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Cole J. Batty

@colebatty.bsky.social
227 followers 290 following 68 posts

NIH T32 Fellow in the Marasco Lab at Dana Farber/Harvard Medical School studying B cells in aging

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Reposted by Cole J. Batty
bioRxiv Immunology @biorxiv-immuno.bsky.social · 05/10/2026
CHAIR an antigen-resolved antibody-reactome resource for healthy adult immune aging www.biorxiv.org/content/10.64898/20…
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Cole J. Batty @colebatty.bsky.social · 04/10/2026
Thems some bangers
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Reposted by Cole J. Batty
Elizabeth Wood, PhD @lizbwood.bsky.social · 24/09/2026
Introducing: continuous variational synthesis 📄 jurabio.com/s/cvs.pdf We’re pleased to announce a new advance in our ability to synthesize generative model-designed DNA sequences at petascale.
jurabio.com
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Cole J. Batty @colebatty.bsky.social · 22/09/2026
Preprint came out a while ago but here's a cool and useful technique: In vitro induction of human germinal center B cells | Science Immunology www.science.org/doi/full/10....
science.org
In vitro induction of human germinal center B cells
Human induced GC-like B (iGCB) cells are generated in vitro from circulating naive or marginal zone cells.
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Reposted by Cole J. Batty
Alex Rubinsteyn @alexr.bsky.social · 16/09/2026
I'm working on an AI eval project that needs domain expert human graders across different corners of biology. Let me know if you want a wacky consulting project, the biological domain likely can be whatever you already do research on. (ideally post-PhD)
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Cole J. Batty @colebatty.bsky.social · 16/09/2026
🙋 B cells, vaccines/immuno
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Cole J. Batty @colebatty.bsky.social · 11/09/2026
They have a program for academics, and Rosalind specifically for life sciences, but the academic pricing is a wait-list and it seems like the Rosalind access has to be negotiated by your institution
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Cole J. Batty @colebatty.bsky.social · 11/09/2026
claude.com/programs/tea... You have to use your institutional email and get approved, but our group's approval was immediate. Then regular plan is free and premium (~equivalent to max) is I think $30/mo. It has no effect on token prices through API.
claude.com
Claude Team plan for scientists | Claude by Anthropic
Scientists at academic and nonprofit research institutions around the world can now get Claude at no cost to start. Shared projects, Claude Science, and admin controls at rates built for grant budgets...
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Cole J. Batty @colebatty.bsky.social · 11/09/2026
I'm not having that issue. My account is through our group's 'Team plan for scientists'-- maybe that affects it? It's also free/discounted that way
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Cole J. Batty @colebatty.bsky.social · 09/09/2026
Isn't that the spot where the lanes are most needed?
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Cole J. Batty @colebatty.bsky.social · 31/08/2026
Thank you for making me aware of this symptom which I realize I got from a concussion
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Cole J. Batty @colebatty.bsky.social · 28/08/2026
In four short years he met his every goal!
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Reposted by Cole J. Batty
bioRxivpreprint @biorxivpreprint.bsky.social · 05/08/2026
Tfh dysfunction underlies poor responses to HBV vaccination www.biorxiv.org/content/10.64898/20…
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Cole J. Batty @colebatty.bsky.social · 04/08/2026
Aight then magazine
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Cole J. Batty @colebatty.bsky.social · 28/07/2026
The feed I had before was broken and this works for me.
