iiinova — where your digital self keeps evolving

Jeannine Hess @jeanninehess.bsky.social · 18/02/2026

🚨 Come and join the team! I have a 4-year PhD position available at The Francis Crick Institute. 🧪 You'll build on our LAMP-D technology to design metal-based molecules to develop new therapeutic strategies. Application deadline: 17 March. www.crick.ac.uk/careers-stud...

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Reposted by Jeannine Hess

The Francis Crick Institute @crick.ac.uk · 11/02/2026

Watch as Crick researchers @jeanninehess.bsky.social and Lars Stevens Cullinane take you inside their red-lit lab, where they explain how they’re developing a tool that could help fight back against the increasing threat of antimicrobial resistance. youtu.be/FhLg3q_vz1U

youtu.be

This Powder Could Rescue Antibiotics

YouTube video by The Francis Crick Institute

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Jeannine Hess @jeanninehess.bsky.social · 13/10/2025

📣Fully-funded 4-Year PhD available in my lab! Join the team to shape the future of metal-based antibiotic drug discovery. Application deadline 5th of November! Spread the word www.crick.ac.uk/careers-stud...

crick.ac.uk

Hess Lab | Metal-based Heterobifunctional Scaffolds to Capture Challenging Proteins

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Reposted by Jeannine Hess

The Francis Crick Institute @crick.ac.uk · 07/10/2025

2026 PhD recruitment is now open. As well as our main PhD recruitment, which is open to all, we are pleased to be offering scholarships for candidates of Black or mixed Black heritage. Learn more and apply on our website: www.crick.ac.uk/careers-stud...

crick.ac.uk

PhD student recruitment

PhD recruitment information.

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Reposted by Jeannine Hess

Eachan Johnson @eachan.scbir.org · 06/10/2025

📆 Deadline: 14 November. 🩺 Doctoral Clinical Fellows programme (3-year PhD) 🤝 Exciting collaboration with the amazing @jeanninehess.bsky.social Curating bioactive chemical space in pathogenic bacteria using accumulation signatures across species ✍️ Apply here: www.crick.ac.uk/careers-stud...

crick.ac.uk

Johnson lab and Hess lab | Curating bioactive chemical space in pathogenic bacteria using accumulation signatures across species

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Jeannine Hess @jeanninehess.bsky.social · 23/09/2025

🧪 Excited to share our new work on reactive metallo-scaffolds (r-mS)! We combine metal complexes with chemoproteomics to discover new liganding sites across the proteome! Shout out to a great collaboration with GSK! Fantastic team effort 🫶🏻 chemrxiv.org/engage/chemr...

chemrxiv.org

Proteome-Wide Target Identification Using Reactive Metallo-Scaffolds (r-mS): A Platform for Metallodrug Discovery

Metal complexes offer unique opportunities as scaffolds in chemical biology and drug discovery, with tuneable geometry, modular coordination environments, and structural features not readily accessibl...

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Reposted by Jeannine Hess

Alexandre Hofer @hofalex.bsky.social · 24/07/2025

Imagine a small molecule that degrades a target protein like PROTACs, but does so independently of any of the host cell's degradation machinery, so you can go and do targeted protein degradation in gram-negative bacteria: doi.org/10.26434/che...

Light-Activated Metal-Dependent Protein Degradation (LAMP-D)

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Jeannine Hess @jeanninehess.bsky.social · 24/07/2025

📣Preprint 📣 You want to degrade a protein in Gram-negatives? We have tackled this challenge! Detailed study of our Light-Activated Metal-Dependent Protein Degradation LAMP-D system in targeting and rescuing NDM-1 activity. What an amazing team effort 🫶🏻 doi.org/10.26434/che...

doi.org

Light-Activated Metal-dependent Protein Degradation (LAMP-D): A Heterobifunctional Ruthenium(II) Photosensitizer Targeting New Delhi Metallo-β-lactamase 1

The growth of antimicrobial resistance (AMR) is a significant global health threat, yet despite this alarming trend, antibiotic drug discovery has significantly slowed. Most compounds entering the cli...

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Jeannine Hess @jeanninehess.bsky.social · 13/03/2025

🚨Less than a week left to apply (deadline 19/03/25) for this exciting fully funded 4 Year Phd position in my group. Multidisciplinary project on the design of novel metallo-NBTIs including all the fun of chemistry and much more! Please RT! Apply here: www.crick.ac.uk/careers-stud...

crick.ac.uk

Hess Lab | Metal-based Heterobifunctional Scaffolds to Capture Challenging Proteins

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