Antibody response variability contributes to differential individual responses and disease outcomes. Here authors show that genetic variation to the IG kappa and IG lambda loci is an important determi...

Abstract. Accurate characterization of adaptive immune receptor repertoires through high-throughput sequencing is critical for understanding immune respons

Genetic variation within immunoglobulin heavy chain constant (IGHC) genes modulates interactions between antibodies and other immune receptors and effector cells, directing cell killing and the cleara...

The rise of T cell receptor (TCR) sequencing technologies is driving both new understandings of the immune system and the development of novel clinica…

Immunoglobulin sequence alignment tool

Variation in antibody (Ab) responses contributes to disease outcomes and therapeutic responsiveness, the determinants of which remain incompletely understood. This study demonstrates that polymorphism...

The immunoglobulin heavy chain constant (IGHC) domain of antibodies (Ab) is responsible for a variety of effector functions critical to Ab mediated immunity. In human, this domain is encoded by genes ...

Genetic diversity within the human immunoglobulin heavy chain (IGH) locus influences the expressed antibody repertoire and susceptibility to infectious and autoimmune diseases. However, repetitive seq...

Abstract. Adaptive Immune Receptor Repertoire sequencing (AIRR-seq) is critical for our understanding of the adaptive immune system’s dynamics in health an