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PhD Project - (BBSRC NWD CASE) Unravelling the origins, mechanisms and implications of species differences in cellular stress response pathway capacities at University of Liverpool, listed on FindAPhD...

The authors use selective ribosome profiling to define how and when factors for N-glycosylation and membrane insertion engage and disengage from the core Sec61 translocation channel during biogenesis ...

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Cryo–electron tomography visualizes stress granules in situ, revealing their spatial interplay with translation machinery.

Genetic screens using endogenous reporters map key modulators of cellular iron, including the transcriptional regulator SETD2.

Bexley et al. report that rapid metabolic shifts mediate immediate, protective changes in RNA metabolism following energy depletion. In yeast, protein production is regulated by tuning enzymatic const...

Metabolic dysfunction–associated steatohepatitis (MASH) is a progressive disease driven by obesity-related hepatic inflammation and oxidative stress. …

Nature Chemical Biology - Glutarate rewires cell metabolism through conjugation to proteins or fatty acids, but how glutarylation is regulated is unclear. ABHD11 was identified as a...

Maintenance of mitochondrial redox homeostasis is of fundamental importance to cellular health. Mitochondria harbor a host of intrinsic antioxidant defenses, but the contribution of extrinsic, nonmito...

Redox signalling is emerging as an important regulator of metabolism and physiology, which is dysregulated in ageing and disease. Here, the authors show that redox regulation of a key redox sensitive ...

Pyruvate is the end-product of glycolysis and a central metabolite involved in many biochemical pathways. However, a lack of high-performance (i.e., Δ F / F > 10) single fluorescent protein (FP)-base...

Targeting a non-natural micropeptide ‘killswitch’ to several biomolecular condensates altered condensate compositions and revealed condensate functions in human cells

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Infection-causing fungi responsible for millions of deaths a year will spread significantly to new regions as the planet heats up, new research predicts —and the world is not prepared.

Uechi et al. found that a small-molecule lipoamide dissolves stress granules (SGs) by targeting SFPQ, a redox-sensitive disordered SG protein, alleviating pathological phenotypes caused by amyotrophic...

Wei et al. report that MBD2 forms condensates through phase separation in diverse cancers where it assembles the NuRD complex. MBD2 condensates are redox-sensitive and mediate transcriptional repressi...

Identifying the metabolic and genetic changes that confer evolutionary novelty is essential for understanding the factors facilitating or constraining the occurrence of traits. We show that dimethyl d...

Here, Paul et al. show that APMAP is an ER-localized paraoxonase-like enzyme that suppresses lipid oxidation and redox stress at the ER network. APMAP loss leads to ER stress, redox disruption, phosph...