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Eachan Johnson

@eachan.scbir.org
178 followers 209 following 16 posts

Group leader at The Francis Crick Institute in London. Opinions are my own. he/him 🦠 M. tuberculosis, K. pneumoniae, other pathogenic bacteria 🧫 antimicrobial resistance 🧬 molecular genetics ⚗️ chemical biology

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Reposted by Eachan Johnson
Matt Fuchter @fuchtermatt.bsky.social · 09/04/2026
Come and join my group at @oxfordchemistry.bsky.social! We have an opening for a postdoc position in photopharmacology. Prior experience with photoswitches and photopharmacology essential. Deadline 27th April. For more details see my.corehr.com/pls/uoxrecru... #Chemsky
my.corehr.com
Job Details
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Eachan Johnson @eachan.scbir.org · 07/04/2026
We're hiring a Postdoctoral Fellow! How does Mycobacterium tuberculosis survive drug treatment? You'll use molecular genetics and single-cell approaches to investigate how gene expression variability drives drug-tolerant subpopulations. Full details and application instructions below.
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Derek Lowe @dereklowe.bsky.social · 23/03/2026
The latest AI/ML tools for co-folding proteins around small molecule ligands can produce impressive results. Until you start looking at them closely.
science.org
AI-Predicting Compound Affinity. We Aren't There Yet.
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Parise Lockwood @lockwop.bsky.social · 14/03/2026
Very excited to share our recently published work on NTM and their response to acid stress! As my first paper, I’m especially grateful for the support and guidance from @luizcarvalholab.bsky.social , Rachel and @maxgg.bsky.social . More to come!
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Prof Tanya Parish @proftanya13.bsky.social · 19/02/2026
Are you interested in being the first biologist in our new team? Come join our small but growing group. Deadline for applications is 3rd March. #Tuberculosis 🧪🦠 #TBDrugDiscovery
app.vacancy-filler.co.uk
Technical Programme Manager | Liverpool School of Tropical Medicine
Technical Project ManagerLocation: LiverpoolContract: Fixed-term contract until March 2028Salary: £47,389 - £59,967The Parish Lab at the Liverpool School of Tropical Medicine focuses on antimicrobial ...
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Borden Lacy @bordenlacy.bsky.social · 18/02/2026
I am happy to share our recent publication in @nature.com on a mucosal immunization strategy that clears C. difficile colonization in mice. Congratulations to Audrey Thomas, lead author on the work. www.nature.com/articles/s41...
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Eachan Johnson @eachan.scbir.org · 17/02/2026
📢 4-year PhD position in my lab at @crick.ac.uk Using active learning & chemical genomics to find new antibiotics with new targets in pathogenic bacteria. Looking for: chemistry / chem bio / comp bio / micro backgrounds with coding interest. Deadline 17 March. www.crick.ac.uk/careers-stud...
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Eachan Johnson @eachan.scbir.org · 04/02/2026
I’m looking forward to this incredible opportunity to advance the science of antibiotic discovery with the Gr-ADI consortium.
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Martin Steinegger 🇺🇦 @martinsteinegger.bsky.social · 30/01/2026
FoldMason is out now in @science.org. It generates accurate multiple structure alignments for thousands of protein structures in seconds. Great work by Cameron L. M. Gilchrist and @milot.bsky.social. 📄 www.science.org/doi/10.1126/... 🌐 search.foldseek.com/foldmason 💾 github.com/steineggerla...
science.org
Multiple protein structure alignment at scale with FoldMason
Protein structure is conserved beyond sequence, making multiple structural alignment (MSTA) essential for analyzing distantly related proteins. Computational prediction methods have vastly extended ou...
