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Christian Staehr

@chrstaehr.bsky.social
384 followers 282 following 35 posts

MD, PhD. Postdoc studying cerebral circulation, neurovascular coupling. Dad of three amazing kids.

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Reposted by Christian Staehr
Søren Grubb @sorengrubb.bsky.social · 20/11/2025
New on bioRxiv! 🚨 “Pericyte and Endothelial Primary Cilia and Centrioles have Disparate Organization Across the Brain Microvasculature” This project studying #microvascular cells took an unexpected turn when we discovered that #pericytes have primary #cilia! 🔗 www.biorxiv.org/content/10.1... 🧪 🧵1/8
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Emilie Macé @mace-lab.bsky.social · 11/09/2025
Thrilled to share that our work is now published in Science! ✨ We found a preference for visual objects in the mouse spatial navigation system where they dynamically refine head-direction coding. In short, objects boost our inner compass! 🧭 www.science.org/doi/10.1126/... 🧵1/
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Experimental Physiology @expphysiol.bsky.social · 25/06/2025
🚨CALL FOR PAPERS🚨 For our "Integrative physiological considerations of the human vasculature system" #SpecialIssue, which will showcase further insights into vascular haemodynamics and multi-organ diseases, as well as the technology used to monitor and treat cardiovascular disease. 🔗 buff.ly/HN7wlPr
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Søren Grubb @sorengrubb.bsky.social · 10/06/2025
🔗 Full Open Access manuscript: link.springer.com/article/10.1... 👇 Curious to hear more about #PrecapillarySphincters? Check out these threads about the subject: Characterization: x.com/SorenGrubb/s... Ultrastructure: x.com/SorenGrubb/s...
link.springer.com
Brain precapillary sphincters modulate myogenic tone in adult and aged mice - GeroScience
Brain precapillary sphincters, which are surrounded by contractile pericytes and are located at the junction of penetrating arterioles and first-order capillaries, can increase their diameter by ~ 30%...
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Christian Staehr @chrstaehr.bsky.social · 11/06/2025
Fantastic study shedding new light on regulation of cerebral microcirculation 👇👇👇
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Hajime Hirase @hajimehirase.bsky.social · 19/03/2025
Vittani, Lee, Wang, Hiraoka, et al. KI mouse expressing red fluorescent blood In situ SpyTag/Catcher attachment of biosensor ECS SpyCatcher to capture BBB leak doi.org/10.1101/2025... We hope this method is useful to a wide range of the biology community.
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Baptiste Lacoste @blacoste.bsky.social · 06/01/2025
Once again, someone else says it: "Aβ accumulation affecting brain vessel function could be a very early pathology leading to neurodegenerative disease." doi.org/10.1186/s131... #cerebrovascular
doi.org
The cerebral blood flow response to neuroactivation is reduced in cognitively normal men with β-amyloid accumulation - Alzheimer's Research & Therapy
Background Accumulation of β-amyloid (Aβ) in the brain is a hallmark of Alzheimer’s Disease (AD). Cerebral deposition of Aβ initiates deteriorating pathways which eventually can lead to AD. However, t...
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Martin Lauritzen @mlauritz.bsky.social · 06/05/2025
Your brain functions not only as a thinking organ but also as a miniature water factory. We here calculate how much water neuronal mitochondria produce by glucose oxidation: 300-400 ml. Of that amount, 100 ml go into brain's interstitial fluid. fluidsbarrierscns.biomedcentral.com/articles/10....
fluidsbarrierscns.biomedcentral.com
A budget for brain metabolic water production by glucose catabolism during rest, rises in activity and sleep - Fluids and Barriers of the CNS
Maintaining brain fluid homeostasis is of critical importance for creating a stable environment conducive to optimal neuronal functioning, nutrient distribution, and waste product removal. In this stu...
