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PAIN

@painthejournal.bsky.social
422 followers 103 following 527 posts

PAIN is the official publication of the International Association for the Study of Pain (IASP). PAIN publishes original research on pain and provides a multidisciplinary forum for the dissemination of basic and applied pain research.

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PAIN @painthejournal.bsky.social · 16h
Van Diepen et al. find that pain affects over 50% of advanced pancreatic cancer patients and can be reduced by chemotherapy, highlighting the need for regular pain assessments and personalized management. Learn more in #PAIN bit.ly/4wPzsEg
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PAIN @painthejournal.bsky.social · 05/10/2026
Wu et al. find that melatonin may provide modest pain relief and improve sleep in chronic musculoskeletal pain, but evidence remains limited and supports its use as an adjunct rather than a primary treatment. Learn more in #PAIN bit.ly/4ik5O6e
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PAIN @painthejournal.bsky.social · 02/10/2026
In this week’s #PAIN Featured Image, massih.bsky.social et al. propose a model of the hippocampus in pain, where vulnerability factors converge on the hippocampus to shape its structure and function. Learn more at bit.ly/4ihZLz1
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PAIN @painthejournal.bsky.social · 01/10/2026
Chao et al. find that inhibiting monoacylglycerol lipase alleviates pain-induced depression and sensory hypersensitivity through distinct CB1 receptor mechanisms. Learn more in #PAIN bit.ly/4ik5QuS
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PAIN @painthejournal.bsky.social · 30/09/2026
Rau et al. assert that the diagnostic criteria included in the ICD-11 are ill-suited for diagnosing pediatric patients with chronic primary headache and propose implementing pediatric coding notes. Learn more in #PAIN bit.ly/4xdsv0H
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PAIN @painthejournal.bsky.social · 29/09/2026
@johnstreicher1 et al. find that inhibition of heat shock protein 90 (Hsp90) in mouse spinal cord leads to protein kinase C-β signaling in calcitonin gene-related peptide neurons, which mediates enhanced opioid antinociception. Learn more in #PAIN bit.ly/4wJC7iL
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PAIN @painthejournal.bsky.social · 28/09/2026
Lillo Vizin et al. find that experimental post-traumatic headache is selectively driven by trigeminal orexin B/orexin receptor 2 (OX2R) signaling in male mice. Learn more in #PAIN bit.ly/4xdRQYr
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PAIN @painthejournal.bsky.social · 25/09/2026
In this week’s #PAIN Featured Image, Su et al. illustrate trigeminal sensory pathways, with a focus on pain and proprioception. Learn more at bit.ly/4ik5NPI
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PAIN @painthejournal.bsky.social · 25/09/2026
In this week’s #PAIN Featured Image, Su et al. illustrate trigeminal sensory pathways, with a focus on pain and proprioception. Learn more at bit.ly/4ik5NPI
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PAIN @painthejournal.bsky.social · 24/09/2026
Roy et al. find that rhythmic visual stimulation elicited frequency-specific brain responses but did not alter thermal, laser, or electrical pain perception, regardless of frequency or duration. Learn more in #PAIN bit.ly/3UJ58xo
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PAIN @painthejournal.bsky.social · 23/09/2026
Start learning before Bangkok with recorded #IASP2026 Refresher Courses on pain research, clinical practice, policy & education.~$29/course for IASP members; $49 for non-members. Separate PERC registration: bit.ly/46tW02C #PainEducation
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PAIN @painthejournal.bsky.social · 23/09/2026
Miao et al. find that altered frontocentral theta and gamma oscillations are associated with knee osteoarthritis and may reflect central adaptations related to persistent pain. Learn more in #PAIN bit.ly/4ik5PXQ
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PAIN @painthejournal.bsky.social · 22/09/2026
Andres et al. find that increasing pain over time is associated with steeper rates of cognitive decline, but partly attenuated by sociodemographic and health variables, as shown by their large, nationally representative study. Learn more in #PAIN bit.ly/4xhoJn4
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PAIN @painthejournal.bsky.social · 21/09/2026
Pain Awareness Month Week 4: ADVANCE. Turn awareness into action through learning, collaboration & evidence sharing. Explore IASP's resources and share how you are advancing pain research, education or care: bit.ly/4zSCeLB #PainAwarenessMonth #IASP2026
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PAIN @painthejournal.bsky.social · 21/09/2026
Lambert et al. present dual-frequency spinal cord stimulation for chronic pain, a novel approach that exploits the Gate Control mechanism to improve responder rates over conventional stimulation. Learn more in #PAIN bit.ly/3TYKhGi
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PAIN @painthejournal.bsky.social · 18/09/2026
In this week’s #PAIN Featured Image, Hodges et al. outline a transparent process through which agreement on the definition of “central sensitization” may be achieved. Learn more at bit.ly/4xb0iYd
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PAIN @painthejournal.bsky.social · 17/09/2026
Madasu et al. identify a novel role for peripheral kappa opioid receptors in cold hypersensitivity associated with chemotherapy in a mouse model. Learn more in #PAIN bit.ly/4wE9XWc