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Tracy Palmer @proftracypalmer.bsky.social · 23/01/2026
www.findaphd.com/phds/project... interested in bacterial antagonism? PhD opportunity in our team, see below. Please repost!
findaphd.com
Characterising antibacterial toxins in the food-borne pathogen Listeria monocytogenes at Newcastle University on FindAPhD.com
PhD Project - Characterising antibacterial toxins in the food-borne pathogen Listeria monocytogenes at Newcastle University, listed on FindAPhD.com
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Guillaume Thibault @gthibault.bsky.social · 17/01/2026
We’ve discovered how the superbug E. faecalis prevents chronic wounds from healing. It’s not a toxin. It’s metabolism. The bacteria use extracellular electron transport (EET) to electrochemically generate ROS, effectively "freezing" skin cells in place. doi.org/10.1126/sciadv.aeb5297
doi.org
Enterococcus faecalis redox metabolism activates the unfolded protein response to impair wound healing
E. faecalis EET generates ROS, which induces the UPR in keratinocytes, inhibiting in vitro migration.
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Heng Li @lh3lh3.bsky.social · 14/01/2026
I am looking for a postdoc to develop high-performance algorithms in computational genomics. Email or DM me if interested. For more information, see hlilab.github.io/vacancies. RTs appreciated!
hlilab.github.io
HLi Lab - Vacancies
Openings
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pen(Taka) @iwatobipen.bsky.social · 10/01/2026
Collaboration of AI and wet experiments with high thoughput technology is the one of solution IMHO.
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Luiz Pedro Carvalho, PhD @luizcarvalholab.bsky.social · 22/12/2025
We’re excited to share our latest study that reshapes our understanding of Mycobacterium tuberculosis (Mtb) lipid composition, with major implications for drug discovery, immunity, and vaccine development. www.nature.com/articles/s41... A thread.
nature.com
Mycobacterium tuberculosis overcomes phosphate starvation by extensively remodelling its lipidome with phosphorus-free lipids - Nature Communications
Here, the authors show that Mycobacterium tuberculosis manipulates lipid metabolism to overcome host restriction, by remodelling its lipidome and utilising host lipids as an alternative phosphate sour...
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Michel Nivard @michelnivard.bsky.social · 20/12/2025
"Across the highest adult performance, peak performance is negatively correlated with early performance" Is uite literally what you'd see if coliderbias:
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Zamin Iqbal @zaminiqbal.bsky.social · 20/12/2025
@peterfineran.bsky.social and colleagues develop Tn-seq for phages by leveraging anti-CRISPR (Acr) as a positive selectable marker in the presence of CRISPR-Cas counter-selection, and identify essential genes in phage from non model orgs www.biorxiv.org/content/10.6...
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Carolyn Bertozzi @carolynbertozzi.bskyverified.social · 20/12/2025
Multidisciplinary training, over time, produces the highest impact people www.science.org/doi/10.1126/...
science.org
Recent discoveries on the acquisition of the highest levels of human performance
Scientists have long debated the origins of exceptional human achievements. This literature review summarizes recent evidence from multiple domains on the acquisition of world-class performance. We re...
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Science X / Phys.org @sciencex.bsky.social · 28/11/2025
Light-activated metal complexes have been shown to disable antibiotic resistance enzymes in E. coli, significantly enhancing the effectiveness of existing antibiotics without harming human cells. doi.org/hbcxrb
phys.org
How phototherapy could reverse antibiotic resistance
Lars Stevens-Cullinane works in a dark room. But he's not processing negatives and printing photographs on light-sensitive paper; he's testing whether brief flashes of light can make drug-resistant bacteria sensitive to antibiotics.
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Hannah Long @hannahlong.bsky.social · 10/11/2025
📣 Paper alert! I am delighted that our paper exploring the impact of Neanderthal-derived variants on the activity of a disease-associated craniofacial enhancer has been published in Development today! journals.biologists.com/dev/article/...
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Eachan Johnson @eachan.scbir.org · 01/11/2025
🚨Deadline for our Senior Scientist applications is next week. If you want to develop your academic career in London and help us tackle next-generation drug discovery for Gram-negative infections, apply!
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The Francis Crick Institute @crick.ac.uk · 27/10/2025
Crick group leaders work across disciplines, supported by core funding and mentoring to build ambitious, curiosity-driven research. Apply now to join us ➡️ www.crick.ac.uk/careers-stud...
