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Derivery Lab - MRC LMB

@deriverylab.bsky.social
885 followers 703 following 30 posts

Asymmetric cell division | Microscopy tech development | Synthetic biology | Fly models | All views are our own

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Derivery Lab - MRC LMB @deriverylab.bsky.social · 02/10/2026
🚨🚨🚨Check out the latest from our lab-neighbours!🚨🚨🚨 FXR proteins load mRNA onto dynein, and BICD2 gets the motor moving!
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Derivery Lab - MRC LMB @deriverylab.bsky.social · 24/09/2026
Alison has joined our lab as a postdoc to continue our research on synthetic polarity, now in multicellular systems. Welcome to the lab, Alison!
Alison stands in our lab space wearing a white lab coat and white nitrile gloves. She is holding a pink eppindorf tube and a pipette above her incredibly tidy lab bench.
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MRC Laboratory of Molecular Biology @mrclmb.ac.uk · 11/09/2026
Ready to take the next step in your research career? The LMB is now accepting applications for PhD placements starting in October 2027. Deadline: 08 December 2026 (allow time for reference submission). Discover what we offer here: mrclmb.ac.uk/careers-and-people/phd…
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Derivery Lab - MRC LMB @deriverylab.bsky.social · 30/06/2026
Deeply honored to be elected as an EMBO member. This would not have been possible without the incredible past and present members of my lab - thank you for your dedication, creativity and total lack of fear over the years 🔬🪰🧪
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Alison Kickuth @alisonkickuth.bsky.social · 18/06/2026
I am honoured to have received the Otto Hahn Medal! Thank you Jan @brugueslab.bsky.social, @ursa-ursic.bsky.social, Michael Staddon, @mpi-cbg.de, and @poldresden.bsky.social for your support during this scientific journey!
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Meg Clapperton @meganclapperton.bsky.social · 24/04/2026
It was an absolute honour to win the #BSCB poster prize at #DynamicCellVI ! Its my first ever dynamic cell and I already can't wait for the next one! Make sure to come to our other talk today on using this tech to study endosomal dynamics?
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Derivery Lab - MRC LMB @deriverylab.bsky.social · 19/03/2026
Check out this preprint from the @simonbullock11.bsky.social lab, amazing work led by @lucas-albacete-x2.bsky.social ! 🔬
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Derivery Lab - MRC LMB @deriverylab.bsky.social · 19/02/2026
🚨🚨🚨Check out this new preprint from the Löwe lab proposing that microtubule architecture and dynamics evolved in Asgard archaea prior to eukaryogenesis! Happy to have had a little contribution by showing that Asgard tubulin displays a key hallmark of eukaryotic tubulins: dynamic instability! 🚨🚨🚨
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Derivery Lab - MRC LMB @deriverylab.bsky.social · 18/12/2025
Steven has joined us as an RA to assist in the design, production and characterization of a panel of binders to be used as biosensors to image sorting of endogenous cargos in cells using multispectral microscopy, or as modulators of activities of sorting machineries! Welcome to the lab, Steven!
Steven stands on a link-corridor at the MRC LMB. In the background there are meeting rooms, social areas and windows into labs.
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MRC Laboratory of Molecular Biology @mrclmb.ac.uk · 25/11/2025
There’s just ONE WEEK left to apply to join our amazing PhD programme next year! Visit our website for more information: www2.mrc-lmb.cam.ac.uk/students/int... Applications close on 2nd DEC 2025
Join the LMB's PhD programme!
Applications now open for October 2026
Deadline 2nd December 2025
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James Manton @jamesdmanton.bsky.social · 15/09/2025
We present a simple method to easily increase the imageable depth of an expansion microscopy gel on a typical inverted microscope ten-fold, using some carefully placed FEP film and a water dipping objective lens:
A comparison of imaging an expansion microscopy hydrogel with a water dipping objective lens, using either eye gel as an immersion medium or a combination of Immersol W, water and a thin FEP film. In both cases, the sample is supported by a thin FEP film rather than a coverglass.
