Boosting dopamine in healthy volunteers actually impaired the brain's ability to prioritize goal-relevant information, supporting the theory that dopamine disruption in psychosis may drive both negative and positive symptoms.
biologicalpsychiatryjournal.com
Dexamphetamine-induced striatal hyperdopaminergia attenuates reward-related neural activation: A11C-PHNO PET-fMRI study
Ventral striatum (VS) and ventromedial prefrontal cortex (vmPFC) encode the value of stimulus and outcome phases in a context-dependent manner to support motivated behaviour. In psychosis, disrupted…
