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Shosei Imai

@sikmys.bsky.social
18 followers 26 following 0 posts

Department of Chemistry The University of Tokyo Campbell Lab PhD candidate

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Reposted by Shosei Imai
Ryan Fink @finkryan.bsky.social · 24/04/2026
PinkyCaMP is finally published!! My first paper co-first authored with @sikmys.bsky.social where we make a great optogenetic and multiplex compatible red calcium indicator. Thank you to @massecklab.bsky.social and @campbell-lab.bsky.social for guiding this journey www.nature.com/articles/s41...
nature.com
PinkyCaMP: an mScarlet-based calcium sensor with enhanced brightness, photostability and multiplexing capabilities - Nature Methods
PinkyCaMP is a red genetically encoded calcium indicator with improved brightness and photostability. Derived from mScarlet, it does not exhibit photoswitching upon blue light illumination and is ther...
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Reposted by Shosei Imai
bioRxiv Molecular Biology @biorxiv-molbio.bsky.social · 18/04/2025
High-performance genetically-encoded green and red fluorescent biosensors for pyruvate www.biorxiv.org/content/10.1101/202…
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Reposted by Shosei Imai
Robert E. Campbell @campbell-lab.bsky.social · 19/04/2025
New tools! GreenPy and ApplePy are fluorescent biosensors for pyruvate with huge responses (20–40x in vitro) and a range of affinities (10s of μM to mM). These should be game changers for imaging of metabolism! Great work by Shosei Imai @sikmys.bsky.social and team 👏. www.biorxiv.org/content/10.1...
biorxiv.org
High-performance genetically-encoded green and red fluorescent biosensors for pyruvate
Pyruvate is the end-product of glycolysis and a central metabolite involved in many biochemical pathways. However, a lack of high-performance (i.e., Δ F / F > 10) single fluorescent protein (FP)-base...
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