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Mike Hubank

@generoom.bsky.social
594 followers 468 following 229 posts

Clinical Genomics in the UK. Scientific Director of Clinical Genomics at the Royal Marsden and North Thames GLH. Prof of Translational Genomics at ICR, London

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Reposted by Mike Hubank
Zornitza Stark @zornitza.bsky.social · 24/09/2026
What have we learned from >10K newborns in gNBS studies? 🇺🇸🇧🇪🇦🇺 🧬extraction from Guthrie cards is feasible ✅ screen positive rate is 1.6-3.7% We now need: 📈Scalability ⚖️ Equity 💰Cost effectiveness 🤓 Policy frameworks and implementation models @genomeseb.bsky.social @heidicope.bsky.social
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Mike Hubank @generoom.bsky.social · 16/09/2026
UCL Genomics reunited at Genome Science UK in Manchester 😃
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Jonathan Coxhead @4130chromo.bsky.social · 16/09/2026
Cheers, Genome Science UK and thank you Manchester! 🍺 Another fantastic meeting, brilliant sponsors, and excellent speakers. Above all one of the best meetings in the calendar for catching up with old genomics friends and as ever, making new ones. See you all next year 🧬
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Mike Hubank @generoom.bsky.social · 12/09/2026
www.bbc.co.uk/news/article... "I think mistakes are opportunities". Fine if you sell beauty products. I run a cancer testing lab...
bbc.co.uk
The one thing you need to do to succeed - according to top bosses
What makes someone stand out in a crowded workplace? Six business leaders tell us what they look for.
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Ewan Birney @ewanbirney.bsky.social · 04/09/2026
Two weeks ago the @economist.com had a leader "In praise of designer-ish babies". I wrote a letter to the Editor about this, explaining why the UK system is so confident that this should remain unlawful. The Economist has kindly published a shortened form+ my full letter below lnkd.in/p/ef-n78N8
lnkd.in
Full letter to Economist, response to "In praise of designer-ish babies" | Ewan Birney
Two weeks ago the The Economist published a leader titled "In praise of designer-ish babies". I wrote a letter to the editor in response to this. The Economist was kind enough to publish a shortened f...
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The Seldom Seen Kid @seldom-seen-kid.bsky.social · 01/09/2026
They're all dead, Dave.
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Cancer Research UK Cambridge Institute @cruk-ci.bsky.social · 02/09/2026
Are you our next Director? We’re looking for an inspirational scientific leader who is ready to shape the direction of one of the world's leading cancer discovery research centres, a department of @cam.ac.uk and core-funded by @cancerresearchuk.org More info: wittkieffer.com/positions/a1...
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Mike Hubank @generoom.bsky.social · 25/08/2026
There's rules about being a fit and proper person to be a director of a foootball club, and there's rules about being a fit and proper person to be a director of Leeds United #dirtyleeds www.bbc.co.uk/news/article...
bbc.co.uk
Leeds and Rangers co-owner jailed after prostitution arrest
Jed York pleaded no contest to two charges in Ohio after being arrested for soliciting prostitution.
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Florent Mouliere @florentmouliere.bsky.social · 25/08/2026
Happy to share our new work in @cp-cellrepmed.bsky.social ortsmedicine.bsky.social We present the ACT score, a #liquidbiopsy #cfDNA approach for predicting first-line treatment failure in large B cell lymphoma using a plasma sample collected after one cycle of therapy. www.cell.com/cell-reports...
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Keith Robison @omicsomics.bsky.social · 19/08/2026
HiFi's Not Very Pacific Waters omicsomics.blogspot.com/2026/08/hifi...
omicsomics.blogspot.com
HiFi's Not Very Pacific Waters
PacBio had a major shakeup early this month. First came a large round of layoffs, which caught several individuals who were very much the fa...
