Blood-brain barrier (BBB) dysfunction and mesial temporal lobe epilepsy (MTLE) are considered to be engaged in a pathological feedback loop, with the consequent worsening of both conditions. However, ...

Pain in rheumatoid arthritis (RA) often persists despite effec...

Explore the impact of stroke and the latest research on stem cell therapy aimed at improving recovery from ischemic strokes.

Mesoscopic brain imaging, enabled by advances in tissue cleari...

Effects of psilocybin and related compounds on neuroprotection...

Nature - Custom CRISPR—Cas9 PAM variants via scalable engineering and machine learning

Han et al. report the existence of neural stem cells (NSCs) outside the central nervous system and show that these peripheral NSCs display features similar to brain NSCs, including the ability to diff...

During infections, CD4+ Foxp3+ regulatory T (Treg) cells must control autoreactive CD4+ conventional T (Tconv) cell responses against self-peptide antigens while permitting those against pathogen-deri...

NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Supplemental Guidance to the 2024 NIH Grants Policy Statement: Indirect Cost Rates NOT-OD-25-068. OD

Lifestyle matters for genetic Alzheimer’s disease risk: In vivo imaging of mouse blood vessels and neurons shows that APOE4 reduces neurovascular function most in an already-stressed system, when neur...

The peripheral immune system communicates with the brain through diverse anatomical routes to shape brain physiology. Here we discuss why such diversity is needed and explore how these routes are leve...