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Mike Ando

@dmikeando.bsky.social
2.2K followers 2K following 116 posts

ML @ Calico. Previously at Google Research and UCSF. Still amazed and excited by the power of microscopy to understand biology.

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Reposted by Mike Ando
Jody Mou @moujo.bsky.social · 29/09/2026
Excited to share a preprint of my main PhD work in @nickpolizzi.bsky.social's lab - introducing LUCI-tag, a new orthogonal self-labeling protein tag based on K-Ras(G12C) and its covalent inhibitors! www.biorxiv.org/content/10.6... (1/16)
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Cell Biology J-Club @cellclub.bsky.social · 28/09/2026
www.biorxiv.org/content/10.6...
biorxiv.org
PRISM: A Plasmid-based Reporter for Intracellular Spectral Microscopy
Organelles form an interconnected network whose morphology, positioning and interactions reflect cellular state. However, reproducibly quantifying these organelle phenotypes across large cell populati...
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Alejandro Montenegro @aemonten.bsky.social · 27/09/2026
That the Oxford comma is essential, and I will add it to all your manuscripts.
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napari @napari.org · 26/09/2026
🚀 napari is hiring Remote Developers-in-Residence! Join us to build the future of interactive n-dimensional data visualization in Python. 💻 60% Dev / 20% Maintenance / 20% Community & Outreach ⏱️ Contract, 14–35 hrs/wk 🌍 Global 100% Remote Learn more and apply today: napari.org/island-dispa...
napari.org
We’re hiring Developers-in-Residence! — napari blog documentation
Organization: napari (a NumFOCUS Sponsored Project) Position Type: Independent contractor agreement. Global, 100% Remote. Duration: One year, possibility to extend. Commitment: 0.4 to 1.0 FTE…
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Ksena Longrin @ksenart.bsky.social · 25/09/2026
Day 3 of acute #Toxoplasma infection - parasites dividing snugly between the TWO nuclei of one skin cell. And no, binucleation is not an AI artifact. Unlike the 1st place #NikonSmallWorldinMotion 🟦 Parasite shell (GAP45) 🟨🟧🟥🟪 DNA (depth colour-coded) Zeiss LSM980, 100x #Microscopy #Science
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Jake Bailey @jakebailey.dev · 24/09/2026
that scene from the matrix except it's me reading articles, talk slides, PR descriptions, saying "that's Claude", "that's GPT", "that's Claude", "Claude", "GPT", ...
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🇵🇸Tim Henke (tɪm 'ɦɛŋ.kə) @timhenke.bsky.social · 24/09/2026
I've unfortunately been cursed by an evil wizard so that if I ever skip any talk at a conference, the very next person I chat with and ask "and what do you work on?" will turn out to have been the speaker
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BK. Titanji @boghuma.bsky.social · 24/09/2026
"I’m saying that I would personally mouth-pipette a solution of pure chloroform right now, today, in front of God and the NIH Director and the entire Office of Research Safety, if it meant a young scientist in my department could get a payline above 20%." substack.com/home/post/p-...
substack.com
Opinion: I Miss When The NIH Payline Was 40% And We All Mouth-Pipetted Phenol
By Dr. Douglas R. Waverly, Professor Emeritus of Biochemistry, Yale University
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Johannes Soltwedel @jo-soltwedel.bsky.social · 23/09/2026
🚨New release: NGFF specification 0.6 🚨 Last week, we formally released the latest version of the NGFF specification: 0️⃣.6️⃣( ngff.openmicroscopy.org/specificatio...) Let's take a small tour through the things possible with #ome-zarr 0.6 now that this is out! 👇
ngff.openmicroscopy.org
Version 0.6 — NGFF documentation
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Loïc A. Royer 💻🔬🧪 @loicaroyer.bsky.social · 23/09/2026
What if any dataset, any size, any number of dimensions, opened in a browser tab from a link? 🔬🧪💻 Luxar is out today: write it in Python, share it as a link, explore it in any browser. Open source. 🧵 @biohub.org Preprint: doi.org/10.5281/zen... Code: github.com/royerlab/luxar
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Nico Schuck @nicoschuck.bsky.social · 21/09/2026
2023: 8,039 proposals 2024: 10,360 proposals 2025: 17,066 proposals 2026: 21,627 proposals Something's gotta give
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Steve Gale @stevewg.bsky.social · 22/09/2026
Colley Hill, Surrey: coffee break from birding the steep scrub. Love the plaque on the bench I’m sitting on
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Caroline Bartman @cbartman.bsky.social · 22/09/2026
PROPOSAL: an a capella group that sings about low carb diets The Key Tones
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Anh Hoang Le, PhD 🏳️‍🌈🏴󠁧󠁢󠁳󠁣󠁴󠁿🇻🇳 @anhhle2702.bsky.social · 21/09/2026
Happy #MicroscopyMonday. I found this very pretty COS-7 cell expressing LifeAct-mCherry from my old data. Look at how dense its actin network is. Also, many of the moving dots are endosomal to seemingly push them through the cytoplasm, similar to actin comet tail, but just a lot shorter.
