Nitsch et al. show that short-chain acylations of histone H4K16, acetylation (C2), propionylation (C3), and butyrylation (C4) modulate chromatin structure in vitro. These effects can translate in vivo...

Enhancers control tissue-specific gene expression across metazoans. Although deep learning has enabled enhancer prediction and design in mammalian cell lines and invertebrate systems, it remains uncle...

Accurate reconstruction of gene regulatory networks (GRNs) from single-cell transcriptomic data remains a major methodological challenge. Recent machine learning approaches, particularly graph neural ...

Pioneer transcription factors are crucial for regulating zygotic genome activation and cell differentiation during mouse pre-implantation development. However, how pioneer factors function collectivel...

Nature Communications - Reversibility, regulation, and the community of development: the legacy of Sir John B. Gurdon

Nature Communications - Reversibility, regulation, and the community of development: the legacy of Sir John B. Gurdon

Nature Communications - Reversibility, regulation, and the community of development: the legacy of Sir John B. Gurdon

President Trump’s immigration crackdown ensnared Kseniia Petrova, a scientist who fled Russia after protesting its invasion of Ukraine. She fears arrest if she is deported there.

Kseniia Petrova was returning to the US from a trip to France when officials revoked her visa and detained her

Kseniia Petrova has been in U.S. detention since mid-February after having her visa revoked, according to friends and independent Russian media

Kseniia Petrova has been in U.S. detention since mid-February after having her visa revoked, according to friends and independent Russian media

The expansion of the neocortex is a hallmark of human evolution and is closely linked to neural stem cell biology. Yet, the epigenetic mechanisms driving divergent gene regulation during primate neuro...

Evolution of developmental mechanisms, especially axial patterning. Experimental embryology. 🪸🪼

This study investigates how reprogramming success in vivo varies across cell types, revealing that gene expression of the previous somatic cell identity hinders proper differentiation. By following si...

Directed migration of single cells is central to a large number of processes in development and adult life. Corrections to the migration path of cells are often characterized by periodic loss of polar...

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Abstract. Progressing transcription and replication machineries profoundly impact their underlying chromatin template. Consequently, transcription-replicat

Losing parental histones during DNA replication fork passage challenges differentiation competence and cell viability.

In a world beset by attempts to undermine scientific evidence and evidence-based policy, we emphasize their important role in helping humanity rise to the challenges of our time.

We reflect on what science tells us about the importance of diversity.

Transcription initiation limits histone acetylation and H2AZ incorporation at promoters.