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Bisrat Debeb

@debeblab.bsky.social
884 followers 268 following 20 posts

Associate Professor at MD Anderson Cancer Center- investigating the biology of brain metastasis in aggressive breast cancers, Inflammatory breast cancer (IBC), TNBC. Posts are my own.

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Reposted by Bisrat Debeb
LeahCookPhD @leahcookphd.bsky.social · 30/06/2026
Dr. Lisa Coussens giving her well-deserved award lecture for the MRS Women in Science Achievement award. Congratulations @coussenslab.bsky.social! #MRS2026
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Wendy Woodward, MD, PhD @ibcradiation.bsky.social · 19/04/2026
Excited about our @mdanderson.bsky.social Inflammatory Breast Cancer abstracts at #AACR26! Great job from our IBC lab teams! @debeblab.bsky.social
Abstracts Sunday at 2 and Monday at 2 about IBC
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Wendy Woodward, MD, PhD @ibcradiation.bsky.social · 10/04/2026
Awesome nerd day today with our amazing and fun TRIUMP IBC Team talking science and updating our advisory board! @debeblab.bsky.social @annalee-nguyen.bsky.social @mdanderson.bsky.social @utaustin.bsky.social #bcsm #cansky
Team posingElevator selfie
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Elizabeth McKenna @elizsmckenna.bsky.social · 04/08/2025
Now online in Cancer Discovery @aacrjournals.bsky.social: Mitochondrial Glutathione Import Enables Breast Cancer Metastasis via Integrated Stress Response Signaling - by Hsi-wen Yeh, Nicole Del Gaudio, Kivanç Birsoy, and colleagues doi.org/10.1158/2159... @rockefelleruniv.bsky.social
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Aguirre-Ghiso Lab @jaguirreghisolab.bsky.social · 30/07/2025
Delighted to see this story out and collaborate with amazing teams led by @jdegregori.bsky.social Mercedes Rincon & @roelvermeulen.bsky.social. Proud to see science propelled by our lab @cdi-einstein.bsky.social expanded to better understand cancer dormancy. Congrats! www.nature.com/articles/s41...
nature.com
Respiratory viral infections awaken metastatic breast cancer cells in lungs - Nature
Mouse models show that respiratory infections from viruses such as influenza and SARS-CoV-2 can trigger metastasis of dormant breast cancer cells in the lungs, a finding supported by epidemiological d...
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Liz Essley Whyte @lizessleywhyte.bsky.social · 30/07/2025
UPDATE: The pause was scrapped Tuesday evening after intervention by top White House officials. www.wsj.com/politics/pol...
wsj.com
Trump Administration Scraps Effort to Pause Health-Research Funding
The administration halted and then restarted billions in new research grants flowing from the National Institutes of Health.
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Jeremy Berg @jeremymberg.bsky.social · 29/07/2025
New Science story about multi-year funding and it potential catastrophic consequences www.science.org/content/arti... 1/n
science.org
Odds of winning NIH grants plummet as new funding policy and spending delays bite
Funding multiyear grants up front will sharply cut number of investigators receiving awards
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Bloomberg News @bloomberg.com · 24/07/2025
President Donald Trump’s cuts to research funding are putting the US at risk of losing the technological race against other countries including China, said former US Commerce Secretary Penny Pritzker
bloom.bg
Penny Pritzker Warns Trump Cuts Threaten US in Global Tech Race
President Donald Trump’s cuts to research funding are putting the US at risk of losing the technological race against other countries including China, said Penny Pritzker, former US commerce secretary and chair of Harvard University’s powerful governing body.
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Nancy Parmalee @nparmalee.bsky.social · 24/07/2025
In light of today’s news about the National Cancer Institute announcing a 4% payline, it’s really important to communicate to people that the previous 10% payline was still effectively a lottery and the result of decades of underfunding the NIH. Paylines used to be 25%.
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Roel Verhaak @roelverhaak.bsky.social · 23/07/2025
PO just confirmed that our 5th percentile R01 is not getting funded. Past NCI Payline at 4 percent. Cant believe it.
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Dr. Ahna Skop @ahnaskop.bsky.social · 20/07/2025
“Simply put, there is never a good time to pull out of an investment that continually pays such strong dividends and directly benefits the citizens of our state.” Cuts to research funding risk the collapse of U.S. science and technology | Guest Column | wyomingnews.com
wyomingnews.com
Fay: Cuts to research funding risk the collapse of U.S. science and technology
I started as an assistant professor of molecular biology at the University of Wyoming in 2001.
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Bisrat Debeb @debeblab.bsky.social · 16/07/2025
Funding scientific research is the only way we will cure cancer penncapital-star.com/commentary/f...
penncapital-star.com
Funding scientific research is the only way we will cure cancer • Pennsylvania Capital-Star
The proposed federal budget for next year includes a 55% cut to the National Science Foundation (NSF) and a 44% cut to National Institutes of Health (NIH).
