Using a novel intersectional genetic strategy for sparse neuronal labeling, Grossouw, Heijmink, et al. reconstruct individual midbrain dopamine neurons throughout development, adulthood, and degenerat...

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Accumulating evidence implicates non-neuronal cells in ALS pathogenesis. Using patient-derived cerebral organoids, Ljubikj et al. reveal reduced microglial

Mutations in GFAP alter lineage commitment of organoids. The severity of this commitment defect is dependent on the method of embryoid body formation. GFAP is expressed in iPSCs and during early st...

Here, we present a protocol for generating long-term microglia-containing air-liquid-interface cortical organoid (MG-ALI-CO) cultures. This approach m…

The fourth session of the 2024 European Society of Toxicologic Pathology (ESTP) Congress brought together lectures focused on the use of in vitro and in vivo mo...

Neural circuit development requires precisely coordinated guidance of migrating neurons to their targets within the nervous system. A diverse array of…

9-10 October 2025, Leuven, Belgium Organized in partnership with Cell Press

🎥 Kijktip: ALS Centrum in Driedubbel Gezond   Vandaag is de eerste aflevering van het nieuwe EO-programma Driedubbel Gezond, die geheel in het teken staat van…

European Journal of Human Genetics - An observational study of pleiotropy and penetrance of amyotrophic lateral sclerosis associated with CAG-repeat expansion of ATXN2

9-10 October 2025, Leuven, Belgium Organized in partnership with Cell Press

Our summerschool is aimed at advanced master students and starting PhD students with the goal to teach them on recent advances in neural circuit development and plasticity from an interdisciplinary pe...

De Decker et al. show that ALS-associated mutations in C21ORF2 disrupt primary cilia on motor neurons, leading to defective downstream sonic hedgehog signa

Molecular neuroscience; Developmental neuroscience; Cellular neuroscience