Reposted by Colin M. HammondSvetlana Dodonova @dodonova-sveta.bsky.social · 19hNew preprint from Dodonova lab 🔔! Capturing multiple states by cryo-EM❄️, we show for the first time how archaeal RNA Polymerase engages a nucleosome and forms direct contacts with histones! 🧬 Great work by Gabriele & a fantastic collaboration with Dina Grohmann! 🧵 www.biorxiv.org/content/10.6... 18229
Colin M. Hammond @needfuzz.bsky.social · 12hWell done Vale and Boyang! Sounds like a great project 🎉 000
Reposted by Colin M. HammondMolecular & Clinical Cancer Medicine (MCCM) @livunicancer.bsky.social · 19/09/2026Congrats to @ainhoamielgo.bsky.social & @mcschmid.bsky.social for receiving the Excellence in Research Award from North West Cancer Research! A fantastic recognition for the brilliant Liverpool Tumour Microenvironment Team @liverpooluni.bsky.social 131
Reposted by Colin M. HammondMolecular & Clinical Cancer Medicine (MCCM) @livunicancer.bsky.social · 19/09/2026A special mention to PhD student Jayden Gittens, who was shortlisted for the Rising Star in Research Award from North West Cancer Research ⭐️ We are excited to see what the future holds for Jayden & how he will undoubtedly contribute to cancer medicine & research in the upcoming years! 021
Reposted by Colin M. HammondHiten Madhani @hitenmadhani.bsky.social · 17/09/2026Reading and discussing (good) papers is one of the best ways to learn how to do good science. The struggle trains the mind. AI is not particularly good at judgement or critical thinking. Especially when the flaws are not obvious. 0104
Reposted by Colin M. HammondShiori Iida @shiori-iida.bsky.social · 08/09/2026Happy to share that this paper is now published in Nature Genetics! Grateful to everyone who supported this work throughout this long journey. I’m proud to see it out! www.nature.com/articles/s41...nature.comCohesin prevents local mixing of condensed euchromatic domains in living human cells - Nature GeneticsSingle-nucleosome imaging/tracking and super-resolution three-dimensional structured illumination microscopy within euchromatic regions show that cohesin-mediated loops constrain condensed euchromatic... 22612
Reposted by Colin M. HammondTeif lab @teiflab.bsky.social · 30/08/2026AlBawardi et al, 2026. Irregular nucleosome positioning governs a crystalline to liquid-like phase transition and tunes chromatin accessibility www.biorxiv.org/content/10.6... ▶️heterochromatin-like sequences produce compact fibres ▶️positional irregularity (>2-3 bp) triggers a state transition 0197
Reposted by Colin M. HammondStacey Ogden 🦔 @labogden.bsky.social · 27/08/2026Reading the old* literature from your field is ALWAYS a good idea 🧪 *Papers from before you started your research project. *Papers you haven't read since they came out ~years~ ago. *Papers from pioneers in your field. 4425
Reposted by Colin M. HammondThe Groth lab @grothlab.bsky.social · 21/08/2026‼️🚨Out now in Molecular Cell - Our latest study 𝐫𝐞𝐯𝐞𝐚𝐥𝐢𝐧𝐠 𝐧𝐞𝐰 𝐢𝐧𝐬𝐢𝐠𝐡𝐭𝐬 𝐢𝐧𝐭𝐨 𝐅𝐀𝐂𝐓 𝐟𝐮𝐧𝐜𝐭𝐢𝐨𝐧 𝐚𝐧𝐝 𝐭𝐡𝐞 𝐢𝐦𝐩𝐨𝐫𝐭𝐚𝐧𝐜𝐞 𝐨𝐟 𝐧𝐮𝐜𝐥𝐞𝐨𝐬𝐨𝐦𝐞 𝐨𝐫𝐠𝐚𝐧𝐢𝐬𝐚𝐭𝐢𝐨𝐧 𝐟𝐨𝐫 𝟑𝐝 𝐠𝐞𝐧𝐨𝐦𝐞 𝐦𝐚𝐢𝐧𝐭𝐞𝐧𝐚𝐧𝐜𝐞: tinyurl.com/2xctvx38. It was a pleasure to lead this collaborative effort alongside @nilskrietenstein.bsky.social More in🧵below 🪡tinyurl.comMaintenance of nucleosome organization through replication and transcription counteracts aberrant coalescence of active chromatinNucleosomes with their associated modifications organize and regulate the genome. It is unclear how this is integrated with the requirement of replica… 17227
Reposted by Colin M. HammondJulian Sale @juliansalelab.bsky.social · 31/07/2026Working with a hugely engaged group of editors (all of whom are practising scientists), authors and reviewers, and a great publisher, is a hugely rewarding way to contribute to the community. Your chance to get involved! 045