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Bisrat Debeb @debeblab.bsky.social · 15/07/2025
Pan-cancer human brain metastases atlas at single-cell resolution: Cancer Cell www.cell.com/cancer-cell/...
cell.com
Pan-cancer human brain metastases atlas at single-cell resolution
Xing et al. construct a comprehensive pan-cancer human brain metastasis (BrM) atlas at single-cell resolution, uncovering five major BrM ecotypes associated with distinct phenotypic characteristics. T...
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Dr. David Miller 🏳️‍🌈 @davidimiller.bsky.social · 10/07/2025
🧪 BREAKING (good news): Senate subcommittee says NO! to Trump's proposed slashes to NASA & NSF funding. Today, the subcommittee said to keep NASA + NSF funding at $33.9 billion, the same as in FY24. See 7:15 below. Full Senate appropriations committee meets tomorrow about it. 🧵 1/3
appropriations.senate.gov
Subcommittee Markup of the Commerce, Justice, Science, and Related Agencies Appropriations Act | United States Senate Committee on Appropriations
United States Senate Committee on Appropriations
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UT MD Anderson Cancer Center @mdanderson.bsky.social · 10/07/2025
Patients with advanced melanoma who received nivolumab + relatlimab before and after surgery had lasting results four years later. Biomarkers may help predict who benefits most. spr.ly/633224xKCO #EndCancer
spr.ly
Most patients with advanced melanoma who received pre-surgical immunotherapy remain alive and disease free four years later
Four years after pre-surgery treatment with a novel combination of immune checkpoint inhibitors, nivolumab and relatlimab, 87% of patients with stage III melanoma remained alive, according to new results from a study led by researchers at The University of Texas MD Anderson Cancer Center.
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Kevin Pruitt @dr-kevin-pruitt.bsky.social · 03/07/2025
After years of searching, we now describe elusive roles of Dishevelled, a potent regulator of development, co-opted in #cancer. Dalia, a talented postdoc, along w/ our amazing team describe new dimensions of DVL1 function. Please check it out soon @natcomms.nature.com ❤️ @dalimartinez.bsky.social 🧪
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Alisa @ibc-advocate.bsky.social · 29/06/2025
Important research on IBC that can also benefit understanding other types of aggressive #breastcancer
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Wendy Woodward, MD, PhD @ibcradiation.bsky.social · 27/06/2025
Exciting new ideas about how LMD happens! @debeblab.bsky.social #cansky
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Bisrat Debeb @debeblab.bsky.social · 27/06/2025
Huge thanks to our collaborators and funders - @DoD, @METAvivor, @ACS, @NIH/NCI … And big congrats to Xiaoding Hu for leading this impactful work!👏👏👏 @mdanderson.bsky.social
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Bisrat Debeb @debeblab.bsky.social · 27/06/2025
Excited to share our latest pre-print “Soluble E-cadherin Drives Brain Metastasis in Inflammatory Breast Cancer” led by the outstanding Xiaoding Hu, an instructor in my lab. #Breastcancer #Brainmetastasis #IBC #Ecadherin #ReactiveAstrocytes #CXCR2 👉 biorxiv.org/content/10.110…
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Tennessee Lookout @tennesseelookout.com · 20/06/2025
Vanderbilt University Medical Center, one of the largest academic research and hospital care systems in the southeast, expects to lay off 650 employees as a result of grant and other funding cuts made by the Trump Administration, it said in a statement. From @anitawadhwani.bsky.social.
tennesseelookout.com
Vanderbilt University Medical Center to lay off up to 650 after Trump administration grant cuts • Tennessee Lookout
Vanderbilt University Medical Center, expects to lay off 650 employees as a result of grant and funding cuts by the Trump Administration,
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Congressman Bill Foster @repbillfoster.bsky.social · 01/05/2025
The massive funding cuts Trump and DOGE have made to scientific research should concern everyone; they will stifle American innovation and reduce economic growth. Researchers found that "a 50 percent reduction in funding would lower [GDP] nearly 7.6 percent" and cause permanent economic damage:
nytimes.com
Trump’s Cuts to Science Funding Could Hurt U.S. Economy, Study Shows
Reducing federal support for research and development could cause long-run economic damage and reduce government revenue.
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Dr. Suzanne Le Menestrel @drsl.bsky.social · 02/05/2025
The Spencer Foundation is offering rapid response bridge funding for those who lost NSF research grants. www.spencer.org/grant_types/...
spencer.org
Rapid Response Bridge Funding Program
In the face of recent abrupt shifts in federal funding for education research, including large-scale terminations of National Science Foundation (NSF) research grant awards, we have developed a rap...
