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Feldman Lab@WashU

@feldmanlab.bsky.social
1K followers 307 following 30 posts

We love bacteria!! Especially Acinetobacter and Bacteroides. The lab is in Dept. of Molecular Microbioloy @WashU in St Louis

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Reposted by Feldman Lab@WashU
STCmicrobeblog @stcmicrobeblog.bsky.social · 02/02/2026
#ProtistsOnSky no 'swimming' by 𝘝𝘢𝘮𝘱𝘺𝘳𝘦𝘭𝘭𝘢, definitively no 'staying still'. just a relaxed walk towards the lunch...
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Feldman Lab@WashU @feldmanlab.bsky.social · 04/02/2026
We are hiring postdocs :)
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Feldman Lab@WashU @feldmanlab.bsky.social · 16/01/2026
Thank you Katya for this piece discussing our recent work on intracellular Acinetobacter thetech.com/2026/01/15/f...
thetech.com
The bacterial fugitives behind hospital-acquired pneumonia | The Tech
Hospital-acquired 'A. baumannii' infections are notoriously hard to treat. A new study shows how these microbes can prolong infection by hiding from antibiotics inside immune cells.
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Feldman Lab@WashU @feldmanlab.bsky.social · 31/10/2025
Happy Halloween!!
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Feldman Lab@WashU @feldmanlab.bsky.social · 08/10/2025
Congratulations Evan, or I should say Dr. Pardue now!
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Feldman Lab@WashU @feldmanlab.bsky.social · 30/09/2025
Acinetobacter exhibits cyrcadian rhythms! These bugs can predict the light cycles and adjust the expression of genes accordingy. Amazing collaboration with Alejandra Mussi's team from Rosario, Argentina, my city!! rdcu.be/eIQzL
rdcu.be
The critical human pathogen Acinetobacter baumannii exhibits light-regulated circadian rhythms
Communications Biology - Gene expression studies in the critical pathogen Acinetobacter baumannii identified the existence of daily rhythms displaying a robust response to light, as well as...
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Feldman Lab@WashU @feldmanlab.bsky.social · 29/09/2025
I said I will never work on phages, but having @micheleleroux.bsky.social next door made me change my mind. Here is Alexis's new paper showing how different phages deal with the capsular barrier to infect Acinetobacter! A great collaboration between our labs! journals.plos.org/plospathogen...
journals.plos.org
Acinetobacter phages use distinct strategies to breach the capsule barrier
Author summary Acinetobacter baumannii causes life-threatening and often antibiotic-resistant infections thereby posing a global threat. Accordingly, there is an urgent need for alternative treatments...
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Feldman Lab@WashU @feldmanlab.bsky.social · 28/09/2025
Happy to share the last pre-print from my lab. Just in time for Evan’s thesis defense www.biorxiv.org/content/10.1...
biorxiv.org
Dual Membrane-spanning Anti-Sigma 2 Controls OMV biogenesis and Colonization Fitness in Bacteroides thetaiotaomicron
Bacteroides spp. are Gram-negative, gut commensals that shape the enteric landscape by producing outer membrane vesicles (OMVs) that degrade dietary fibers and traffic immunomodulatory biomolecules. U...
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Reposted by Feldman Lab@WashU
Emmanuele Severi @emmseveri.bsky.social · 20/09/2025
www.biorxiv.org/content/10.1... #microsky
biorxiv.org
A Protein Antibiotic Inhibits the BAM Complex to Kill Without Cell Entry
Many antibiotics are ineffective against Gram-negative pathogens such as Pseudomonas aeruginosa because they cannot penetrate the bacterial outer membrane. Here, we show that protein antibiotics calle...
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Feldman Lab@WashU @feldmanlab.bsky.social · 08/07/2025
The Feldman lab in the Acinetobacter conference in Niagara Falls
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Feldman Lab@WashU @feldmanlab.bsky.social · 18/06/2025
@benmicrobesmtg.bsky.social the organizers if the beneficial microbes conferences uninvited a scientist from the conference just based on their nationality. This act of racism should not be tolerated. I am happy I am not attending this conference. Shame on the organizers!