Reposted by Colin M. HammondAlex Radzisheuskaya @a-radzisheuskaya.bsky.social · 23/07/2026Transcription and Chromatin UK is back! Join us in York 18–20 November for three days of exciting science and networking. We look forward to seeing you there. www.eventsforce.net/biochemsoc/f... 089
Colin M. Hammond @needfuzz.bsky.social · 18/06/2026Here's a short article about our recent Molecular and Clinical Cancer Medicine away day. It was great to present some of the things we are working on and gain positive feedback from colleagues. Thanks to Jacqueline, Michael and Mark for organising! www.liverpool.ac.uk/systems-mole...liverpool.ac.uk Cancer Research Away Day 2026 | Stories | Institute of Systems, Molecular and Integrative Biology | University of Liverpool 000
Reposted by Colin M. HammondPeter Ly @peterlylab.bsky.social · 19/05/2026Excited to share our latest paper! We found that large pieces of the human genome can transfer between cells upon direct contact, endowing recipient cells with heritable phenotypic changes. @cp-cell.bsky.social (1/7) www.cell.com/cell/fulltex... 1116667
Colin M. Hammond @needfuzz.bsky.social · 12/05/2026A friend of mine got a major starting grant today, I am so happy for them in achieving this success. Needed and deserved! I really hope for similar successes for my fellow early career group leaders. Good luck!🤞 010
Reposted by Colin M. HammondLorna Young @drlornayoung.bsky.social · 16/04/2026Happy to share! My first official PhD position is open for applicants 😃(self-funded!) This is an interdisciplinary, multi-supervised project, bringing together experts from UoL's Cancer Department, Population Health (Ffion Curtis) & the Centre for Innovation in Education (Ben McGrae) 113
Reposted by Colin M. HammondKarolin Luger @nucleosomepolice.bsky.social · 28/02/2026Paper alert from @codyz.bsky.social y.social and Yang Liu. New mechanism for chromatin remodeling by ATRX. Super cool story. Congrats to #lugerlab alumni. www.biorxiv.org/content/10.6... 0278
Colin M. Hammond @needfuzz.bsky.social · 27/02/2026Dr Christopher Switzer from the University of Leicester gave a great chemical biology perspective on Reactive Sulphur Species involvement in the hypoxia response today in Liverpool. Very impressed. 000
Reposted by Colin M. HammondThe Groth lab @grothlab.bsky.social · 25/02/2026DNA replication globally disrupts the epigenome. But does this create a chromatin-access opportunity for TF binding to facilitate cell identity change? Now 𝐫𝐞𝐩𝐥𝐢-𝐀𝐓𝐀𝐂-𝐬𝐞𝐪 shows 𝘥𝘦 𝘯𝘰𝘷𝘰 chromatin opening & TF binding occurs specifically post-replication, in cellular differentiation & reprogramming!cell.comPost-replicative chromatin accessibility predicts cell fate changeKnudsen and colleagues use repli-ATAC-seq to compare replicated and unreplicated chromatin in two models of cell identity change. They find that lineage-specific elements are accessible earlier in rep... 17127
Reposted by Colin M. HammondProteostasis UK @proteostasisuk.bsky.social · 03/02/2026📢 Next Proteostasis Consortium Seminar – Tomorrow, Wednesday 4 February 2026 at 4:00 pm GMT (10:00 am CT) Speaker: David Glass (Regeneron Pharmaceuticals) Title: Proteostatic Mechanisms Involved in Age‑Associated Disease 👉Link & Updates here: www.proteostasisconsortium.com/seminars/proteostasisconsortium.comProteostasis Consortium Seminars | Proteostasis Consortium 022
Reposted by Colin M. HammondBrain Tumour Research @braintumourrsch.bsky.social · 13/01/2026Less Survivable Cancers receive just 19% of research funding despite causing 40% of all cancer deaths. This glaring inequality is why we're calling for government to #CloseTheResearchGap. @lesssurvivable.bsky.social 👉 bit.ly/3Ngg6qF 031
