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Greg Harrison

@bactophile.bsky.social
229 followers 267 following 27 posts

Postdoc at Tufts University Studying C. difficile 🔬 Chicago > St. Louis > Boston 👨‍🔬🪴📚🍷🏳️‍🌈

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Reposted by Greg Harrison
Daniel Kierzkowski @kierzkowskilab.bsky.social · 12/09/2026
🌱We are looking for an Assistant Professor in Plant Molecular Genetics @irbv.bsky.social If you are passionate about genetics, molecular biology, or imaging, this is your chance to join a community of researchers working on plant development, cell biology, evolution, ecology, and biodiversity. 👇
rh-carriere-dmz-eng.synchro.umontreal.ca
Careers
Through your undergraduate and graduate-level teaching, and your research activities, you will contribute to the faculty’s pursuit of excellence. Furthermore, you will promote your discipline and actively participate in the daily activities of a renowned institution. As such, you will:
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Reposted by Greg Harrison
Petra Levin @redrockcity.bsky.social · 19/09/2026
4 years (!) in the making, in this review Jade Wang and I detail the fundamental processes underlying growth, the cell autonomous nature of homeostatic control, and the contribution of stochasticity to both. TL;DR Bacteria are more like teenagers than you think. www.nature.com/articles/s41...
nature.com
Bacterial growth rate in populations and single cells - Nature Microbiology
In this Perspective, Levin and Wang give a brief history of bacterial growth rate and discuss how it is connected to nutrient availability and macromolecule synthesis, with a focus on (p)ppGpp as a ce...
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Anita Devineni @anitadevineni.bsky.social · 13/09/2026
My department (Biology at Emory) is hiring for a teaching track position! These are stable, well-respected, long-term positions with a path to promotion and ppl often staying for decades. The dept is wonderfully supportive and filled with amazing humans (faculty + staff) apply.interfolio.com/191814
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PBS News @pbsnews.org · 11/09/2026
After President Donald Trump told attendees at the Republican midterm convention Thursday night that "we want honesty in our elections," he led them in a pledge to "cheat like hell" and "go out and vote" in the midterm elections. to.pbs.org/4yTjfzl
to.pbs.org
WATCH: Trump leads RNC in pledge to 'cheat like hell' in November elections
After President Donald Trump told attendees at the Republican midterm convention Thursday night that “we want honesty in our elections,” he led them in a pledge to “cheat like hell” and “go out and vo...
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Reposted by Greg Harrison
Michael Clemens @mclem.org · 12/09/2026
The US President's new proposal to tax international students has been approved by the White House for release this week. It's an unprecedented $100,000 tax on int'l grads who stay to work after graduation on Optional Practical Training (most grads do), a crucial bridge to remaining by any channel.
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Joe Zackular @joeyzacks.bsky.social · 03/09/2026
Excited to share new work from my lab showing that early-life colonization with C. difficile remodels the developing infant gut, published today in @science.org! This study was co-led by two truly amazing scientists: @haidermanzer.bsky.social and Alexa Semon. www.science.org/doi/10.1126/...
science.org
Early-life colonization with Clostridioides difficile remodels the developing gut
Clostridioides difficile causes severe disease in adults but commonly colonizes infants asymptomatically. The consequences of early-life colonization on host development remain unknown. In a neonatal ...
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Reposted by Greg Harrison
Haider Manzer @haidermanzer.bsky.social · 03/09/2026
Is asymptomatic colonization with Clostridioides difficile (C. diff) early in life truly “silent?” In my first publication from the Zackular Lab, out today in @science.org, I teamed up with my amazing lab-mate, Alexa Semon, to find the answer. Link here: www.science.org/doi/10.1126/...
science.org
Early-life colonization with Clostridioides difficile remodels the developing gut
Clostridioides difficile causes severe disease in adults but commonly colonizes infants asymptomatically. The consequences of early-life colonization on host development remain unknown. In a neonatal ...
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Reposted by Greg Harrison
Ákos T Kovács @evolvedbiofilm.bsky.social · 03/09/2026
Flagellar toxicity: Flagellar synthesis is lytic for Bacillus subtilis in the absence of PBP1 PNAS from Dan Kearns lab www.pnas.org/doi/10.1073/... #MicroSky
pnas.org
Flagellar toxicity: Flagellar synthesis is lytic for Bacillus subtilis in the absence of PBP1 | PNAS
Flagella are large transenvelope nanomachines but how they transit the peptidoglycan in gram-positive bacteria is poorly understood. A recent model...
