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Karel Břinda

@brinda.eu
949 followers 1.3K following 43 posts

‖ Permanent Researcher / INRIA Start. Faculty @ INRIA Rennes 🇫🇷 ‖ BioInfo/CompBio: algorithms, genomics, pathogens & rapid diagnostic of antibiotic resistance《 brinda.eu | github.com/karel-brinda 》

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Reposted by Karel Břinda
Peter Fabian @fabianlab.bsky.social · 10/06/2026
A session about how much information is transferred from sperm to the offsprings in a form of RNA was mind blowing 🤯 so cool! #EED2026
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Emilia @lazerwalker.com · 19/04/2026
It’s absolutely incredible that one of the largest Japanese-run Go servers, which has been running since 1992, is still accessed entirely via Telnet. And while most players use GUI clients that use Telnet under the hood, you can still connect manually and get ASCII graphics streamed to you
A screenshot of a white-on-black terminal depicting a 19x19 go board in ascii graphics, with empty grid intersections as periods, and black and white as Os and #s
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Aude Bernheim @audeber.bsky.social · 02/04/2026
How diverse is bacterial immunity ? We report in @science.org how language models allowed us to predict 2.4M antiphage proteins spanning >23K novel potential systems. 👏 @emordret.bsky.social, @alexhv.bsky.social & al doi.org/10.1126/scie... Explore them here defensefinder.mdmlab.fr/wiki/refseq_...
science.org
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Sam Horsfield @samuelhorsfield.bsky.social · 13/04/2026
ggCallaroo v0.1.0 is now out! This snakemake pipeline predicts, clusters and annotates bacterial genes using ggCaller, Panaroo and Bakta. It generates Panaroo files with functional annotations already integrated, which can then be used with the usual downstream tools. github.com/samhorsfield...
github.com
GitHub - samhorsfield96/ggCallaroo: A snakelike pipeline combining ggCaller and Panaroo.
A snakelike pipeline combining ggCaller and Panaroo. - samhorsfield96/ggCallaroo
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Sam Horsfield @samuelhorsfield.bsky.social · 31/03/2026
Two new bioinformatics internships available in @johnlees.bacpop.org group at EMBL-EBI: 1) testing and developing ML methods for identification of bacterial promoter regions; 2) Applying innovations in protein structure prediction to search massive datasets. Apply here: www.bacpop.org/jobs/
bacpop.org
Jobs
Working with us
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Reposted by Karel Břinda
Jim Shaw @jimshaw.bsky.social · 27/03/2026
Myloasm, our long-read metagenome assembler, is now published! w/ @mgmarin.bsky.social and @lh3lh3.bsky.social Very rewarding after > a year of development and countless hours thinking about assembly. Thanks to beta testers, Li lab, and reviewers who gave very helpful feedback. rdcu.be/famFj
rdcu.be
High-resolution metagenome assembly for modern long reads with myloasm
Nature Biotechnology - A long-read metagenome assembly method recovers circular and complete genomes better than existing tools.
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Sam Horsfield @samuelhorsfield.bsky.social · 30/03/2026
ggCaller v1.5.0 is out! We've removed the integrated clustering to enable users to benefit from new Panaroo features. Now, ggCaller generates GFFs that can be used with any clustering method. But for fans of an integrated ggCaller pangenome workflow read on... github.com/bacpop/ggCal...
github.com
GitHub - bacpop/ggCaller: Bifrost graph gene caller.
Bifrost graph gene caller. Contribute to bacpop/ggCaller development by creating an account on GitHub.
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Zamin Iqbal @zaminiqbal.bsky.social · 21/03/2026
For those writing code with agents, this *excellent* article by Timo Bingmann (who wrote COBS, for kmer geeks) is super interesting on how one can conceptualise it in terms of dependencies, and how it affects development. V fun analogies (QWERTY, cooking, money) panthema.net/2026/0318-Vi...
panthema.net
Vibe Coding, QWERTY, and US Healthcare - or: The Future of Software Engineering? - panthema.net
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Karel Břinda @brinda.eu · 12/03/2026
A really fascinating read – with ideas underlying so many current topics across different subdomains of bioinformatics.
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Karel Břinda @brinda.eu · 09/03/2026
I was pleased to give an interview to @radiopraguefr.bsky.social about my academic journey across Czechia, France, and the United States, and about my research. english.radio.cz/karel-brinda...
english.radio.cz
Karel Břinda on research at Harvard and working with bacteria as if they were books
Karel Břinda sheds light on how curiosity, mobility, and interdisciplinarity can shape a modern researcher’s path in a world where science increasingly transcends borders.