Colin M. Hammond @needfuzz.bsky.social · 13/01/2026Check out our recent update from the J domain protein community! Thanks to Janine Kirstein, Rina Rosenzweig, Paolo De Los Rios, Pierre Genevaux, Jaroslaw Marszalek and Harm H. Kampinga for leading this effort www.sciencedirect.com/science/arti...sciencedirect.comJ-domain proteins: from molecular mechanisms to diseasesJ-domain proteins (JDPs) are known to drive the functional specificity of Hsp70 chaperone machines. Here we report on the latest findings presented at… 030
Reposted by Colin M. HammondMathieu M.J.E. Rebeaud @chercheurjuteux.com · 19/12/2025J-domain proteins: from molecular mechanisms to diseases We wrote a paper on the conference about JDPs in Gdansk and I have several of my latest research explained and presented in it. www.sciencedirect.com/science/arti...sciencedirect.comJ-domain proteins: from molecular mechanisms to diseasesJ-domain proteins (JDPs) are known to drive the functional specificity of Hsp70 chaperone machines. Here we report on the latest findings presented at… 284
Reposted by Colin M. HammondAnja Groth @groth-anja.bsky.social · 28/03/2025A few days left to apply for exciting PhD and Postdoc opportunities in wonderful Copenhagen and join our efforts in understanding Epigenetic Cell Memory. 12432
Reposted by Colin M. HammondNatalia Sanchez-Soriano @natsansor.bsky.social · 17/11/2025Funded 4-year BBSRC NWD PhD to advance neuroscience through vCLEM techniques. 🧠 Are you passionate about EM, neurons, ageing, neurodegeneration? Come and join us! 🙏repost this project with @ianprior.bsky.social @natsansor.bsky.social @aliemliv.bsky.social www.findaphd.com/phds/project...findaphd.com(BBSRC NWD) Developing a vCLEM pipeline for high-resolution analysis of neurons of the Drosophila brain at University of Liverpool on FindAPhD.comPhD Project - (BBSRC NWD) Developing a vCLEM pipeline for high-resolution analysis of neurons of the Drosophila brain at University of Liverpool, listed on FindAPhD.com 054
Colin M. Hammond @needfuzz.bsky.social · 12/11/2025The caterpillar, an epigenetic wonder! Recent birthday celebrations in the lab. 040
Reposted by Colin M. HammondJames Davies @jojdavies.bsky.social · 05/11/2025Our latest paper has just been published in Cell! doi.org/10.1016/j.ce... We developed a new method called MCC ultra, which allows 3D chromatin structure to be visualised with a 1 base pair pixel size. 621079
Colin M. Hammond @needfuzz.bsky.social · 01/11/202512 and a bit 5km runs in October, challenge complete! Thanks for all the sponsorship. £585 raised for Cancer Research, and almost £1M nationally - which is amazing! @cancerresearchuk.org fundraise.cancerresearchuk.org/page/colins-... 020
Colin M. Hammond @needfuzz.bsky.social · 01/11/2025Another great opportunity for a PhD linking hypoxia to cell matrix mechanobiology! 032
Colin M. Hammond @needfuzz.bsky.social · 30/10/2025Very excited to receive this Spatial Biology in Neuro-Oncology Grant to pump-prime our studies into histone supply biology in high grade glioma patient samples! Thanks to @standardbiotools.bsky.social and @eanoassociation.bsky.social for your generous support!🙂 🥳🧬🙌Exciting times ahead!! 🤸🧬🥳 050
Colin M. Hammond @needfuzz.bsky.social · 28/10/2025Great opportunities for chromatin transcription related PhDs or a postdoc, with a cool boss in Birmingham! 000
Colin M. Hammond @needfuzz.bsky.social · 27/10/2025That's £10 per km. Thanks a lot for all the donations! 010
Colin M. Hammond @needfuzz.bsky.social · 25/10/2025Thats me finished my 10th 5k in October! My best time yet, 26 min 40s. Sponsorship goes to @cancerresearchuk.org £355 raised so far, please sponsor it all goes to a good cause. fundraise.cancerresearchuk.org/page/colins-... 020
Colin M. Hammond @needfuzz.bsky.social · 23/10/2025www.thewaltoncentre.nhs.uk/news/walton-...thewaltoncentre.nhs.ukWalton Centre Neurosurgeon receives prestigious award | News 010