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Christian Staehr @chrstaehr.bsky.social · 21/05/2025
Excited to share our new paper in @acta_physiol: SorCS2—involved in trafficking and synaptic signaling—is important for neurovascular coupling: doi.org/10.1111/apha... Whisker stim in Sorcs2 KO 🐭 led to ⬇️NVC, ⬇️astrocyte Ca²⁺ signals & disrupted glutamate receptor trafficking.
pmc.ncbi.nlm.nih.gov
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Christian Staehr @chrstaehr.bsky.social · 16/05/2025
🇦🇺🦘Just wrapped up 6 incredible weeks of science, collaboration at the University of the Sunshine Coast. Thanks to Vicki Hinkley for such a productive partnership—I’m excited to continue this collaboration across 🇩🇰 and 🇦🇺. I’m also grateful to the USC CONNECT Programme for the funding 🙏
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Christian Staehr @chrstaehr.bsky.social · 04/05/2025
Also fascinating: cerebral arteries show a stronger myogenic response at lower pressures than extracranial vessels—likely a protective mechanism to prevent a pressure surge to the brain when drinking (🤯 avoided!).
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Christian Staehr @chrstaehr.bsky.social · 04/05/2025
🦒🫀Measuring hemodynamics in awake giraffes sounds like a wild challenge 🤯. New paper by Christian Aalkjaer et al in @actaphysiologica.bsky.social 🔓: onlinelibrary.wiley.com/doi/full/10.... 🦒 While drinking🚰: ⬇️ Heart rate ➡️ Arterial blood pressure ➡️ Carotid blood flow ⬆️ CSF pressure 🧠
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Mikkel Heide Schierup @mikkelschierup.bsky.social · 04/05/2025
Come join us at the Bioinformatics Research Centre at Aarhus University. Tenure track/associate professor position available with application deadline June 1, 2025. Application details here: international.au.dk/about/profil...
international.au.dk
Tenure-Track Assistant Professor / Associate Professor in Bioinformatics at Aarhus University, Denmark - Vacancy at Aarhus University
Vacancy at Department of Molecular Biology and Genetics - BiRC - Bioinformatics Research Center, Aarhus University
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Søren Grubb @sorengrubb.bsky.social · 18/03/2025
Join our #PhDcourse on #openscience datasets and tools in #Neurophysiology! We'll dive into #EM, #inVivo #physiology, behavioural analysis tools, and a talk on creating animations from open data! @quorumetrix.bsky.social 📢 Free for NorDoc PhD students, but open to all! Apply now! lnkd.in/dU_fxqqu
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Søren Grubb @sorengrubb.bsky.social · 19/03/2025
Amazing work out by Hirase Lab 🤩
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Hao Yin @haoyin.bsky.social · 19/04/2025
Oral Glycine supplementation (DT-109 Gly-Gly-Leu) ⏬#Atherosclerosis & lesional #Calcification in ♂️Monkeys A potential role of Glycine in GSH antioxidant & #Inflammasome in #SmoothMuscleCell #SignalTransductTargetTher 2025 www.nature.com/articles/s41...
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Christian Staehr @chrstaehr.bsky.social · 16/04/2025
#StainAI: A deep learning tool trained on 8,695 manually labeled cells to classify #microglia into 6 distinct morphotypes (www.nature.com/articles/s42...). A powerful step toward automated and scalable morphology analysis. #AI #neuroimmunology #cardiacarrest
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Christian Staehr @chrstaehr.bsky.social · 16/04/2025
#StainAI: A deep learning tool trained on 8,695 manually labeled cells to classify #microglia into 6 distinct morphotypes (www.nature.com/articles/s42...). A powerful step toward automated and scalable morphology analysis. #AI #neuroimmunology #cardiacarrest
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Hao Yin @haoyin.bsky.social · 02/04/2025
Vascular Tone of pressurized🐭distal MCA (sham & #IschemicStroke)⏫by BKCa inhibitor Brain Arterial #EndothelialCell BKca & TRPV4 (immunofluorescence)⏫by acute (0.5~2 h) #Hypoxia or #Stroke across🐁🐀🐖🚶‍♂️ @chrstaehr.bsky.social #ActaPhysiol 2025 onlinelibrary.wiley.com/doi/10.1111/...
