Human induced GC-like B (iGCB) cells are generated in vitro from circulating naive or marginal zone cells.

Farzad et al. present a spatial multi-omics atlas of human lymph nodes spanning ages 18–86 years. Senescent-like B cells are heterogeneous and shift spatially from interfollicular zones into germinal ...

B cell responses that bound to future H1N1 and influenza B virus strains, but not H3N2 strains, were elicited in adults by the 1994 influenza vaccine.

In absence of telomerase, short telomeres trigger senescence. Here, the authors find using single-telomere-single-cell approaches in budding yeast, that one critically short telomere is required and s...

The Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard in Cambridge MA, together with the Departmen

Alzheimer’s disease is a severe neurodegenerative disorder, with multifactorial mechanisms of disease development and progression. Evidence from genetic association studies, animal models, and clinica...

Just a few weeks ago, researchers and educators connected to immunology lost a wonderful friend and colleague: Michael Cancro, professor of pathology and lab medicine at the University of Pennsylvania, passed away suddenly at his home just outside Philadelphia. He will be deeply missed.

The nasal mucosa is the first immunologically active site that respiratory viruses encounter and establishing immunity at the initial point of path...

To understand the influence and longevity of early influenza imprinting, Spangler et al. investigate the response to an H2 HA vaccine in individuals with and without exposure to H2N2 virus 50 years ago. They find that those with prior exposure have a…

The Trump administration has for weeks been blocking the U.S. National Institutes of Health process for issuing new research grants for everything from Lyme disease to lung and heart disease, according to researchers, a departing NIH official and documents.

NIH-related updates to the Federal Register, which are required for the scheduling of study sections and advisory councils, are on hold indefinitely, according to an email reviewed by <i>The Transmitt...

ALT: a poster that says if life gives you lemon make lemonade on it

The immunoglobulin heavy chain constant (IGHC) domain of antibodies (Ab) is responsible for a variety of effector functions critical to Ab mediated immunity. In human, this domain is encoded by genes ...

Nature Biotechnology - Metabolites can be quantified using a combination of aptamers and DNA barcodes.

Here the authors use a tonsil organoid culture model system to investigate the roles of human CD4+ and CD8+ regulatory T cells in controlling self-reactive immune responses. CD4+ regulatory T cells we...

Nature Communications - Pyridoxal 5’-phosphate (PLP, vitamin B6) is crucial for various metabolic processes. Here, the authors identified SLC25A38 as a key regulator of mitochondrial PLP...