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Reposted by Cole J. Batty
bioRxiv Immunology @biorxiv-immuno.bsky.social · 07/07/2026
FCRL5 is a fucose-sensitive IgG-Fc receptor with binding properties distinct from classical Fcγ receptors www.biorxiv.org/content/10.64898/20…
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Cole J. Batty @colebatty.bsky.social · 24/06/2026
I get that there's an AI bubble and all but bro is deliberately obtuse about AI capabilities and it saps credibility from his more cogent analyses
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Reposted by Cole J. Batty
Eric Chevet @ericchevet.bsky.social · 16/06/2026
A spatial multi-omics atlas of immunosenescence reveals germinal-center B cell alteration in human lymph nodes: Cell Press Blue www.cell.com/cell-press-b...
cell.com
A spatial multi-omics atlas of immunosenescence reveals germinal-center B cell alteration in human lymph nodes
Farzad et al. present a spatial multi-omics atlas of human lymph nodes spanning ages 18–86 years. Senescent-like B cells are heterogeneous and shift spatially from interfollicular zones into germinal ...
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Cole J. Batty @colebatty.bsky.social · 10/06/2026
Clinical research coordinator for donor recruitment retention and data/sample organization
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Cole J. Batty @colebatty.bsky.social · 07/06/2026
The S is part of the acronym, stands for substances or surfactants.
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Cole J. Batty @colebatty.bsky.social · 10/05/2026
Cropped image of the legend from the map which shows a bunch of overlapping and nonsensical age ranges, perhaps because the original map was ai generated
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Cole J. Batty @colebatty.bsky.social · 02/05/2026
Not sure how true that is, I think it's just laziness.
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Reposted by Cole J. Batty
Journal of Clinical Investigation @jci.org · 12/04/2026
From earlier this week: Do cells of different lineages age differently? doi.org/10.1172/JCI1... Sundeep Khosla & team compare the senescence phenotype of mesenchymal versus immune cells from murine bone and bone marrow, revealing important differences between them.
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Reposted by Cole J. Batty
Javi Ibarrondo @jibarrondo.bsky.social · 01/04/2026
Historic 1994 influenza vaccine cohorts define breadth of antibody and B cell responses toward future influenza A and B viruses | Science Translational Medicine www.science.org/doi/10.1126/... 🧪
science.org
Historic 1994 influenza vaccine cohorts define breadth of antibody and B cell responses toward future influenza A and B viruses
B cell responses that bound to future H1N1 and influenza B virus strains, but not H3N2 strains, were elicited in adults by the 1994 influenza vaccine.
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Reposted by Cole J. Batty
Alex Rubinsteyn @alexr.bsky.social · 28/03/2026
Any immunologists looking for a 1yr staff scientist job in NC? I’m not sure if I’m staying at UNC past 2027 but I’m feeling the weight of accumulating experimental backlog. Ideally already in the area, experienced in T-cell assays like IFNg ELISpot, ICS, MHC multimer flow, &c
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Reposted by Cole J. Batty
Thiago Carvalho @cyrilpedia.bsky.social · 21/03/2026
'Using single-telomere & sc analyses combined with mathematical modeling, we identify a threshold length at which telomeres switch into dysfunction. A single shortest telomere below the threshold length is necessary & sufficient to trigger the onset of replicative senescence in a majority of cells'
nature.com
Both genome instability and replicative senescence stem from the shortest telomere in telomerase-negative cells - Nature Communications
In absence of telomerase, short telomeres trigger senescence. Here, the authors find using single-telomere-single-cell approaches in budding yeast, that one critically short telomere is required and s...
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Reposted by Cole J. Batty
bioRxiv Immunology @biorxiv-immuno.bsky.social · 24/02/2026
Strain-specific differences in the response to egg-derived versus recombinant protein influenza vaccines www.biorxiv.org/content/10.64898/20…
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Cole J. Batty @colebatty.bsky.social · 23/02/2026
Thank you for listening to your constituents!
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Cole J. Batty @colebatty.bsky.social · 22/02/2026
Interesting, I thought there would be a section about building impenetrable berms in the bike lane at every corner to render the cleared lanes useless?
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Cole J. Batty @colebatty.bsky.social · 16/02/2026
Massive resource!
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Cole J. Batty @colebatty.bsky.social · 25/01/2026
Followed you for sf stuff and now you're sharing an amazing immunology paper that inspired my current research!