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Kalev Freeman @uvmtraumalab.bsky.social · 29/03/2025
Futile reperfusion of ischemic tissue after #stroke increases the risk of death and disabilities. Spatial transcriptomics provides new insights into the vascular alterations that drive this process. #BBB #cerebrovascular #neurosky #emedsky #medsky 🧪
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Kalev Freeman @uvmtraumalab.bsky.social · 29/03/2025
Changes in endothelial cell large conductance calcium-activated potassium channels (BKCa) after #hypoxia may explain the altered myogenic tone which impacts blood flow following ischemic #stroke. #ionchannels #vascularbiology #physiology #cerebrovascular #endothelium #neurosky #emedsky #medsky
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Hao Yin @haoyin.bsky.social · 28/03/2025
#SpatialTranscriptomics #Proteomics acute stage of #IschemicStroke (🐭tMCAO 24h) Molecular drivers of mural cell hyperconstriction & BBB disintegration in post-stroke futile reperfusion? A dual non-neuronal role of Calcineurin? @chrstaehr.bsky.social #Stroke 2025 www.ahajournals.org/doi/10.1161/...
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Christian Staehr @chrstaehr.bsky.social · 25/03/2025
Thank you, Anna 🙏
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Christian Staehr @chrstaehr.bsky.social · 25/03/2025
🚨 Publication alert!🚨 Our new study (onlinelibrary.wiley.com/doi/full/10....) in Acta Physiologica shows that #stroke/#hypoxia induces the expression of BK-Ca channels in the #cerebrovascular #endothelium across species 🧔🏻‍♂️🐭🐷🐀. These channels, absent in normoxia, regulate post-stroke arterial tone.
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Christian Staehr @chrstaehr.bsky.social · 24/03/2025
Our review did not only focus on cardiac arrest but acute treatment of hyperkalemia in general. Anyways, thanks for sharing 👍 an interesting study indeed.
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The Microcirculatory Society (MCS) @mcsociety.bsky.social · 12/02/2025
Hello All Scientists! We are the Microcirculatory Society and we are excited to join the community here at BlueSky! Follow us for fun updates happening in the microvascular community and the amazing science being done by our scientists! #microcirculation #science
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Hao Yin @haoyin.bsky.social · 21/02/2025
Is this real? I published it again on Brain @brain1878.bsky.social 😆 Truly appreciate the leadership of @rrust.bsky.social on this great project (>300 refs!)🫡👇 The blood–brain barrier: a help & a hindrance #Aging #Stroke #Neurodegeneration Crossing #BBB 😎 academic.oup.com/brain/advanc...
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Ruslan Rust @rrust.bsky.social · 21/02/2025
New review from our lab in @brain1878.bsky.social We explore how molecular blood-brain barrier (BBB) changes in aging, neurodegeneration and stroke affect disease progression, delivery of therapeutics, and much more! academic.oup.com/brain/advanc...
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Hao Yin @haoyin.bsky.social · 27/01/2025
#Pericyte #PulmonaryHypertension 1/2 A subpopulation of Higd1b+ lung capillary pericytes 👉Migrate to distal arteriole 👉Upregulate Vimentin 👉Acquire #SmoothMuscleCell identity (α-SMA, circumferential wrapping) in🐭Hypoxic PH #SciArt Ke Yuan lab @embojournal.org 2025 www.embopress.org/doi/full/10....
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Ke Yuan @kekeyuan.bsky.social · 27/01/2025
This is a groundbreaking study for pericyte fans. We discovered the unique pericyte marker Higd1b which only labels pericytes without any off-target effect from other mural cells.
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Catherine Hall @cathnaledi.bsky.social · 30/01/2025
New paper led by @silvia-anderle.bsky.social Lifestyle matters for genetic Alzheimer’s disease risk: APOE4 reduces neurovascular function most in an already-stressed system,  when neurons are active and mice do less exercise. I'll tell you all about it! 🧪 #neuroscience #alzheimers rdcu.be/d74uh
rdcu.be
APOE4 and sedentary lifestyle synergistically impair neurovascular function in the visual cortex of awake mice
Communications Biology - Lifestyle matters for genetic Alzheimer’s disease risk: In vivo imaging of mouse blood vessels and neurons shows that APOE4 reduces neurovascular function most in an...
