Reposted by Cole J. BattybioRxiv Immunology @biorxiv-immuno.bsky.social · 05/10/2026CHAIR an antigen-resolved antibody-reactome resource for healthy adult immune aging www.biorxiv.org/content/10.64898/20… 011
Reposted by Cole J. BattyElizabeth Wood, PhD @lizbwood.bsky.social · 24/09/2026Introducing: continuous variational synthesis 📄 jurabio.com/s/cvs.pdf We’re pleased to announce a new advance in our ability to synthesize generative model-designed DNA sequences at petascale.jurabio.com 134
Cole J. Batty @colebatty.bsky.social · 22/09/2026Preprint came out a while ago but here's a cool and useful technique: In vitro induction of human germinal center B cells | Science Immunology www.science.org/doi/full/10....science.orgIn vitro induction of human germinal center B cellsHuman induced GC-like B (iGCB) cells are generated in vitro from circulating naive or marginal zone cells. 011
Reposted by Cole J. BattyAlex Rubinsteyn @alexr.bsky.social · 16/09/2026I'm working on an AI eval project that needs domain expert human graders across different corners of biology. Let me know if you want a wacky consulting project, the biological domain likely can be whatever you already do research on. (ideally post-PhD) 231
Cole J. Batty @colebatty.bsky.social · 11/09/2026They have a program for academics, and Rosalind specifically for life sciences, but the academic pricing is a wait-list and it seems like the Rosalind access has to be negotiated by your institution 000
Cole J. Batty @colebatty.bsky.social · 11/09/2026claude.com/programs/tea... You have to use your institutional email and get approved, but our group's approval was immediate. Then regular plan is free and premium (~equivalent to max) is I think $30/mo. It has no effect on token prices through API.claude.comClaude Team plan for scientists | Claude by AnthropicScientists at academic and nonprofit research institutions around the world can now get Claude at no cost to start. Shared projects, Claude Science, and admin controls at rates built for grant budgets... 100
Cole J. Batty @colebatty.bsky.social · 11/09/2026I'm not having that issue. My account is through our group's 'Team plan for scientists'-- maybe that affects it? It's also free/discounted that way 101
Cole J. Batty @colebatty.bsky.social · 09/09/2026Isn't that the spot where the lanes are most needed? 010
Cole J. Batty @colebatty.bsky.social · 31/08/2026Thank you for making me aware of this symptom which I realize I got from a concussion 010
Reposted by Cole J. BattybioRxivpreprint @biorxivpreprint.bsky.social · 05/08/2026Tfh dysfunction underlies poor responses to HBV vaccination www.biorxiv.org/content/10.64898/20… 022
Cole J. Batty @colebatty.bsky.social · 28/07/2026The feed I had before was broken and this works for me. 000
Reposted by Cole J. BattybioRxiv Immunology @biorxiv-immuno.bsky.social · 07/07/2026FCRL5 is a fucose-sensitive IgG-Fc receptor with binding properties distinct from classical Fcγ receptors www.biorxiv.org/content/10.64898/20… 022
Cole J. Batty @colebatty.bsky.social · 24/06/2026I get that there's an AI bubble and all but bro is deliberately obtuse about AI capabilities and it saps credibility from his more cogent analyses 010
Reposted by Cole J. BattyEric Chevet @ericchevet.bsky.social · 16/06/2026A spatial multi-omics atlas of immunosenescence reveals germinal-center B cell alteration in human lymph nodes: Cell Press Blue www.cell.com/cell-press-b...cell.comA spatial multi-omics atlas of immunosenescence reveals germinal-center B cell alteration in human lymph nodesFarzad et al. present a spatial multi-omics atlas of human lymph nodes spanning ages 18–86 years. Senescent-like B cells are heterogeneous and shift spatially from interfollicular zones into germinal ... 063
Cole J. Batty @colebatty.bsky.social · 10/06/2026Clinical research coordinator for donor recruitment retention and data/sample organization 020
Cole J. Batty @colebatty.bsky.social · 07/06/2026The S is part of the acronym, stands for substances or surfactants. 130
Cole J. Batty @colebatty.bsky.social · 02/05/2026Not sure how true that is, I think it's just laziness. 010
Reposted by Cole J. BattyJournal of Clinical Investigation @jci.org · 12/04/2026From earlier this week: Do cells of different lineages age differently? doi.org/10.1172/JCI1... Sundeep Khosla & team compare the senescence phenotype of mesenchymal versus immune cells from murine bone and bone marrow, revealing important differences between them. 033
Reposted by Cole J. BattyJavi Ibarrondo @jibarrondo.bsky.social · 01/04/2026Historic 1994 influenza vaccine cohorts define breadth of antibody and B cell responses toward future influenza A and B viruses | Science Translational Medicine www.science.org/doi/10.1126/... 🧪science.orgHistoric 1994 influenza vaccine cohorts define breadth of antibody and B cell responses toward future influenza A and B virusesB cell responses that bound to future H1N1 and influenza B virus strains, but not H3N2 strains, were elicited in adults by the 1994 influenza vaccine. 1137
