The Kapahi lab seeks postdocs to lead innovative projects exploring how circadian clocks & nutrient-responsive pathways influence eye & neuronal degeneration.

Researchers in Leeds have joined experts from across the world in warning that Earth is reaching the first of many climate tipping points that will cause catastrophic harm without urgent action.

In our new Understanding Ageing: Meet the Scientists series, we’ve invited experts in their field to talk about their research and what it means for each of us as we get older. You don’t need any scie...

This EMBO Workshop on C. elegans Biology is t he IV Latin American Worm Meeting. It will convene in Mérida, Mexico. The overall mission of this meeting is to create an inclusive environment that pro…

The Max Perutz Labs - one of Europe’s leading institutes for basic research in the life sciences - invite applications for a Full Professorship in Molecular Mechanisms of Disease. We are seeking outst...

Mauthe et al. find that protein aggregate clearance requires fragmentation of the aggregate by a chaperone module and a proteasomal regulatory particle for recruitment and clustering of selective auto...

We are recruiting Programme Leader Track positions focusing on 1) Metabolic Physiology using murine and/or human in vivo models and 2) Immunometabolism.

Li et al. uncover a lysosomal surveillance response whereby intestinal lumen deacidification induces a transcriptional programme that boosts lysosomal activity and improves protein aggregate clearance...

RNA splicing enables the functional adaptation of cells to changing contexts. Impaired splicing has been associated with diseases, including retinitis pigmentosa, but the underlying molecular mechanis...

Harasimov, Gorry, Welp, Penir, Horokhovskyi et al. analyse proteostasis in mammalian oocytes and ovaries: the maintenance of oocytes involves exceptional protein longevity, and many of the extremely l...

High mutational load tumors mitigate effects from protein-damaging mutations by up-regulating complexes that buffer against misfolding stress, revealing therapeutic vulnerabilities and suggesting disr...

Supporting internationally mobile postdoctoral researchers in Europe and around the world

Join a global community of excellence Karolinska Institutet, Department of Cell and Molecular Biology Are you a bold, creative researcher ready to shape the future of medical science? Karolinska Insti

Chou et al. generate transdifferentiated human neurons from fibroblasts from young or aged individuals and patients with Alzheimer’s disease. Studies of endolysosomes and proteostasis suggest a role f...

There have been 8,064 reported cases of whooping cough in the U.S., compared with 3,835 for the same time in 2024, according to CDC data.

Welcome to the 2025 joint “Autophagy UK and Proteostasis UK” conference!

Cells constantly surveil and monitor their proteome to ensure proper function. These processes, spanning multiple steps from protein synthesis to folding and degradation, are collectively known as pr…

A symposium marking the contributions of Len Stephens and Phillip Hawkins

Study in mice and human cadavers hints that a brain-protective gene in the chromosome becomes more active with age.