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Rubén Marín-Juez @rmarinjuez.bsky.social · 24/01/2025
🚨We are hiring!🚨 We have postdoctoral positions available! If you're passionate about studying cardiac regeneration and development, join our team in vibrant and beautiful Montreal! Please help spread the word 🫶 For more details see here research.chusj.org/RECHERCHE/fi...
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Hao Yin @haoyin.bsky.social · 28/01/2025
Amazing organotypic effects of PDGFRβ+ #Pericyte Paracrine #Orangogenesis Pericytic BDNF/HGF KO🐭P1➡️ ⬇️Lung #Angiogenesis #Alveologenesis P21 No🧠effect Pericytic Nodal KO➡️ ⬇️Brain #Angiogenesis Disrupted #BBB Astrogliosis No🫁effect @ralfhadams.bsky.social 2025 www.researchsquare.com/article/rs-5...
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Christian Staehr @chrstaehr.bsky.social · 30/01/2025
Thanks for sharing. Nice with an update on CVD stats!
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Hao Yin @haoyin.bsky.social · 29/01/2025
Alert for Cardiovascular Grant writers, a must-archived 620-page paper😆 2025 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Association Table 29 At-a-Glance Summary✌️ #Circulation 2025 @ahajournals.bsky.social www.ahajournals.org/doi/10.1161/...
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Hao Yin @haoyin.bsky.social · 29/01/2025
SM22α+ #SmoothMuscleCell ATF3 KO🐭➡️ #AorticAneurysm #AorticRupture by AngII or #Aging ATF3 physically sequestrates MDM2 (E3 ligase for p21) ATF3 deficiency➡️ ⏬p21 protein stability ⏫ds DNA breaks ⏫Micronuclei ⏫cGAS-STING in SMCs #AortaEd Clin Transl Med 2024 onlinelibrary.wiley.com/doi/10.1002/...
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Hao Yin @haoyin.bsky.social · 27/01/2025
Cellular #Senescence & Compromised #TightJunction in #SubmandibularGland in🐭Natural #Aging (18-mo) or D-galactose (for 8 wk) Interestingly, SA β-Gal activity was only evident in aged SMG, not parotid or sublingual glands. #AgingCell 2025 onlinelibrary.wiley.com/doi/full/10....
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NEJM.org @nejm.org · 27/01/2025
In the PARAMEDIC-3 trial involving adults with out-of-hospital cardiac arrest, an intraosseous-first strategy for vascular access did not result in a higher incidence of 30-day survival than an intravenous-first strategy. Full trial results: nej.md/48uYv4A #MedSky #CardioSky
The New England Journal of Medicine     
Drug Route in Out-of-Hospital Cardiac Arrest 
A PLAIN LANGUAGE SUMMARY    

Illustration of medication delivery for out-of-hospital cardiac arrest.    

Read the full Plain Language Summary at NEJM.org.
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Rachael Ott @rachaelott.bsky.social · 24/01/2025
For #FluorescenceFriday, microtubules (magenta) are shown with tau in a primary hippocampal neuron 🔬 #Neuroscience #Microscopy
Microtubules (magenta) and tau protein (cyan/green) are shown in a primary hippocampal neuron.
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Jens Lund @lundjens.bsky.social · 26/01/2025
"It's much more fun when your hypothesis is wrong - I have learned much more from being wrong than from being right. Don't sweep contrary findings under your intellectual rug." - 10 lessons learned by Barry Levin 👇 pmc.ncbi.nlm.nih.gov/articles/PMC...
pmc.ncbi.nlm.nih.gov
10 lessons learned by a misguided physician
It was a great and humbling honor to receive the 2016 Distinguished Career Award from my SSIB colleagues. This paper summarizes the major points of my DCA talk at the 2016 annual meeting. It is a refl...
