iiinova — where your digital self keeps evolving

Jarrod Dudakov @dudakov-lab.bsky.social · 09/10/2026

But really, email is my Achilles heal. I did like this paragraph from the article:

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Jarrod Dudakov @dudakov-lab.bsky.social · 09/10/2026

I see myself in this article and I don’t like it.

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Jarrod Dudakov @dudakov-lab.bsky.social · 23/07/2026

Second Annual Dudakov Summer Lab Olympics in the bag. Challenges included: calculations of solute concentration; speed BSL2 PPG dressing; read the tiny hidden text under the microscope; blindfolded pipetting; and Gatorade mouth pipetting. Great day and amazing organization by Emma Lederer.

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Jarrod Dudakov @dudakov-lab.bsky.social · 13/06/2026

Hard for me to believe but we had a beach day to celebrate the labs 10th anniversary (and promotion to full Professor). What a fantastic group of people (past and present) who have made it possible!

Cake saying 10 years with a drawing of a mouse.

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Jarrod Dudakov @dudakov-lab.bsky.social · 19/10/2025

Coming out of retirement for just one last epic score.

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Jarrod Dudakov @dudakov-lab.bsky.social · 18/10/2025

Amazing that one guy in Portland could start a movement.

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Jarrod Dudakov @dudakov-lab.bsky.social · 11/09/2025

Moreover, despite the increase in IFNg, we also found that thymic epithelial cells (TECs) actually decreased their MHCI expression after damage, making them vulnerable to NK-mediated killing. Given the central importance of TECs for all thymic function, their killing after damage inhibits repair.

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Jarrod Dudakov @dudakov-lab.bsky.social · 11/09/2025

But to our surprise, although upregulated in response to IL-18, this inhibitory effect was not mediated by IFNg. Instead, both perforin and granzyme could limit thymic regeneration, but only perforin was regulated by IL-18.

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Jarrod Dudakov @dudakov-lab.bsky.social · 11/09/2025

Using a slew of mouse strains and assays including imaging, single-cell sequencing, parabiosis, and more, David found that IL-18 released by hematopoietic (DC/macrophage) and non-hematopoietic (mesothelial) cells activated NK cells (but not ILC1) limiting repair via their cytotoxic function.

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Jarrod Dudakov @dudakov-lab.bsky.social · 11/09/2025

David found that indeed there was an activation of pro-inflammatory IL-1 and IL-18, and that this was not just a feature of ionizing radiation-induced injury but was a common response across a range of damage modalities including corticosteroid stress, LPS, and cytoreductive chemotherapy.

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Jarrod Dudakov @dudakov-lab.bsky.social · 11/09/2025

This has been a really fun one, not least of which because it was driven by our first bona fide graduate student, an incredibly talented MSTP student @david-granadier.bsky.social.

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Jarrod Dudakov @dudakov-lab.bsky.social · 10/06/2025

How on Earth is he still referred to as a vaccine skeptic? I think we are well beyond that now. www.nytimes.com/2025/06/09/h...

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Jarrod Dudakov @dudakov-lab.bsky.social · 03/06/2025

Great piece and highlights what we need to be making clearer.

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Jarrod Dudakov @dudakov-lab.bsky.social · 09/02/2025

This rings very true for me and my science awakening really. Realizing that this work we had published added a small (probably very small) but meaningful contribution to a chain of knowledge stretching back through human history was one of the most powerful - almost religious - experiences I’ve had.

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Jarrod Dudakov @dudakov-lab.bsky.social · 28/01/2025

Uh oh. www.statnews.com/2025/01/27/n...

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Jarrod Dudakov @dudakov-lab.bsky.social · 03/01/2025

Interested in T cells and where they come from? Then now is the perfect opportunity to register for ThymUS (www.thymusmeeting.org). Don't miss out on what is shaping up to be a fantastic meting in gorgeous Kauai.

Graphic showing information for the upcoming ThymUS meeting in Kauai April 27-May 1 (thymusmeeting.org)

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Jarrod Dudakov @dudakov-lab.bsky.social · 19/11/2024

Post a perfect album from the 90s that isn’t Nirvana, Pearl Jam, Soundgarden, or Alice in Chains.

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Jarrod Dudakov @dudakov-lab.bsky.social · 01/11/2023

Happy Halloween from the Dudakov Lab Muppets!

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Jarrod Dudakov @dudakov-lab.bsky.social · 15/09/2023

Wonderful day at Mayo Clinic Arizona visiting Drs. Lancaster, Maharlooei, Borges da Silva and other superstars. 🔥Immunology program they have built in the desert - and I'm told only a balmy 98 degrees today!

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