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Matthew Facciani @matthewfacciani.bsky.social · 20/04/2025
Academia isn’t perfect, but it offers a rare space to pursue knowledge for its own sake. If research were fully privatized, only profit-driven questions would get asked. Yet many of the most transformative discoveries began as curiosity-driven inquiries whose value wasn’t clear for years.
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Bisrat Debeb @debeblab.bsky.social · 02/04/2025
Congratulations Drs Woodward and Lynce on developing a new #IBC scoring system to improve IBC diagnosis. #IBCdiagnosis
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Wendy Woodward, MD, PhD @ibcradiation.bsky.social · 02/04/2025
Thrilled to share work from our @mdanderson.bsky.social IBC team & the IBC team at @dfcibreastonc.bsky.social led by Dr. Filipa Lynce Komen and @ibcresearch1.bsky.social support to validate a new IBC scoring system to improve IBC diagnosis! #medsky #ibcsky #cansky academic.oup.com/jnci/advance...
academic.oup.com
Development of a Multi-Institutional Dataset to Validate a Novel Inflammatory Breast Cancer Diagnostic Score
AbstractPurpose. Susan G. Komen, the Inflammatory Breast Cancer (IBC) Research Foundation, and the Milburn Foundation convened patient advocates, clinician
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Eric Topol @erictopol.bsky.social · 29/03/2025
A huge loss at FDA. Peter Marks originated rhe Operation Warp Speed Covid vaccine idea and has overseen so many essential biotech programs such as genome editing cures www.wsj.com/politics/top...
wsj.com
Exclusive | Top Vaccine Official Out at FDA
In his resignation letter, Dr. Peter Marks cited ‘misinformation and lies’ from Health and Human Services Secretary RFK Jr.
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Eric Topol @erictopol.bsky.social · 28/03/2025
How does exercise and fitness promote healthy brain aging? An outstanding, comprehensive review @thelancet.bsky.social reduced neuroinflammmation, preserves blood-brain-barrier, neurogenesis, role of exerkines, and much more www.thelancet.com/journals/lan...
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Leonidas Platanias, MD @leonidasplatan1.bsky.social · 28/03/2025
“Medical research is a gift-a legacy that we leave for the next generation. The beauty of our National Cancer Program is that we have all lived to see its gifts—the even million Americans whose lives have been saved.” Mary Lasker (1900 - 1994)
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Wendy Woodward, MD, PhD @ibcradiation.bsky.social · 28/03/2025
Congrats @drrebeccahowell.bsky.social on this well-deserved achievement!! 🎉🎉🙌@mdanderson.bsky.social
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Denis Wirtz @deniswirtz.bsky.social · 27/03/2025
This is just horrible. The FY25 CR obliterates the already small funding allocations for the development of new treatments for patients with pancreatic cancer, lung cancer and glioblastoma.... for what purpose? These are three of the deadliest types of cancer.
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Rachael Sirianni, PhD @docsirianni.bsky.social · 27/03/2025
They are cutting cancer research. They are cutting cancer research. They can deny it all they want, but they are cutting cancer research. These are the cuts being made the DoD CDMRP cancer funding mechanism www.fightcancer.org/sites/defaul...
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Mike Feigin 🥯 @mikefeigin.bsky.social · 22/03/2025
The new Defense department budget erases $20 MILLION DOLLARS for pancreatic cancer research. $20,000,000 gone, for a disease with a 5-year survival rate of 13%.
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Nature Cancer @natcancer.nature.com · 22/03/2025
Betty Kim & Wen Jiang and colleagues report the design and characterization of an antibody–toxin conjugate targeting CD47, promoting anti-tumor immunity in preclinical cancer models. @bettykimmdphd.bsky.social @wenjiang-nano.bsky.social @mdanderson.bsky.social ⬇️ www.nature.com/articles/s43...
nature.com
An antibody–toxin conjugate targeting CD47 linked to the bacterial toxin listeriolysin O for cancer immunotherapy - Nature Cancer
Schrank et al. report the design and characterization of an antibody–toxin conjugate targeting CD47, promoting anti-tumor immunity in preclinical cancer models.
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Mark Cuban @mcuban.bsky.social · 22/03/2025
From 2010 to 2016 (latest data I have ), NIH research contributed to EVERY drug approved by the FDA
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Kelton Minor @keltonminor.bsky.social · 18/03/2025
There are days in life that shake you. I’m shattered 💔 to share that I just found out that the US Government terminated my 2024 NIH Director’s Early Independence Award (~$2 million), threatening my long-promised assistant professor job at Columbia University & academic career... 1/🧵
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Jason Shepherd @jasonsynaptic.bsky.social · 18/03/2025
Our university’s NIH CTSA (Clinical and Translational Science Award) was just cancelled for having some keywords that just mean it will serve ALL people in Utah. This funds research that moves discovery science into clinical therapies. This is literally the mandate of the NIH! 😰 🧪
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Soragni:Lab @alice.soragnilab.com · 18/03/2025
The NCI grant supporting the Columbia comprehensive cancer center was terminated. Tell me how terminating support for cancer research helps the economy. taggs.hhs.gov/Content/Data...