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Reposted by Greg Harrison
Prahathees Eswara @eswaralab.bsky.social · 02/09/2026
Thrilled to share this insightful work of Asher King @subtisilly.bsky.social and Pilar Horigian @pilarhorigian.bsky.social! #ProudPI #MicroSky #AMR #SubtiWiki In this work, we reveal the *magic* behind the protective effects of magnesium in Bacillus subtilis. Read Asher's 🧵 below for more details.
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Asher King @subtisilly.bsky.social · 02/09/2026
I am so excited to share my first first-author manuscript regarding the mysterious effects of magnesium in Bacillus subtilis! 🧵⬇️ www.biorxiv.org/content/10.6... #MicroSky
biorxiv.org
Magnesium induces iron starvation and metabolic rewiring to support the viability of cell envelope mutants and antibiotic-stressed cells
Magnesium supplementation permits deletion of otherwise essential genes involved in cell envelope biogenesis in the Gram-positive model bacterium Bacillus subtilis. Yet, the specific underlying mechan...
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Ardem Patapoutian @ardemp.bskyverified.social · 31/08/2026
NIH's Aug 2026 proposal would scrap exact scores and percentiles for three broad bins (top = top 25%). With funding rates at 5% or lower, too much then rides on administrative discretion. It devalues peer review and is a deterrent to engage. Tell NIH before Oct 13. grants.nih.gov/grants/guide...
grants.nih.gov
NOT-OD-26-088: Request for Information (RFI) on Proposed Changes to Reporting Outcomes from NIH Peer Review
NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Request for Information (RFI) on Proposed Changes to Reporting Outcomes from NIH Peer Review NOT-OD-26-088. NIH
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Seth Dickey @dickeylab.bsky.social · 28/08/2026
I’m thrilled to share our newest study in which @thesbhowmick.bsky.social y.social developed and applied a genome-wide platform to uncover genetic interactions in Staphylococcus aureus and MRSA. www.biorxiv.org/content/10.6... 1/10
biorxiv.org
A genome-wide genetic interaction platform for MRSA reveals connections between cell division and the cell envelope
The bacterial cell cycle is an ensemble of integrated pathways that coordinates cell growth and division. Although these pathways contain a suite of promising antimicrobial targets, their functional o...
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Greg Harrison @bactophile.bsky.social · 27/08/2026
Gotta say that I’m extra proud of this team effort out in JB! Our understanding of Cdif division is in its infancy & there’s so much work to be done. Shoutout to @shailab.bsky.social for laying the foundation & starting this cool project with @polakuhn.bsky.social!! journals.asm.org/doi/10.1128/...
journals.asm.org
Defining the order of assembly of the Clostridioides difficile divisome complex | Journal of Bacteriology
Bacterial cell division has been extensively studied in model systems, but little is known about how this essential process occurs in the clinically important pathogen Clostridioides difficile. Studie...
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Jacquelyn Gill @jacquelyngill.bsky.social · 21/08/2026
Hey folks, this hasn’t gotten much attention, but remember those proposed OMB rule changes we all commented on recently? There’s a new attempt to sneak them just for NSF. We have three days to comment. Please don’t sleep on this!
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Félix Ramos-León @felixrl.bsky.social · 18/08/2026
Excited to share my latest work in the @ramamurthilab.bsky.social, now in @cp-cellreports.bsky.social! We show that division geometry organizes surface adhesins in S. aureus and enables the formation of abscess communities that protect bacteria from immune cells. www.cell.com/cell-reports...
cell.com
Orthogonal cell division mediated by PcdA organizes surface virulence factors to drive staphylococcal abscess community formation
Staphylococcus aureus divides along sequential orthogonal planes, but the function of this geometry has remained unclear. Ramos-León et al. show that orthogonal division promotes uniform deployment of...
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Jeremy Berg @jeremymberg.bsky.social · 15/08/2026
New story from @jocelynkaiser.bsky.social at Science on K award changes. www.science.org/content/arti... 1/13
science.org
NIH is ending a key grant for budding clinical researchers
Agency will no longer allow K career awards to fund clinical trials
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Princess Vimentin PhD | Cancer Biologist @princess-vimentin.bsky.social · 14/08/2026
You can post your comment here. The period is open until Oct 13. rfi.grants.nih.gov?s=6a2b1c22c3...