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CRUK Convergence Science Centre @crukconvergence.bsky.social · 12/08/2026
Can AI predict cancer's next move? @stephensammut.bsky.social is using #AI to understand how #BreastCancer changes during treatment, personalising #Cancer care. 👉 buff.ly/P9vBRKq This is the first in our Assistant Director Research Spotlight series. Follow for more from the Centre. @icr.ac.uk
Photo of Stephen with a quote saying "We're trying to use AI to build clinical 'crystal balls', tools that can help predict the right drug, for the right person, at the right time."
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Mike Hubank @generoom.bsky.social · 07/08/2026
Exciting times in the translational #genomics lab at #RoyalMarsden London, as we begin to introduce clinical long read sequencing and new ctDNA testing to help patients receive better treatments, faster. Want to help us do it? www.royalmarsden.nhs.uk/current-vaca...
royalmarsden.nhs.uk
Current vacancies | The Royal Marsden
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Maria Secrier @mariasecrier.bsky.social · 05/08/2026
Interested in using AI, computational genomics and single-cell/spatial omics to tackle breast cancer dormancy and late recurrence? Join our team and work in collaboration with @magnanilab.bsky.social at ICR on an exciting interdisciplinary postdoc project: www.ucl.ac.uk/work-at-ucl/...
ucl.ac.uk
UCL – University College London
UCL is consistently ranked as one of the top ten universities in the world (QS World University Rankings 2010-2022) and is No.2 in the UK for research power (Research Excellence Framework 2021).
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Mike Hubank @generoom.bsky.social · 05/08/2026
Source: YouTube share.google/TKJckioDnE5H... Time for Poly. eins zvei drei vier!
share.google
X-Ray Spex - Genetic Engineering
Enjoy the videos and music you love, upload original content, and share it all with friends, family, and the world on YouTube.
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Jonathan Coxhead @4130chromo.bsky.social · 22/07/2026
🚨 Abstract submission deadline closes this Friday 📝🏃🏼🚨
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KaminskiMed @kaminskimed.bsky.social · 20/07/2026
Finally!! The World Medical Association send letter to Israel's Prime Minister, about Dr. Abu Safiya demanding immediate access to independent medical care, evaluation for torture; due process or release; end to solitary confinement #SaveDrAbuSafiya www.wma.net/news-post/wm...
wma.net
WMA - The World Medical Association-WMA renews urgent appeal to Israeli authorities over detained Gaza physicians, citing “grave concerns” for Dr Abu Safiya’s life
WMA - The World Medical Association
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Mike Hubank @generoom.bsky.social · 21/06/2026
Uruguay: the Leeds United of international football.
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Mike Hubank @generoom.bsky.social · 19/06/2026
Archeologists: Speed up your excavations by simply digging two holes that already align with the summer solstice. That way you'll discover "how they were revering the heavens" without having to move tons of mud with a teaspoon and a paintbrush. #TopTip www.bbc.co.uk/news/article...
bbc.co.uk
Simpler, older version of Stonehenge found three miles from famous site
The structure consisted of two posts that lined up with the solstices 5,000 years ago.
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Eric Topol @erictopol.bsky.social · 15/06/2026
A @nejm.org editorial today on the Office of White House Management and Budget (OMB) regarding their new funding proposal and politicization of science www.nejm.org/doi/full/10....
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By Cory Doctorow (GPG 0xBF3D9110957E5F4C) @doctorow.pluralistic.net · 11/06/2026
Douglas Adams: > Anything in the world when you're born is normal, ordinary and a natural part of the world. Anything invented between when you’re 15-35 is new, exciting and revolutionary and you can get a career in it. Anything invented after you're 35 is against the natural order of things. 1/
A blasted wasteland with a mushroom cloud rising over it. In the foreground are swarms of drowning people climbing over each other to escape into the limbs of a dead tree, and a crowd of agonized skeletons. All sourced from Dore engravings illustrating the Old Testament.
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Brian Stevenson Ph.D. spirochete lab @bstevensonlab.bsky.social · 13/06/2026
Wash cycle complete! At the Institute for Cancer Research / Royal Marsden Hospital with @generoom.bsky.social
Two sciency-guys standing next to a multimillion dollar washing machine. 
