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Martin Lauritzen

@mlauritz.bsky.social
320 followers 218 following 2 posts

Professor of Translational Neurobiology at University of Copenhagen. Research interests are brain aging, blood-brain barrier, drug delivery, brain blood vessels, brain energy and metabolic water and cortical spreading depolarization.

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Reposted by Martin Lauritzen
Søren Grubb @sorengrubb.bsky.social · 10/06/2025
🐭🧠 #PrecapillarySphincters (PS) at the #arteriole–#capillary junction rapidly dilate ~30% in seconds during #SensoryStimulation—regulating #capillary #BloodFlow dynamically. Here we investigated whether they protect downstream microvessels during abrupt #BloodPressure surges 🧪🧵
Showing how a precapillary sphincter dilates during high blood pressure
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Martin Lauritzen @mlauritz.bsky.social · 06/05/2025
Your brain functions not only as a thinking organ but also as a miniature water factory. We here calculate how much water neuronal mitochondria produce by glucose oxidation: 300-400 ml. Of that amount, 100 ml go into brain's interstitial fluid. fluidsbarrierscns.biomedcentral.com/articles/10....
fluidsbarrierscns.biomedcentral.com
A budget for brain metabolic water production by glucose catabolism during rest, rises in activity and sleep - Fluids and Barriers of the CNS
Maintaining brain fluid homeostasis is of critical importance for creating a stable environment conducive to optimal neuronal functioning, nutrient distribution, and waste product removal. In this stu...
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Reposted by Martin Lauritzen
Baptiste Lacoste @blacoste.bsky.social · 06/01/2025
Once again, someone else says it: "Aβ accumulation affecting brain vessel function could be a very early pathology leading to neurodegenerative disease." doi.org/10.1186/s131... #cerebrovascular
doi.org
The cerebral blood flow response to neuroactivation is reduced in cognitively normal men with β-amyloid accumulation - Alzheimer's Research & Therapy
Background Accumulation of β-amyloid (Aβ) in the brain is a hallmark of Alzheimer’s Disease (AD). Cerebral deposition of Aβ initiates deteriorating pathways which eventually can lead to AD. However, t...
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Reposted by Martin Lauritzen
Shannon Macauley @macauleylab.bsky.social · 06/01/2025
The cerebral blood flow response to neuroactivation is reduced in cognitively normal men with β-amyloid accumulation alzres.biomedcentral.com/articles/10....
alzres.biomedcentral.com
The cerebral blood flow response to neuroactivation is reduced in cognitively normal men with β-amyloid accumulation - Alzheimer's Research & Therapy
Background Accumulation of β-amyloid (Aβ) in the brain is a hallmark of Alzheimer’s Disease (AD). Cerebral deposition of Aβ initiates deteriorating pathways which eventually can lead to AD. However, t...
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