Graham Erwin @grahamerwin.bsky.social · 18/08/2026The Baylor College of Medicine Conference on Structural Variants and DNA Repeats is back, and this year it has a new home! Join us in person in Houston November 19th–20th. Or join online. Virtual registration is FREE! ErwinLab.org/svar-conference 168
Graham Erwin @grahamerwin.bsky.social · 17/10/2025ASHG25 Poster 4106 Today at 2:30pm! Whole-genome long-read sequencing from 10 NANOGRAMS, not micrograms! ULI-HiFi delivers: ✅ 99.82% F1 for SNVs ✅ 98.9% TR accuracy ✅ Discovered LIMD1 TR expansion progressively increasing from normal→polyp→adenocarcinoma, with evidence of function 120
Graham Erwin @grahamerwin.bsky.social · 15/10/2025At ASHG25 RIGHT NOW: Deep-coverage PacBio HiFi sequencing reveals hotspots of tandem repeat variation in the male germline. 12 men, paired blood/sperm, 1.7M repeats analyzed. What we found about mutational bias will surprise you! Poster 6044W, 2:30-4:30pm today. Lucas Finot presenting. 000
Graham Erwin @grahamerwin.bsky.social · 08/10/2025Proud to announce that we received the NIH Director's New Innovator Award to develop a new class of genome editing tools! 2263
Reposted by Graham ErwinJeremy Berg @jeremymberg.bsky.social · 15/04/2025A follow-up to my quote of the day this morning: A short Bluetorial about Vannevar Bush and his legacymedia.tenor.coma cartoon says hey everybody an old man 's talking while bart simpson looks onALT: a cartoon says hey everybody an old man 's talking while bart simpson looks on 29838
Graham Erwin @grahamerwin.bsky.social · 21/05/2025Interested in modern grant writing in the age of AI? Join us this summer through Stanford Continuing Studies! continuingstudies.stanford.edu/courses/prof...continuingstudies.stanford.eduModern Grant Writing with AIAI is transforming grant writing—turning a time-intensive task into a more strategic, efficient process that elevates both research and storytelling. This hands-on course explores how to integrate AI ... 020
Reposted by Graham ErwinEthan Mollick @emollick.bsky.social · 20/05/2025Big: The final version of a randomized, controlled World Bank study finds using a GPT-4 tutor with teacher guidance in a six week afterschool program in Nigeria had "more than twice the effect of some of the most effective interventions in education" ("equating to 1.5 to 2 years" of standard school) 1216833
Reposted by Graham ErwinDisabledInSTEM @disabledinstem.bsky.social · 19/05/2025I had such a powerful experience at BCM SKY Retreat this weekend led by @grahamerwin.bsky.social and met so many amazing people! It was a thought-provoking and reflective weekend with lessons that I will carry with me! What a privilege to partake in such a transformative experience! 🥰 051
Reposted by Graham ErwinPacBio @pacbio.bsky.social · 24/04/2025A first in human genomics: a 4-generation pedigree reference, now in Nature. Built with #PacBio HiFi, it maps de novo mutation rates, reveals paternal bias, and captures high mutation rates in tandem repeats—even in Y and repeat-rich regions. Paper here: go.nature.com/4lGMPlP #TheresHiFiForThatgo.nature.comHuman de novo mutation rates from a four-generation pedigree reference - NatureAnalysis of more than 95% of each diploid human genome of a four-generation, twenty-eight-member family using five complementary short-read and long-read sequencing technologies provides a truth set t... 1106
Graham Erwin @grahamerwin.bsky.social · 16/04/2025There are a number of tools (Elicit, Perplexity, Google's Deep Research, Consensus within ChatGPT) to find references. One of the complaints from academics is these tools don't find "the right papers". So far, ChatGPT Deep Research and their o3 model have the best "taste" that I have found. (1/3)chatgpt.comChatGPTA conversational AI system that listens, learns, and challenges 110