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James Manton @jamesdmanton.bsky.social · 16/09/2025
The final version of our multispectral microscopy manuscript is now online at Nature Photonics: www.nature.com/articles/s41... The main additions are some further comparisons to yet more unmixing algorithms, in which we find that our algorithm is still the most accurate.
nature.com
Multispectral live-cell imaging with uncompromised spatiotemporal resolution - Nature Photonics
A tree-like arrangement of dichroic mirrors and multiple cameras coupled with an iterative spectral unmixing algorithm enables multispectral imaging of live cells in up to eight spectral channels with...
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Derivery Lab - MRC LMB @deriverylab.bsky.social · 18/09/2025
We are very happy that the amazing PhD work of our previous PhD student, @akaashkumar.bsky.social is out in Nature Photonics!
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MRC Laboratory of Molecular Biology @mrclmb.ac.uk · 23/06/2025
Great opportunity for a Research Support Officer to join @cellbiol-mrclmb.bsky.social, supporting @deriverylab.bsky.social in their studies of the molecular mechanisms behind receptor sorting in endosomes. More info: www.nature.com/naturecareer... Apply by 10 JUL #ScienceJobs
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Derivery Lab - MRC LMB @deriverylab.bsky.social · 23/06/2025
🚨 JOB ALERT 🚨 We're hiring a Research Assistant – no PhD needed! Join us to explore the molecular mechanisms of receptor sorting in endosomes. Experience in protein expression/purification, cloning & cell culture desired 🧫🔬 Apply now 👉 www.nature.com/naturecareer... #STEMCareers #ResearchJobs
A picture of 3 rows of people on steps at the MRC LMB. From left to right - top row: Akaash, Vic, Lara - Middle row: Kerrie, Manu, Paddy - bottom row: Meg  and Julie
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MRC Laboratory of Molecular Biology @mrclmb.ac.uk · 16/04/2025
Emmanuel Derivery (@deriverylab.bsky.social in @cellbiol-mrclmb.bsky.social) speaks to @jcellsci.bsky.social about the motivations behind his career, the exciting field of protein design & advice for new Group Leaders. Full interview: journals.biologists.com/jcs/article/... #LMBintheNews
Portrait photo of Emmanuel Derivery stood in a lab space
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Journal of Cell Science @jcellsci.bsky.social · 14/04/2025
In our latest interview, we hear from the 2024 @bscb-official.bsky.social Hooke Medal winner Emmanuel Derivery @deriverylab.bsky.social. Emmanuel tells us about his research, what winning the Hooke Medal means to him & his advice on building a successful lab. journals.biologists.com/jcs/article/...
Emmanuel Derivery. Image Credit MRC Laboratory of Molecular Biology.
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Jonny Nixon-Abell @abelljonny.bsky.social · 24/03/2025
😊 Very happy to see this out! A real group effort from the Hyslop lab (@thecimr.bsky.social) including brilliant collaborations with @knowleslab.bsky.social, Vendruscolo lab, @michael-e-ward.bsky.social lab, @deriverylab.bsky.social lab, @profmarciniak.bsky.social lab 🎉🎉🎉
nature.com
ANXA11 biomolecular condensates facilitate protein-lipid phase coupling on lysosomal membranes - Nature Communications
Nixon-Abell et al. show that ANXA11 condensation on lysosomal membranes causes a coupled phase transition of the underlying lipids and mechanical stiffening of the overall ensemble involved in RNP gra...
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MRC Laboratory of Molecular Biology @mrclmb.ac.uk · 04/03/2025
Are you an undergraduate student considering a career in academic research? Don’t miss the opportunity to gain hands-on experience at the LMB with our Student Placement Scheme – open now for applications! Apply by 30th March. More info: www2.mrc-lmb.cam.ac.uk/students/stu...
