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Graham Erwin

@grahamerwin.bsky.social
178 followers 218 following 41 posts

Asst. Professor, Baylor College of Medicine. Previously Stanford and UW–Madison. We use molecules and genomes to understand repetitive DNA sequences. #FirstGenAcademic ErwinLab.org

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Graham Erwin @grahamerwin.bsky.social · 18/08/2026
The Baylor College of Medicine Conference on Structural Variants and DNA Repeats is back, and this year it has a new home! Join us in person in Houston November 19th–20th. Or join online. Virtual registration is FREE! ErwinLab.org/svar-conference
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Graham Erwin @grahamerwin.bsky.social · 17/10/2025
ASHG25 Poster 4106 Today at 2:30pm! Whole-genome long-read sequencing from 10 NANOGRAMS, not micrograms! ULI-HiFi delivers: ✅ 99.82% F1 for SNVs ✅ 98.9% TR accuracy ✅ Discovered LIMD1 TR expansion progressively increasing from normal→polyp→adenocarcinoma, with evidence of function
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Graham Erwin @grahamerwin.bsky.social · 15/10/2025
At ASHG25 RIGHT NOW: Deep-coverage PacBio HiFi sequencing reveals hotspots of tandem repeat variation in the male germline. 12 men, paired blood/sperm, 1.7M repeats analyzed. What we found about mutational bias will surprise you! Poster 6044W, 2:30-4:30pm today. Lucas Finot presenting.
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Graham Erwin @grahamerwin.bsky.social · 08/10/2025
Proud to announce that we received the NIH Director's New Innovator Award to develop a new class of genome editing tools!
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Jeremy Berg @jeremymberg.bsky.social · 15/04/2025
A follow-up to my quote of the day this morning: A short Bluetorial about Vannevar Bush and his legacy
media.tenor.com
a cartoon says hey everybody an old man 's talking while bart simpson looks on
ALT: a cartoon says hey everybody an old man 's talking while bart simpson looks on
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Graham Erwin @grahamerwin.bsky.social · 21/05/2025
Interested in modern grant writing in the age of AI? Join us this summer through Stanford Continuing Studies! continuingstudies.stanford.edu/courses/prof...
continuingstudies.stanford.edu
Modern Grant Writing with AI
AI is transforming grant writing—turning a time-intensive task into a more strategic, efficient process that elevates both research and storytelling. This hands-on course explores how to integrate AI ...
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Ethan Mollick @emollick.bsky.social · 20/05/2025
Big: The final version of a randomized, controlled World Bank study finds using a GPT-4 tutor with teacher guidance in a six week afterschool program in Nigeria had "more than twice the effect of some of the most effective interventions in education" ("equating to 1.5 to 2 years" of standard school)
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DisabledInSTEM @disabledinstem.bsky.social · 19/05/2025
I had such a powerful experience at BCM SKY Retreat this weekend led by @grahamerwin.bsky.social and met so many amazing people! It was a thought-provoking and reflective weekend with lessons that I will carry with me! What a privilege to partake in such a transformative experience! 🥰
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PacBio @pacbio.bsky.social · 24/04/2025
A first in human genomics: a 4-generation pedigree reference, now in Nature. Built with #PacBio HiFi, it maps de novo mutation rates, reveals paternal bias, and captures high mutation rates in tandem repeats—even in Y and repeat-rich regions. Paper here: go.nature.com/4lGMPlP #TheresHiFiForThat
go.nature.com
Human de novo mutation rates from a four-generation pedigree reference - Nature
Analysis of more than 95% of each diploid human genome of a four-generation, twenty-eight-member family using five complementary short-read and long-read sequencing technologies provides a truth set t...
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Graham Erwin @grahamerwin.bsky.social · 16/04/2025
There are a number of tools (Elicit, Perplexity, Google's Deep Research, Consensus within ChatGPT) to find references. One of the complaints from academics is these tools don't find "the right papers". So far, ChatGPT Deep Research and their o3 model have the best "taste" that I have found. (1/3)
chatgpt.com
ChatGPT
A conversational AI system that listens, learns, and challenges
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Graham Erwin @grahamerwin.bsky.social · 11/04/2025
The LLM (AMIE in this case) performs higher (59.1% top-10 accuracy) than the clinician with the LLM (51.7%). Another study consistent with what @emollick.bsky.social has been sharing for a while now. www.nature.com/articles/s41...
Table 1 Top-1 and top-10 accuracy of DDx lists produced with AMIE and Search assistance
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Ethan Mollick @emollick.bsky.social · 04/04/2025
Updated this chart with the newest Gemini. It shows the rapid progress in AI over less than two years: costs for GPT-4 class models has dropped 99.7% and even the most advanced models (beating PhDs at the GPQA) are still 82% cheaper than GPT-4. Probably not worth betting on this trend ending soon.
