iiinova — where your digital self keeps evolving

Reposted by Søren Grubb

Sasha (Aleksandra) Petrovskaya @sashapetrovskaia.bsky.social · 16/08/2026

We’re back after a great @naddenmark.bsky.social workshop, devoted to brain barriers & fluids, and headache. It broadened my knowledge about migraine targets beyond CGRP, barriers beyond the BBB and “good” sides of CSD…Thank you - @chrstaehr.bsky.social @sorengrubb.bsky.social and other organizers!

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Reposted by Søren Grubb

Mill_lab @cilialab.bsky.social · 13/01/2026

Double PI act @sorengrubb.bsky.social @amreenmughal.bsky.social continuing in brains with #cilia & #centrosome diversity across microvascular system, with striking species differences on cilia metrics & directionality of spaces sampled. Deep read: www.biorxiv.org/content/10.1... #UKCilia 5/8

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Søren Grubb @sorengrubb.bsky.social · 12/01/2026

Want to know about our latest research on #primarycilia and #centrosomes in #brain #microvasculature? Join this e-symposium tomorrow! 🧪

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Søren Grubb @sorengrubb.bsky.social · 16/12/2025

Thanks for a great 2025!🎆🥳🎉 We’re proud to share highlights from this year at Neuroscience Academy Denmark (NAD) – showcasing the incredible work of our PhD students. 👩‍🎓👨‍🎓 A big thank you to @lundbeckfonden.bsky.social for supporting our mission. 🙏 #Neuroscience #PhD #Research #Collaboration 🧪

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Søren Grubb @sorengrubb.bsky.social · 20/11/2025

New on bioRxiv! 🚨 “Pericyte and Endothelial Primary Cilia and Centrioles have Disparate Organization Across the Brain Microvasculature” This project studying #microvascular cells took an unexpected turn when we discovered that #pericytes have primary #cilia! 🔗 www.biorxiv.org/content/10.1... 🧪 🧵1/8

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Søren Grubb @sorengrubb.bsky.social · 14/11/2025

🎥 NAD 2025 Annual Meeting Highlights From Oct 3–5, Neuroscience Academy Denmark hosted: ✅ 400+ participants ✅ 100 posters ✅ Keynotes on precision psychiatry, brain barriers, ultrasound treatments, brain stimulation, sleep & circadian rhythms We look forward to next year! #Neuroscience #NAD2025 🧪

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Reposted by Søren Grubb

Ghouly Hoye 👻🇨🇦 @hollyhoye.bsky.social · 08/09/2025

“Well I don’t like that study because it doesn't give me the result I want’

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Reposted by Søren Grubb

Hajime Hirase @hajimehirase.bsky.social · 02/07/2025

We are excited to report: Cerebral blood flow is modulated by astrocytic cAMP elevation independently of IP3R2-mediated Ca2+ signaling in mice Vittani et al. PNAS (2025) pnas.org/doi/10.1073/...

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Søren Grubb @sorengrubb.bsky.social · 24/06/2025

The first Master’s student with me as main supervisor graduated today! I’m proud 🥹

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Søren Grubb @sorengrubb.bsky.social · 10/06/2025

🐭🧠 #PrecapillarySphincters (PS) at the #arteriole–#capillary junction rapidly dilate ~30% in seconds during #SensoryStimulation—regulating #capillary #BloodFlow dynamically. Here we investigated whether they protect downstream microvessels during abrupt #BloodPressure surges 🧪🧵

Showing how a precapillary sphincter dilates during high blood pressure

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Søren Grubb @sorengrubb.bsky.social · 02/05/2025

Playing around with my 3yo daughter and an antique microscope. Looked at some #dandelion petals and a stamen using a Carl Zeiss P.A. 35 microscope using reflected light. 🧪

Dandelion petal under a Carl Zeiss P.A. 35 microscope

Dandelion stamen under a Carl Zeiss P.A. 35 microscope

Pollen on the dandelion stamen under a Carl Zeiss P.A. 35 microscope

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Søren Grubb @sorengrubb.bsky.social · 02/05/2025