Student Placement Scheme
Research internships available for undergraduate students
Apply by 30 March 2025
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Derivery Lab - MRC LMB @deriverylab.bsky.social · 06/02/2025
We are super proud of @lara-kruger.bsky.social who is leaving to start her own lab at @institutcurie.bsky.social - you're going to be missed in the Derivery lab!
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James Manton @jamesdmanton.bsky.social · 22/01/2025
Our automatic parameter-free deconvolution code is now 2–3× faster while still producing exactly the same results as before. If you want to try it out, we have a Google Notebook implementation available at beryl.mrc-lmb.cam.ac.uk/rlgc_notebook/. Manuscript WIP.
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Derivery Lab - MRC LMB @deriverylab.bsky.social · 20/01/2025
Congrats to @juliemiesch.bsky.social who was awarded a Postdoc Mobility grant by @snf-ch.bsky.social to support her research for two years. Her postdoc research will focus on the biophysical regulation of water buffering in the cell.
Picture of Julie wearing a red top and black bottoms, holding a bottle of champagne
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The EMBO Journal @embojournal.org · 15/01/2025
How does tRNA-modifier #Elongator stabilize microtubules during asymmetric cell division? Vicente Planelles Herrero @deriverylab.bsky.social et al find subcomplexes binding to microtubule ends & tubulin dimers, & enriching microtubules with polyglutamylated tubulin www.embopress.org/doi/full/10....
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Derivery Lab - MRC LMB @deriverylab.bsky.social · 17/01/2025
During revisions, we've added lots of exciting new data, so be sure to check out the paper! Most importantly, we now demonstrate that Elongator regulates polyglutamylation levels of spindle microtubules, both in cells and in vivo.
Figure 5. Elongator is a tubulin polymerase selective for polyglutamylated monomers.
(A, B) Elp456 binds preferentially to polyglutamylated tubulin. (A) Affinity measurement between eGFP-Elp456 and indicated αβ-tubulin heterodimers using microscale thermophoresis. Estimated dissociation constant (Kd) values are indicated (mean ± s.d.; n = 3).  (B) Estimated dissociation constants for the indicated tubulins. Elp456 binds with similar affinity to recombinant Drosophila α1β1-tubulin, pig brain tubulin, mouse brain tubulin and mouse brain tubulin lacking K40 acetylation. However, the binding to tubulin purified from TTLL1/7-double KO mouse brains (lacking polyglutamylation) and HeLa S3 cells (lacking polyglutamylation, K40 acetylation and Δ2 deletion is similar and ~18 times lower than other tubulins. (C) Experimental assay to detect polyglutamylation in polymerized microtubules in vitro. (D) Microtubules polymerized in the presence of Elongator are significantly enriched in polyglutamylated tubulin when using a 50:50 pig brain tubulin:HeLa S3 tubulin mix. Correspondingly, when using HeLa S3 tubulin, which is not polyglutamylated, no effect is observed. P values for an Ordinary one-way ANOVA test followed by two-tailed Turkey multiple comparison test are indicated (E–G) Elongator depletion results in decreased polyglutamylation levels at the spindle. mean ± standard deviation. P values for an Ordinary one-way ANOVA test on independent experiments (N = 3) followed by two-tailed Turkey multiple comparison test are indicated. (E) Drosophila S2 cells depleted for Elongator have significantly decrease levels of polyglutamylated tubulin at the mitotic spindle.
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Derivery Lab - MRC LMB @deriverylab.bsky.social · 17/01/2025
In the original draft, we showed that Elongator binds to microtubules irrespective of their PTMs, but selectively elongates them using polyglutamylated tubulin subunits. As a result, Elongator rewrites the tubulin code of dynamic microtubules. How cool is that?
Elongator, an established tRNA-modifying complex, can also stabilize microtubules during asymmetric cell division. This study shows that Elongator subcomplexes achieve this by binding to microtubule ends as well as tubulin dimers, and enriching microtubules with polyglutamylated tubulin.