Reposted by Cole J. BattyAlex Rubinsteyn @alexr.bsky.social · 28/03/2026Any immunologists looking for a 1yr staff scientist job in NC? I’m not sure if I’m staying at UNC past 2027 but I’m feeling the weight of accumulating experimental backlog. Ideally already in the area, experienced in T-cell assays like IFNg ELISpot, ICS, MHC multimer flow, &c 033
Reposted by Cole J. BattyThiago Carvalho @cyrilpedia.bsky.social · 21/03/2026'Using single-telomere & sc analyses combined with mathematical modeling, we identify a threshold length at which telomeres switch into dysfunction. A single shortest telomere below the threshold length is necessary & sufficient to trigger the onset of replicative senescence in a majority of cells'nature.comBoth genome instability and replicative senescence stem from the shortest telomere in telomerase-negative cells - Nature CommunicationsIn absence of telomerase, short telomeres trigger senescence. Here, the authors find using single-telomere-single-cell approaches in budding yeast, that one critically short telomere is required and s... 032
Reposted by Cole J. BattybioRxiv Immunology @biorxiv-immuno.bsky.social · 24/02/2026Strain-specific differences in the response to egg-derived versus recombinant protein influenza vaccines www.biorxiv.org/content/10.64898/20… 032
Cole J. Batty @colebatty.bsky.social · 22/02/2026Interesting, I thought there would be a section about building impenetrable berms in the bike lane at every corner to render the cleared lanes useless? 100
Cole J. Batty @colebatty.bsky.social · 25/01/2026Followed you for sf stuff and now you're sharing an amazing immunology paper that inspired my current research! 110
Cole J. Batty @colebatty.bsky.social · 20/01/2026Kynurenine pathway dysregulation plays a key role in so many different conditions (including aging). IDO/TDO inhibition has not worked out well so far, but this paper suggests some other targets. 010
Cole J. Batty @colebatty.bsky.social · 09/01/2026You should correct your post. it's phone footage and that's an important distinction in this context 000
Cole J. Batty @colebatty.bsky.social · 17/12/2025I've been successfully using Burton's buffers with dawn and no Triton for staining an endosomally localized membrane protein. 031
Cole J. Batty @colebatty.bsky.social · 17/12/2025If you really optimized the vax formulation mRNA is not gonna make anything better imo. 000
Reposted by Cole J. BattyBryan Bryson @thebrysonlab.bsky.social · 07/12/2025The @ragoninstitute.bsky.social is launching a new faculty search for a computational immunologist! Applications are open now and reviewed on a rolling basis. Please share broadly with your networks! #immunosky www.nature.com/naturecareer...nature.comComputational Immunologist - Boston, Massachusetts (US) job with Ragon Institute of MGH, MIT, & Harvard | 12849577The Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard in Cambridge MA, together with the Departmen 01620
Reposted by Cole J. BattyWaggoner Lab @labwaggoner.bsky.social · 03/12/2025Plasma-localized IgG glycosylation is dynamically altered by the endothelium www.pnas.org/doi/10.1073/... 141
Reposted by Cole J. BattyWaggoner Lab @labwaggoner.bsky.social · 26/11/2025A common progenitor gives rise to fibroblastic reticular cells and vascular smooth muscle cells in murine lymph nodes @jem.org rupress.org/jem/article/... 031
Reposted by Cole J. BattybioRxiv Immunology @biorxiv-immuno.bsky.social · 01/11/2025B lymphocytes that enter the germinal center late preferentially differentiate into memory cells that recognize subdominant epitopes www.biorxiv.org/content/10.1101/202… 072
Reposted by Cole J. BattybioRxiv Immunology @biorxiv-immuno.bsky.social · 20/10/2025Autoantibody origins in lupus and in relapse post CAR-T therapy www.biorxiv.org/content/10.1101/202… 031
Reposted by Cole J. BattybioRxiv Immunology @biorxiv-immuno.bsky.social · 02/10/2025Enhanced human antigen-specific B cell responses using in vitro 3D tonsil cultures containing stromal cells www.biorxiv.org/content/10.1101/202… 031
Reposted by Cole J. BattyAdrian Liston @labliston.bsky.social · 20/09/2025In the US it is called “Dawn”. We haven’t tried this, but the U.K. and Belgian brands both work fine. If you try Dawn please let us all know! 221
Reposted by Cole J. BattyAdrian Liston @labliston.bsky.social · 19/09/2025Just take a look. The Foxp3 fix/perm kit is good for TFs, but kills endogenous GFP. The eBio preserves GFP, but is incomplete at allowing TF staining. Burton's Best Buffer is as good as the best under all conditions (except phospho-flow), and preserves dye integrity too. Plus it is dirt cheap. 🎤 2205
Reposted by Cole J. BattybioRxiv Immunology @biorxiv-immuno.bsky.social · 01/09/2025PRDM1 shapes germinal center B-cell clonal diversity by gating chromatin accessibility during light-to-dark zone transition www.biorxiv.org/content/10.1101/202… 011