taggs.hhs.gov
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Sherry Pagoto, PhD @drsherrypagoto.bsky.social · 12/03/2025
New report shows that NIH grants fueled $95 billion in economic activity and 407,782 jobs in 2024. That's not to mention the countless lives that biomedical research has saved. Show me a better investment than that. www.forbes.com/sites/michae...
forbes.com
NIH Grants Fueled $95 Billion In FY 2024 Economic Activity, Finds New Report
National Institutes of Health grants generated almost $95 billion in economic activity nationwide in FY 2024 according to a new report by United for Medical Research.
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Denis Wirtz @deniswirtz.bsky.social · 13/03/2025
NIH is the best investment there is. www.forbes.com/sites/michae...
forbes.com
NIH Grants Fueled $95 Billion In FY 2024 Economic Activity, Finds New Report
National Institutes of Health grants generated almost $95 billion in economic activity nationwide in FY 2024 according to a new report by United for Medical Research.
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Bisrat Debeb @debeblab.bsky.social · 10/03/2025
Thrilled to kick off this exciting project with an incredible team! Grateful for the support from the UT-MDACC Accelerator Grant as we push forward innovative drug development for IBC and other aggressive breast cancers. #IBC #breastcancer #bcsm #TRIUMPH-IBC @mdanderson.bsky.social
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Annalee Nguyen @annalee-nguyen.bsky.social · 09/03/2025
So thrilled to be working with Drs. Woodward and Debeb at MDACC to make strides in aggressive BC therapy! It’s incredible to team up with such fantastic experts. We’re also joined by Drs. Adam Klivans, Everett Stone, Brant Gracia, Danny Diaz, and Axel Brilot at UT Austin - dream team!
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Wendy Woodward, MD, PhD @ibcradiation.bsky.social · 09/03/2025
Our @mdanderson.bsky.social inflammatory breast cancer team led by @debeblab.bsky.social joined protein gurus Dr. Jen Maynard, Dr @annalee-nguyen.bsky.social & others @utaustin.bsky.social & won a $4M accelerator grant for our TRIUMPH-IBC drug development program!! So excited! #bcsm #cansky
Myself, Bisrat Debeb, Jennifer Maynard, Annalee Nguyen in from of the MDACC line through cancer logo. Slide welcoming attendees to the UT Austin MDACC collaborative accelerator grant kickoff.
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Chise @sailorrooscout.bsky.social · 09/03/2025
THIS IS HUGE! Researchers at Stanford University have developed a dual-antibody treatment that remains effective against ALL SARS-CoV-2 variants by targeting a less-mutable part of the virus. This breakthrough could lead to longer-lasting therapies that OUTPACE viral evolution. 🧪🧵⬇️
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Derek Thompson @dkthomp.bsky.social · 27/02/2025
Unbelievable news. Pancreatic is one of the deadliest cancers. New paper shows personalized mRNA vaccines can induce durable T cells that attack pancreatic cancer, with 75% of patients cancer free at three years—far, far better than standard of care. www.nature.com/articles/s41...
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PombeDoc @pombedoc.bsky.social · 27/02/2025
The Atlantic story on the situation at NIH is sobering. We are so screwed. www.theatlantic.com/health/archi...
theatlantic.com
Inside the Collapse at NIH
Administration officials pressured NIH to avoid clear advice from the agency’s own lawyers to restart grant funding now.
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Stephanie Hicks @stephaniehicks.bsky.social · 27/02/2025
Friends, I am at a loss of words for how devastating it would be to lose the entire intramural #NIH program. Some of the biggest medical and scientific breakthroughs have come from scientists in the NIH Intramural program. #SaveTheNIH 🧬🧪 🖥️ 🧠 www.science.org/content/arti...
science.org
NIH ban on renewing senior scientists adds to assaults on its in-house research
Policy follows firings of tenure-track scientists and suspension of training programs
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Pam Herd @pamherd.bsky.social · 26/02/2025
As federal research grants continue to be frozen, and NIH staff is being gutted, please note this study was funded by federal research grants, including from NIH. If they continue with staff cuts, and continue to freeze new awards, this is just one example of what we lose.
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Chise @sailorrooscout.bsky.social · 26/02/2025
THIS IS HUGE! A cancer vaccine developed by Yale University and DFCI shows MAJOR promise. Results of an early-phase trial reveal ALL patients with ADVANCED stage kidney cancer had successful anti-cancer immune responses AND have remained CANCER-FREE approximately THREE years after treatment. 🧪🧵⬇️
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