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Dual binding mechanism: Elongator binds microtubule ends and free αβ-tubulin heterodimers via its Elp123 and Elp456 subcomplexes, respectively.
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Microtubule stabilization: Coupled activity of Elp123 and Elp456 reduces the tubulin concentration required for microtubule elongation, increasing microtubule growth speed and reducing their catastrophe rate.
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Selective tubulin recognition: Elp456 binds with higher affinity to polyglutamylated tubulin, resulting in preferential incorporation of polyglutamylated tubulin into Elongator-assembled microtubules.
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Tubulin code rewriting: By enriching microtubules with polyglutamylated tubulin, Elongator modifies the tubulin code in vitro, in cells and in vivo in Drosophila sensory organ precursor cells.
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Derivery Lab - MRC LMB @deriverylab.bsky.social · 17/01/2025
🚨 Paper Alert 🚨 Our preprint describing Elongator as a selective microtubule polymerase that rewrites PTMs on microtubules is now published! Check it out: www.embopress.org/doi/full/10....
embopress.org
Elongator is a microtubule polymerase selective for polyglutamylated tubulin | The EMBO Journal
imageimageElongator, an established tRNA-modifying complex, can also stabilize microtubules during asymmetric cell division. This study shows that Elongator subcomplexes achieve this by binding to mic...
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MRC Laboratory of Molecular Biology @mrclmb.ac.uk · 16/12/2024
Congrats to @akaashkumar.bsky.social who has won the PhD Award from the Cambridge Centre for Physical Biology for his work developing a novel microscopy system with @deriverylab.bsky.social & @jamesdmanton.bsky.social in @cellbiol-mrclmb.bsky.social. www.physbiol.cam.ac.uk/akaash-kumar #LMBintheNews
Akaash Kumar stands next to his multispectral imaging hardware which features several cameras. Behind him, a computer screen shows a colourful cellular image captured with his new microscopy system.
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Derivery Lab - MRC LMB @deriverylab.bsky.social · 11/12/2024
An overview of Akaash's multispectral camera tree can be seen in the graphical abstract (which you can read more about here: www.physbiol.cam.ac.uk/prizes ). Peek at some colourful cells!

‪Derivery Lab - MRC LMB‬ ‪@deriverylab.bsky.social‬
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Congrats to Akaash, a postdoc in the lab, for winning the PhD Award from the Cambridge Centre for Physical Biology. His PhD research worked on the development of a multispectral imaging system capable of imaging up to 8 fluorophores similtaneously and tackling complex biological questions with this!
Photograph of Akaash in posed infront of a computer monitor with a colourful cell imaged using his multispectral camera tree which is to the right of him.
ALT
Derivery Lab - MRC LMB
‪@deriverylab.bsky.social‬
An overview of Akaash's multispectral camera tree can be seen in the graphical abstract (which you can read more about here: www.physbiol.cam.ac.uk/prizes ). Peek at some colourful cells!
1a) Schematic of multispectral imaging hardware, b) photo of multispectral imaging hardware. 2a) Raw recorded data, b) emission spectra of fluorophores used in sample, c) unmixed data using novel algorithm, d) merge of data in c, e-f) other examples of simultaneous multispectral live cell imaging
ALT
December 11, 2024 at 11:20 AM
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1a) Schematic of multispectral imaging hardware, b) photo of multispectral imaging hardware. 2a) Raw recorded data, b) emission spectra of fluorophores used in sample, c) unmixed data using novel algorithm, d) merge of data in c, e-f) other examples of simultaneous multispectral live cell imaging
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Derivery Lab - MRC LMB @deriverylab.bsky.social · 11/12/2024
Congrats to @akaashkumar.bsky.social , a postdoc in the lab, for winning the PhD Award from the Cambridge Centre for Physical Biology. His PhD research worked on the development of a multispectral imaging system to image up to 8 fluorophores similtaneously for tackling complex biological questions!