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Colin Nichols Lab @colinnicholslab.bsky.social · 23/01/2025
Check out our new publication "Control of neurovascular coupling by ATP-sensitive potassium channels" A 🧵 1 journals.sagepub.com/doi/10.1177/...
journals.sagepub.com
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Catherine Hall @cathnaledi.bsky.social · 24/01/2025
Get your cerebral blood flow and metabolism abstracts in for Brain and BrainPET 2025 in Seoul! Deadline Feb 1st!! I’m so excited! www.brain2025.org
brain2025.org
Brain & Brain PET 2025
The 32nd International Symposium on Cerebral Blood Flow, Metabolism and Function & The 17th International Conference on Quantification of Brain Function with PET
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Christian Staehr @chrstaehr.bsky.social · 23/01/2025
💉 Should calcium be used to treat #hyperkalemia? Our new systematic review in #Resuscitation (🔓 www.sciencedirect.com/science/arti...) found no evidence supporting calcium for hyperkalemia management. @ercresus.bsky.social #ILCOR
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Thomas Elbenhardt Jensen @elbenhardt.bsky.social · 21/01/2025
Our new FASEBJ paper. We looked into mTOR Ser1261 phosphorylation in human and mouse muscle, proposed by Diane Fingar's lab to be first an Akt and then AMPK site regulating mTORC1 and 2 activity. Clearly AMPK site but impact on mTORC unclear in our hands faseb.onlinelibrary.wiley.com/doi/10.1096/...
faseb.onlinelibrary.wiley.com
mTOR Ser1261 is an AMPK‐dependent phosphosite in mouse and human skeletal muscle not required for mTORC2 activity
mTOR Ser1261 is an AMPK-dependent phosphosite in human and mouse skeletal muscle that responds to exercise but not insulin, plays an unclear role in mTORC1 regulation, and is not required for mTORC2 ....
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Hao Yin @haoyin.bsky.social · 21/01/2025
Bladder tissue regeneration using acellular synthetic PRS scaffold + instillation of conditioned medium from #MesenchymalStemCell & CD34+ HSPC vs blank media ⏫Smooth muscularization ⏫Size of regenerated blood vessel ⏫Innervation ⏫Urodynamics #AdvTher 2024 onlinelibrary.wiley.com/doi/10.1002/...
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Hao Yin @haoyin.bsky.social · 21/01/2025
#SpatialTranscriptomics #Cartana in situ sequencing +snRNAseq 🐭Kidney development e15.5/18.5 P3 #SciArt A Critical Milestone KSTAT/Kidney Spatial Transcriptome Analysis Tool➡️ Single-cell mapping of regulon & enriched pathway biorRxiv 2024 @ondinecleaver.bsky.social www.biorxiv.org/content/10.1...
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Christian Staehr @chrstaehr.bsky.social · 21/01/2025
In today's therapeutic landscape, primary prophylactic treatment of #migraine is often based on trial and error. Our study contributes to understanding migraine #genetics, paving the way for treatments based on underlying pathophysiological mechanisms. #PersonalizedMedicine.
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Christian Staehr @chrstaehr.bsky.social · 21/01/2025
For the first time, we identified a link between homozygous variants in the voltage-gated sodium channel (#NaV1.1) gene #SCN1A and increased #migraine risk. 🤯 Unexpectedly, these homozygous carriers were protected against #epilepsy.
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Christian Staehr @chrstaehr.bsky.social · 21/01/2025
Variants causing loss-of-function of the Na,K-ATPase (#ATP1A2 gene) and gain-of-function of #CaV2.1 (#CACNA1A gene) increase the risk of migraine. ⚡️These changes may lead to a more depolarized cell membrane potential 🧠!
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Christian Staehr @chrstaehr.bsky.social · 21/01/2025
💡 Whole-exome sequence data from 454,706 individuals were examined. 💡 Carriers were compared with non-carriers in a burden analysis. 💡 A machine learning-based approach (#LoGoFunc) was used to predict whether variants resulted in gain-of-function, loss-of-function or neutral effect
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