Abstract. For more than 50 years, the linear sequence and the multiple sequence alignment have been the foundational data structures of protein science, and they remain central to homology search, phy...

Science progress over the first year-ish of the DiffUSE Project

Podcast Episode · The Tortured Proteins Department · August 30 · 1h 5m

A genetically engineered bacterium can rapidly break down one of Earth’s most abundant minerals, opening a promising new pathway for removing CO2 from the atmosphere and recovering critical elements, ...

This Perspective discusses current challenges in macromolecular ensemble prediction and the infrastructure and methodological advances needed to overcome these barriers.

A new nonprofit called Radial is launching with at least $500 million to modernize the scientific process for the AI era.

Malaria parasites are transmitted to humans through a bite from an infected female Anopheles mosquito. Within the mosquito midgut, malaria parasite gametes are activated and undergo fertilisation. If ...

Author summary Malaria is spread when an infected Anopheles mosquito bites a human. Within the female Anopheles mosquito, malaria parasite fertilisation occurs in the mosquito midgut. If you inhibit p...

This is the official web page for the James Fraser Lab at UCSF.

Nanobodies have emerged as promising tools for many biotechnological applications due to their small size, high stability, and remarkable binding specificity. Next-Generation Sequencing (NGS) enables ...

Viewing protein evolution through the lens of complex systems theory may offer new insights into the principles driving biological adaptation. In this Comment we explore how characteristics such as se...

This is the official web page for the James Fraser Lab at UCSF.

La-Proteina: Atomistic Protein Generation via Partially Latent Flow Matching

Telomerase ribonucleoprotein (RNP) synthesizes telomeric repeats at chromosome ends using a telomerase reverse transcriptase (TERT) and a telomerase RNA (hTR in humans). Previous structural work showe...

Please note: authors do not need to have already posted their research as a preprint for an initial evaluation by eLife. During submission authors can indicate if they have already posted a preprint, and if not, can ask us to deposit the work as a preprint to bioRxiv or medRxiv, as appropriate.

Pyruvate is the end-product of glycolysis and a central metabolite involved in many biochemical pathways. However, a lack of high-performance (i.e., Δ F / F > 10) single fluorescent protein (FP)-base...

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Details about the current priorities for UCSF Advocates.

Machine learning (ML) has revolutionized protein biology, solving long-standing problems in protein folding, scaffold generation and function design tasks. A range of architectures have shown success ...