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PAIN @painthejournal.bsky.social · 16/09/2026
Fialho et al. find that neuropilin-1 drives nerve growth factor-dependent sensitization in trigeminal nociceptors and oral cancer pain. Targeting neuropilin-1 blocks tumor-derived algogens, offering a safer, nonopioid therapeutic strategy #PAIN bit.ly/4wCwhzq
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PAIN @painthejournal.bsky.social · 15/09/2026
Zheng et al. find that somatosensory alpha neurofeedback alleviates tonic pain through dual pathways. Oscillation-to-network reorganization reduces sensory intensity, while performance-to-affect reinforcement alleviates unpleasantness. Learn more in #PAIN bit.ly/4ik5OmK
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PAIN @painthejournal.bsky.social · 14/09/2026
Nadinda et al. identify variations in the network structure of cognitive-affective-behavioral factors in individuals with chronic low back pain, indicating the need for a more personalized approach. Learn more in #PAIN bit.ly/4qb8Xr6
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PAIN @painthejournal.bsky.social · 11/09/2026
In this week’s #PAIN Featured Image, @khannalabuf.bsky.social et al. depict the computational pipeline converting the endogenous proresolving lipid maresin 1 into a stable small-molecule agonist of the satellite glial receptor GPR37L1. Learn more at bit.ly/4qqnBL0
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PAIN @painthejournal.bsky.social · 10/09/2026
Registration reopened. Additional seats are now available for the #IASP2026 Hands-On Workshop, Non-Invasive Neuromodulation for Pain, on 26 October in Bangkok, with hands-on rTMS & tDCS demonstrations. Additional registration required: bit.ly/3Svdg49 #PainEducation
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International Association for the Study of Pain - Hands-on Workshops
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PAIN @painthejournal.bsky.social · 10/09/2026
Gungormus et al. find that the type of everyday acoustic environment significantly influences clinical and experimental pain in individuals with fibromyalgia syndrome, with urban sound exposure associated with greater pain. Learn more in #PAIN bit.ly/3ShwZ7a
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PAIN @painthejournal.bsky.social · 09/09/2026
Jenkins et al. report that psychological factors partly explain progression from acute low back pain to future disability, identifying pain self-efficacy as the dominant mediator. Learn more in #PAIN bit.ly/4wdrJPS
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PAIN @painthejournal.bsky.social · 08/09/2026
Li et al. find that adolescent females had higher chronic postsurgical pain (CPSP) after spinal fusion than males. Postsurgical behavioral distraction and emotion-avoidance coping partially mediated sex differences in long-term CPSP #PAIN bit.ly/4hW0FB3
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PAIN @painthejournal.bsky.social · 07/09/2026
Pain Awareness Month: ADVOCATE. Explore resources to help people living with pain prepare for care conversations, partner with health professionals & build self-management skills. Share what supports participation in pain care: bit.ly/4zSCeLB #PainAwarenessMonth
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PAIN @painthejournal.bsky.social · 07/09/2026
Liang et al. find that acute radicular pain disrupts hierarchical processing linked to energy metabolism dysregulation, whereas chronic pain involves affective-attentional reorganization linked to synaptic plasticity. Learn more in #PAIN bit.ly/3TEBUiY
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PAIN @painthejournal.bsky.social · 04/09/2026
In this week’s #PAIN Featured Image, Litewczuk et al. present a schematic representation of their study design. Results confirm the essential role of capsaicin-sensitive nociceptors for heat pain. Learn more at bit.ly/4q0dvjQ
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PAIN @painthejournal.bsky.social · 03/09/2026
In a prospective diary study capturing a high prevalence of intrusive mental imagery in chronic secondary pain, Grabherr et al. find that imagery vividness, emotional intensity, and valence were linked to postimage pain. Learn more in #PAIN bit.ly/4xru0rI
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PAIN @painthejournal.bsky.social · 02/09/2026
Gibler et al. present an abbreviated, 7-item version of the Tampa Scale of Kinesiophobia that demonstrates strong psychometric properties for use in youth with chronic pain. Learn more in #PAIN bit.ly/3TZrPgw
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PAIN @painthejournal.bsky.social · 01/09/2026
De Martino et al. use TMS + electroencephalography to reveal distinct cortical connectivity profiles in nociceptive, neuropathic, nociplastic pain, with lower cortical complexity and synchrony consistently associating with greater symptom severity #PAIN bit.ly/45e2Zfj
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PAIN @painthejournal.bsky.social · 31/08/2026
Hardowar et al. find that astrocytes maintain dorsal horn capillary health through VEGF-A signaling. Astrocyte dysfunction disrupts endothelium integrity, alters angiogenic and inflammatory pathways, and triggers pain hypersensitivity. Learn more in #PAIN bit.ly/45LqwV7
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PAIN @painthejournal.bsky.social · 28/08/2026
In this week’s #PAIN Featured Image, Spanswick et al. present their results, indicating that LAT8881 suppresses ectopic firing at the level of the DRG. Learn more at bit.ly/4wgKpOL
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PAIN @painthejournal.bsky.social · 27/08/2026