rfi.grants.nih.gov
Request For Information
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Reposted by Greg Harrison
Princess Vimentin PhD | Cancer Biologist @princess-vimentin.bsky.social · 14/08/2026
From the administration that likes to tout "transparency". Usually, the research team that writes the #NIH grant sees funding scores (percentiles, impact scores) from the reviewers. Now, this won't be available. Why? The only reason: political meddling. 🧪 grants.nih.gov/grants/guide...
grants.nih.gov
NOT-OD-26-088: Request for Information (RFI) on Proposed Changes to Reporting Outcomes from NIH Peer Review
NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Request for Information (RFI) on Proposed Changes to Reporting Outcomes from NIH Peer Review NOT-OD-26-088. NIH
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Rita Tamayo @ritatamayo.bsky.social · 13/08/2026
New from the lab--C. diff uses phase variation to initiate infection in a virulent state but that phenotype presents a fitness cost as disease develops. A programmed reset mechanism primes Clostridioides difficile virulence at the onset of infection | Science Advances www.science.org/doi/10.1126/...
science.org
A programmed reset mechanism primes Clostridioides difficile virulence at the onset of infection
Clostridioides difficile is a major cause of antibiotic-associated diarrhea. This pathogen produces toxins essential for disease and flagella that promote intestinal colonization. Flagella and toxins ...
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Reposted by Greg Harrison
George O'Toole (he/him/his) @geiselbiofilm.bsky.social · 10/08/2026
Pls share: Three open posions in Bacteriology at Wisconsin: bact.wisc.edu/bacteriology...
bact.wisc.edu
Bacteriology is Hiring!
Bioeconomy Assistant Professor The Department of Bacteriology is seeking applicants at the Assistant Professor level to launch a research program in the New Bioeconomy. Applicants may be interested in...
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Greg Harrison @bactophile.bsky.social · 10/08/2026
Congratulations @polakuhn.bsky.social on the fabulous work! Truly found the needle in the haystack regarding the SINGLE CamA methylation site (out of THOUSANDS) that regulates sporulation - and super surprising findings for sigma factor activation/commitment in Cdif sporulation (vs Bacillus) 🤩
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Lars Dietrich @laahrs.bsky.social · 28/06/2026
Phenazine Pride #PrideMonth #bacterial_pigments Agar art by Marina Smiley
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Drew Hryckowian @a-hryckowian.bsky.social · 24/06/2026
New preprint from the lab led by Alex Dobrila! We show that butyrate-dependent toxin release in C. difficile is mediated by a broadly-conserved endolysin (EndD), which is under the control of the sporulation sigma factor SigK. Excited to share this story! 👇 www.biorxiv.org/content/10.6...
biorxiv.org
EndD mediates butyrate-dependent toxin release in Clostridioides difficile
Clostridioides difficile is an urgent threat to human health. Current treatments for C. difficile infections (CDIs) are antibiotics and microbiome restoration therapy (MRT) for recurrent cases. Howeve...
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Jenna Norton @jenna-m-norton.bsky.social · 09/06/2026
“Who would benefit from the proposed [OMB] rules? For one, politically connected industries — including those that may want to obscure scientific links between their products and harmful health effects.” Good op-ed in @nytimes.com www.nytimes.com/2026/06/09/o...
nytimes.com
Opinion | Trump’s Assaults on Scientific Research Just Got Worse
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Trends in Microbiology @cp-trendsmicrobiol.bsky.social · 06/06/2026
Cultivating the Pride in Microbiology Network
dlvr.it
Cultivating the Pride in Microbiology Network
Rising anti-2SLGBTQIA+ hostility creates a crisis of exclusion in science. Queer and Trans microbiologists often navigate their careers in isolation, facing systemic barriers that limit their retention. To counter this, we established the Pride in Microbiology Network in 2023. Here, we share strategies for building safe, decentralized networks beyond institutional and geographic borders and argue that resilient scientific ecosystems depend on diversity, inclusion, and support structures that enable 2SLGBTQIA+ scientists to remain, connect, and lead.
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Alex Wild @alexwild.bsky.social · 30/05/2026
tl,dr; Scientists no longer allowed to use federal funding to publish, attend meetings, or talk to the public. They cannot collaborate internationally. Grants can be cancelled for any reason, at any time, political appointees have a final say over what gets funded, and who gets funded.
