Key Points. A four–residue IPRR insertion enhances kindlin-3 membrane recruitment and promotes β2 integrin activationFERMT3 alternative splicing dynamicall

Jha et al. show that the transmembrane protein CD44 restricts EGFR mobility to maintain an EGFR–PI3K–Rac gradient during bleb-based cell migration.

SHANK proteins form core postsynaptic density (PSD) scaffolds that organise synaptic signalling complexes through multiple protein-protein interaction domains, including PDZ domains that typically rec...

SHANK proteins form core postsynaptic density (PSD) scaffolds that organise synaptic signalling complexes through multiple protein-protein interaction domains, including PDZ domains that typically rec...

Vocal fold cancer tumours lose some of their malignant traits when mechanically stimulated by physiological stretch or vibrations, mimicking the opening and closing of vocal folds and phonation.

Iu et al. uncover a Ca2+ signaling pathway promoting cell migration by facilitating actin assembly in protrusions. Ca2+ influx through TRPV4 channel activates RhoA in lamellipodia via CaMKII and TEM4,...

We study cell migration in health and disease