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David Calderwood

@calderwoodlab.bsky.social
383 followers 201 following 11 posts

The Calderwood Lab (Yale University, USA) uses biochemistry, cell biology and structural biology to study cell adhesion, signaling and the cytoskeleton.

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Reposted by David Calderwood
Matthias Krause @matthias-krause.bsky.social · 02/09/2026
Postdoc position available - deadline in 2 weeks! Exciting 3-yr BBSRC project studying cell biology of Wnt signaling: advanced imaging, genome editing and embryology. Apply now! Join Matthias Krause and Karen Liu labs. @karenjliu.bsky.social @wntuk.bsky.social www.kcl.ac.uk/jobs/155745-...
kcl.ac.uk
Research and Innovation Associate | King's College London
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Yale Pharmacology @yalepharm.bsky.social · 26/08/2026
Yale Pharmacology is looking to expand our department and bring on an Assistant Professor of Pharmacology. More details on the position and how to apply can be found at the link in the comments below. Please feel free to share with your network and anyone that may be interested.
Ad for a new job listing in the Yale Pharmacology Department: Assistant Professor of Pharmacology. Applications are currently being accepted, and the review process will begin on November 20, 2026.
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Magdalena Skipper @magdalenaskipper.bsky.social · 08/05/2026
Happy 100th birthday to Sir David Attenborough! 🎉 An inspiration to me & millions of others around the globe & across the generations! We share more than our passion for the natural world but also a deep appreciation for ceramics! His collection is magnificent! 🧪 www.nature.com/immersive/d4...
nature.com
A life in pictures: Celebrating Attenborough at 100
As the British naturalist celebrates a milestone birthday, we take a look at how his work has shaped science.
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David Calderwood @calderwoodlab.bsky.social · 08/05/2026
Happy Birthday!
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Jim Bear @coronin.bsky.social · 07/05/2026
This was a really fun story to see develop. OptoPLC does some fascinating things to cell motility
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Institute for Protein Innovation @ipiproteins.bsky.social · 04/05/2026
Looking for integrin antibodies? With the recent addition of Anti-Integrin beta 1 [IPI-TS2/16] and Anti-Integrin beta 2 [IPI-TS1/18], our Integrin Antibody Collection now comprises nearly 30 antibodies! View the collection: buff.ly/a52As0G
buff.ly
Integrin Antibody Collection
Highly specific recombinant integrin antibodies, validated for Flow cytometry applications. Buy with Addgene!
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Reposted by David Calderwood
Chris Baraniuk @chrisbaraniuk.com · 04/05/2026
You should read this cool piece by my friend @richardfisher.bsky.social about David Attenborough's childhood obsession with fossils! www.bbc.com/future/artic...
bbc.com
'It was one of the key moments of my life': The thrilling fossil discoveries that sparked Attenborough's love for nature
Fossils fascinated Sir David Attenborough throughout his childhood. The BBC retraces the steps of Sir David's formative experiences roaming the British countryside.
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Nature @nature.com · 23/04/2026
Nature research paper: Myosin forces remodel F-actin for mechanosensitive protein recognition go.nature.com/4sTeWAq
go.nature.com
Myosin forces remodel F-actin for mechanosensitive protein recognition - Nature
Structural studies demonstrate that myosin generates forces that cause structural changes in actin, modulating cooperative binding by α-catenin and thus signal transduction and intercellular communication via adhesion complexes.
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Journal of Cell Science @jcellsci.bsky.social · 23/03/2026
In their Perspective, Jozafina Haj-Shomaly, Alejandro Castillo-Kauil, Carla Bloom, Kairbaan Hodivala-Dilke and Gabriela D'Amico discuss how leveraging cell biology can improve immunotherapy and anti-angiogenic strategies in lung cancer therapy. journals.biologists.com/jcs/article/...
Graphical summary of current and emerging therapies for lung cancer. (A) Schematic representation of the current clinical approach to treat non-resectable lung cancer, which does not specifically target the tumour vasculature. These standard strategies often yield suboptimal outcomes, partly due to abnormal, untreated tumour blood vessels impairing drug delivery and immune cell infiltration. SOC, standard-of-care treatment. (B) A conceptual framework (proposed in this Perspective) illustrating emerging therapeutic strategies that combine vascular normalisation or promotion with ICIs. The aim of these vascular modulation approaches is to correct tumour vascular dysfunction, alleviate hypoxia, and enhance both drug delivery and the immune response, thereby improving clinical outcomes in non-resectable lung cancer patients. Created in BioRender by Castillo-Kauil, A., 2026. https://BioRender.com/nmgf1w1. This figure was sublicensed under CC-BY 4.0 terms.
