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Atishay Jay

@atishayjay.bsky.social
9 followers 13 following 0 posts

Bioengineering PhD student at UPenn

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Reposted by Atishay Jay
Golnaz Vahedi @vahedilab.bsky.social · 26/11/2025
I am very excited to share our collaborative work on multiome profiling of gene expression and chromatin accessibility of more than 1 million immune cells in pancreatic lymph nodes and spleens in human type 1 diabetes in @sciimmunology.bsky.social scim.ag/4o12TOZ
scim.ag
Joint profiling of gene expression and chromatin accessibility in pancreatic lymph nodes and spleens in human type 1 diabetes
Joint chromatin accessibility and transcriptomic profiling of human and mouse pancreatic lymph nodes uncovers distinct features of CD4 T cells in T1D.
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Reposted by Atishay Jay
Waggoner Lab @labwaggoner.bsky.social · 04/12/2025
Lineage-determining transcription factors (EBF1 TCF1) radially position enhancers within gene loci to enable multi-enhancer regulation of key oncogenes @ single-allele level @natcellbio.nature.com @pennmedicine.bsky.social @atishayjay.bsky.social @vahedilab.bsky.social www.nature.com/articles/s41...
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Reposted by Atishay Jay
Golnaz Vahedi @vahedilab.bsky.social · 02/12/2025
Beyond excited to share the collaborative work with @faryabi.bsky.social led by stars Yeqiao Zhou and @atishayjay.bsky.social; Walking along thousands of chromosomes has shown us just how essential it is to measure chromatin fiber geometry to truly understand enhancer biology. tinyurl.com/2st3afwf
nature.com
Lineage-determining transcription factors constrain cohesin to drive multi-enhancer oncogene regulation - Nature Cell Biology
Zhou, Jay et al. report that in mantle cell lymphoma and T cell leukaemia, lineage-determining transcription factors share a mechanism to regulate how multiple enhancers control oncogene expression th...
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Reposted by Atishay Jay
Yeqiao Zhou @yeqiaoz.bsky.social · 02/12/2025
Three new manuscripts from Faryabi and Vahedi labs on chromatin folding, ORCA, oncogene regulation and T1D immunology. Individually great, collectively unstoppable. @faryabi.bsky.social @vahedilab.bsky.social @atishayjay.bsky.social tinyurl.com/4nwfbeu2 tinyurl.com/4zaw5cn7 tinyurl.com/25snbf4j
cell.com
OLIVE provides rapid visualization and analysis of chromatin tracing experiments
Zhou et al. develop the optical looping interactive viewing engine (OLIVE), a web-based application for browsing and exploring user-generated and publicly available chromatin tracing datasets.
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Reposted by Atishay Jay
Golnaz Vahedi @vahedilab.bsky.social · 26/06/2025
🚨 New #preprint alert! We're excited to share the latest work from the brilliant Sora Yoon: "Inference of multi-enhancer interactions in T lymphocytes using Hi-Cociety"🔗 www.biorxiv.org/content/10.1...
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Reposted by Atishay Jay
Golnaz Vahedi @vahedilab.bsky.social · 19/03/2025
Congrats to Atishay and Carlos for their review article on the epigenetics regulation of T cells: www.nature.com/articles/s41...
nature.com
The epigenetic landscape of fate decisions in T cells - Nature Immunology
Vahedi and colleagues review the mechanisms shaping the epigenetic landscape of CD4+ and CD8+ T cells during development and differentiation.
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