Graham Erwin @grahamerwin.bsky.social · 11/04/2025The LLM (AMIE in this case) performs higher (59.1% top-10 accuracy) than the clinician with the LLM (51.7%). Another study consistent with what @emollick.bsky.social has been sharing for a while now. www.nature.com/articles/s41... 110
Reposted by Graham ErwinEthan Mollick @emollick.bsky.social · 04/04/2025Updated this chart with the newest Gemini. It shows the rapid progress in AI over less than two years: costs for GPT-4 class models has dropped 99.7% and even the most advanced models (beating PhDs at the GPQA) are still 82% cheaper than GPT-4. Probably not worth betting on this trend ending soon. 58519
Reposted by Graham ErwinLaura Kiessling @laurakiessling.bsky.social · 27/03/2025A new means of selectively imaging the inner mycolate of mycobacteria using a compound that covalently modifies an enzyme intercepts to create a new intermediate with the Kim lab, @thebrysonlab.bsky.social and the Bernhardt lab. #TB 13210
Reposted by Graham ErwinHarriet Dashnow @hdashnow.bsky.social · 26/03/2025The strchive.org paper is out!! The paper describes STRchive as a resource to improve the diagnosis of tandem repeat disorders, then goes beyond it to consider what can be learned about childhood onset and population prevalence of these diseases. 🖥️ 🧬 link.springer.com/article/10.1...link.springer.comSTRchive: a dynamic resource detailing population-level and locus-specific insights at tandem repeat disease loci - Genome MedicineApproximately 8% of the human genome consists of repetitive elements called tandem repeats (TRs): short tandem repeats (STRs) of 1–6 bp motifs and variable number tandem repeats (VNTRs) of 7 + bp moti... 2125
Reposted by Graham ErwinAaron Quinlan (he/him) @aaronquinlan.bsky.social · 26/03/2025A new article from Laurel Hiatt and @hdashnow.bsky.social describing STRchive is now available at Genome Medicine. genomemedicine.biomedcentral.com/articles/10.... Check out the database resource, as STRchive "streamlines TR variant interpretation at disease-associated loci." strchive.orggenomemedicine.biomedcentral.comSTRchive: a dynamic resource detailing population-level and locus-specific insights at tandem repeat disease loci - Genome MedicineApproximately 8% of the human genome consists of repetitive elements called tandem repeats (TRs): short tandem repeats (STRs) of 1–6 bp motifs and variable number tandem repeats (VNTRs) of 7 + bp moti... 0158
Reposted by Graham ErwinEthan Mollick @emollick.bsky.social · 21/03/2025Evidence that a well prompted LLM can help learning from a (small, single-subject) randomized controlled trial at Harvard: “here we show that students learn more than twice as much in less time with an AI tutor compared to an active learning classroom, while also being more engaged and motivated.” 26110
Reposted by Graham ErwinMark Cuban @mcuban.bsky.social · 14/03/2025We don't spend a penny on marketing. It's all word of mouth for @costplusdrugs.com That's how we keep prices so low. Please spread the word ! 980340489080
Reposted by Graham ErwinDerek Lowe @dereklowe.bsky.social · 12/03/2025The first bifunctional protein degrader to deliver Phase III data! It seems to work, but people were definitely expecting more:science.orgA Bifunctional Degrader Reads Out in Phase 3 26418
Reposted by Graham ErwinClement Chow @clementychow.bsky.social · 12/03/20255 yr anniversary of the day I started my COVID ICU visit 1413
Reposted by Graham ErwinFyodor Urnov @urnov.bsky.social · 10/03/2025Spectacular news this morning for CRISPR gene editing to treat genetic disease from Beam Therapeutics. This method was developed by David Liu's lab at the Broad. = "academic" science produces innovations that enables the biotech sector to build medicines investors.beamtx.com/news-release...investors.beamtx.com 17115
