In eukaryotes, DNA-associated protein complexes coevolve with genomic sequences to orchestrate chromatin folding. We investigate the relationship between DNA sequence and the spontaneous loading and a...

O-GlcNAcylation is a post-translational modification characterized by the covalent attachment of a single moiety of GlcNAc on serine/threonine residues in proteins. Tyrosine hydroxylase (TH), the rate...

Discussions on diversity in the workplace can be heated and contentious. But the data still shows more diverse teams outperform their less diverse peers. Here's how.

July 10–13, 2025 | Durham, N.C.

Joan Soto-Angel and Pawel Burkhardt describe a comb jelly with the ability to reverse its development to an earlier stage of life.

Dietary fructose enhances tumour growth in animal models of melanoma, breast cancer and cervical cancer indirectly via metabolite transfer.

AlphaFold-Multimer predicts complex formation by three sperm proteins conserved in vertebrates. Their interaction is experimentally confirmed and shown to bridge sperm and egg during fertilization by interacting with evolutionarily unrelated egg proteins.

Approaches for profiling the spatial proteome in tissues are the basis of atlas-scale projects that are delivering on their promise for understanding biological complexity in health and disease.

Video made by Cagri Cevrim. (hpa = hours post amputation)

Wesseldijk et al. compare the genomic information collected from Ludwig van Beethoven with population-based datasets used to quantify musical achievement.

In Lepidoptera (butterflies and moths), the genomic region around the gene cortex is a “hotspot” locus, repeatedly implicated in generating intraspecific melanic wing color polymorphisms across 100 mi...

npj Metabolic Health and Disease - Insulin resistance reduction, intermittent fasting, and human growth hormone: secondary analysis of a randomized trial

Cell competition is a quality control acting from development to the adult that eliminates cells that are less-fit than their neighbours. How winner cells induce the elimination of losers during this ...

The evolutionary water-to-land transition involved the separation of the skull from the pectoral girdle, though these musculoskeletal changes have not been deeply characterised. Here they show that th...

Although the heart has its own nervous system, its organization and functionality remain largely unknown. Here, the authors reveal the molecular, chemical, and functional diversity of neurons within t...

Studying RNA dynamics in vivo often relies on fluorogenic approaches, but these can be hampered by factors such as limited sensitivity and sample autofluorescence. Here, the authors describe an ultras...

Szalay et al. discuss cross-kingdom similarities and differences in 3D chromatin folding in relation to gene regulation, including in bacteria, archaea, mammals and plants. This comparison reveals cer...

The efficient characterization of glycan structures remains a critical challenge. Direct glycan sequ