Congrats to Akaash, a postdoc in the lab, for winning the PhD Award from the Cambridge Centre for Physical Biology. His PhD research worked on the development of a multispectral imaging system capable of imaging up to 8 fluorophores similtaneously and tackling complex biological questions with this!
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Derivery Lab - MRC LMB @deriverylab.bsky.social · 22/11/2024
And now we welcome our new PhD student @paddyod.bsky.social !
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Derivery Lab - MRC LMB @deriverylab.bsky.social · 22/11/2024
Then, only last week, post-doc @vicenteph.bsky.social was promoted to Senior Investigator Scientist and will remain in the group to develop new methods in protein design, in vitro reconstitutions, multispectral imaging assays and his work on Elongator!
Vicente stands behind a table holding a dinosaur plush toy. In front of him is a table which contains the blue-green box from which the dinosaur plush appeared, and a minions celebration cake which has dinosaur decorations on cocktail sticks on top of it.
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Derivery Lab - MRC LMB @deriverylab.bsky.social · 22/11/2024
Later in October, the LMB had their yearly annual symposium with Post-doc Lara Kruger winning the Steitz Prize for her talk and @akaashkumar.bsky.social winning the Perutz Prize for his PhD work!
On the bottom left is Akaash Kumar, bottom right is Lara Kruger, behind lara is Manu Derivery and behind Akaash is James Manton, all holding glasses of champagne.
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Derivery Lab - MRC LMB @deriverylab.bsky.social · 22/11/2024
Then, in September @akaashkumar.bsky.social passed his PhD viva, becoming the latest doctor to emerge from the lab! He then won the RMS Early Career Award 2024 in October.
Akaash stands in front of some stairs, holding a bottle of champagne whilst wearing a suit.
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Derivery Lab - MRC LMB @deriverylab.bsky.social · 22/11/2024
In June, @akaashkumar.bsky.social and @jamesdmanton.bsky.social had their Multispectral live-cell imaging paper released on to the BioRxiv www.biorxiv.org/content/10.1...
biorxiv.org
Multispectral live-cell imaging with uncompromised spatiotemporal resolution
Multispectral imaging is an established method to extend the number of colours usable in fluorescence imaging beyond the typical limit of three or four, but standard approaches are poorly suited to li...
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Derivery Lab - MRC LMB @deriverylab.bsky.social · 22/11/2024
We then had two new Post Docs join the group: @meganclapperton.bsky.social and @juliemiesch.bsky.social !
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Derivery Lab - MRC LMB @deriverylab.bsky.social · 22/11/2024
Catching the blue-world up with the last 6 months of Derivery group shenanigans: First up: in April Manu was the recipient of the 2024 Hooke Medal from BSCB!
A picture of Emmanuel Derivery wearing a grey jumper standing with his arms folded in front of a blurred wet-lab background.
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Derivery Lab - MRC LMB @deriverylab.bsky.social · 21/11/2024
Could we be added to this pack please?
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Derivery Lab - MRC LMB @deriverylab.bsky.social · 21/11/2024
Could we be added to this pack please?
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Derivery Lab - MRC LMB @deriverylab.bsky.social · 21/11/2024
Could we be added to this pack please?
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Derivery Lab - MRC LMB @deriverylab.bsky.social · 21/11/2024
Could we be added to this pack please?
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Derivery Lab - MRC LMB @deriverylab.bsky.social · 21/11/2024
Could we be added to this pack please?
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Derivery Lab - MRC LMB @deriverylab.bsky.social · 21/11/2024
Could we be added to this pack please?
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Derivery Lab - MRC LMB @deriverylab.bsky.social · 21/11/2024
Could we be added in please?
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Derivery Lab - MRC LMB @deriverylab.bsky.social · 21/11/2024
We are excited to be over here on BlueSky! @DeriveryLab on the other app.
media.tenor.com
a white cat is laying on its back on the floor and says `` hello . hello ... ''
ALT: a white cat is laying on its back on the floor and says `` hello . hello ... ''
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