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Alexis Verger 🧬🧫🧪 @alexis-verger.cpesr.fr · 21/09/2026
Nice talk, really perfect for teaching Everything you've always wanted to know about #AlphaFold, iPTM, PAE, pLDDT, and ipSAE but were afraid to ask
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Kresten Lindorff-Larsen @lindorfflarsen.bsky.social · 19/09/2026
Ca. 1/10 of randomly perturbed (with a "single-atom change") parent molecules had a >10x increased potency in experimental tests I wonder for how many iterations one could increase affinity in this way?
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Rosemary Mosco @rosemarymosco.com · 18/09/2026
Humaning.
A four-panel comic. In panel 1, a Northern Cardinal and American Goldfinch perch above a busy crowd in a city, looking down. The cardinal says "It's a nice day to go humaning." The goldfinch says "Just look at them. Majestic." In panel 2, a close-up of the two birds. The cardinal says "Nobody tells you that you'll reach a certain age and suddenly get into humaning. I hit 3 years old, and then bam."The birds are looking out over the crowd scene. In panel 3, the cardinal says "Their calls sound funny to us, but each one has a unique meaning." Below, people are saying various things: "I'm tired." "Where's my phone?" "I'd murder a burrito." In panel 4, the birds look down excitedly at a man walking by. The cardinal says "Wait, is that a guy who got dressed in the dark and put his shirt on inside out and backwards?" And the goldfinch exclaims, "Holy... that's a lifer!"
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paveltomancak.bsky.social @paveltomancak.bsky.social · 18/09/2026
In light of this growing controversy, I would like to direct attention to the stunning videos 2-31! www.nikonsmallworld.com/galleries/20...
nikonsmallworld.com
A tiny roundworm and a single-celled Dileptus explore their microscopic world | 2026 Small World in Motion Competition
Nguyen Nam Nhat - A tiny roundworm and a single-celled Dileptus explore their microscopic world
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Per Engzell @pengzell.bsky.social · 18/09/2026
A paper is finished when the embarrassment of submitting it becomes smaller than the embarrassment of still working on it
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Marie Walde 🌊🦠🔬 @mariescopy.bsky.social · 18/09/2026
The #microscopy community has serious concerns about this year’s winning #NikonSmallWorld in Motion video. @healthcare.nikon.com, could you please comment on the raw data and acquisition process to clarify whether AI was used? Transparency would help maintain confidence in the competition.
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Chenxin Li, PhD @chenxinli2.bsky.social · 17/09/2026
Pretty funny
A poster with organic chemistry joke. It reads “struggling in organic chemistry? Does the following meme describe you?” The meme reads “I am triene but I am diene”
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Nicola Rennie @nrennie.bsky.social · 17/09/2026
I love overly honest READMEs
Screenshot of GitHub README saying known issues: coding style only a mother could love
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Bethany Brookshire @beebrookshire.bsky.social · 17/09/2026
People are using AI to impersonate real science journalists. And one even got PUBLISHED. In Science. www.linkedin.com/posts/caroli...
linkedin.com
Fake Caroline update: The person who was impersonating me managed to get an article published in Science, under my by-line. And they got paid for it! I've seen the pitches (bad), and the email…...