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Naba Lab UIC @nabalabuic.bsky.social · 20/03/2026
Today I would like to share a publication that is particularly meaningful to me. Our tribute to my late mentor, Richard Hynes, has just been published in Matrix Biology. I hope you will take a moment to read and celebrate the legacy of an extraordinary scientist and mentor. doi.org/10.1016/j.ma...
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Ardem Patapoutian @ardemp.bskyverified.social · 04/03/2026
New paper from the lab led by @ericmulhall.bsky.social addresses how PIEZO1 and PIEZO2 are tuned to different types mechanical forces. From nanometer-scale super-resolution microscopy to in vivo experiments, links single-molecule observations to physiological function. www.nature.com/articles/s41...
nature.com
The molecular basis of force selectivity by PIEZO2
Nature - PIEZO2 is intrinsically more rigid than PIEZO1, and disparate mechanical stimuli paradoxically evoke opposite conformational and gating responses in each channel.
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American Society for Cell Biology @ascbiology.bsky.social · 09/02/2026
How do cells generate, sense & resist force? MBoC highlights recent advances in mechanobiology in its Forces on and within Cells collection — spanning cytoskeletal dynamics, membrane mechanics, and beyond. 🔗 www.ascb.org/science-news/exploring…
ascb.org
Exploring the Forces That Shape Cells - ASCB
Cells are constantly pushing, pulling, and responding to the physical forces around them—and those forces play a critical role in shaping cell behavior, organization, and function. Molecular Biology of the Cell (MBoC), ASCB’s flagship journal, brings these dynamics into focus through its Forces on and within Cells collection. Spanning molecular mechanics, cytoskeletal dynamics, and force-driven…
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Guillaume Jacquemet @guijacquemet.bsky.social · 21/01/2026
🚨 We are hiring TWO postdocs to join the Cell Migration Lab (cellmig.org) 🇫🇮 as part of the new Centre of Excellence in Immune–Endothelial Interfaces (IMMENs). Join us to decode immune regulation & develop next-gen imaging tools! 🧪🔬 Details in thread 🧵👇 #ScienceSky #Postdoc #AcademicJobs Please RT🫶
cellmig.org
CELL MIGRATION LAB
We study cell migration in health and disease
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Yoshi Ichikawa @ichikawa-lab.bsky.social · 07/01/2026
New collaborative preprint! A striking result: a disordered linker in KANK1 binds as many as 15 LC8 dimers, forming a protein rod that bridges cell membranes and microtubules! www.biorxiv.org/content/10.1...
Disordered linker of Kank1 forms rigid protein rod upon binding to 15 LC8 molecules and bridge the gap between membrane and microtubule.
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Stephen Grant (he/him) @stephengrant631.bsky.social · 07/01/2026
I am honored to be selected to give a talk at #ASBMB26 on the work I have done in the @benturklab.bsky.social! We have developed a strategy to selectively activate specific LKB1 substrates. Looking forward to presenting, connecting, and seeing great science at this conference! @asbmb.bsky.social
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PMC Protein Modules Community @pmc-modularity.bsky.social · 07/01/2026
We are back on Jan 19 at 3pm CET! Our first seminar for 2026 will feature Prof. Benjamin Turk (@benturklab.bsky.social) and Dr. Giorgia Massacci. Register to attend: tinyurl.com/PMCseminar2 Previous seminars: www.youtube.com/@PMCModularity
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Denis Wirtz @deniswirtz.bsky.social · 18/12/2025
We wrote two reviews on cell migration, published today in Nature Methods. They provides practical guidelines how to select a cell-migration assay and how to analyze cell-migration data Review 1: nature.com/articles/s41... Review 2: nature.com/articles/s41...
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Institute for Protein Innovation @ipiproteins.bsky.social · 17/12/2025
We’re excited to announce our plans for a course on antibody validation and characterization — and we need your help! Fill out this survey to shape the course (it’s quick, we promise!) ➡️ buff.ly/KoyJfU9
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David Calderwood @calderwoodlab.bsky.social · 14/12/2025
Need a short break from the lab this Thursday evening? Stop by Cafe Nine in New Haven to hear my sons' band Skrom play cafenine.com/products/eve...
cafenine.com
Skrom / Problem With Kids Today / Qween Kong - Thursday 12/18/2025 - 8:00 PM EDT
Thursday, December 18, 2025 at 8:00 PM EDT Skrom Genre ambiguous music to crash your car to from Burlington VT The Problem With Kids Today New Haven, CT-based band The Problem With Kids Today a...
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Yale Pharmacology @yalepharm.bsky.social · 08/12/2025
Join us in welcoming our next 2025–2026 Pharmacology Seminar Series speaker: Dr. Greg Alushin of The Rockefeller University. He will be presenting his work at 12 pm on Thursday, December 11th in the Brady Auditorium.
