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Complete, haplotype-resolved genome assemblies have provided unprecedented insight into the evolution of structurally complex, rapidly evolving regions of human genomes; however, population-scale pang...

Author summary Most of the genetic variants associated with complex traits are located outside genes, limiting functional interpretation. Genetic colocalisation helps identify candidate causal genes b...

A grounded take from the messy middle of an AI revolution

Cells adjust their proteome to environmental conditions, but it remains unclear whether the proteome can be transmitted from parents to offspring. This study analyses the intergenerational effects of dietary restriction in C. elegans and shows that maternal mTORC1 activity governs the transfer of ribosomes, thereby modulating early growth and development.

Background The ability to deposit histone H3K27-trimethyl (me3) marks is essential for transcriptional repression by Polycomb Repressive Complex 2 (PRC2). This is largely attributed to Polycomb repres...

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Genome-wide association studies have identified thousands of intergenic variants associated with disease, most of which are presumed to act by affecti…

Abstract. CX-5461 (CX) is under investigation for the treatment of late-stage cancers. While CX was first described as an RNA polymerase I inhibitor, it ha

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The Department of Biochemistry and Molecular Biology at UTMB Health invites applications for multiple tenure-track positions at all ranks; assistant,

The University of Chicago is a private, nondenominational, culturally rich and ethnically diverse coeducational research university located in Hyde Park, Chicago.

An Intuitive Primer on Effective Functional Genomic Study Design by Yoav Gilad addresses the unique challenges of designing experiments in the rapidly evolving field of functional genomics. Unlike tra...

Abstract. Inflammation has enduring impacts on organismal immunity. However, the precise mechanisms by which tissue-restricted inflammation conditions syst

The purpose of this call for proposals is to meet the current moment by supporting timely, actionable health equity research that has been interrupted by shifts in federal funding.

In primates, loci associated with adaptive trait variation often fall in noncoding regions. Understanding the mechanisms linking these regulatory vari…