Reposted by Graham ErwinChristopher Barnes @cobarnes27.bsky.social · 06/03/2025Excited to share the peer-reviewed version of our paper, which is out today!! Bispecific antibodies targeting the N-terminal and receptor binding domains potently neutralize SARS-CoV-2 variants of concern | Science Translational Medicine www.science.org/doi/10.1126/...science.orgBispecific antibodies targeting the N-terminal and receptor binding domains potently neutralize SARS-CoV-2 variants of concernBispecific antibodies incorporating a cross-reactive NTD-specific antibody are resilient to SARS-CoV-2 variants of concern. 46811
Reposted by Graham ErwinSarafan ChEM-H @stanford-chemh.bsky.social · 06/03/2025Researchers from @pollyfordyce.bsky.social lab explore what makes some transcription factors more or less selective for their DNA ligands. This work could guide the design of more selective DNA-binding proteins for many bioengineering applications:buff.lyMutations to transcription factor MAX allosterically increase DNA selectivity by altering folding and binding pathways - Nature CommunicationsIn this work, high-throughput microfluidic assays reveal how allosteric substitutions that alter folding-and-binding pathways shape DNA specificity and selectivity landscapes in the human… 0114
Reposted by Graham ErwinSimon Willison @simonwillison.net · 05/03/2025ChatGPT Code Interpreter is still my favorite implementation of the pattern where an LLM can write code, run it, see any errors and iterate to fix them It's been stuck on GPT-4o for ages - today it got a huge upgrade and now work with GPT4.5 and o3-mini! simonwillison.net/2025/Mar/5/c...simonwillison.netDemo of ChatGPT Code Interpreter running in o3-mini-highOpenAI made GPT-4.5 available to Plus ($20/month) users today. I was [a little disappointed](https://simonwillison.net/2025/Feb/27/introducing-gpt-45/) with GPT-4.5 when I tried it through the API, bu... 4562
Reposted by Graham ErwinPacBio @pacbio.bsky.social · 19/02/2025As #AGBT approaches, discover how #PacBio SPRQ chemistry for Revio is advancing #HiFisequencing efficiency, reducing costs, and unlocking new research possibilities. bit.ly/4g89HXK #AGBT25bit.lyLighting a SPRQ: How new Revio chemistry fuels innovative research - PacBioNew SPRQ chemistry for the Revio system is revolutionizing HiFi sequencing with increased efficiency, affordability, and reduced DNA input. Learn about its impact on research in rare diseases, cancer, and multiomics. 083
Reposted by Graham ErwinEthan Mollick @emollick.bsky.social · 19/02/2025We are starting to see what "AI will accelerate science" actually looks like. This Google paper describes novel discoveries being made by AI working with human co-scientists (something I think we have all been waiting to see), along with an early version of an AI scientist for wider use. 19712
Reposted by Graham ErwinSteven Boeynaems @boeynaemssteven.bsky.social · 15/02/2025At #BPS2025? Check out the posters by @sovannytaylor.bsky.social and @gtleung.bsky.social on Monday. Venom peptides as tools to study cell penetrance and designer condensates to probe cytoplasmic rheology across length scales. 082
Graham Erwin @grahamerwin.bsky.social · 15/02/2025Highly recommend the Unpaywall extension to access manuscripts — it's easier than Sci-Hub, and legal! unpaywall.org/products/ext...unpaywall.orgUnpaywall 001
Reposted by Graham ErwinDerek Lowe @dereklowe.bsky.social · 10/02/2025Here’s my post on the NIH indirect costs slash-and-burn. God, these people are exhausting:science.orgThe Continuing NIH/NSF Crisis, Part III: Indirect Costs 311244
Reposted by Graham ErwinEthan Mollick @emollick.bsky.social · 04/02/2025You will never guess the report that took Deep Research the longest to generate of any I made before. 30 pages, 10,600 words, and actually super interesting to read based off a single prompt. Full report (and prompt): chatgpt.com/share/67a152... 5806
