The proposal, which would have given President Donald Trump greater influence over health grant decisionmaking, could still advance in a new form.

Combinatorial pairing of independently recombined T cell receptor (TCR) α- and β-chains is central to diversifying the TCR repertoire. Although sequence motifs in one chain correlate with epitope reco...

Emerging evidence indicates the functional importance of the thymus in adult health and may influence oncological outcomes, yet current radiotherapy (RT) practice does not consider the thymus as an or...

ALT: Simpsons: Homer and Bart Say 'Join Us'

YouTube video by Endless Frontier Film

The Office of Management and Budget (OMB) proposes to revise the Guidance for Federal Financial Assistance to improve government- wide policies and requirements related to the management of grants, co...

The role of non-infiltrating aged CD8+ T cells in brain function remains unclear. Sucharov et al. reveal that aged circulating cytotoxic T cells are drivers of age-related cognitive decline. Removal of aged T cells, or their secreted factor granzyme K, rescues cognition in mice. These findings have promise for therapeutics that target immune factors in circulation to restore brain function.

A raft of research is recasting the thymus from a bit player to a potent regulator of aging and immune health.

Interactions with haematopoietic and stromal cells in the thymus are essential for T cell development. Here, the authors develop an unbiased genetic system based on synthetic Notch receptors to label ...

New landmark studies using AI to determine thymus health and its link to major outcomes

It was thought that the thymus serves its purpose for the immune system early in life. Insights about the organ in adults reveal its importance for later well-being.

Interactions with haematopoietic and stromal cells in the thymus are essential for T cell development. Here, the authors develop an unbiased genetic system based on synthetic Notch receptors to label ...

Nature - Ontogeny and transcriptional regulation of Thetis cells

CD44 expressed by fibroblastic reticular cells in secondary lymphoid organs regulates trafficking of dendritic cells, and thus has an essential role in the priming of T cells and the adaptive immune r...

Using lipid nanoparticle delivery of mRNAs to the liver in aged mice, T cell function and declining immune cues can be restored.

A quiet policy change means the government is making fewer bets on long-term science.