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The Francis Crick Institute @crick.ac.uk · 30/10/2025
Just a few weeks left to apply for our clinical PhD programme. We're looking for clinicians who are passionate about research to join the 3-year fully funded programme. Learn more and see what positions are available ⬇️ www.crick.ac.uk/careers-and-...
crick.ac.uk
Doctoral clinical fellows
The Crick's clinical PhD programme.
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Eachan Johnson @eachan.scbir.org · 24/10/2025
📢 We're searching for a PhD-level Senior Research Scientist to develop a next-generation antibacterial drug discovery strategy for Gram-negative infections. If you're looking to combine CRISPRi and high-throughput assays, reach out to me by email or apply below. www.linkedin.com/jobs/view/43...
linkedin.com
The Francis Crick Institute hiring Senior Laboratory Research Scientist in London Area, United Kingdom | LinkedIn
Posted 2:43:22 PM. Senior Laboratory Research Scientist - Johnson LabDetails of the role:Reports to: Eachan Johnson…See this and similar jobs on LinkedIn.
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Eachan Johnson @eachan.scbir.org · 09/10/2025
Join our community of more than 120 ambitious research programmes in infectious disease, chemical biology, and many other areas of biomedicine - all under one roof with fantastic facilities and support.
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Tom Scriba @tomscriba.bsky.social · 09/10/2025
We are inviting applications for postdoctoral fellows in immunology of TB at the South African Tuberculosis Vaccine Initiative, University of Cape Town. For more information see the attached ad: idm.uct.ac.za/media/739223
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Shabaana Khader @khadershabaana.bsky.social · 05/10/2025
Dear #microbiology and #immunology community- I took a break from social media after I deleted my Twitter account, but am back here. Please help me rebuild my community by following me and amplifying this message- I will follow you back. Thank you and I look forward to our many interactions!
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David Tobin @tobinlab.bsky.social · 06/10/2025
Important piece from Sarah Stanley at Berkeley on new NIH definitions that can be construed to arbitrarily halt research that is both safe and important to public health and future cures www.statnews.com/2025/10/06/g... via @statnews.com
statnews.com
The NIH ordered me to stop my ‘dangerous’ gain-of-function research. It isn’t dangerous at all
Safe gain-of-function research is necessary to identify new treatments for diseases like for tuberculosis — but the NIH has imposed unfounded stops.
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Jeannine Hess @jeanninehess.bsky.social · 23/09/2025
🧪 Excited to share our new work on reactive metallo-scaffolds (r-mS)! We combine metal complexes with chemoproteomics to discover new liganding sites across the proteome! Shout out to a great collaboration with GSK! Fantastic team effort 🫶🏻 chemrxiv.org/engage/chemr...
chemrxiv.org
Proteome-Wide Target Identification Using Reactive Metallo-Scaffolds (r-mS): A Platform for Metallodrug Discovery
Metal complexes offer unique opportunities as scaffolds in chemical biology and drug discovery, with tuneable geometry, modular coordination environments, and structural features not readily accessibl...
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Eachan Johnson @eachan.scbir.org · 06/10/2025
📢 PhD Opportunity @crick.ac.uk Want to help fight against antimicrobial resistance? Join us in London! Open to international applicants. We have non-clinical & clinical PhD positions to accelerate antibiotic discovery across bacterial species. November deadlines. More details ⬇️🧵
crick.ac.uk
PhD students
Our PhD programme attracts the brightest scientific minds and is an opportunity for talented people to embark on their career in biomedical research.
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David Balchin @davidbalchin.bsky.social · 19/09/2025
Our article on human multidomain protein biogenesis is now published in @natsmb.nature.com www.nature.com/articles/s41...
nature.com
The human ribosome modulates multidomain protein biogenesis by delaying cotranslational domain docking - Nature Structural & Molecular Biology
By studying dynamic folding intermediates on the human ribosome, Pellowe et al. show that newly made domains help each other to fold but do not stably interact until synthesis is complete, avoiding in...