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Rob Finn @robdfinn.bsky.social · 03/03/2026
I got the chance to feature on this week’s BBC More or Less podcast with the excellent Tom Colls, talking about how scientists count life on Earth, specifically the microbes. Have a listen: www.bbc.co.uk/programmes/p...
bbc.co.uk
BBC Radio 4 - More or Less, Has a company really discovered a million new species?
Investigating whether Basecamp Research found hundreds of thousands of bacteria species
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Zamin Iqbal @zaminiqbal.bsky.social · 26/02/2026
I should have said, this takes us to about 2.8 million genomes in total. We don't have annotations, etc for the latest data yet, this will be an ongoing process
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Zamin Iqbal @zaminiqbal.bsky.social · 26/02/2026
Courtesy of @martibartfast.bsky.social , we have a new release of AllTheBacteria which adds another 322,920 assemblies, covering all ENA (illumina, isolate) prokaryotes to May 2025. allthebacteria.readthedocs.io/en/latest/ov...
allthebacteria.readthedocs.io
Overview — AllTheBacteria documentation
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Rob Patro @robp.bsky.social · 17/02/2026
How would you design a *multithreaded*, *concurrent* & *dynamic* hash table if you are focused specifically on common k-mer workloads, where streaming query & insertion are common? Jamshed, Prashant and I explore this in kache-hash, a cache-friendly k-mer hash table! www.biorxiv.org/content/10.6...
biorxiv.org
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Vaughn Cooper @vscooper.micropopbio.org · 16/02/2026
🧵 New preprint! Our 4-lab team evolved Streptococcus pneumoniae in antibiotic-treated mice of varying immune states and discovered something surprising: bacteria rarely evolved resistance. Instead, they found a different way to survive — by rewiring RNA turnover. 🔗 www.biorxiv.org/content/10.6...
biorxiv.org
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Zamin Iqbal @zaminiqbal.bsky.social · 17/02/2026
Delighted to see over 17 million new protein structure predictions from novel proteins in AllTheBacteria are now integrated into the AlphaFold Database at @ebi.embl.org ! Huge work from @gbouras13.bsky.social @oschwengers.bsky.social and friends to generate these. www.ebi.ac.uk/about/news/u...
ebi.ac.uk
AlphaFold Database welcomes community datasets
Latest AlphaFold Database update adds high-value datasets for microbial and viral proteins, generated by specialist communities
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Michael Baym @baym.lol · 13/02/2026
He may have only barely known about bacteria, and not at all about viruses, but Darwin was right about hating an ill-defined species concept
A quote from a letter from Darwin to Hooker in 1858 reading “Oh my God how I do hate species & varieties.”
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Zamin Iqbal @zaminiqbal.bsky.social · 11/02/2026
What's the best place to look up current estimates of how many truncated/non-functional genes each of us have? there was a paper from @dgmacarthur.bsky.social and co around 2014 that had an estimate from the 1000 genomes project (around 40 per person?), but I guess we have better estimates now.
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Zamin Iqbal @zaminiqbal.bsky.social · 09/02/2026
We're also happy to see a second paper out today, led by Nicola de Maio, which develops methods to identify and account for mutation rate variation and recurrent errors. www.nature.com/articles/s41...
nature.com
Rate variation and recurrent sequence errors in pandemic-scale phylogenetics - Nature Methods
Performing pandemic-scale phylogenetic analysis poses multifaceted challenges. This study develops methods for identifying and accounting for mutation rate variation and recurrent sequence errors, lea...
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Sam Horsfield @samuelhorsfield.bsky.social · 07/02/2026
At long last, my final PhD chapter is out: we developed a novel evolutionary simulator of bacterial pangenomes, Pansim, fitting it to data from >600K genomes using a likelihood-free framework, PopPUNK-mod, to explore neutral and adaptive pangenome dynamics www.biorxiv.org/content/10.6...
biorxiv.org
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John Lees @johnlees.bacpop.org · 09/02/2026
How do bacterial pangenomes evolve, what controls their dynamics, why do they exist? Fitting a mechanistic model to 450 species from allthebacteria.org suggesting fast vs slow gene exchange (i.e. amount of MGEs) is a major differentiating factor, correlated with phylogeny rather than lifestyle
Proportion of fast genes, as a trait mapped on the bacteria-wide phylogeny
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Stephen Turner @stephenturner.us · 19/01/2026
A comprehensive survey of genome language models in #bioinformatics academic.oup.com/bib/article/... 🧬🖥️🧪
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Heng Li @lh3lh3.bsky.social · 14/01/2026
I am looking for a postdoc to develop high-performance algorithms in computational genomics. Email or DM me if interested. For more information, see hlilab.github.io/vacancies. RTs appreciated!
hlilab.github.io
HLi Lab - Vacancies
Openings
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Ragnar {Groot Koerkamp} @curiouscoding.nl · 18/01/2026
Just came across the 2021 Turing Lecture. Has a lot of nice observations regarding the increasing gap between compute and memory bandwidth. It advocates "communication avoiding" algorithms and notes how algorithms can only be future proof if they scale with threads. dl.acm.org/doi/10.1145/...
dl.acm.org
The evolution of mathematical software | Communications of the ACM
Tracing how software and algorithms follow the hardware.