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Jacquelyn Gill @jacquelyngill.bsky.social · 29/05/2026
🧵 Public science in the US has taken some heavy hits over the last year, but the White House OMB is proposing a series of changes that will result in a TKO for science as we know it unless we fight back. Here's what's happening, and why it matters. 1/n
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Nigel Goldenfeld @nigelgoldenfeld.bsky.social · 28/05/2026
🧪More information will be forthcoming about this *critical* development, and the Federal Register website will be open for public comments tomorrow. Thanks to @standupforscience.net for sounding the alarm. Background: an op-ed from @cdelawalla.bsky.social et al www.theguardian.com/commentisfre...
theguardian.com
Trump’s new ‘gold standard’ rule will destroy American science as we know it | Colette Delawalla
The new executive order allows political appointees to undermine research they oppose, paving the way for state-controlled science
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Carl T. Bergstrom @carlbergstrom.com · 22/05/2026
“Units of the NIH are privately directing grantees to request permission in advance for any co-authorship with a scholar affiliated with a foreign institution, even if all the work was done in the United States.” Grantees also told to remove papers with foreign authors from progress reports.
science.org
U.S. researchers face new restrictions on publishing with foreign collaborators
NIH, NASA grantees are confused and concerned amid agencies’ piecemeal communication
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Hiten Madhani @hitenmadhani.bsky.social · 12/05/2026
Nice piece that includes my colleague Kevan’s pioneering research. Yet another reason to fund more science, not less! How an ‘Impossible’ Idea Led to a Pancreatic Cancer Breakthrough www.nytimes.com/2026/05/12/h...
nytimes.com
How an ‘Impossible’ Idea Led to a Pancreatic Cancer Breakthrough
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Drug Monkey @drugmonkey.bsky.social · 07/05/2026
Demographics of the PIs of suspended NIH grants drugmonkey.wordpress.com/2026/05/06/d...
drugmonkey.wordpress.com
Demographics of the PIs of suspended NIH grants
A new paper in the Lancet by Fielding-Miller and colleagues reports on the principal investigators of grants that were terminated from January to May in 2025. This includes terminations based on th…
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Greg Harrison @bactophile.bsky.social · 23/04/2026
Fabulous work from @amelia-mckitterick.bsky.social using phages to better understand the bacterial cell envelope! #phagesky
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Molecular Microbiology @molmicrounihoh.bsky.social · 03/03/2026
The next International Conference on Gram-Positive Bacteria will take place between 29 June – 2 July 2027 in Ljubljana, Slovenia. #subtiwiki
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Jeff Bourgeois, PhD @bourgeoisjs.bsky.social · 08/04/2026
The Bourgeois Lab is recruiting a postdoc to work on our DoD-funded human genetics project aimed at understanding Lyme disease outcomes. wpi.wd5.myworkdayjobs.com/WPI_External...
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Jeremy Berg @jeremymberg.bsky.social · 26/03/2026
My NIH update Let me start by saying again how glad I am that NIH is now posting these curves on the Reporter front page. It is satisfying that leading by example from outside has led to this change and (I hope) reflects a commitment for NIH_leadership™ to hold itself accountable for this. 1/6
A graph from the from page of the NIH Reporter website showing the number of extramural awards award by month for fiscal years 2022-2026. The curve for fiscal year 2026 lies below the other curves.
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Drug Monkey @drugmonkey.bsky.social · 19/03/2026
NIH Fellowship awards for FY2025 by race drugmonkey.wordpress.com/2026/03/19/n...
drugmonkey.wordpress.com
NIH Fellowship awards for FY2025 by race
The NIH Data Book page reporting Research Project Grants (RPG) and Fellowship awards by race has been updated for FY2025. Completely unsurprisingly, despite the impression that may have been convey…
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Max Kozlov @maxkozlov.bsky.social · 27/02/2026
Congress rejected massive cuts to US science budgets for 2026, but much of the money still isn’t flowing to researchers. The culprit? The White House Office of Management and Budget (OMB) is quietly slow-walking the release of funds. 🧵👇
nature.com
White House stalls release of approved US science budgets
The US Congress rejected sweeping cuts to science agencies. But the NIH, the NSF and NASA have had their spending slowed.
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ACLU @aclu.org · 18/02/2026
BREAKING: The Department of Education has ended its directive that attempted to restrict diversity, equity, and inclusion efforts in schools nationwide. This is a victory for academic freedom and education equity.
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Wiep Klaas Smits (ExpBac/CMAT) @smitslab.bsky.social · 13/02/2026
The CspC:CspA heterodimer transduces germinant and co-germinant signals during Clostridioides difficile spore germination dx.plos.org/10.1371/jour...
dx.plos.org
The CspC:CspA heterodimer transduces germinant and co-germinant signals during Clostridioides difficile spore germination
Unlike other bacteria, C. difficile must detect both a germinant signal and a co-germinant signal to trigger spore germination, but how these cues are sensed is unknown. This study finds that the CspC...