Fake Caroline update: The person who was impersonating me managed to get an article published in Science, under my by-line. And they got paid for it! I've seen the pitches (bad), and the email chai...
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Carolyn Bertozzi @carolynbertozzi.bskyverified.social · 16/09/2026
Learn more about The Protein Observatory @stanford-chemh.bsky.social, led by institute scholar @pollyfordyce.bsky.social. A data-generating foundation for AI-enabled protein function prediction and design. openminds.stanford.edu/support/stor...
openminds.stanford.edu
The protein observatory
Polly Fordyce is building a global engine for protein discovery—one that could help researchers harness AI to create new medicines, materials, and climate solutions.
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Kevin A. Scott, PhD @sculpturatus.bsky.social · 17/09/2026
found at ucsf
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Dr. Jennifer Wade @volcanojw.bsky.social · 14/09/2026
Do you like maps?? I’m in a briefing where the USGS shared these amazing 3D Elevation images that are just so cool. Find your state/district, and behold this example of DC! www.usgs.gov/3d-elevation...
A 3D Elevation Program image from the USGS of the District of Columbia, depicting (in their words) “the ‘bare earth’ surface, stripping away vegetation and structures, revealing ground surface.
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Dylan Burnette @mag2art.bsky.social · 13/09/2026
A cell dividing into two new daughter cells photographed through a microscope. #CellBiology
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Matt Henderson @matthen.com · 14/09/2026
chaos from bouncing a ball in a circle- at each point, I simulate a bunch of futures with slightly different velocities- showing how predictable the system would be with measurement error. The system seems to move between Stable Eras and Chaotic Eras, where it is hard to predict four bounces ahead
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Sergey Ovchinnikov @sokrypton.org · 14/09/2026
Finally a more intuitaive way to learn pLDDT/pAE? 😎 sokrypton.github.io/protein_figh... (Character idea from @hannes-stark.bsky.social & Alex Waldherr)
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nat alison @tesseralis.site · 10/09/2026
mathematicians now feel like they have to be secretive about what they do in case it gets stolen by AI. graph theorists arent too worried about this though because they’ve already been doing discreet mathematics
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Nikolay Tumanov @ntumanovxray.bsky.social · 12/09/2026
Yep, sure, I trust you 1000%. #SupplementsSaga #chemchat #chemsky
Some BS from a supplement company "Our premium formulations are grounded in rigorous scientific research, ensuring that each
ingredient is not only effective but also safe." on the same page with ingredient L-glycine.
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Michael Baym @baym.lol · 13/09/2026
Ten years ago Tami, Roy, and I released a movie we made of antibiotic resistance evolving in real time. I thought maybe a couple thousand people tops would see it. I couldn't have imagined it would be seen millions of times, and be taught from middle school through the graduate level worldwide
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hardmaru @hardmaru.bsky.social · 12/09/2026
Do large language models actually understand the world, or are they just very good at pretending? Does it even matter? Our recent Royal Society special issue explores this: royalsocietypublishing.org/rsta/issue/3...
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Celeste Ng @pronounced-ing.bsky.social · 12/09/2026
TIL the Japanese soft serve place near me offers Lactaid and honestly? Brilliant
A screenshot of a touchscreen menu. The second-to-last item is "soft serve banana milk" and the last item is Lactaid, which costs $0.10
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Jess Pendley @jesspendley.bsky.social · 11/09/2026
Future me watching temporary -productivity-burst me commit to meetings and calls.
A small machine, the front resembles a smiling face, and its back reflected in the mirror behind it resembles a horrified face.
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Chise @sailorrooscout.bsky.social · 11/09/2026
GOOD NEWS! A personalized mRNA vaccine has SUCCEEDED in keeping melanoma, a deadly skin cancer, from returning. Phase III trial results in MORE THAN 1,100 patients shows the vaccine SIGNIFICANTLY extended the time patients lived without their melanoma returning AND reduced the risk of metastasis.
statnews.com
Moderna and Merck say mRNA cancer vaccine succeeded in late-stage melanoma trial
A personalized mRNA cancer vaccine succeeded in a late-stage melanoma study, results that could herald a new, powerful approach in oncology.