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Laura Kiessling @laurakiessling.bsky.social · 27/03/2025
A new means of selectively imaging the inner mycolate of mycobacteria using a compound that covalently modifies an enzyme intercepts to create a new intermediate with the Kim lab, @thebrysonlab.bsky.social and the Bernhardt lab. #TB
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Harriet Dashnow @hdashnow.bsky.social · 26/03/2025
The strchive.org paper is out!! The paper describes STRchive as a resource to improve the diagnosis of tandem repeat disorders, then goes beyond it to consider what can be learned about childhood onset and population prevalence of these diseases. 🖥️ 🧬 link.springer.com/article/10.1...
link.springer.com
STRchive: a dynamic resource detailing population-level and locus-specific insights at tandem repeat disease loci - Genome Medicine
Approximately 8% of the human genome consists of repetitive elements called tandem repeats (TRs): short tandem repeats (STRs) of 1–6 bp motifs and variable number tandem repeats (VNTRs) of 7 + bp moti...
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Aaron Quinlan (he/him) @aaronquinlan.bsky.social · 26/03/2025
A new article from Laurel Hiatt and @hdashnow.bsky.social describing STRchive is now available at Genome Medicine. genomemedicine.biomedcentral.com/articles/10.... Check out the database resource, as STRchive "streamlines TR variant interpretation at disease-associated loci." strchive.org
genomemedicine.biomedcentral.com
STRchive: a dynamic resource detailing population-level and locus-specific insights at tandem repeat disease loci - Genome Medicine
Approximately 8% of the human genome consists of repetitive elements called tandem repeats (TRs): short tandem repeats (STRs) of 1–6 bp motifs and variable number tandem repeats (VNTRs) of 7 + bp moti...
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Ethan Mollick @emollick.bsky.social · 21/03/2025
Evidence that a well prompted LLM can help learning from a (small, single-subject) randomized controlled trial at Harvard: “here we show that students learn more than twice as much in less time with an AI tutor compared to an active learning classroom, while also being more engaged and motivated.”
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Mark Cuban @mcuban.bsky.social · 14/03/2025
We don't spend a penny on marketing. It's all word of mouth for @costplusdrugs.com That's how we keep prices so low. Please spread the word !
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Derek Lowe @dereklowe.bsky.social · 12/03/2025
The first bifunctional protein degrader to deliver Phase III data! It seems to work, but people were definitely expecting more:
science.org
A Bifunctional Degrader Reads Out in Phase 3
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Clement Chow @clementychow.bsky.social · 12/03/2025
5 yr anniversary of the day I started my COVID ICU visit
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Fyodor Urnov @urnov.bsky.social · 10/03/2025
Spectacular news this morning for CRISPR gene editing to treat genetic disease from Beam Therapeutics. This method was developed by David Liu's lab at the Broad. = "academic" science produces innovations that enables the biotech sector to build medicines investors.beamtx.com/news-release...
investors.beamtx.com
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Christopher Barnes @cobarnes27.bsky.social · 06/03/2025
Excited to share the peer-reviewed version of our paper, which is out today!! Bispecific antibodies targeting the N-terminal and receptor binding domains potently neutralize SARS-CoV-2 variants of concern | Science Translational Medicine www.science.org/doi/10.1126/...
science.org
Bispecific antibodies targeting the N-terminal and receptor binding domains potently neutralize SARS-CoV-2 variants of concern
Bispecific antibodies incorporating a cross-reactive NTD-specific antibody are resilient to SARS-CoV-2 variants of concern.
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Sarafan ChEM-H @stanford-chemh.bsky.social · 06/03/2025
Researchers from @pollyfordyce.bsky.social lab explore what makes some transcription factors more or less selective for their DNA ligands. This work could guide the design of more selective DNA-binding proteins for many bioengineering applications:
buff.ly
Mutations to transcription factor MAX allosterically increase DNA selectivity by altering folding and binding pathways - Nature Communications
In this work, high-throughput microfluidic assays reveal how allosteric substitutions that alter folding-and-binding pathways shape DNA specificity and selectivity landscapes in the human…
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Simon Willison @simonwillison.net · 05/03/2025
ChatGPT Code Interpreter is still my favorite implementation of the pattern where an LLM can write code, run it, see any errors and iterate to fix them It's been stuck on GPT-4o for ages - today it got a huge upgrade and now work with GPT4.5 and o3-mini! simonwillison.net/2025/Mar/5/c...
simonwillison.net
Demo of ChatGPT Code Interpreter running in o3-mini-high
OpenAI made GPT-4.5 available to Plus ($20/month) users today. I was [a little disappointed](https://simonwillison.net/2025/Feb/27/introducing-gpt-45/) with GPT-4.5 when I tried it through the API, bu...