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Pride in Microbiology @prideinmicro.bsky.social · 13/02/2026
This Friday, February 13th, we'll have our first ☕️ Coffee Hours ☕️ event of the year at 12-1 PM (EST)! Check your emails for the Zoom link. If you're not yet signed up for our newsletter, you can do so at prideinmicrobiology.github.io! 🏳️‍🌈 #PrideInSTEM #Microbiology #PrideinMicrobiology
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Mike Feigin 🥯 @mikefeigin.bsky.social · 06/02/2026
Do you: 1) Live near/in Buffalo? 2) Like to organize stuff? 3) Hate what the government is doing to science? If you answered yes, help me organize the Stand Up for Science rally on March 7th! I need reps from UB, Buff State, Canisius, D’Youville to spread the word. I need general support. DM me!
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Drew Hryckowian @a-hryckowian.bsky.social · 06/02/2026
Postdoc position available in my lab! Project will focus on how the microbiome-derived metabolite butyrate shapes C. difficile fitness and pathogenesis & will build on our previous/ongoing work in this space. Apply here: hr.wisc.edu/postdoc-and-...
hr.wisc.edu
Postdoc, Postgrad, and Research Intern Vacancies
Browse Postoc and Research Intern vacancies at UW–Madison.
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Greg Harrison @bactophile.bsky.social · 04/02/2026
Very cool analysis of sporulation genes in the Paenibacillaceae from the @heatherfeaga.bsky.social group! 🤩
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George O'Toole (he/him/his) @geiselbiofilm.bsky.social · 04/02/2026
rince & JB Editor's Choice: Lin, Prince & Feaga identified sporulation genes via analyzing almost 1500 genomes. They show that that an unusual membrane-localized variant of Spo0B is found throughout Paenibacillaceae. journals.asm.org/doi/10.1128/... @asm.org #JBacteriology
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Feldman Lab@WashU @feldmanlab.bsky.social · 04/02/2026
We are hiring postdocs :)
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PLOS Biology @plosbiology.org · 03/02/2026
Unlike other #bacteria, C. difficile must detect both germinant & co-germinant signals to trigger #spore #germination. This study finds that the CspC:CspA complex is a key signaling node that integrates environmental cues to regulate #Cdifficile spore germination @plosbiology.org 🧪 plos.io/4rtCKdZ
 Model for Clostridioides difficile germination. Top: Model of the C. difficile proteins required for germination during sporulation. From left to right: interdomain processing of the CspBA fusion protein by the protease YabG occurs in the spore coat layer; heterodimerization of CspC and CspA and homodimerization of CspB; and loading of key germination proteins into the cortex region of the mature spore. Bottom right: Model of a C. difficile spore undergoing germination. Sensing of germinant and co-germinant signals (either directly or indirectly) by the CspC:CspA heterodimer (1) leads to the heterodimer adopting an active conformation (2). Bottom left: CspC:CspA heterodimer space-filling model. Residues at the center of the CspC:CspA heterodimer binding interface (I.) play important roles in transducing germinant and co-germinant signals, while residues at the periphery of the binding interface (II.) help stabilize the complex. Signal transduction by the CspC:CspA heterodimer initiates the activation of CspB (either directly or indirectly) (3). Active CspB then proteolytically activates the cortex-lytic enzyme SleC (4), which will go on to degrade the spore cortex (5), allowing for rehydration of the spore core and resumption of metabolic activity.
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Dana Shaw @shawlab.bsky.social · 02/02/2026
My department at Washington State University is recruiting an Assistant or Associate Professor in vector-borne disease 🕷️🦟🦠 Full job description is linked below. Come join us on the Palouse!
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Pride in Microbiology @prideinmicro.bsky.social · 27/01/2026
📢 🏳️🌈🦠 We are expanding our matching program for 2SLGBTQIA+ microbiologists! Whether you need a mentor, a collaborator, or community support, we can help you. 🔗 Mentorship & Geo-matching: tinyurl.com/5cdyppys 🔗 Research Interest Groups: tinyurl.com/4p88bm4k #Microbiology #QueerInSTEM
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Tina Smith @smith.senate.gov · 25/01/2026
You may have voted for him. You may have supported what he said Operation Metro Surge was going to be. But it’s okay to say you changed your mind. It’s okay to say he’s gone too far.
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Caroline Bartman @cbartman.bsky.social · 26/01/2026
Can’t do good science in an unfree country. Defund ICE.
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