Aging is a risk factor for neurodegenerative diseases associated with protein aggregation. Here the authors identify age-related hyperactivation of EPS8/RAC signaling in C. elegans as a driver of path...

Mutations in the C9orf72 gene represent the most common genetic cause of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. Using patient-derived neurons and C. elegans models, w...

Nature - STING induces ZBP1-mediated necroptosis independently of TNFR1 and FADD

Transcription factors shape cell identity, but mapping their genomic targets remains challenging. Here the authors present DynaTag, a modified CUT&Tag method for profiling TF occupancy in bulk and...

Transcription factors shape cell identity, but mapping their genomic targets remains challenging. Here the authors present DynaTag, a modified CUT&Tag method for profiling TF occupancy in bulk and...

Ein Forschungsteam der Universität zu Köln hat eine Methode mit dem Namen DynaTag entwickelt, die die Bindung von Proteinen an die DNA sogar in einer einzelnen Zelle nachweist. Interaktionen von Prote...