Colin M. Hammond @needfuzz.bsky.social · 21/10/2025Run 9/10 5ks in October and my first night run for a long time. I am surprised it wasnt faster. I tried to pick a flatter route, but I couldn't always see my feet! One to go!! 💸💸💸 fundraise.cancerresearchuk.org/page/colins-...fundraise.cancerresearchuk.orgA post from Colin's Giving PageRun 9/10 5ks in october and my first night run for a long time. I am surprised it wasnt faster. I tried to pick a flatter route, but I couldn't always see my feet! One to go!! 💸💸💸 120
Colin M. Hammond @needfuzz.bsky.social · 17/10/2025Run 7. Heart rate suggests my fitness is improving. Valiant sprint finish attempt to break 28 mins but denied by a whisker: 28m08s! 7/10 5ks during october! Am I becoming a runner again? Please send @cancerresearchuk.org some money on my behalf 💸💸💸 fundraise.cancerresearchuk.org/page/colins-...fundraise.cancerresearchuk.orgA post from Colin's Giving PageRun 7! Heart rate suggests fitness is improving. Valiant sprint finish attempt to break 28 mins. 7/10 5ks during october! Am I becoming a runner again? 000
Colin M. Hammond @needfuzz.bsky.social · 14/10/2025Latest run is in....28m15s....6/10 5ks in October! £290 raised so far for @cancerresearchuk.org. Thanks for the support 🥳 fundraise.cancerresearchuk.org/page/colins-... 010
Colin M. Hammond @needfuzz.bsky.social · 11/10/202527m20s. 5/10 5k runs for Cancer Research UK. Please sponsor me: fundraise.cancerresearchuk.org/page/colins-... 111
Colin M. Hammond @needfuzz.bsky.social · 09/10/2025Steadily improving my time. Run four complete as of yesterday morning! 10x 5k in October for Cancer Research UK fundraise.cancerresearchuk.org/page/colins-...fundraise.cancerresearchuk.orgA post from Colin's Giving PageSteadily improving my time. Run four complete! 010
Colin M. Hammond @needfuzz.bsky.social · 06/10/2025As of this lunch time, 3/10 5k runs in October are now complete and £200 raised for Cancer Research UK. Thanks for all of the donations, please sponsor my efforts! @livunicancer.bsky.social fundraise.cancerresearchuk.org/page/colins-... 011
Colin M. Hammond @needfuzz.bsky.social · 01/10/20251st run complete, please donate to the cause. fundraise.cancerresearchuk.org/page/colins-...fundraise.cancerresearchuk.orgColin's Giving PageI am running this in memory of my aunty Mandy who passed away this year because of neuroendocrine cancer. Many happy memories to help me back to fitness! Thanks for visiting my fundraising page. I’m ... 000
Colin M. Hammond @needfuzz.bsky.social · 18/09/2025That was quick. I have reached the £50 mark - sufficient to buy enough glass slides for a scientist to examine 1,470 tumour samples through a microscope. A little goes a long way!! fundraise.cancerresearchuk.org/page/colins-... 021
Colin M. Hammond @needfuzz.bsky.social · 16/09/2025I’m going to be taking on the 10 Days of 5k Challenge this October to help raise money for Cancer Research UK. Please show your support and help fund life-saving research by donating to my page. fundraise.cancerresearchuk.org/page/colins-...fundraise.cancerresearchuk.orgColin's Giving PageThanks for visiting my fundraising page. I’m going to be taking on the 10 Days of 5k Challenge this October to help raise money for Cancer Research UK. Please show your support and help fund life-savi... 020
Reposted by Colin M. HammondWendy Bickmore @wbickmor.bsky.social · 11/09/2025Honoured to be in Birmingham to mark Bryan Turner’s retirement- a gentleman and giant of epigenetics. 29115
Colin M. Hammond @needfuzz.bsky.social · 13/09/2025Debatably, the first red brick university. Thanks to the organisers for a great conference! 010
Colin M. Hammond @needfuzz.bsky.social · 07/07/2025Landmark! Last week we had the inaugural new group leaders and lab members day out @ New Brighton's Championship Adventure Golf Course 😎. New annual tradition? I will try not to win every year 🫣😅 010
Colin M. Hammond @needfuzz.bsky.social · 04/07/2025RIP Diogo Jota and André Silva. Very sad. YWNWA ♥️ 010