Abstract. Tumor cells commonly exhibit a preferential uptake of glutamine to support the heightened metabolic demands. However, the therapeutic potential of targeting glutamine metabolism is severely ...

Processing bodies (P-bodies) are cytoplasmic membrane-less organelles which host multiple mRNA processing events. While the fundamental principles of P-body organization are beginning to be elucidated...

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Kage et al. report a novel phosphorylation-dependent interaction between INF2 and VAP proteins. Increased cytoplasmic calcium stimulates INF2 phosphorylation, which, in turn, allows VAP binding. The I...

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Cell-state diversity drives tissue adaptability, repair, and disease resilience, but capturing this complexity is a challenge. Current approaches rely on transcriptional profiling and overlook organel...

High-throughput proteomics now spans several technologies that differ in biological breadth, precision, specificity, sensitivity, cost, and method(s) of quantification; however, investigators currentl...

A rapid autopsy programme provides valuable resources to enable detailed molecular and genetic analyses of the temporal evolution of aggressive histological subtypes and therapy resistance in metastat...

Radulovic et al. show that phosphatidylinositol 3-phosphate (PI3P), produced by the phosphatidylinositol 3-kinase PIK3C3, is formed on ER domains after lysosome damage. ER domain PI3P helps to recruit...

médecine/sciences (M/S), revue internationale dans le domaine de la recherche biologique, médicale et en santé

Whether annulate lamellae (AL) occur in normal somatic cells was an open question. Here, the authors demonstrate that AL drive nuclear pore complex assembly and nuclear expansion during G1, defining a...

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Zhou et al. found that phosphatidylserine (PS) regulates ER Ca2+ homeostasis by modulating IP3R-mediated Ca2+ release. Manipulating phospholipid composition through the phospholipid-SREBP axis normalizes IP3R-mediated Ca2+ release during PS deficiency.

Inflammatory bowel disease (IBD) is a chronic condition caused by altered cytokine signaling, maladaptive immunity, dysbiosis, and intestinal barrier dysfunction. Although current therapies aim to cor...