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Rashmi Priya @rashmi-priya.bsky.social · 19/09/2025
Development does not happen in isolation! Material properties, geometry, stiffness, fluid flows...can all steer how development unfolds. If you’re exploring these kinds of questions, we’d love to see your work @dev-journal.bsky.social More info below ⬇️
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Cell - a Cell Press journal @cp-cell.bsky.social · 15/09/2025
Now online! Mining the CD4 antigen repertoire for next-generation tuberculosis vaccines
dlvr.it
Mining the CD4 antigen repertoire for next-generation tuberculosis vaccines
Systematic antigen selection is an enduring challenge in tuberculosis (TB) vaccine development. An antigen screen ranks protective CD4 T cell antigens and yields a novel trivalent mRNA vaccine that protects against TB challenges in mice.
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Ashley Ringer McDonald @aringermcdonald.bsky.social · 17/09/2025
Be my colleague! Cal Poly San Luis Obispo is hiring two tenure-track positions for Fall 2026, chemical education and coatings technology. Chen Ed: jobs.calpoly.edu/en-us/job/55... Coatings: jobs.calpoly.edu/en-us/job/55...
jobs.calpoly.edu
Cal Poly - Details - Tenure Track Position - Chemistry
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John Lees @johnlees.bacpop.org · 17/09/2025
The EMBL PhD programme is open until 13th October (entry ~Sep 2026): www.embl.org/about/info/e... We have three positions in microbial genomics at EMBL-EBI, including one in my group. Please do apply, or if you know anyone that would be interested pass on to them
embl.org
EMBL International PhD Programme – Unique in the world and waiting for you!
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Polly Fordyce @pollyfordyce.bsky.social · 17/09/2025
Please apply to our tenure-track faculty position at @stanford-chemh.bsky.social! We are searching for a new colleague working at the interface between computation and molecular sciences. See post below and pls forward widely! chemh.stanford.edu/opportunitie...
chemh.stanford.edu
Faculty Recruitment
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Cara Boutte @caraboutte.bsky.social · 16/09/2025
My institution is looking to hire a new microbiologist: apply.interfolio.com/173702. Please share, and let me know if you have any questions about the position or UTA.
apply.interfolio.com
Apply - Interfolio {{$ctrl.$state.data.pageTitle}} - Apply - Interfolio
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Matthew Saunders @mjsaunder.bsky.social · 10/09/2025
So...what would happen to the global TB epidemic if we hypothetically "eliminated" undernutrition? In this preprint, we combined estimates from our new review (doi.org/10.1093/ije/...) with population-specific BMI distributions to find out...(doi.org/10.1101/2025...)
doi.org
Global, regional, and national estimates of tuberculosis incidence averted by eliminating undernutrition in adults: a modelling study
Background Current efforts to reduce global tuberculosis incidence have proved insufficient, highlighting that urgent action is needed to address underlying modifiable risk factors such as undernutrit...
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pen(Taka) @iwatobipen.bsky.social · 26/08/2025
How to make training data from tacit knowledge in medicinal chemistry is one of the big challenges.
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Emmanuele Severi @emmseveri.bsky.social · 22/08/2025
www.nature.com/articles/s41... #microsky
nature.com
Discovery of a widespread chemical signalling pathway in the Bacteroidota - Nature
The N-acyl-cyclolysine system regulates the expression of co-localized operons encoding diverse secreted molecules in Bacteroidota.
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Henrik Strahl @henrikstrahl.bsky.social · 22/08/2025
A new methods paper from us, this time with a focus on reliable monitoring membrane potential and cell lysis at different growth stages and cell densities. Also, note the surprisingly high level of background lysis in seemingly healthy B. subtilis cultures. www.biorxiv.org/content/10.1...
biorxiv.org
Monitoring single cell bioenergetic status and cell lysis in dense and differentiating Bacillus subtilis cultures
Bacillus subtilis is a major model organism for studying population heterogeneity in clonal bacterial cultures due to its high genetic tractability and ability to differentiate into subpopulations wit...
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Sateriale Lab @saterialelab.bsky.social · 20/08/2025
Now available in a polished format! An important step toward accelerated functional genomics for the Cryptosporidium parasite. Brought to you by the incomparable @lucy-watson.bsky.social www.nature.com/articles/s41...
nature.com
Targeted CRISPR screens reveal genes essential for Cryptosporidium survival in the host intestine - Nature Communications
Cryptosporidium is an important threat to public health, yet it lacks a robust genetic toolkit. Here, Watson et al. introduce a targeted CRISPR-based screening method to identify parasite genes that a...