Reposted by Graham ErwinDerek Lowe @dereklowe.bsky.social · 04/02/2025A long post about what’s happening to the science funding agencies in the US and why. As mentioned, this one just kept getting longer even as I kept stripping curse words from it. www.science.org/content/blog...science.orgWhat's Happening Inside the NIH and NSF 20413291
Reposted by Graham ErwinYoav Gilad @ygilad.bsky.social · 10/01/2025Friends and colleagues, I’ve written a book on effective functional genomics study design, which will be available on Amazon in a couple of weeks. Sharing the TOC to spark interest. I hope students and those planning genomics experiments will find it useful! I’ll share updates soon 69937
Reposted by Graham ErwinMatt Bogyo @mbogyo.bsky.social · 09/01/2025First real post on @bsky.app! Check out our latest work identifying covalent fragments as inhibitors of the Fph serine hydrolases in S. aureus. Great work from Tulsi Upadhyay and our many collaborators. www.researchsquare.com/article/rs-5...researchsquare.comCovalent-fragment screening identifies selective inhibitors of multiple Staphylococcus aureus serine hydrolases important for growth and biofilm formationStaphylococcus aureus is a leading cause of bacteria-associated mortality worldwide. This is largely because infection sites are often difficult to localize and the bacteria forms biofilms which are n... 2456
Reposted by Graham ErwinDerek Lowe @dereklowe.bsky.social · 05/01/2025I think you're describing science, IMO. Everything is atop a foundation of basic research. An example: at a previous company, I worked on a series of small-molecule inhibitors of Hormone-Sensitive Lipase, a possible target for Type II diabetes and related conditions. (1/10) 37314
Reposted by Graham ErwinCarolyn Bertozzi @carolynbertozzi.bskyverified.social · 31/12/2024Deeply saddened by the news of Fraser Stoddart’s passing. Here is a piece I wrote on the occasion of his 2016 @nobelprize.bsky.social at ACSCentSci. pubs.acs.org/doi/10.1021/...pubs.acs.orgDesign, Synthesis, Action! Molecular Machines Take the 2016 Nobel Prize in Chemistry 311126
Reposted by Graham ErwinThiago Carvalho @cyrilpedia.bsky.social · 01/01/2025'But that’s not the only reason Science has named lenacapavir its 2024 Breakthrough of the Year. The off-the-charts success of the drug as PrEP sprang from a basic research advance: a new understanding of the structure and function of HIV’s capsid protein, which lenacapavir targets'science.orgScience’s 2024 Breakthrough of the Year: Opening the door to a new era of HIV preventionA drug with a novel mechanism protects people against the AIDS virus for 6 months. It could speed the end of the epidemic—if those who need it most get access 14428
Reposted by Graham ErwinAlphaFold Unofficial @alphafold.bsky.social · 17/12/2024🎶 Hark! The folded proteins sing, Stable chains and everything. Joyful folds in ribboned form, Structures bright, precise, and warm.* 🎶 Life depends on such designs, Aligned through microscopic lines. Peace on Earth and molecules bring, Hark! The folded proteins sing. 🎶 0154
Reposted by Graham ErwinStephen Turner @stephenturner.us · 09/12/2024Turn a GitHub repo into a single text file for LLM-friendly input: app takes a GitHub repo URL, displays the directory structure, lets you choose which files to include, and provides a single plain text file you can feed into any LLM. blog.stephenturner.us/p/github-rep... w/ #rstats example 6324
Reposted by Graham ErwinArjun Raj @arjunraj.bsky.social · 09/12/2024Apparently, Biorender now does graphing. Do not use. Terms of service likely include them owning your first-born child. 1294
Reposted by Graham ErwinEthan Mollick @emollick.bsky.social · 07/12/2024Models like o1 suggest that people won’t generally notice AGI-ish systems that are better than humans at most intellectual tasks, but which are not autonomous or self-directed Most folks don’t regularly have a lot of tasks that bump up against the limits of human intelligence, so won’t see it 815526