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Reposted by Feldman Lab@WashU
Michael Brockhurst @brockhurstlab.bsky.social · 04/05/2025
Highlights how the AMR crisis is also a cancer research issue Redirecting just a tiny fraction of cancer research funding to AMR would be transformative
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Feldman Lab@WashU @feldmanlab.bsky.social · 30/04/2025
For those who have not seen Guy Cornelis in years, here you have the pic we took today. He looks the same, its quite remarkable!!
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Feldman Lab@WashU @feldmanlab.bsky.social · 30/04/2025
Today I gave a talk in Namur with a special guest: Guy Cornelis, the scientist that discovered T3SS and who was my postdoc advisor. He is retired now, came to my talk. I could not resist the temptation to take a selfie when I started my seminar! Academia has these great moments
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Feldman Lab@WashU @feldmanlab.bsky.social · 29/04/2025
Yes! @manonjanet.bsky.social preprint is out! We show using BALF transfer that intracelular Acinetobacter baumannii can seed an infection in a susceptible mouse, suggesting that intracellular bacteria may be reservoir for recurrent infections nam10.safelinks.protection.outlook.com?url=https%3A...
nam10.safelinks.protection.outlook.com
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Reposted by Feldman Lab@WashU
giseladivenanzio.bsky.social @giseladivenanzio.bsky.social · 29/04/2025
Deadline for the travel awards is tomorrow! Check the conference website for more information events.faseb.org/event/biolog...
events.faseb.org
Biology of Acinetobacter XIV
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Feldman Lab@WashU @feldmanlab.bsky.social · 11/04/2025
The Feldman lab preparing the traditional empanadas for the department TGIF tomorrow.
Prepa
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Reposted by Feldman Lab@WashU
Feldman Lab@WashU @feldmanlab.bsky.social · 13/11/2024
The Acinetobacter conference will be held in USA for the first time. The program is coming soon. events.faseb.org/event/biolog...
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Reposted by Feldman Lab@WashU
Gerry Wright @gdwantibiotics.bsky.social · 26/03/2025
The latest discovery from the lab and great colleagues at McMaster and U Illinois, Chicago. Lariocidin, a new lasso peptide antibiotic that inhibits the ribosome. rdcu.be/efdha
rdcu.be
A broad-spectrum lasso peptide antibiotic targeting the bacterial ribosome
Nature - A new lasso peptide antibiotic exhibits broad-spectrum activity against Gram-negative and Gram-positive bacteria by interfering with bacterial protein synthesis, is unaffected by common...
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Reposted by Feldman Lab@WashU
samuel mehr @mehr.nz · 22/03/2025
so far I'm seeing a lot of universities respond to grant terminations with "oh I guess now we don't have that grant anymore" instead of "your assertion of a grant termination is executive overreach, see you in court" So, universities: respectfully, what the fuck?
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Maureen Barr @barrlab.bsky.social · 20/03/2025
In a science round table discussion yesterday, my NJ senator @kim.senate.gov suggested a strong argument for NIH and federal funding is global competitiveness. We US-based scientists should start weaving this into our narratives.
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Feldman Lab@WashU @feldmanlab.bsky.social · 19/03/2025
Travel awards for trainees and early-stage investigators to attend the 2025 Acinetobacter conference are available. Deadline for applications is April 30. Please rt. events.faseb.org/event/1b872d...
events.faseb.org
Biology of Acinetobacter XIV
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Feldman Lab@WashU @feldmanlab.bsky.social · 11/03/2025
Time to register to the 2025 Acinetobacter Conference in Niagara falls! Spaces are filling fast! We will soon announce some travel grants for graduate students/postdocs! events.faseb.org/event/biolog...
events.faseb.org
Biology of Acinetobacter XIV
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Mark Copelovitch @mcopelov.bsky.social · 08/03/2025
👇🎯 The public isn't going to understand this, unless the presidents of R1 universities around the country <loudly> & <collectively> get out into the public square & start explaining this & calling out the existential threat to the entire 🇺🇸 university system. The silence is deafening right now.
