Interactions with haematopoietic and stromal cells in the thymus are essential for T cell development. Here, the authors develop an unbiased genetic system based on synthetic Notch receptors to label ...

Chemotherapy-induced WNT ligand secretion by bone marrow (BM) stroma drives acute lymphoblastic leukaemia (ALL) chemoresistance. WNT pathway inhibition disrupts this cross-talk and restores therapeut....

Interactions with haematopoietic and stromal cells in the thymus are essential for T cell development. Here, the authors develop an unbiased genetic system based on synthetic Notch receptors to label ...

Allotransplantation provides a lifesaving treatment to hundreds of thousands of patients worldwide every year, including among others heart, kidney, liver and bone marrow (BM) transplants [1,2]. Yet, ...

Hematopoietic cells are mesodermal in origin and emerge through a highly regulated process known as endothelial-to-hematopoietic transition (EHT), which yields various hematopoietic progenitors 1,2 In...

Allotransplantation provides a lifesaving treatment to hundreds of thousands of patients worldwide every year, including among others heart, kidney, liver and bone marrow transplants1,2. Yet, thousand...

ASH Commits More than $12 Million to Address Research Threats

Use this form to share information with Nature’s news team, or to make suggestions for future coverage.

The biochemist introduced the first heel-prick tests for newborn babies in Spain, protecting infants from life-changing metabolic conditions.

Sickle Cell Disease (SCD) is a blood disorder affecting millions worldwide. Emerging evidence reveals that SCD pathophysiology increases risk of myeloid malignancies and hematopoietic stem cell (HSC) ...

Leukemia - A CADASIL NOTCH3 mutation leads to clonal hematopoiesis and expansion of Dnmt3a-R878H hematopoietic clones