@pkpd-babe.bsky.social Can I be added to the science post? My orcID: orcid.org/0000-0002-67...

orcid.org

ORCID

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Søren Grubb @sorengrubb.bsky.social · 19/03/2025

Amazing work out by Hirase Lab 🤩

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Søren Grubb @sorengrubb.bsky.social · 18/03/2025

Join our #PhDcourse on #openscience datasets and tools in #Neurophysiology! We'll dive into #EM, #inVivo #physiology, behavioural analysis tools, and a talk on creating animations from open data! @quorumetrix.bsky.social 📢 Free for NorDoc PhD students, but open to all! Apply now! lnkd.in/dU_fxqqu

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Reposted by Søren Grubb

Eric Topol @erictopol.bsky.social · 12/01/2025

Publications in the past week built substantially on our knowledge of the brain's waste disposal system—glymphatics—and the implications on sleep and brain aging. Featuring exceptional work by Nedergaard Lab and @jonykipnis.bsky.social erictopol.substack.com/p/our-sleep-... open-access

erictopol.substack.com

Our Sleep, Brain Aging, and Waste Clearance

How sleep prevents "dirty" brains that age faster

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Reposted by Søren Grubb

Asaf (Klaf) Weisman @asafklaf.bsky.social · 25/12/2024

🤘🏻The study I have been waiting for 30 years! Only Scandinavians can pull this out let alone publish it in a Scandinavian pain journal 🤘🏻 #painscience #physio #painresearch #ignobel2025 www.degruyter.com/document/doi...

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Reposted by Søren Grubb

Altmetric @altmetric.com · 11/12/2024

SERVICE UPDATE We normally don't ask you to "share like and subscribe" but please distribute this. You are now able to delete the link after it embeds on your post so you can get those precious extra characters, and we will catch your post mentioning research. #AcademicSky #Medsky #HigherEd

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Reposted by Søren Grubb

Andrew Payne @andrewcpayne.bsky.social · 03/12/2024

🧪 E11 Bio is excited to share a major step towards brain mapping at 100x lower cost, making whole-brain connectomics at human & mouse scale feasible (🧠→🔬→💻). Critical for curing brain disorders, building human-like AI systems, and even simulating human brains. Read more: e11.bio/news/roadmap

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Søren Grubb @sorengrubb.bsky.social · 01/12/2024

You can generate a #podcast with two hosts discussing a research paper using notebooklm.google.com I have tried it with a couple of papers (including my own 😂), it is a nice way of getting a summary. Try it out!

notebooklm.google.com

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Søren Grubb @sorengrubb.bsky.social · 30/11/2024

🧠NON-NEUROCENTRIC STARTER PACKS FOR BRAIN RESEARCH: I this thread 🧵 I will post starter packs for fields of research not directly related to neurons: #meninges, #vasculature, #glia, #immunecells, #dementia, #headache, #microscopy, and resources to get started with #Bluesky.

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Søren Grubb @sorengrubb.bsky.social · 30/11/2024

Here we show how 🧠 #precapillarysphincters react to #CorticalSpreadingDepolarization which is associated with #migraine with #aura 🤕. #CSD has 3 phases: constriction, dilation, and a long lasting constriction that interrupts #bloodflow🩸 to #capillaries (Tinyurl.com/euasfses).

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Søren Grubb @sorengrubb.bsky.social · 29/11/2024

#Neurovasculature changes from the #arterial to the #venular end. Here I have tried to draw the #cell morphologies realistically. #Endothelialcells go from spindle shaped to rhombic shaped and #muralcells from #smoothmuscle to #pericytes. #Astrocytes same shape. www.sciencedirect.com/science/arti...