Flyer for the Yale Pharmacology Seminar Series 2025–2026. This flyer indicates that Greg Alushin, PhD will be presenting his work at 12 pm on Thursday, December 11, 2025 in the Brady Auditorium. Dr. Alushin is an Associate Professor of Biochemistry, Biophysics, Chemical Biology, and Structural Biology and Head of the Laboratory of Structural Biophysics and Mechanobiology at The Rockefeller University. The title of his talk is "Visualizing Cellular Force-Sensing Through the Cytoskeleton."
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Jon Humphries @jdhl18.bsky.social · 03/11/2025
A single-chain derivative of an integrin-activating antibody potentiates organoid growth in Matrigel and collagen hydrogels www.nature.com/articles/s41...
nature.com
A single-chain derivative of an integrin-activating antibody potentiates organoid growth in Matrigel and collagen hydrogels - Nature Biotechnology
Epithelial organoids are grown without Matrigel using a single-chain antibody.
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Reposted by David Calderwood
Yale Pharmacology @yalepharm.bsky.social · 13/10/2025
Join us in welcoming our 2025-2026 Alan C. Sartorelli Lectureship speaker, Dr. Tobias Meyer. He will be presenting his work at 4 pm on Thursday, October 16th in The Anlyan Center.
Flyer for Yale Pharmacology's 2025–2026 Alan C. Sartorelli Lecture, presented by Tobias Meyer, PhD. Dr. Meyer will be presenting his work at 4 pm on Thursday, October 16, 2025 in The Anlyan Center (TAC) N107, with a reception to follow from 5-6 pm. Dr. Meyer is the Joseph Hinsey Professor of Cell & Developmental Biology and Professor of Biochemistry & Biophysics at Weill Cornell Medicine. The title of his talk is "Both Structural and Signaling Polarity Mechanisms Direct Cell Migration."
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Sarah CP Williams @sarahcpwilliams.bsky.social · 09/10/2025
How do cells move, divide, & sense their surroundings? The answer lies in the cytoskeleton--and when it malfunctions, cancer & birth defects follow. @alushinlab.bsky.social at @rockefeller.edu is developing new tools to probe this tiny, dynamic cell scaffolding. www.rockefeller.edu/news/38446-h...
rockefeller.edu
How cells move and change shape—and why it matters for our health - News
Inside each of your cells, there’s a microscopic scaffolding that helps determine what the cell looks like, how it moves, and how it responds to its surroundings. This internal structure, called the c...
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Sam Aytekin @samaytekin.bsky.social · 06/10/2025
Garcia Lab did it again! Such a fantastic read if you are interested in FAs mechanics and biology. Congratulations to @garcialabgt.bsky.social
science.org
Mechanochemical waves in focal adhesions during cell migration
Traction force and FAK signaling exhibit oscillatory temporal coupling in adhesive structures.
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Rainero lab @erainerolab.bsky.social · 24/09/2025
The integrin odyssey - a journey full of fundamental discoveries. pubmed.ncbi.nlm.nih.gov/40988584/
pubmed.ncbi.nlm.nih.gov
The integrin odyssey - a journey full of fundamental discoveries - PubMed
Integrins are widely expressed cell adhesion receptors that link extracellular matrix proteins to the cytoskeleton. Most integrins connect to the actin cytoskeleton through different types of adhesion...
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Jeremy Hollis @jeremyahollis.bsky.social · 10/09/2025
So excited to see the first part of my thesis work with @harmitmalik.bsky.social and @melodygcampbell.bsky.social in print! www.science.org/doi/10.1126/... We have a bit of evolution and a whole lotta structure to figure out how new protein domains work
science.org
Molecular exaptation by the integrin αI domain
An ancient protein domain insertion seamlessly preserved conformational signaling while providing a novel surface for adaptation.
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Journal of Cell Biology @jcb.org · 10/09/2025
📢 Attention #undergraduates, #gradstudents, and early-career #postdocs! Apply for JCB’s Alan Hall & Norton B. Gilula Travel Awards ✈️ that support your attendance at #CellBio2025 (Dec. 6-10) in Philadelphia! Apply by October 17 👉 rupress.org/jcb/pages/al... @ascbiology.bsky.social
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Yale Pharmacology @yalepharm.bsky.social · 15/04/2025
Excellent talk from Yossi Schlessinger at the ASBMB Meeting. He gave the Herbert Tabor Research Award Lecture to a capacity crowd.
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Yale Pharmacology @yalepharm.bsky.social · 14/04/2025
Join us in welcoming our next 2025 Pharmacology Seminar Series speaker, Jim Collins. He will be presenting his work at 12 pm on Thursday, April 17th in the Brady Auditorium.