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Reposted by Feldman Lab@WashU
Oded Rechavi @odedrechavi.bsky.social · 07/03/2025
can you explain this 3 year gap in your resume? yeah the paper was under review
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Feldman Lab@WashU @feldmanlab.bsky.social · 05/03/2025
Program is ready and registration is open! Acinetobacter aficionados join us in Niagara Falls for some days of great science. events.faseb.org/event/biolog...
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Christina Stallings @stallingslab.bsky.social · 04/03/2025
For the sake of humanity, it's time to get out there and Stand Up For Science!! Spread the word!
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Feldman Lab@WashU @feldmanlab.bsky.social · 27/02/2025
Some good news: BV study section is being rescheduled for end of March beginning of April, process just started. Fingers crossed!
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Mariana Byndloss @maribyndloss.bsky.social · 23/02/2025
On March 7th we will Stand Up For Science! You can use the link to find the protest location in your city. standupforscience2025.org
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Gemma Reguera 🌎 @microgem.bsky.social · 23/02/2025
The Pope is in critical condition due to a"polymicrobial infection” of the lungs. What is this? An infection caused by multiple “germs”, most likely bacteria given the severity of the condition. One of many examples on why microbiology research matters. www.livescience.com/health/virus...
livescience.com
What is double pneumonia? Pope Francis's diagnosis explained.
Pope Francis is being treated in hospital for double pneumonia — but what is this condition, and why might the pope be particularly vulnerable to it?
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ᐯIᑕTOᖇ ᑎIᘔET, ᗰᗪ @nizet.bsky.social · 23/02/2025
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Gregg Gonsalves @gregggonsalves.bsky.social · 22/02/2025
The presidents of all universities should hold a press conference together at the National Press Club in Washington DC condemning the attacks on science and universities and outline the stakes for all Americans. 1/
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NPR @npr.org · 22/02/2025
The National Institutes of Health had to stop considering new grant applications, delaying funding for research into diseases ranging from heart disease and cancer to Alzheimer's and allergies.
npr.org
NIH funding freeze stalls applications on $1.5 billion in medical research funds
The National Institutes of Health had to stop considering new grant applications, delaying funding for research into diseases ranging from heart disease and cancer to Alzheimer's and allergies.
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Feldman Lab@WashU @feldmanlab.bsky.social · 22/02/2025
Next time a fiend or family member needs a new treatment for cancer, autoimmune diseases, infections or mental health issues, remember the Trump administration stopped ALL research in USA
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Vaughn Cooper @vscooper.micropopbio.org · 21/02/2025
Nice reporting by Ben Mueller on the Federal Register block www.nytimes.com/2025/02/21/s...
nytimes.com
Trump Administration Stalls Scientific Research Despite Court Ruling
Using an arcane law, officials have effectively delayed funding from the National Institutes of Health, leaving medical studies in jeopardy.
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Feldman Lab@WashU @feldmanlab.bsky.social · 19/02/2025
The Bacterial Virulence study section that was scheduled for today was cancelled…today! We just got the communication this morning. This is disheartening…
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Emmanuele Severi @emmseveri.bsky.social · 14/02/2025
www.nature.com/articles/s41...
nature.com
Phages carry orphan antitoxin-like enzymes to neutralize the DarTG1 toxin-antitoxin defense system - Nature Communications
Toxin-antitoxin systems make up a branch of the bacterial anti-phage immune system. Here, Johannesman et al demonstrate that some phages have co-opted an orphan antitoxin to counter a DNA ADP-ribosylt...
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Reposted by Feldman Lab@WashU
Mark Follman @markfollman.bsky.social · 12/02/2025
Incredible: Russ Vought’s daughter has cystic fibrosis and benefits from a “miracle drug” made possible by the National Institutes of Health—an agency Vought now aims to gut as part of the Project 2025 attack www.motherjones.com/politics/202... Scoop from @motherjones.com’s @metrauxjulia.bsky.social
motherjones.com
Project 2025 is gutting medical funding that helped Russell Vought's own kid
Its architect's daughter has cystic fibrosis—and benefits from a "miracle drug" backed by an agency he's attacking.
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Willem van Schaik @wvschaik.bsky.social · 11/02/2025
Heterologous protein over-expression in E. coli is now woke because of 'inclusion bodies'
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Feldman Lab@WashU @feldmanlab.bsky.social · 12/02/2025
Super proud to see our startup Omniose involved in these very important studies with several world leaders in the Klebsiella field. This will guide our and other’s efforts to get a vaccine against Klebsiella!