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Søren Grubb @sorengrubb.bsky.social · 28/11/2024

Here is a #precapillarysphincter. As #arterioles 🟢 dive into the 🧠, they branch to smaller vessels. When larger arterioles (15-25um) branch into #capillaries, they need a #sphincter (3-4um) to reduce #RBC flow⚫️ and pressure in the #capillary. The resistance is provided by #muralcell🔴 encirclement.

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Søren Grubb @sorengrubb.bsky.social · 26/11/2024

Here we show how #microglia contact #pericytes and #endothelialcells in the #venule end of the #capillary bed. Note also how a #primarycilium of an #interneuron invaginates the microglia. But why? 🤔 journals.sagepub.com/doi/full/10.... @gazz4science.bsky.social

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Science News @scinews.bsky.social · 24/11/2024

Three must read papers for PhD students. #scisky #PhD #science #research #academicsky 1. The importance of stupidity in scientific research Open Access journals.biologists.com/jcs/article/...

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Hashmat Ghanizada, MD, PhD @hashmatghanizada.bsky.social · 26/11/2024

Tell me, If you want to join the Migraine @ Headache starter pack. #Migraine #Headache #neuroscience #Neurology #pain go.bsky.app/U8U8wfW

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Reposted by Søren Grubb

Rose 🌹 @rose.bsky.team · 26/11/2024

You wanted starter packs to be searchable. Our engineers are busy keeping us online, so in the meantime, an independent developer built a new searchable library of starter packs. This is the beauty of building in the open 🦋

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Søren Grubb @sorengrubb.bsky.social · 25/11/2024

Here is a starter pack on the #Meninges, #CSF, and #Glymphatics. Please share and let me know if you should be on the list and I will add you! go.bsky.app/NLcabwc

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Gary Morris @gazz4science.bsky.social · 19/11/2024

Calling all #pericyte researchers! Here's a list of us to start a community on Bluesky. Please feel free to reply to get added and share with your colleagues as more join! go.bsky.app/GhVdxzC

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Reposted by Søren Grubb

Ulrike Boehm @ulrikeboehm.bsky.social · 16/11/2024

🔬 Are you eager to dive into the world of light microscopy & learn from top-notch microscopists about its essential techniques for life science applications? If that sounds exciting, don’t miss out on this free, in-depth iBiology series! 👉 www.ibiology.org/online-biolo...

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Søren Grubb @sorengrubb.bsky.social · 22/11/2024

Did you know that #neuronal #processes arrange perpendicular to #vascular direction around #penetratingarterioles and arterial end #capillaries? 🤔 I have speculated that this may enhance #neurovascularcoupling. Here I show examples in the #human #brain. 🧠 vb.bioscientifica.com/view/journal...

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Søren Grubb @sorengrubb.bsky.social · 21/11/2024

Here is an overview of the pial #macrophages 🔵 in the #MICrONS dataset. Between an #arteriole 🔴 and a #venule 🟣 3 macrophages are hanging out on top of the #piamater #fibroblasts 🟡. The #primarycilia of each of the fibroblasts are touching a macrophage. What are they communicating? 🤔

Pial surface of the MICrONS dataset. Pial arterioles 🔴 and venules 🟣 and macrophages 🔵 are 3D rendered based on volume electron microscopy. Maybe you can spot the lymphocytes 🟡 also?

Macrophages 🔵 with rounded cell bodies in between a penetrating arteriole 🔴 and ascending venule 🟣 are touched by fibroblast 🟡 primary cilia. Maybe the primary cilia tell the macrophages to stay where they are, so they are equally distributed across the pial surface?

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Søren Grubb @sorengrubb.bsky.social · 21/11/2024

As my first post on #Bluesky I am showing my #3Drendering of a pial #macrophage 🔵 squeezing between #fibroblast 🟡 processes next to a #penetratingarteriole. Nuclei in 🟢. Macrophages move around and help clean up waste in the #cerebrospinalfluid. www.biorxiv.org/content/10.1...

Shown from a different angle without arteriole. The thin lines on the fibroblasts are primary cilia.

Closeup of macrophage between fibroblast processes.

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