Gallant-Behm et al. find that di-siRNA targeting SCN9A produces long-lasting Nav1.7 knockdown and powerful analgesia in rats, supporting its potential as a nonopioid approach to pain treatment. Learn more in #PAIN bit.ly/3TzKQpR
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PAIN @painthejournal.bsky.social · 26/08/2026
Arnold et al. find that RCTs investigating neuropathic pain often contain psychiatric-related exclusion criteria, potentially reducing the generalizability to a substantial population subset that experiences comorbid psychiatric disorders #PAIN bit.ly/4coVqGs
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PAIN @painthejournal.bsky.social · 25/08/2026
Brief cognitive behavioral therapy for chronic pain is an abbreviated psychotherapy that rapidly yields clinically significant improvement in pain interference compared with usual care alone. Learn more in Beehler et al. #PAIN bit.ly/4qcxVGr
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PAIN @painthejournal.bsky.social · 24/08/2026
McDermott et al. affirm that third-wave psychological therapies can reduce the impact of chronic pain by helping patients feel safer confronting pain-related sensations, thoughts, feelings. Learn more in #PAIN bit.ly/4xwW4tX. Learn more in #PAIN bit.ly/4xwW4tX
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PAIN @painthejournal.bsky.social · 20/08/2026
Diaz et al. find that restoring neurotrophic signaling after skin injury improves sensory recovery and reduces neuropathic pain in RDEB, suggesting a therapeutic approach for pain with impaired nerve regeneration. Learn more in #PAIN bit.ly/4w9D0AD
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PAIN @painthejournal.bsky.social · 19/08/2026
In youth with chronic pain, Sanabria-Mazo et al. find that pain interference was linked to higher emotional symptoms, with peer relationships mediating depressive effects and past bullying amplifying concurrent vulnerability. Learn more in #PAIN bit.ly/4xlO4vt
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PAIN @painthejournal.bsky.social · 18/08/2026
Huft et al. find that youth with chronic pain and hypermobility show greater functional impairment and altered neural activity, but not increased sensitization, compared with those with chronic pain alone. Learn more in #PAIN bit.ly/3U3VB3L
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PAIN @painthejournal.bsky.social · 17/08/2026
Júnior et al.’s RCT showed that amitriptyline was safe but not superior to placebo for leprosy-related neuropathic pain, while symptom-based phenotypes captured persistent clinical burden. Learn more in #PAIN bit.ly/4hTZnqb
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PAIN @painthejournal.bsky.social · 14/08/2026
In this week’s #PAIN Featured Image, Scuffi et al. illustrate the differences between endometriosis and adenomyosis and related rodent models. Learn more at bit.ly/4wiDDrQ
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PAIN @painthejournal.bsky.social · 13/08/2026
In a formal comparison of heat-evoked skin conductance analysis approaches, Delity et al. find that combining automated scoring with manual artifact detection reveals strongest associations with pain. Learn more in #PAIN bit.ly/3TYPqhl
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PAIN @painthejournal.bsky.social · 12/08/2026
Herrero Babiloni et al. find that evening chronotypes have higher odds of chronic pain, suggesting that chronotype may be an important marker of pain vulnerability and a potential target for personalized interventions. Learn more in #PAIN bit.ly/4wiwCHf
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PAIN @painthejournal.bsky.social · 11/08/2026
Lim et al. find that children experiencing pain and exposed to adverse life events showed accelerated brain maturation in emotion- and pain-associated regions, demonstrating additive effects on brain development. Learn more in #PAIN bit.ly/3SnUAmF
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PAIN @painthejournal.bsky.social · 10/08/2026
Da Silva et al. find that peripheral administration of capsaicin leads to the reversal of maladaptive brain networks in rats with trigeminal nerve injury, which may attribute to long-lasting analgesia. Learn more in #PAIN bit.ly/4wmH01j
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PAIN @painthejournal.bsky.social · 07/08/2026
In this week’s #PAIN Featured Image, Coulombe-Leveque et al. depict key pathophysiological changes in PTSD and nociplastic pain that form the basis of a proposed PTSD-inspired pathophysiological and conceptual model for nociplastic pain. Learn more at bit.ly/4pzT8ts
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PAIN @painthejournal.bsky.social · 06/08/2026
Two #WC2026 workshops examine placebo/nocebo mechanisms, featuring @christianbuchel.bsky.social and @ulrikebingel.bsky.social. Register: bit.ly/4qx0aOI
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PAIN @painthejournal.bsky.social · 06/08/2026
Zadeh et al. find that focused ultrasound stimulation of somatosensory cortex and thalamic VPL altered heat pain and warm detection thresholds, highlighting thalamocortical roles in sensory modulation and neuromodulatory potential. Learn more in #PAIN bit.ly/4wl4e7N
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PAIN @painthejournal.bsky.social · 05/08/2026
Cook et al. report that remote CBT-CP approaches are beneficial across a variety of demographic and clinical characteristics, although patient adherence is critical and likely merits support among those using online self-directed programs #PAIN bit.ly/4bnGurF
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