RNA degradation is linked to cellular metabolism, but the underlying mechanisms are not fully understood. Here, the authors show that the glycolytic metabolite fructose 1,6‑bisphosphate inhibits PNPas...

Nishimoto et al. experimentally evolve bacteria during infection, revealing a ribosomal “crash and reboot” strategy as a mechanism of antibiotic tolerance. Mutations in the RNA degradosome allow RNA t...

We are excited to present our recent research published in PNAS in collaboration with the Yap lab from Northwestern. Congrats to Jacob Mattingly who led our structural biology efforts and Anna Lipońsk...

Issue #11

L’université de Strasbourg applique déjà en partie la majoration des frais d’inscription pour les étudiants étrangers non européens, que le gouvernement voudrait généraliser. Cinq d’entre eux racontent leurs difficultés à s’acquitter des 3 941 euros demandés et leur crainte de devoir renoncer à leur parcours.

The Erm rRNA methyltransferase superfamily represents the most prevalent determinant of MLS resistance in nosocomial Gram-negative and Gram-positive bacteria. Previous studies have established that erm expression is primarily governed by upstream ribosome stalling peptide and the 5′ untranslated regions. Using the widespread S. aureus ermBL-ermB (ermB+) operon as a model system, we unexpectedly identified second-site mutations in purR that synergistically enhance MLS resistance in an ermB+ background. Loss of purR function derepresses nucleotide biosynthesis and ribosome production, thereby promoting bacterial growth under antibiotic stress. While numerous purR single-nucleotide polymorphisms across multiple species have been associated with antibiotic resistance, no study has directly linked these sequence polymorphisms to their regulatory function. Our results highlight the critical role of ribosome abundance and nucleotide metabolism in shaping antibiotic efficacy.

Kohl et al. combine high-resolution Ribo-seq and cryo electron microscopy to show that the bacterium Staphylococcus aureus uses extended Shine-Dalgarno motifs to initiate translation, which can m...

A quiet policy change means the government is making fewer bets on long-term science.

L’administration a mis à la porte un très grand nombre de scientifiques dans les agences fédérales. Celles et ceux qui restent se taisent et doivent censurer leurs travaux. Mais la mobilisation s’organise, avec une première mobilisation internationale vendredi 7 mars.