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PacBio @pacbio.bsky.social · 19/02/2025
As #AGBT approaches, discover how #PacBio SPRQ chemistry for Revio is advancing #HiFisequencing efficiency, reducing costs, and unlocking new research possibilities. bit.ly/4g89HXK #AGBT25
bit.ly
Lighting a SPRQ: How new Revio chemistry fuels innovative research - PacBio
New SPRQ chemistry for the Revio system is revolutionizing HiFi sequencing with increased efficiency, affordability, and reduced DNA input. Learn about its impact on research in rare diseases, cancer, and multiomics.
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Ethan Mollick @emollick.bsky.social · 19/02/2025
We are starting to see what "AI will accelerate science" actually looks like. This Google paper describes novel discoveries being made by AI working with human co-scientists (something I think we have all been waiting to see), along with an early version of an AI scientist for wider use.
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Steven Boeynaems @boeynaemssteven.bsky.social · 15/02/2025
At #BPS2025? Check out the posters by @sovannytaylor.bsky.social and @gtleung.bsky.social on Monday. Venom peptides as tools to study cell penetrance and designer condensates to probe cytoplasmic rheology across length scales.
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Graham Erwin @grahamerwin.bsky.social · 15/02/2025
Highly recommend the Unpaywall extension to access manuscripts — it's easier than Sci-Hub, and legal! unpaywall.org/products/ext...
unpaywall.org
Unpaywall
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Derek Lowe @dereklowe.bsky.social · 10/02/2025
Here’s my post on the NIH indirect costs slash-and-burn. God, these people are exhausting:
science.org
The Continuing NIH/NSF Crisis, Part III: Indirect Costs
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Ethan Mollick @emollick.bsky.social · 04/02/2025
You will never guess the report that took Deep Research the longest to generate of any I made before. 30 pages, 10,600 words, and actually super interesting to read based off a single prompt. Full report (and prompt): chatgpt.com/share/67a152...
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Derek Lowe @dereklowe.bsky.social · 04/02/2025
A long post about what’s happening to the science funding agencies in the US and why. As mentioned, this one just kept getting longer even as I kept stripping curse words from it. www.science.org/content/blog...
science.org
What's Happening Inside the NIH and NSF
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Yoav Gilad @ygilad.bsky.social · 10/01/2025
Friends and colleagues, I’ve written a book on effective functional genomics study design, which will be available on Amazon in a couple of weeks. Sharing the TOC to spark interest. I hope students and those planning genomics experiments will find it useful! I’ll share updates soon
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Matt Bogyo @mbogyo.bsky.social · 09/01/2025
First real post on @bsky.app! Check out our latest work identifying covalent fragments as inhibitors of the Fph serine hydrolases in S. aureus. Great work from Tulsi Upadhyay and our many collaborators. www.researchsquare.com/article/rs-5...
researchsquare.com
Covalent-fragment screening identifies selective inhibitors of multiple Staphylococcus aureus serine hydrolases important for growth and biofilm formation
Staphylococcus aureus is a leading cause of bacteria-associated mortality worldwide. This is largely because infection sites are often difficult to localize and the bacteria forms biofilms which are n...
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Derek Lowe @dereklowe.bsky.social · 05/01/2025
I think you're describing science, IMO. Everything is atop a foundation of basic research. An example: at a previous company, I worked on a series of small-molecule inhibitors of Hormone-Sensitive Lipase, a possible target for Type II diabetes and related conditions. (1/10)
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Carolyn Bertozzi @carolynbertozzi.bskyverified.social · 31/12/2024
Deeply saddened by the news of Fraser Stoddart’s passing. Here is a piece I wrote on the occasion of his 2016 @nobelprize.bsky.social at ACSCentSci. pubs.acs.org/doi/10.1021/...
pubs.acs.org
Design, Synthesis, Action! Molecular Machines Take the 2016 Nobel Prize in Chemistry
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Thiago Carvalho @cyrilpedia.bsky.social · 01/01/2025
'But that’s not the only reason Science has named lenacapavir its 2024 Breakthrough of the Year. The off-the-charts success of the drug as PrEP sprang from a basic research advance: a new understanding of the structure and function of HIV’s capsid protein, which lenacapavir targets'
science.org
Science’s 2024 Breakthrough of the Year: Opening the door to a new era of HIV prevention
A drug with a novel mechanism protects people against the AIDS virus for 6 months. It could speed the end of the epidemic—if those who need it most get access
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AlphaFold Unofficial @alphafold.bsky.social · 17/12/2024
🎶 Hark! The folded proteins sing, Stable chains and everything. Joyful folds in ribboned form, Structures bright, precise, and warm.* 🎶 Life depends on such designs, Aligned through microscopic lines. Peace on Earth and molecules bring, Hark! The folded proteins sing. 🎶
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Stephen Turner @stephenturner.us · 09/12/2024
Turn a GitHub repo into a single text file for LLM-friendly input: app takes a GitHub repo URL, displays the directory structure, lets you choose which files to include, and provides a single plain text file you can feed into any LLM. blog.stephenturner.us/p/github-rep... w/ #rstats example
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Arjun Raj @arjunraj.bsky.social · 09/12/2024
Apparently, Biorender now does graphing. Do not use. Terms of service likely include them owning your first-born child.