Flyer for the Yale Pharmacology Seminar Series. This flyer indicates that Jim Collins, Ph.D. will be presenting his work at 12 pm on Thursday, April 17, 2025 in the Brady Auditorium. Dr. Collins is the Termeer Professor of Medical Engineering and Science and Professor of Biological Engineering at Massachusetts Institute of Technology and is a Founding Core Faculty Member of the Wyss Institute at Harvard University. The title of his talk is "Deep Learning for Antibiotic Discovery."
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David Calderwood @calderwoodlab.bsky.social · 03/04/2025
congratulations Moi and team!
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David Calderwood @calderwoodlab.bsky.social · 26/03/2025
Congratulations Yansheng and colleagues! Turnover atlas of proteome and phosphoproteome across mouse tissues and brain regions: Cell www.cell.com/cell/fulltex...
cell.com
Turnover atlas of proteome and phosphoproteome across mouse tissues and brain regions
This study presents a comprehensive atlas of protein and phosphoprotein turnover across 16 mouse tissues and brain regions using advanced proteomics and isotope labeling. It reveals tissue-specific pr...
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David Calderwood @calderwoodlab.bsky.social · 21/03/2025
Very sorry to hear about Mike's passing
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David Calderwood @calderwoodlab.bsky.social · 20/03/2025
Congrats to the Gupta lab and collaborators in the @moitrayee-lab.bsky.social, Yansheng Liu and Jim Rothman labs. bit.ly/proteinlibrary
bit.ly
‘Molecular library’ opens up new frontier of biological space-time
A new platform from the Yale Nanobiology Institute provides access to numerous membrane proteins – key targets in the fight against resistant disease
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shawnferguson.bsky.social @shawnferguson.bsky.social · 17/03/2025
It’s an honor to host Dario Alessi for our Department of Cell Biology seminar series tomorrow! #parkinsonsresearch
Seminar announcement for Dr Alessi
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Eric Topol @erictopol.bsky.social · 11/03/2025
Today marks the beginning of OpenRxiv, which replaces bioRxiv and medRxiv, the world's largest preprint platform for life and medical science openrxiv.org/introducing-... @openrxiv.bsky.social
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Yale Pharmacology Graduate Program @yalepharmgrad.bsky.social · 05/02/2025
BBS-Wide Joint Cultural Foods Social Hour! This Friday :)
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David Calderwood @calderwoodlab.bsky.social · 31/01/2025
@fda.govFDA Approves Novel Non-Opioid Treatment for Moderate to Severe Acute Pain www.fda.gov/news-events/...
fda.gov
FDA Approves Novel Non-Opioid Treatment for Moderate to Severe Acute Pain
The FDA approved Journavx (suzetrigine) 50 mg oral tablets, a first-in-class non-opioid analgesic to treat moderate to severe acute pain in adults.
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Yale Pharmacology @yalepharm.bsky.social · 22/01/2025
Titus Boggon will be speaking at the next seminar in our 2025 Pharmacology Seminar Series. Join us at 12 pm on Thursday, January 23 in the Brady Auditorium to hear about his exciting work.
Flyer for the Yale Pharmacology Seminar Series. This flyer indicates that Titus Boggon, Ph.D. will be presenting on Thursday, January 23, 2025 in the Brady Auditorium. The title of his talk is "Revisiting RasGAP: New insights from the first GTPase Activating Protein for Ras."
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David Calderwood @calderwoodlab.bsky.social · 16/01/2025
Looking forward to Tim's Tai-Shun Lin Memorial lecture this afternoon
Poster announcing Timothy Springer as the 2025 Tai-Shun Lin Memorial lecturer in Dept. Pharmacology, at Yale School of Medicine
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Marco Hein @marco.heinlab.org · 14/01/2025
Time to share our organelle proteome paper out in @cellcellpress.bsky.social: doi.org/nzwz We created a spatial map of human cells using organelle immunoprecipitation at scale. Locate your fav protein among the 7,600 we mapped across 19 subcellular compartments: organelles.sf.czbiohub.org/ 1/3 🧪
Graphical abstract of the Organelle Profiling paper, showing the workflow:
Endogenously tagged organelle library;
Native IP proteomics;
Data-driven graph clustering;
resulting in a subcellular proteome map with
more than 7,600 proteins localized across 19 subcellular compartments.
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Evangelia Petsalaki @epetsalaki.bsky.social · 21/11/2024
PhosX is out! doi.org/10.1093/bioi... Leveraging the latest kinase specificity maps by the Cantley, Yaffe, and Turk labs and a rank sum statistic we created PhosX so now we can predict activities for nearly all kinases in your phosphodata, including the understudied ones. Check it out!
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