(Actually, a high throughput DNA sequencer)
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Angry People in Local Newspapers @apiln.bsky.social · 10/06/2026
In an unexpected turn of events, the damaged lamp post is pointing at the angry councillor. www.nwemail.co.uk/news/2617566...
An angry green councillor in a lime green top, jeans and purple boots, standing next to a damaged lamp post. There are three arrows painted on the post, pointing at her.
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CRUK Convergence Science Centre @crukconvergence.bsky.social · 08/06/2026
🧬How can #genomics help us uncover cancer's vulnerabilities? Join us to hear how novel genomic approaches are revealing new insights into #cancer evolution and identifying potential therapeutic targets. #ConvergingOnCancer International Seminar 📅 2 July, 10-11am BST
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Jon Lim, FRCP PhD @drjonlim.bsky.social · 07/06/2026
Almost 2️⃣ years in… Our MANIFEST AGM convened scientists, clinicians, patient partners & industry. Keynotes from Prof Levesque & Prof Rattray + Prof Turajlić setting the course ahead. Big thank you to all for continuing to believe in the vision; to tackle the hard questions in #CancerImmunotherapy.
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Eric Topol @erictopol.bsky.social · 05/06/2026
Two of the most powerful technologies we've ever known—CRISPR human embryo editing and self-improving A.I.—are getting actualized, and carry known and unforeseen risks nytimes.com/2026/06/04/s... wsj.com/tech/ai/anth... @anthropicai.bsky.social
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Dan Landau @landau.bsky.social · 04/06/2026
Exciting breakthrough technology from the lab, now live in @cellcellpress.bsky.social ! Instead of cutting the genome where proteins bind (e.g., Cut&Tag), D&D-seq scars the DNA with a deaminase, allowing single cell genome mapping of TFs and chromatin remodellers!
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Mike Hubank @generoom.bsky.social · 02/06/2026
Finally caught up with Borrelia guru, friend and former partner in crime on the rubgy pitch, @bstevensonlab.bsky.social after a (very) long time. Beers were had 🍺 We need to get a bigger labcoat for next time. 😃
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Eric Topol @erictopol.bsky.social · 02/06/2026
Big progress vs cancer, folks. The kind of event curves from randomized trials that we've not seen before for a couple of the most deadly cancers. Congrats to the oncology research community for getting these trial done.
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Mike Hubank @generoom.bsky.social · 27/05/2026
Roses are red Judge Dredd is the law
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Becki Lee @beckilee.bsky.social · 22/05/2026
Pleased to share results from the CAcTUS Phase II trial of ctDNA-guided therapy in BRAF-mutant advanced melanoma are now published! 🌵🧬 CAcTUS is the first melanoma trial to adapt treatment based on ctDNA testing. Read: www.nature.com/articles/s41...
nature.com
Use of circulating tumour DNA to prospectively guide a switch from targeted to immune therapy in BRAF mutant advanced melanoma: the randomised phase II CAcTUS trial - Nature Communications
Targeted therapy (with BRAK and MEK inhibitors) and immune checkpoint blockade have improved survival for patients with advanced BRAF-mutant cutaneous melanoma, however, the optimal scheduling for the...