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Jen Herman 🌪️ @jukebarosh.bsky.social · 16/08/2025
My Friday night hot take is that replication studies are largely a waste of time & $ If a result is worth following up on, it's better to address from a different angle & see if it holds water. Strong ideas withstand this Conversely, there R infinite ways a replication can fail that teach you zip
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Stephan Hacker @stephanhacker2.bsky.social · 10/08/2025
Are you excited about using cyclic #peptides in #DrugDiscovery? Here is a great opportunity to perform a #postdoc with a great mentor in the group of @ljwalport.bsky.social at @imperialcollegeldn.bsky.social! www.linkedin.com/posts/louise... #ChemBio #Chemistry #ChemSky
linkedin.com
🚨 Looking for a new research opportunity?🚨 | Louise Walport
🚨 Looking for a new research opportunity?🚨 We are looking to recruit two talented postdocs to join our group based at the Molecular Science Research Hub at Imperial College London: - Both to join ou...
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Sean Gibbons 🦠💩 @gibbological.bsky.social · 24/07/2025
Interesting work on characterizing steroid-modifying enzymes in commensal gut bacteria: "Identification of gut bacteria reductases that biotransform steroid hormones" www.nature.com/articles/s41...
nature.com
Identification of gut bacteria reductases that biotransform steroid hormones - Nature Communications
Here, the authors identify and characterize three gut bacterial enzyme families that metabolize endogenous and synthetic steroid hormones, showing to act on diverse substrates, to exhibit gene fusions...
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Mireille Kamariza @kamariza.bsky.social · 25/06/2025
Working link here! www.biorxiv.org/content/10.1...
biorxiv.org
Tre-DST: A new drug susceptibility test for Mycobacterium tuberculosis using solvatochromic trehalose probes
Tuberculosis (TB) is the most lethal cause of death from a single infectious agent. In 2024, an estimated 10 million people developed TB, nearly half a million of which were infected with drug-resista...
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bishara marzook @ghostpathogen.bsky.social · 24/07/2025
Our paper has finally graduated from pre-print to peer-reviewed, pretty much unscathed, and is out now! www.cell.com/cell/fulltex...
cell.com
The essential host genome for Cryptosporidium survival exposes metabolic dependencies that can be leveraged for treatment
An arrayed microscopy-based CRISPR screen revealed host genes affecting multiple infection phenotypes of the intracellular parasite Cryptosporidium. Hits in the host cholesterol biosynthesis pathway a...
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Eachan Johnson @eachan.scbir.org · 24/07/2025
Cool to see this elegant approach finally pre-printed!
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Jeannine Hess @jeanninehess.bsky.social · 24/07/2025
📣Preprint 📣 You want to degrade a protein in Gram-negatives? We have tackled this challenge! Detailed study of our Light-Activated Metal-Dependent Protein Degradation LAMP-D system in targeting and rescuing NDM-1 activity. What an amazing team effort 🫶🏻 doi.org/10.26434/che...
doi.org
Light-Activated Metal-dependent Protein Degradation (LAMP-D): A Heterobifunctional Ruthenium(II) Photosensitizer Targeting New Delhi Metallo-β-lactamase 1
The growth of antimicrobial resistance (AMR) is a significant global health threat, yet despite this alarming trend, antibiotic drug discovery has significantly slowed. Most compounds entering the cli...
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Alexandre Hofer @hofalex.bsky.social · 24/07/2025
Imagine a small molecule that degrades a target protein like PROTACs, but does so independently of any of the host cell's degradation machinery, so you can go and do targeted protein degradation in gram-negative bacteria: doi.org/10.26434/che...
Light-Activated Metal-Dependent Protein Degradation (LAMP-D)
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Ash Jogalekar @ashjogalekar.bsky.social · 27/05/2025
New post: The age of the undruggable is over. The age of the unassayable is here. medchemash.substack.com/p/the-age-of...
medchemash.substack.com
The age of the undruggable is over
The age of the unassayable is here
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