Developing effective accessible vaccines to end tuberculosis worldwide. Combining immunoengineering, molecular microbiology & systems biology at MIT.

The Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard in Cambridge MA, together with the Departmen

Mycobacterium tuberculosis (Mtb) persists within macrophages, yet how different host species shape bacterial state remains poorly understood. Here, we directly compared the intracellular transcriptome...

MHC class II immunopeptidomics in human phagocytes infected with Mycobacterium tuberculosis enables vaccine immunogen design and optimization.

Original paper: https://rupress.org/jem/article/222/10/e20250444/278135/Targeting-infection-specific-peptides-in Video summary by Owen Leddy (Massachusetts Institute of Technology) Description: One…

MS-based immunopeptidomics can facilitate vaccine antigen discovery, but self-MHC peptides greatly outnumber pathogen-derived MHC peptides, presenting a ch

The mycobacterial cell envelope plays both infectious and protective roles. Understanding its structure is crucial for unlocking the molecular basis underlying these functions. Studying glycans, the p...