The move, affecting about one-fifth of the National Science Foundation’s primary research budget, is the latest sign of how the White House is asserting more control over grants.

Persistent financial hardship accelerates age-related cognitive decline, according to a new study led by University College London (UCL) researchers.

Leveraging proteomic data from nearly 15,000 women across several cohorts, this study found that menopause is associated with hormone-linked molecular changes that correlate with poorer cognitive outc...

We found that antiviral CD8+ T cells can deputize the local innate immune system to destroy tumors. Thus, CD8+ T cells can kill by proxy, which has ramifications for cancer treatment and general mecha...

Intestinal epithelial cells can present antigen to CD4 T cells. Here the authors show that epithelial cells must present translocated bacterial antigen for local CD4 resident memory T cells to be esta...

HIV reservoir cells are traditionally considered invisible to host immune responses due to viral latency. This work challenges this view by demonstrating that HIV persistence during long-term antiretr...

Engineered fluids could extract metals from fracked reservoirs, supplying materials for solar cells and electric vehicles

What sounds like a jumble of noise is actually a group signal

Companies striving to reduce continent’s reliance on foreign shots must overcome major financial and logistical challenges

Shifts in blood proteins could point to ways to fight menopause “brain fog” and prevent later dementia

Experimental reactor needed much more uranium and heavy water than the country could muster

Scientists are piecing together why elephants make these low calls and what they might mean

Osteoarthritis (OA) is a degenerative joint disease, the progression of which is accelerated by systemic metabolic stress. Here, we identified a neuroendocrine pathway through which hypertension accel...

Micrometer-long peptide amphiphile fibrils enhance neuronal adhesion and function

Blelloch and colleagues create genetically engineered universal human iPSCs, differentiate them into CCR7+ migratory dendritic cells, and dress them with tumor-derived MHC class I-antigen complexes to...

Najia, Le, Borrajo et al. establish “cellular self-reporting,” a technology to export molecular analytes from cells in virus-like particles. The authors demonstrate how mRNA export enables longitudina...

The amoeba Incendiamoeba cascadensis demonstrates that eukaryotic life can withstand temperatures beyond what was thought possible and sheds light on molecular strategies for survival in extreme heat.

The maternal gut microbiome is a predictor of infant eczema.

Aquatic invertebrates are exceptionally nutrient dense, supplying the equivalent annual vitamin B12 and selenium requirements for over 5 billion people.

Optical illusions trick enemies into misjudging the insects’ speed and direction

Google DeepMind team inserts identifiable pattern into protein’s sequence without compromising its structure or function

How politics, bad timing, and skepticism left foundation stones of modern physics unrecognized

Aged cranial bone marrow–derived monocytes fuel chronic neuroinflammation after traumatic brain injury, a process reversed by fenofibrate.

A single-dose topical therapy combining a metalloprotease inhibitor and a β-triketone cures scabies in a porcine model.

Fingertips of Suriname toads are hypersensitive motion detectors, new study reveals

Ethicists are wary of an HHS proposal to loosen rules for “low-risk research”

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...

The AI-based assessment, which wasn’t explicitly described in the funding call, has raised privacy and fairness concerns

Luciana Gatti, who studies carbon uptake in the Amazon, aims to join Brazil’s lower house in this weekend’s elections

Breakthroughs in genetically altering cephalopods pave way for new studies of perception, brain evolution, and more

Twentieth-century immunology was shaped by questions of recognition, diversity, response and tolerance. The next era may be defined by a different class of questions: how immune activity is embedded i...

In the context of severe and worsening science teacher shortages in many countries and a body of literature reliant on retrospective accounts from those already teaching science, this paper explores ...

NASA’s $1.2 billion PRIMA will explore how galaxies evolve and how planets emerge from disks of gas and dust

First clean pictures from a muon beam point to a new way to peer inside suspicious packages and ancient structures

Epithelial barriers represent the first line of defense against pathogens, yet their role in innate immunity is typically relegated to pathogen detection and immune cell recruitment. This perspective ...

Physiological homeostasis is traditionally viewed as an individual process optimized through evolution to minimize the energetic costs of regulation. However, it remains unknown whether social proximi...

Combining manganese with STING agonist into AEC-targeting nanoparticles reverses aged lung immunity for robust vaccine responses.

Our strain-level and species-level analyses showed that the gut microbiome of vaginally delivered infants exhibited higher sharing with the maternal gut or vaginal microbiome, primarily with the gut m...

Perez, Schoenfeldt et al. present an integrated platform and methodology combining automation and machine learning to evaluate thousands of conditions across >400 compounds in yeasts, nematodes, flies...

Gorman et al. isolate VRC49, the second Fab-dimerized glycan-reactive, broadly neutralizing antibody recovered from an HIV-infected human since 2G12. Cryo-EM reveals a distinct dimerization mechanism ...

Type 2 cytokines suppress antitumor immunity through coordinated effects on T cells and dendritic cells. Fabre et al. show that combined blockade of IL-4, IL-13, and TSLP enhances PD-1 checkpoint inhi...

CD40-stimulated B cells drive infiltration, organization, and cytotoxic function of CD8+ T cells in triple-negative breast tumors, advancing our understanding of how B cell interactions with CD8+ T ce...

Clostridioides difficile is a major cause of healthcare-associated infections with substantial diversity in its pathogenic potential. Khanna et al. review the diversity and evolution of C. difficile l...

Agency director announces literature search tool, other plans to improve reliability of science findings

Targeting senescence decreases fibrosis and boosts the response of cancer cells to immunotherapy

The CD1 system responds to lipids, not proteins, driving reactions to bee stings, bacteria, and possibly poison ivy