Here are some thoughts from the 2026 Sage Assembly, Sage Bionetworks comeback meeting tackling “Trust in the Machine: Verification, Agency, and the Future of Scientific Work.”

Abstract. Women faculty experience academia differently from men in many ways, which can lead them to consider leaving their positions. Using a large-scale

Professor Young and Professor Hirschman have come together to create a dataset to analyze all known fraternity infractions since 2008. They use this data to call for the restructuring of Greek Life in...

Timnit Gebru, one of the fiercest voices in the world speaking truth to power, chronicles her journey as a refugee and Black woman in STEM—deliveri...

Hasenhuetl et al. show that neurons innervating the dorsal fan-shaped body of Drosophila form a half-center oscillator, a circuit motif typically found in central pattern generators for locomotion. He...

Recent work suggests that psilocybin, a hallucinogenic 5-HT2AR agonist with rapid and long-lasting anti-depressant actions, facilitates fear extinction retention in adult rodents. However,…

Childhood adversity is robustly linked to differences in amygdala and hippocampal volume. However, findings across studies have been inconsistent and contradictory. This inconsistency stems partly fro...

A small pilot study found that a high dose of psilocybin strengthened an illusion in which a striped pattern looks fainter inside a bold ring. Low doses of LSD did not do the same, though participants still reported subtle changes in how the world looked.

Electrical synapses are expressed ubiquitously across the brain and are crucial components of active neural circuitry and connectomes. Identification of coupled networks in living tissue is limited by...

Dalbir Bindra (1922-1980) Dalbir Bindra, known widely as DB by his friends and colleagues, was an influential figure in the development of the Psychology Department at McGill. Like his brothers, he w...

Children living in areas with unhealthy levels of fine particulate matter or ozone showed smaller two-year gains in cognitive performance and brain maturation than demographically matched peers.

Ontario’s alcohol market overhaul has cut LCBO earnings, while a ban on selling U.S. liquor has left taxpayers paying millions to store unsold stock.

Stable single-neuron recordings are essential for understanding brain function and enabling future neurotechnologies. Here, the authors demonstrate that flexible polymer microelectrodes provide repeat...

ALT: Marvel Avengers: Oh, It's the End Times

Boone et al. delete a recursive exon in CADM2 to understand the role of recursive splicing (RS) and explain these deletions’ association with ADHD. RS loss alters intronic RNA abundance, impacts trans...

Neuropsychopharmacology - Psychedelics produce enduring enhancement of reward responsiveness in male rats

The large-conductance, Ca²+- and voltage-activated K+ (BK) channels are widely distributed in the central nervous system, where they play diverse roles in regulating brain activity. The γ1 (LRRC26) subunit functions as a potent activator of BK channels, inducing a large shift in the voltage dependence of channel activation toward the hyperpolarized direction. Given the large conductance of BK channels, their activators have therapeutic potential for various diseases. To investigate the impact of activator-induced hyperactivity of BK channels on brain function, we generated conditional hLRRC26 transgenic mice in which recombinant human LRRC26 is expressed in the forebrain under the control of the CaMKIIα promoter and the tetracycline Tet-Off system. Experiments included mice of both sexes and data were pooled, as no obvious sex-dependent effects were detected. Histological analysis following postweaning doxycycline withdrawal confirmed hLRRC26 expression in the forebrain, with strong expression in the hippocampus, isocortex, and striatum. Behavioral tests demonstrated that long-term hLRRC26 expression resulted in locomotor hyperactivity, cognitive deficits, and some anxiety- and depression-like behaviors. At 2–4 months of age, hLRRC26 transgenic mice exhibited significantly elevated locomotor activity, with increased movement distance in the open-field test, despite shorter strides in the footprint test. These mice also showed impaired learning performance in the water maze, novel object recognition, and rotarod tests compared with controls. At 12–14 months, transgenic mice continued to display locomotor hyperactivity and cognitive deficits. In conclusion, hLRRC26 transgenic mice demonstrated heightened locomotor activity and cognitive impairments, revealing potential ADHD-like neurological consequences of BK channel hyperactivity.

Xu, Sun, et al. show that neuropathic pain engages anterior cingulate outputs in stages in male mice. Amygdala-projecting neurons contribute to early mechanical hypersensitivity, whereas habenula-proj...

The 2026 Nobel Prize in Physiology or Medicine has been awarded jointly to Karl Deisseroth, Peter Hegemann and Georg Nagel “for discoveries leading to ...

Community members gathered to remember the more than 76,900 Palestinians killed by Israel since late 2023. Nearby, Hillel House, Chabad, and Israel on Campus held an event commemorating the victims of...