant E-P looping www.cell.com/molecular-ce... to a successful clinical trial www.nature.com/articles/s41... all from Brad Bernstein's lab
nature.com
Altered chromosomal topology drives oncogenic programs in SDH-deficient GISTs - Nature
Gastrointestinal stromal tumours can be initiated by gain-of-function mutations of the KIT or PDGFRA oncogenes but also by loss of the metabolic complex succinate dehydrogenase (SDH), which leads to D...
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GOA - Genome Organisation Australia @genome-org-aus.bsky.social · 11/06/2026
Please join us for the next edition of the GOA monthly seminar series Dr Karissa Hansen Registration link: unimelb.zoom.us/webinar/regi...
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Australasian Epigenetic Alliance (AEpiA) @aepia.bsky.social · 13/02/2026
AEpiA 2026 early bird registration open now! Calling all epigenetics researchers, let’s meet, share, and connect! 14–16 Sep | Adelaide 🇦🇺 | National Wine Centre Register: 2026aepia.com.au/registration Abstracts: 2026aepia.com.au/abstracts #AEpiA2026 #Epigenetics #Chromatin
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Lorne Genome Conference, Australia @lornegenome.bsky.social · 30/04/2026
Lorne Genome 2027 will be held 14 to 17th February in Lorne Australia. Our invited speakers will include Karen Arndt, Neil Brockdorff, Laura Banaszynski and Fides Zenk.
Lorne Genome 2027 Poster: 14 to 17th February, at Lorne Australia. Background shows the coast off Lorne. Invited speakers include Karen Arndt, Neil Brockdorff, Laura Banaszynski and Fides Zenk.
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GOA - Genome Organisation Australia @genome-org-aus.bsky.social · 15/05/2026
Please join us for the next edition of the GOA monthly seminar series Dr Matthew Romero Registration link: unimelb.zoom.us/webinar/regi...
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Elphege Nora Lab at UCSF @elphegenoralab.bsky.social · 13/05/2026
Why can't we explain enhancer action despite 2 decades of chromosome conformation technologies? 😬 Our new study spearheaded by Leonid Mirny's group points to a flaw in our assumptions, and to a solution from physical principles By @timothyfoldes.bsky.social 💻& @karissalhansen.bsky.social 🧪 🧵👇
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Rhys Allan @rhyscienceallan.bsky.social · 13/05/2026
Excited to share the final version of our paper with @ajithvasanthan.bsky.social @petermaccc.bsky.social on the gene we discovered, Dreg1 @elife.bsky.social Here we probe a novel knockout to identity a specific role for Dreg1 in group 2 ILC development elifesciences.org/articles/109...
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GOA - Genome Organisation Australia @genome-org-aus.bsky.social · 30/04/2026
Almost time for the next edition of the GOA seminar! Join us to hear from A/Prof. R. Babak Faryabi!
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GOA - Genome Organisation Australia @genome-org-aus.bsky.social · 23/04/2026
One more week until our first GOA for the year!
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Faryabi Lab @UPENN @faryabi.bsky.social · 02/12/2025
Kudos to Yeqiao Zhou, @atishayjay.bsky.social, and @vahedilab.bsky.social for our new @natcellbio.nature.com study www.nature.com/articles/s41...! By integrating chromatin tracing and polymer modeling, we revealed how lineage-determining TFs shape folding of B-cell lymphoma and T-ALL genomes.
nature.com
Lineage-determining transcription factors constrain cohesin to drive multi-enhancer oncogene regulation - Nature Cell Biology
Zhou, Jay et al. report that in mantle cell lymphoma and T cell leukaemia, lineage-determining transcription factors share a mechanism to regulate how multiple enhancers control oncogene expression th...
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GOA - Genome Organisation Australia @genome-org-aus.bsky.social · 08/04/2026
Please join us for the next edition of the GOA monthly seminar series A/Prof. R. Babak Faryabi @faryabi.bsky.social! Registration link: unimelb.zoom.us/webinar/regi...
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Max Planck Institute of Immunobiology and Epigenetics @mpi-ie.bsky.social · 27/03/2026
🚨 Postdoc in 3D genome architecture – join the @jumanaaha.bsky.social lab at the MPI-IE, Freiburg (🇩🇪) The wonderful lab of Jumana AlHaj Abed is pushing the limits of how chromosomes fold and interaction – and we need someone who can code, image, & think across scales. Apply here: s.gwdg.de/9c8838
Illustration of a fly and cellular structures connected by red and black thread-like lines inside a circle with a blue dot labeled 'TF' and text 'AlHaj Abed LAB' and 'Postdoctoral Researcher (m/w/d) Max Planck Institute of Immunobiology & Epigenetics'Text listing tasks in AlHaj Abed lab including Hi-C and Micro-C analysis, adapting multi-way contact genomic tools for Drosophila, building visualization framework for Pore-C data, image analysis, and programming in R and/or PythonText listing reasons to appreciate the Max Planck Institute in Freiburg including collaborative culture, core facilities, grants, scientific network, international diversity, public benefits, family support, relocation service, social life, and location, with a website linkLogo of the Max Planck Society; below text inviting to join the AlHaj Abed Lab with application deadline April 8, 2026, and a project website URL
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Nature Cell Biology @natcellbio.nature.com · 04/03/2026
☕ @kutaylab.bsky.social & co identify #lamin B receptor (LBR) and lamina-associated polypeptide 2 (LAP2) as major factors that tether #heterochromatin to the envelope. Deletion of these proteins causes changes in 3D #genome organization, gene expression and cell fate determination. bit.ly/4aPkNBc
bit.ly
LBR and LAP2 mediate heterochromatin tethering to the nuclear periphery to preserve genome homeostasis - Nature Cell Biology
Lewis et al. identify lamin B receptor (LBR) and lamina-associated polypeptide 2 (LAP2) as major factors that tether heterochromatin to the envelope. Deletion of these proteins causes changes in 3D ge...
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MRC Weatherall Institute of Molecular Medicine @imm.ox.ac.uk · 19/03/2026
#WIMMReads 🧪 From Jim Hughes, Douglas Higgs and Mira Kassouf: actively transcribed genes can define chromatin boundaries, linking gene activity directly to 3D genome organisation. Read more 👇 #GenomeBiology #Chromatin #WIMM @rdm.ox.ac.uk @medsci.ox.ac.uk #AkademicSky
doi.org
A functional overlap between actively transcribed genes and chromatin insulator elements - The EMBO Journal
The mammalian genome is organised into large topologically associating domains (TADs) and smaller sub-TADs or enhancer-promoter loops, which may contribute to the regulation of gene expression. These ...
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