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Mark Peifer (He, him) @peiferlabunc.bsky.social · 13/05/2026
While BioNtech & Moderna become household names because of their Covid vaccines, those emerged from different projects: finding ways to treat the most challenging cancers. They hypothesized that we could vaccinate patients against their own tumors, & evidence is mounting that they were right! 1/n 🧪
https://www.nature.com/articles/s41586-025-10004-2
Individualized mRNA vaccines evoke durable T cell immunity in adjuvant TNBC

    U. Sahin, M. Schmidt, E. Derhovanessian, A. Cortini, I. Vogler, T. Omokoko, E. Godehardt, S. Attig, S. Newrzela, J. Grützner, N. Bidmon, S. Bolte, S. Brachtendorf, T. Stuhlmann, D. Langer, D. Brüne, J. Blake, A. Feldner, H. Lindman, A. Schneeweiss, M. Eichbaum & Ö. Türeci 
Triple-negative breast cancer (TNBC) is frequently associated with metastatic relapse, even at an early stage1. Here we assessed an individualized neoantigen mRNA vaccine in 14 patients with TNBC following surgery and after neoadjuvant or adjuvant therapy. In peripheral blood of nearly all patients, high-magnitude, vaccine-induced, mostly de novo T cell responses to multiple neoantigens were detected that remained functional for several years. Characterization of individual patients revealed that a large proportion of these T cells developed into two subsets: a late-differentiated phenotype with markers indicative of ‘ready-to-act’ cytotoxic effector T cells, and T cells with a stem cell-like memory phenotype. Eleven patients remained relapse-free for up to six years post-vaccination. Recurrence occurred in three patients: the individual with the weakest vaccine-induced T cell response relapsed, but achieved complete remission on subsequent anti-PD-1 therapy; another patient had a tumour with low major histocompatibility complex (MHC) class I expression with MHC class I-deficient cells growing out under vaccination; and the third patient was BRCA-positive and had a recurrence from a genetically distinct primary tumour. These findings demonstrate the feasibility of individualized RNA vaccines in TNBC, document persistence of vaccine-induced, functional neoantigen-specific T cells and provide insights into possible immune escape mechanisms that will guide future approaches.
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Chris Lord and Andrew Tutt’s Lab Institute of Cancer Research @icrlordlab.bsky.social · 06/05/2026
If you are interested in PARP inhibitors and history, this might be of interest to you. www.nature.com/articles/s41.... An attempt to cover the work of thousands and their immense contributions to the development of a targeted approach to treating cancers.
nature.com
Two decades of PARP inhibitor synthetic lethality in cancer - Nature
The past two decades of PARP inhibitor synthetic lethality in cancer is explored.
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Prof Christina Pagel @chrischirp.bsky.social · 01/05/2026
NHS data should be driving innovation & improvement – it’s an amazing resource We just published the sequel to our 2021 "Road to Hell" paper on using NHS data for research... things are worse! Buckle up for a long 🧵about *how COMPLETELY mad* system is for accessing NHS data for research 1/20
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Chris Wallace @chr1sw.bsky.social · 02/05/2026
Very important thread about accessing NHS data for scientific progress. We (our processes, not our researchers) need to get better at this.
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Mike Hubank @generoom.bsky.social · 30/04/2026
My Hotel room for the #genomics meeting in Cardiff tonight. #ifyouknowyouknow
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Alison Harrod @alison-harrod.bsky.social · 23/04/2026
I’m excited to share our new paper in Genome Biology, where we show SMARCA4 protects against genome instability at G4 sites, using analysis of double-strand break mapping and whole genome sequencing. It has been a really interesting and collaborative project! link.springer.com/article/10.1...
link.springer.com
The SMARCA4 subunit of the SWI/SNF complex prevents genome instability at G quadruplexes - Genome Biology
Background G-quadruplex (G4) structures are secondary structures that can form in guanine-rich single stranded DNA sequences. These play important roles in biological processes such as regulation of g...
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Mike Hubank @generoom.bsky.social · 26/04/2026
Sound advice on grant writing from Ewan. Bookmark it!