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eliza hamilton @eliza.vg · 12/09/2026
‘No Way To Prevent This,’ Says Only Frontier Lab Where This Regularly Happens
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Mikel Reparaz @wikiparaz.bsky.social · 11/09/2026
PAUL: What’s in the box? REVEREND MOTHER: Pain. [PAUL hesitantly puts his hand in the BOX, then FROWNS IN CONFUSION. He pulls out A BAGUETTE.] REVEREND MOHER: Hōn hōn,
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Erik A. Rodriguez @erin-rod.bsky.social · 11/09/2026
💧◀️💧Diffusion in reverse!💧◀️💧 I added fluorescein & rhodamine B to a water bath under UV illumination. #FluorescenceFriday #SciArt #SciComm #RealTimeChem #Chemistry
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Andrew G. York @andrewgyork.bsky.social · 11/09/2026
Really happy to see this work from the Shapiro lab. New colleagues in an exciting new field!
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Goutham @kodakandlag.bsky.social · 11/09/2026
Like stars in the night sky 😍 #FluorescenceFriday but make it live cell calcium imaging
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Prasad Jallepalli, MD, PhD @prasad.bsky.social · 10/09/2026
Darth Melanogaster
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adamezracohen.bsky.social @adamezracohen.bsky.social · 10/09/2026
We wrote a tutorial guide on voltage imaging, now out in Neuron: authors.elsevier.com/a/1nlgh3BtfH... Indicators, microscopes, and software have all advanced to the point that it's not so hard -- you can now directly watch the electrical activity of neurons in live animals or in culture.
authors.elsevier.com
Please wait whilst we redirect you
All content on this site: Copyright © 2026 Elsevier B.V., its licensors, and contributors. All rights are reserved, including those for text and data mining, AI training, and similar technologies. For all open access content, the relevant licensing terms apply.
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Melanie D. White @melaniedwhite.bsky.social · 11/09/2026
Happy #FluorescenceFriday! ✨ It's the glue that holds us together, but it looks like a pair of angel wings to me. 👼 This beautiful meshwork of extracellular matrix surrounds the developing tissues of a quail embryo, helping guide cells as they build the body. 📷 @wangjianxiong.bsky.social 🔬
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Anna Bodzeta @annabodzeta.bsky.social · 11/09/2026
While waiting for the manuscript to be uploaded on bioRxiv, here some sneak peek #FluorescenceFriday
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Anna Rogers @annarogers.bsky.social · 10/09/2026
This was fun! One question was: if LLMs do hypotheses, experiments, writeups & reviewing - what remains for scientists? @robysinatra.bsky.social & @iaugenstein.bsky.social's take was 'steering the direction'. But imho the kinds of papers where that's possible just won't stay publishable for long
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Luca Rossi @lrossi.bsky.social · 10/09/2026
at #ECCV. By using using sequence-level margins, PMI correction, token-step margins, and entropy diagnostics they show how models consistently fall back on their textual prior when confronted with counterfactual visuals. To say it clearly, the model will count 4 legs even if your your camel has 5.
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Giuseppe Di Caprio @giudica.bsky.social · 10/09/2026
1/5 🎉 Our lab’s first paper is now on arXiv! arxiv.org/abs/2609.09863 We asked: does it actually matter whether you use a CNN or a Vision Transformer (ViT) to classify individual cells from microscopy images? Our answer: much less than we expected. 🧵
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Alejandro Montenegro @aemonten.bsky.social · 27/07/2026
"This trimodal platform enables a comprehensive understanding of the relationships among gene expression, morphological diversity, and functional properties of single neurons" www.cell.com/cell/fulltex...
cell.com
Multimodal imaging of gene expression, morphology, and activity of the same neuron
This study establishes an imaging-based multimodal characterization (IMC) platform to link in vivo activity, whole-brain morphology, and spatial gene expression in the same cortical projection neurons...
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FocalPlane @focalplane.bsky.social · 27/07/2026
ICYMI: Our preprint list covering the latest research in bioimage analysis is now up on FocalPlane. Let us know if you have any recommendations! focalplane.biologists.com/2026/07/24/m...
focalplane.biologists.com
Microscopy preprints: bioimage analysis - FocalPlane
Microscopy preprints: bioimage analysis - News
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