Reposted by Graham ErwinNEJM.org @nejm.org · 06/12/2024Hello, #MedSky community! We’re excited to begin our Bluesky journey. Here is a sampling of the trusted, influential, and essential information you can expect when you follow us: 32860187
Reposted by Graham ErwinOded Rechavi @odedrechavi.bsky.social · 05/12/2024Scared to share this after 10 freaking years of waiting, but here we go: We found that temperature *perception* can change the biology of the next generations, even when “it’s just in the parents' head”. Read how C. elegans neurons control epigenetic inheritance! www.biorxiv.org/content/10.1...biorxiv.orgPerception of Temperature Even in the Absence of Actual Change is Sufficient to Drive Transgenerational Epigenetic InheritanceCan processes occurring in one individuals nervous system influence the physiology of the descendants? Here we explored the provocative hypothesis that parents sensation or perception of environmental... 36547157
Reposted by Graham ErwinAaron Quinlan (he/him) @aaronquinlan.bsky.social · 03/12/2024Biology of Genomes 2025 is coming up: - meeting dates: May 6 - 10, 2025 - abstract deadline: Feb 14, 2025 We hope to see you there for another great meeting with a fantastic speaker lineup! meetings.cshl.edu/meetings.asp...meetings.cshl.eduBiology of GenomesCold Spring Harbor Laboratory Meetings & Courses -- a private, non-profit institution with research programs in cancer, neuroscience, plant biology, genomics, bioinformatics. 16634
Reposted by Graham ErwinBluesky @bsky.app · 03/12/2024Scientists, academics, researchers: We’re excited to share that @altmetric.com is now tracking mentions of your research on Bluesky! 🧪 456294874995
Reposted by Graham ErwinDerek Lowe @dereklowe.bsky.social · 02/12/2024Fluorescently labeled proteins are essential to research. But we should never forget how messed-up their behavior can be. An example from condensates:science.orgFluorescent Tags Are Basically Never Silent 913538
Reposted by Graham ErwinEthan Mollick @emollick.bsky.social · 02/12/2024You probably aren’t being ambitious enough in your AI experiments. Start with completely out there applications, assess them, and then reign in your ambitions from there. You might be inspired or surprised about how good AI is, or you might discover useful limitations earlier. 4959
Reposted by Graham ErwinVeera Rajagopal @doctorveera.bsky.social · 28/11/2024Striking similarity of some of the genetic signals in mismatch repair genes (MSH3, FAN1 and PMS2) between GWAS of somatic expansion of CAG repeats in TCF4 gene (estimated from UKB WGS data) & GWAS of age at onset of cognitive changes in Huntington's. www.biorxiv.org/content/10.1... 2102
Reposted by Graham ErwinMitch Guttman @mitchguttman.bsky.social · 27/11/2024Gene regulation involves thousands of proteins that bind DNA, yet comprehensively mapping these is challenging. Our paper in Nature Genetics describes ChIP-DIP, a method for genome-wide mapping of hundreds of DNA-protein interactions in a single experiment. www.nature.com/articles/s41...nature.comChIP-DIP maps binding of hundreds of proteins to DNA simultaneously and identifies diverse gene regulatory elements - Nature GeneticsChIP-DIP (ChIP done in parallel) is a highly multiplex assay for protein–DNA binding, scalable to hundreds of proteins including modified histones, chromatin regulators and transcription factors, offe... 9382150
Reposted by Graham ErwinMike Schatz @mikeschatz.bsky.social · 25/11/2024Sometimes you just have to persevere through negative reviews. Reviewers, please be kind :) #methodsmatter bit.ly/gs2-scholar 1425541
Reposted by Graham ErwinJon Lim, FRCP PhD @drjonlim.bsky.social · 23/11/2024🎨 In case anyone need… The NIH BioArt Source is an awesome library of *free* professionally drawn illustrations for scientific presentations or figures. Downloadable in HD. Thank you NIH for this invaluable tool 🙏! Check it out 👇 bioart.niaid.nih.gov 441198491