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Ethan Mollick @emollick.bsky.social · 07/12/2024
Models like o1 suggest that people won’t generally notice AGI-ish systems that are better than humans at most intellectual tasks, but which are not autonomous or self-directed Most folks don’t regularly have a lot of tasks that bump up against the limits of human intelligence, so won’t see it
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NEJM.org @nejm.org · 06/12/2024
Hello, #MedSky community! We’re excited to begin our Bluesky journey. Here is a sampling of the trusted, influential, and essential information you can expect when you follow us:
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Oded Rechavi @odedrechavi.bsky.social · 05/12/2024
Scared to share this after 10 freaking years of waiting, but here we go: We found that temperature *perception* can change the biology of the next generations, even when “it’s just in the parents' head”. Read how C. elegans neurons control epigenetic inheritance! www.biorxiv.org/content/10.1...
biorxiv.org
Perception of Temperature Even in the Absence of Actual Change is Sufficient to Drive Transgenerational Epigenetic Inheritance
Can processes occurring in one individuals nervous system influence the physiology of the descendants? Here we explored the provocative hypothesis that parents sensation or perception of environmental...
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Aaron Quinlan (he/him) @aaronquinlan.bsky.social · 03/12/2024
Biology of Genomes 2025 is coming up: - meeting dates: May 6 - 10, 2025 - abstract deadline: Feb 14, 2025 We hope to see you there for another great meeting with a fantastic speaker lineup! meetings.cshl.edu/meetings.asp...
meetings.cshl.edu
Biology of Genomes
Cold Spring Harbor Laboratory Meetings & Courses -- a private, non-profit institution with research programs in cancer, neuroscience, plant biology, genomics, bioinformatics.
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Bluesky @bsky.app · 03/12/2024
Scientists, academics, researchers: We’re excited to share that @altmetric.com is now tracking mentions of your research on Bluesky! 🧪
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Derek Lowe @dereklowe.bsky.social · 02/12/2024
Fluorescently labeled proteins are essential to research. But we should never forget how messed-up their behavior can be. An example from condensates:
science.org
Fluorescent Tags Are Basically Never Silent
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Ethan Mollick @emollick.bsky.social · 02/12/2024
You probably aren’t being ambitious enough in your AI experiments. Start with completely out there applications, assess them, and then reign in your ambitions from there. You might be inspired or surprised about how good AI is, or you might discover useful limitations earlier.
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Veera Rajagopal @doctorveera.bsky.social · 28/11/2024
Striking similarity of some of the genetic signals in mismatch repair genes (MSH3, FAN1 and PMS2) between GWAS of somatic expansion of CAG repeats in TCF4 gene (estimated from UKB WGS data) & GWAS of age at onset of cognitive changes in Huntington's. www.biorxiv.org/content/10.1...
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Mitch Guttman @mitchguttman.bsky.social · 27/11/2024
Gene regulation involves thousands of proteins that bind DNA, yet comprehensively mapping these is challenging. Our paper in Nature Genetics describes ChIP-DIP, a method for genome-wide mapping of hundreds of DNA-protein interactions in a single experiment. www.nature.com/articles/s41...
nature.com
ChIP-DIP maps binding of hundreds of proteins to DNA simultaneously and identifies diverse gene regulatory elements - Nature Genetics
ChIP-DIP (ChIP done in parallel) is a highly multiplex assay for protein–DNA binding, scalable to hundreds of proteins including modified histones, chromatin regulators and transcription factors, offe...
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Mike Schatz @mikeschatz.bsky.social · 25/11/2024
Sometimes you just have to persevere through negative reviews. Reviewers, please be kind :) #methodsmatter bit.ly/gs2-scholar
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Jon Lim, FRCP PhD @drjonlim.bsky.social · 23/11/2024
🎨 In case anyone need… The NIH BioArt Source is an awesome library of *free* professionally drawn illustrations for scientific presentations or figures. Downloadable in HD. Thank you NIH for this invaluable tool 🙏! Check it out 👇 bioart.niaid.nih.gov
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