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Mike Hubank @generoom.bsky.social · 10/04/2026
Invite is a verb. Invitation is a noun. You may invite me to a genomics meeting by sending me an invitation. Here endeth the lesson. #grumpyoldman
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Ewan Birney @ewanbirney.bsky.social · 09/04/2026
I posted on LinkedIn about my reflections on the genome, 25 years on. www.linkedin.com/posts/ewan-b...
linkedin.com
Thoughts after 25 years of genome from beautiful Barcelona | Ewan Birney
Reflections on DNA in Barcelona
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The Institute of Cancer Research @icr.ac.uk · 09/03/2026
At the ICR, we discover more prototype cancer drugs than any other academic institution in the world. One drug we discovered, abiraterone, has helped to give thousands of men with advanced #ProstateCancer, many more years with their loved ones. www.icr.ac.uk/about-us/icr...
icr.ac.uk
Over a decade of abiraterone: the drug that revolutionised advanced prostate cancer care
This Prostate Cancer Awareness Month, we’re celebrating over 10 years since abiraterone was first recommended by NICE in England as a treatment for advanced prostate cancer.
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Mike Hubank @generoom.bsky.social · 08/03/2026
@4130chromo.bsky.social Ouch. Port Vale might be bottom of league 1, but there are still 3 divisions higher than Macclesfield. Less said about the Cup this season, the better 🙈
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The Institute of Cancer Research @icr.ac.uk · 05/03/2026
We were honoured to welcome legendary West Indies cricketer Sir Clive Lloyd to The Institute of Cancer Research, London, today, as he visited Professor Ros Eeles’ lab to learn more about our world‑leading research into prostate cancer genetics.
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Mike Hubank @generoom.bsky.social · 28/02/2026
Thats our lab done that 😀 And we ran #BRCADirect too. Royal Marsden and North Thames GLH, improving options for people at higher risk of #Cancer.
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Martin Nicholls @martinnicholls.bsky.social · 26/02/2026
In honour of the Sunday Telegraph's editor and offical maddest columnist, we have created the Allister Heath headline generator... stirring-fox-7e1fab.netlify.app
stirring-fox-7e1fab.netlify.app
Allister Heath Headline Generator
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BTOG @btog.bsky.social · 25/02/2026
BTOG's response to England’s 10-Year National Cancer Plan welcomes the ambition — particularly lung cancer screening rollout — but raises concerns about diagnostic capacity, workforce pressures and smoking cessation integration. Delivery must match ambition: ow.ly/YCN150Yk8qI
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Angry People in Local Newspapers @apiln.bsky.social · 25/02/2026
How does he sleep at night?
Irish Independent: Man stole three coffee machines in a week from Monaghan department store.
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Eric Topol @erictopol.bsky.social · 20/02/2026
142,000 participants! The largest randomized trial of a multi-cancer early detection (MCED) test failed its primary endpoint genomeweb.com/cancer/grail... Had the enrollment been risk-based instead of age 50, it would likely have been very positive.
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Nicolas Robine 🇪🇺🇫🇷🇺🇸 @nicorobine.bsky.social · 23/02/2026
Individualized mRNA vaccines evoke durable T cell immunity in adjuvant TNBC. #BioNTech www.nature.com/articles/s41...
nature.com
Individualized mRNA vaccines evoke durable T cell immunity in adjuvant TNBC - Nature
In a phase 1 trial, personalized mRNA vaccines tailored to individual tumour mutations in triple-negative breast cancer induced robust, long-lasting T cell responses and improved prognosis.
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Nature Portfolio @natureportfolio.nature.com · 23/02/2026
A Technical Report published in Nature Cancer presents M-PACT: a deep neural network leveraging low-input cell-free DNA methylation profiles to achieve robust classification of pediatric brain tumors. 🧪
go.nature.com
M-PACT leverages cell-free DNA methylomes to achieve robust classification of pediatric brain tumors - Nature Cancer
Smith et al. present M-PACT, a deep neural network leveraging low-input cell-free DNA methylation profiles to achieve robust classification of pediatric brain tumors and enable cellular deconvolution and sensitive copy-number variation detection.
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Front Line Genomics @flgenomics.bsky.social · 20/02/2026
Liquid biopsies hold promise as companion diagnostics or surrogate endpoints in clinical trials. How does the current regulatory landscape pose challenges for pharma? Read the recent developments in our latest edition of the Liquid Biopsy Playbook. Download now: hubs.la/Q03PFMSp0 #liquidbiopsy
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