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Cole J. Batty @colebatty.bsky.social · 20/01/2026
Kynurenine pathway dysregulation plays a key role in so many different conditions (including aging). IDO/TDO inhibition has not worked out well so far, but this paper suggests some other targets.
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Cole J. Batty @colebatty.bsky.social · 09/01/2026
You should correct your post. it's phone footage and that's an important distinction in this context
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Cole J. Batty @colebatty.bsky.social · 24/12/2025
Wdym ritualistic? Like in mice?
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Cole J. Batty @colebatty.bsky.social · 22/12/2025
So cool
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Cole J. Batty @colebatty.bsky.social · 17/12/2025
I've been successfully using Burton's buffers with dawn and no Triton for staining an endosomally localized membrane protein.
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Cole J. Batty @colebatty.bsky.social · 17/12/2025
If you really optimized the vax formulation mRNA is not gonna make anything better imo.
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Reposted by Cole J. Batty
Bryan Bryson @thebrysonlab.bsky.social · 07/12/2025
The @ragoninstitute.bsky.social is launching a new faculty search for a computational immunologist! Applications are open now and reviewed on a rolling basis. Please share broadly with your networks! #immunosky www.nature.com/naturecareer...
nature.com
Computational Immunologist - Boston, Massachusetts (US) job with Ragon Institute of MGH, MIT, & Harvard | 12849577
The Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard in Cambridge MA, together with the Departmen
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Reposted by Cole J. Batty
Waggoner Lab @labwaggoner.bsky.social · 03/12/2025
Plasma-localized IgG glycosylation is dynamically altered by the endothelium www.pnas.org/doi/10.1073/...
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Reposted by Cole J. Batty
Waggoner Lab @labwaggoner.bsky.social · 26/11/2025
A common progenitor gives rise to fibroblastic reticular cells and vascular smooth muscle cells in murine lymph nodes @jem.org rupress.org/jem/article/...
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Reposted by Cole J. Batty
bioRxiv Immunology @biorxiv-immuno.bsky.social · 01/11/2025
B lymphocytes that enter the germinal center late preferentially differentiate into memory cells that recognize subdominant epitopes www.biorxiv.org/content/10.1101/202…
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Reposted by Cole J. Batty
bioRxiv Immunology @biorxiv-immuno.bsky.social · 20/10/2025
Autoantibody origins in lupus and in relapse post CAR-T therapy www.biorxiv.org/content/10.1101/202…
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Cole J. Batty @colebatty.bsky.social · 21/10/2025
Cooler techniques available every day!
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Cole J. Batty @colebatty.bsky.social · 18/10/2025
Could it be??
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Reposted by Cole J. Batty
bioRxiv Immunology @biorxiv-immuno.bsky.social · 02/10/2025
Enhanced human antigen-specific B cell responses using in vitro 3D tonsil cultures containing stromal cells www.biorxiv.org/content/10.1101/202…
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Reposted by Cole J. Batty
Adrian Liston @labliston.bsky.social · 20/09/2025
In the US it is called “Dawn”. We haven’t tried this, but the U.K. and Belgian brands both work fine. If you try Dawn please let us all know!
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Reposted by Cole J. Batty
Adrian Liston @labliston.bsky.social · 19/09/2025
Just take a look. The Foxp3 fix/perm kit is good for TFs, but kills endogenous GFP. The eBio preserves GFP, but is incomplete at allowing TF staining. Burton's Best Buffer is as good as the best under all conditions (except phospho-flow), and preserves dye integrity too. Plus it is dirt cheap. 🎤
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Reposted by Cole J. Batty
bioRxiv Immunology @biorxiv-immuno.bsky.social · 01/09/2025
PRDM1 shapes germinal center B-cell clonal diversity by gating chromatin accessibility during light-to-dark zone transition www.biorxiv.org/content/10.1101/202…
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Cole J. Batty @colebatty.bsky.social · 22/07/2025
Hard not to get excited about his passion
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