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Seth Shipman @seth-shipman.bsky.social · 02/06/2026

We're launching a major collaborative Center aimed at accelerating phage therapy @gladstoneinst.bsky.social. High-throughput experiments with engineered phages (my lab) and strains (Silas Lab), organoids (Ott Lab), and AI (Pollard Lab). gladstone.org/news/gladsto...

gladstone.org

Gladstone Launches Center for PhAIge Therapy to Harness AI in the Fight Against Drug-Resistant Infections

The center, funded by an NIH grant, will become one of three national centers dedicated to accelerating the development of phage therapy.

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Seth Shipman @seth-shipman.bsky.social · 23/04/2026

Out now in Nature Biotechnology! Alejandro González-Delgado and a fantastic team of collaborators worked across nine labs to get retron recombineering up-and-running in fifteen bacterial species. Molecular parts on addgene: www.addgene.org/browse/artic... Happy editing!

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Seth Shipman @seth-shipman.bsky.social · 18/02/2026

New preprint on Detectrons from @jihoon-han.bsky.social! These are programmable biosensors for RNA that produce DNA barcodes in the presence of their target RNA. Check out Jihoon's quoted thread and the preprint for more: www.biorxiv.org/content/10.6...

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Seth Shipman @seth-shipman.bsky.social · 23/10/2025

Been working on a really strange retron bacterial immune system, here's the preprint: www.biorxiv.org/content/10.1... Type VI retrons are unlike any other. Phage infection triggers reverse transcription of a DNA fragment that activates translation of a toxin to kill the infected cell.

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Seth Shipman @seth-shipman.bsky.social · 08/09/2025

Check out MitoScribe in our new preprint led by Linhan Wang: www.biorxiv.org/content/10.1... It's an analog molecular recorder that uses neutral base edits to the mitochondrial genome to store information about historical signaling in a cell. Single cell resolution at scale (see next post)!

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Seth Shipman @seth-shipman.bsky.social · 18/06/2025

New Preprint!! Alejandro González-Delgado accomplished a major feat on this one: ported retron recombineering, which we love so much in E. coli, into 14 new bacterial species via a massive collaborative effort involving 9 labs! www.biorxiv.org/content/10.1...

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Seth Shipman @seth-shipman.bsky.social · 30/01/2025

We just posted a new preprint where we found retrons in bacteria out in the real world, in dirt and water. We describe the first retrons in a handful of new species, show how they defend against phages, and use them to edit genomes. Read about it here: www.biorxiv.org/content/10.1...

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Seth Shipman @seth-shipman.bsky.social · 10/12/2024

🚨New Pub: High throughput variant libraries and machine learning yield design rules for retron gene editors, now out in Nucleic Acids Research. This is a great one, and the last bit of Kate Crawford's PhD, who is off to David Bakar's Lab for a postdoc. academic.oup.com/nar/advance-...

academic.oup.com

High throughput variant libraries and machine learning yield design rules for retron gene editors

Abstract. The bacterial retron reverse transcriptase system has served as an intracellular factory for single-stranded DNA in many biotechnological applica

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