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Louis Ates @mycolates.bsky.social · 06/01/2026
Congratulations @baym.lol, @brinda.eu and colleagues on the nice work, looks like a great way to identify deletions and deletion-induced fusion genes. In MTBC, genomic deletions called "regions of difference" have long been used for phylogenetic investigation. Yet I found no citations thereof.
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Everyone's least favorite lab mate @kepatitis-c.bsky.social · 06/01/2026
💻 github.com/baymlab/deletion-born-fusion-manuscript 🔧 github.com/aryakaul/prefixsuffix-kmer Many thanks to co-authors @fernpizza.bsky.social , @brinda.eu & @baym.lol + GenScale/Baym lab! Funded by NIH, Packard, Pew, Sloan & a Chateaubriand Fellowship!
github.com
GitHub - baymlab/deletion-born-fusion-manuscript
Contribute to baymlab/deletion-born-fusion-manuscript development by creating an account on GitHub.
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Everyone's least favorite lab mate @kepatitis-c.bsky.social · 06/01/2026
🎉 New year, NEW PREPRINT! Bacteria exhibit astonishing genetic diversity, but where do new genes come from? My best friend Arya Kaul (/labmate in the @baym lab) investigates how advantageous deletions can spawn new genes - "deletion-born fusions." 🧵:
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Michael Baym @baym.lol · 06/01/2026
New preprint from my lab (with Arya Kaul, @fernpizza.bsky.social, and @brinda.eu), in which we explore new genes hitchhiking on the beneficial deletion that fused them together, and find them in the LTEE, M. Tb/bovis, and across the bacterial tree of life
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John Lees @johnlees.bacpop.org · 15/12/2025
We're organising a microbes & deep learning session at SMBE next year -- looking forward to seeing your abstracts!
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Ragnar {Groot Koerkamp} @curiouscoding.nl · 10/12/2025
If you ever need to fuzzy search some DNA, sassy is your tool. Please spread the word; I think many people just outside my own circle could benefit from this :) cc @rickbitloo.bsky.social github.com/RagnarGrootK...
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John Lees @johnlees.bacpop.org · 19/11/2025
Happy to share our new AMR resource which has phenotypic AMR (usually MIC data) collected from publications and databases. This is paired with assemblies and annotations We're excited for users who might train new models, find phenotype/genotype mismatches, or any other use
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Karel Břinda @brinda.eu · 05/12/2025
1/9 Just out: k-mer indexes are the backbone of fast search in genomic data, but many degrade under small k, subsampling, or high diversity. With Ondřej Sladký and @pavelvesely.bsky.social we asked: can we build one that works efficiently for any k-mer set?
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Bioinformatics Advances @bioinfoadv.bsky.social · 05/12/2025
🧮 Just out in Bioinformatics Advances: “FroM Superstring to Indexing: A space-efficient index for unconstrained k-mer sets using the Masked Burrows-Wheeler Transform (MBWT)”  Full article available: doi.org/10.1093/bioadv/vbaf290  Authors include: @pavelvesely.bsky.social, @brinda.eu
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EMBL-EBI @ebi.embl.org · 18/11/2025
Antimicrobial resistance (AMR) is a growing health threat, making infections harder to treat and complicating routine medical care. EMBL-EBI’s new AMR portal brings together laboratory resistance data and bacterial genomes in one open platform. #WAAW2025 #ActOnAMR www.ebi.ac.uk/about/news/t... 🧬💻
ebi.ac.uk
A new gateway to global antimicrobial resistance data
New online portal connects bacterial genomes with experimental resistance data to support antimicrobial resistance research.
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Zamin Iqbal @zaminiqbal.bsky.social · 14/11/2025
Honoured and quite blown-over to receive this award. I have been, and continue to be, very lucky - first with great mentors, and then really prodigious students, postdocs and collaborators. Working with them has been a joy.