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Sarah Tishkoff, PhD @sarahtishkoff.bsky.social · 08/02/2025
Apologies for this long post I put together to explain to non-scientists the impact of NIH cuts: Last night, an “atomic bomb” was dropped on the biomedical science community. We were informed that effective immediately, indirect costs on NIH grants (both current and future) would be fixed at 15%.
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Prasad Jallepalli, MD, PhD @prasad.bsky.social · 08/02/2025
this is a good time to note that the proposed candidate for NIH director has never run a lab, cared for patients, led a major research and healthcare institution, or been a principal investigator on an NIH grant
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Jose Bengoechea @josebengoechea.bsky.social · 06/02/2025
New pre print! We establish an ex vivo blood vessel model to investigate the effect of infection on vascular physiology in real time. We show Klebsiella inhibits vasodilation in a T6SS-dependent manner by targeting eNOs. Superb work by @safimicro.bsky.social www.biorxiv.org/content/10.1...
biorxiv.org
Klebsiella pneumoniae disrupts vasodilation by targeting eNOS post translational modifications via the type VI secretion system and the capsule polysaccharide
Vasodilation is a crucial protective response to inflammation and infection. Endothelial cells control vasodilation through the bioavailability of eNOS-produced nitric oxide (NO), and the generation o...
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Jeremy Berg @jeremymberg.bsky.social · 28/01/2025
Academic Skyers: I am compiling a list of policies and statements from various universities about how they are handling the "pause" in terms of stopping expenditures (or not). Please respond to this post with your institution and materials. THANK YOU!
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Katie Mack @astrokatie.com · 28/01/2025
I think some people hear “grants” and think that without them, scientists and government workers just have less stuff to play with at work. But grants fund salaries for students, academics, researchers, and people who work in all areas of public service. “Pausing” grants means people don’t eat.
washingtonpost.com
White House pauses all federal grants, sparking confusion
The Trump administration has put a hold on all federal financial grants and loans, affecting tens of billions of dollars in payments.
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Ardem Patapoutian @ardemp.bskyverified.social · 26/01/2025
Let’s stop treating "leaving academia" as negative. Scientists train for academia, industry, or what suits them. Industry isn’t an alternative; it’s a choice. In fields like engineering, most PhDs go to industry, and no one calls it "leaving academia." We should train scientists for diverse paths.
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Emma Slack @mucosalimmunology.bsky.social · 26/01/2025
Interested in microbial #metabolism, #mucosalbiology and #UTI? Then check out the open postdoctoral position in the Mucosal Immunology Group at ETH Zurich! NB: All applications must go via the ETH job portal: www.jobs.ethz.ch/job/view/JOP... Closing date: 24th Feburary 🧪🧫🔬
jobs.ethz.ch
Postdoctoral researcher –Understanding bacterial metabolism in the urinary tract
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Victor J. Torres @torreslab.bsky.social · 17/01/2025
Come and join our team at St. Jude Children's Research Hospital! We are seeking a Sr Scientist to advance our research on immune responses to infection/vaccination. This is a financially stable position offering a highly competitive salary and excellent benefits. talent.stjude.org/careers/jobs...
talent.stjude.org
Senior Scientist-Immunology, Vaccinology, Infection in Memphis, Tennessee | St. Jude Careers
St. Jude Careers is hiring a Senior Scientist-Immunology, Vaccinology, Infection in Memphis, Tennessee. Review all of the job details and apply today!
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Andreas Peschel @andreaspeschel.bsky.social · 03/01/2025
Interesting, new regulatory role of peptidoglycan
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Alvaro San Millan @sanmillan.bsky.social · 30/12/2024
www.nature.com/articles/s41... New paper out!!
nature.com
A plasmid-chromosome crosstalk in multidrug resistant enterobacteria - Nature Communications
The authors describe a new crosstalk between a globally disseminated carbapenem resistance plasmid and clinical enterobacteria clones. This crosstalk provides a fitness advantage to the plasmid-carryi...
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