A new study will investigate Candida infections to understand how fungi adapt to the human gut and address the challenge of fungal infections

In contrast to decades of research on gut bacteria, human genetic determinants of the gut fungal community (mycobiome) remain understudied. This investigation presents the first GWAS on the number and...

The near-universal genetic code uses 64 codons to encode the 20 canonical amino acids and protein synthesis. Here we designed and generated Escherichia coli with a 4 Mb synthetic genome in which we re...

xAI trained on >100,000 random peptides predicts and elucidates primary sequence determinants of aggregation.

To Restore Your Gut Health, a Healthy Diet Matters Most on Simons Foundation

The evolutionary origins of the genetic point centromere in the brewer's yeast Saccharomyces cerevisiae, a member of the order Saccharomycetales, are still unknown. Competing hypotheses suggest that t...

Abstract. In RNA interference (RNAi), long double-stranded RNA is cleaved by the Dicer endonuclease into small interfering RNAs (siRNAs), which guide degra

npj Antimicrobials and Resistance - The role of gene copy number variation in antimicrobial resistance in human fungal pathogens

In Lepidoptera (butterflies and moths), the genomic region around the gene cortex is a “hotspot” locus, repeatedly implicated in generating intraspecific melanic wing color polymorphisms across 100 mi...

GGNBP2, CNOT10, and CNOT11 are required for innate immune response after the loss of ADAR1-mediated editing of self dsRNA.

PhD Project - How is epigenetic information inherited across generations in insects? at University of Oxford, listed on FindAPhD.com

An observational longitudinal clinical trial, incorporating a SmartPill and metabolomics, reveals the role of host factors in shaping the gut microbiome in healthy human adults.

Kazachstania pintolopesii is a highly prevalent fungal symbiont that can trigger type 2 immunity and influence the composition of the gut mycobiome, as well as immune and disease phenotypes.

Author summary Candida albicans is an important cause of fungal infections associated with high mortality rates, and the lack of effective treatment options emphasizes the urgency to develop new antif...

Kazachstania pintolopesii is a highly prevalent fungal symbiont that can trigger type 2 immunity and influence the composition of the gut mycobiome, as well as immune and disease phenotypes.

Scientific Reports - Evaluation of DNA extraction kits for long-read shotgun metagenomics using Oxford Nanopore sequencing for rapid taxonomic and antimicrobial resistance detection

Fungal pathogens pose a significant risk to human health, causing approximately 6.5 million invasive infections and 3.8 million deaths yearly (1–3). The populations most vulnerable to systemic fungal ...

Double-strand breaks (DSBs) in DNA are challenging to repair. Here, the authors show that transcript RNAs impact the DSB repair outcomes in human and yeast cells by promoting NHEJ or MMEJ in a sequenc...