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Ewan Birney @ewanbirney.bsky.social · 14/11/2025
Richard so deserves this - a legend in bioinformatics and computational biology - work genome, human genome, Pfam, 1,000 genomes, Sam/bam format, bwa, vcf, psmc… and so many more
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Marc Lipsitch @mlipsitch.bsky.social · 06/10/2025
cisac.fsi.stanford.edu/content/cisa... In my new role at @stanfordcisac.bsky.social, I'm recruiting for a postdoc to define how benefits of risky research should be evaluated. w Tony Mills of @notredame.bsky.social . #philsci #biosecurity #scipolicy
cisac.fsi.stanford.edu
CISAC Fellowship Program
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Ragnar {Groot Koerkamp} @curiouscoding.nl · 01/10/2025
Looking for people to test the latest version of simd-sketch. It's now 2x as fast at sketching, and supports skipping over kmers containing N and other ambiguous bases (which is only ~35% slower). 'cargo install simd-sketch' is right there under your fingertips ;) github.com/RagnarGrootK...
github.com
GitHub - RagnarGrootKoerkamp/simd-sketch: Compute bottom-s sketches and s-buckets sketches, using simd-minimizers crate.
Compute bottom-s sketches and s-buckets sketches, using simd-minimizers crate. - RagnarGrootKoerkamp/simd-sketch
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Zamin Iqbal @zaminiqbal.bsky.social · 25/09/2025
Delighted to see our paper studying the evolution of plasmids over the last 100 years, now out! Years of work by Adrian Cazares, also Nick Thomson @sangerinstitute.bsky.social - this version much improved over the preprint. Final version should be open access, apols. Thread 1/n
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Michael Baym @baym.lol · 01/09/2025
What was antibiotic resistance like before we ever used antibiotics? How did we change what antibiotic resistance genes looked like over 100 years? Our paper looking at resistance genes from a century of NCTC historical isolates now out in mGen: www.microbiologyresearch.org/content/jour...
microbiologyresearch.org
Genomic resistance in historical clinical isolates increased in frequency and mobility after the age of antibiotics
Antibiotic resistance is frequently observed shortly after the clinical introduction of an antibiotic. Whether and how frequently that resistance occurred before the introduction is harder to determin...
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Type VI Sophia System @wheezenfeld.bsky.social · 02/09/2025
This is one of the findings that really motivates my research: yes, antibiotic resistance genes are ancient, but the age of antibiotics has likely contributed to a big change in their mobility and of the landscape of MGEs we see today! Very happy for Arya and to see this published.
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Sina Majidian @sinamajidian.bsky.social · 26/07/2025
This FTP ftp.ebi.ac.uk/pub/database... from EBI www.ebi.ac.uk/gwas/docs/di... seems to have the iconic GWAS diagram
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bioRxiv Genomics @biorxiv-genomic.bsky.social · 26/07/2025
Unwelcome guests: characterizing the ecological niche of insertion sequences within prokaryotic genomes www.biorxiv.org/content/10.1101/202…
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Tatiana Gurbich @tgurbich.bsky.social · 17/07/2025
With the addition of the soil genome catalogue, MGnify now hosts over half a million genomes - exciting milestone for the resource.
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Jonathan Eisen @phylogenomics.bsky.social · 23/07/2025
This looks phenomenal. Hat tip to ‪@vivekmutalik.bsky.social‬
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Eduardo Rocha @epcrocha.bsky.social · 23/07/2025
Here's our new broad review on the extended mobility of plasmids, about all mechanisms driving and limiting their transfer. From conjugation to conduction, phage-plasmids to hitchers, molecular to evolutionary dynamics, ecology to biotech. The state of affairs. 1/9 academic.oup.com/nar/article/...
graphical abstract of the article the extended mobility of plasmids
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Jonathan Eisen @phylogenomics.bsky.social · 12/07/2025
Today's reading: Nature should be the model for microbial sciences journals.asm.org/doi/10.1128/... by @brettbakker.bsky.social @emilyraehyde.bsky.social and @pedroleao.bsky.social Looks ideal for a talk I am working on on model organisms ...
journals.asm.org
Nature should be the model for microbial sciences | Journal of Bacteriology
Historically, our understanding of microbes has been based on laboratory cultures. Much of what we know at a mechanistic level is based on “model organisms” which are species that readily grow in labo...
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CCDD @ccdd-hsph.bsky.social · 25/06/2025
New tool for pangenome analysis! CLARC refines bacterial gene clusters using functional annotation + linkage—not just sequence. New publication by @indragon.bsky.social & collaborators, advised by @mlipsitch.bsky.social & @billhanage.bsky.social. Read more at bit.ly/4ek0Y51
bit.ly
Linkage-based ortholog refinement in bacterial pangenomes with CLARC
Abstract. Bacterial genomes exhibit significant variation in gene content and sequence identity. Pangenome analyses explore this diversity by classifying g
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Michael Baym @baym.lol · 04/07/2025
GRC insisting on the vote for the next location being in person in the name of democracy
A cartoon titled “sampling bias” showing a slide with 99.8 of survey respondents saying they love responding to surveys, and only 0.2% saying “no, I toss them in the bin”
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