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Drew Hryckowian

@a-hryckowian.bsky.social
229 followers 199 following 15 posts

Gut microbiome, bacterial pathogens, bacteriophages. Assistant Professor, Depts. Medicine and Medical Microbiology & Immunology, University of Wisconsin-Madison. Views expressed = mine. hrycklab.medicine.wisc.edu

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Drew Hryckowian @a-hryckowian.bsky.social · 20/08/2026
We're looking for someone who is highly organized & detail-oriented to serve as the central operational node and technical backbone of our growing lab. Time will be split equally between lab management (~20 hours/week) and research (~20 hours/week). Apps due EOD Aug 3 jobs.wisc.edu/jobs/researc...
jobs.wisc.edu
Researcher and Lab Manager – Hryckowian Lab - Madison, Wisconsin, United States
Current Employees: If you are currently employed at any of the Universities of Wisconsin, log in to Workday to apply through the internal application process.Job Category:Academic StaffEmployment Type:Terminal (Fixed Term)Job Profile:Researcher IJob Summary:The Hryckowian Lab is seeking a highly organized, detail-oriented Researcher I to serve as the central operational node and technical backbone of the laboratory. This role splits time roughly equally between comprehensive laboratory management (~20 hours/week) and direct bench research assistance (~20 hours/week).The Hryckowian Lab’s research focuses on understanding how resident microbial communities (microbiomes) act as a "microbial shield" to protect against pathogenic bacterial infections, and how to...
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Drew Hryckowian @a-hryckowian.bsky.social · 24/06/2026
New preprint from the lab led by Alex Dobrila! We show that butyrate-dependent toxin release in C. difficile is mediated by a broadly-conserved endolysin (EndD), which is under the control of the sporulation sigma factor SigK. Excited to share this story! 👇 www.biorxiv.org/content/10.6...
biorxiv.org
EndD mediates butyrate-dependent toxin release in Clostridioides difficile
Clostridioides difficile is an urgent threat to human health. Current treatments for C. difficile infections (CDIs) are antibiotics and microbiome restoration therapy (MRT) for recurrent cases. Howeve...
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Reposted by Drew Hryckowian
Drew Hryckowian @a-hryckowian.bsky.social · 06/02/2026
Postdoc position available in my lab! Project will focus on how the microbiome-derived metabolite butyrate shapes C. difficile fitness and pathogenesis & will build on our previous/ongoing work in this space. Apply here: hr.wisc.edu/postdoc-and-...
hr.wisc.edu
Postdoc, Postgrad, and Research Intern Vacancies
Browse Postoc and Research Intern vacancies at UW–Madison.
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Drew Hryckowian @a-hryckowian.bsky.social · 05/03/2026
Join us in beautiful Madison WI! In addition to the postdoc call I previously announced, I am seeking applicants for a Scientist position. IMO this position is best suited for someone who successfully completed their postdoctoral training, see here for more details: jobs.wisc.edu/jobs/scienti...
jobs.wisc.edu
Scientist I – C. difficile and Gut Microbiome - Madison, Wisconsin, United States
Current Employees: If you are currently employed at any of the Universities of Wisconsin, log in to Workday to apply through the internal application process.Job Category:Academic StaffEmployment Type...
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Reposted by Drew Hryckowian
UW Madison Microbiology Doctoral Training Program @uwmadisonmdtp.bsky.social · 23/02/2026
Join us this week for the MDTP student seminar, featuring Joie Ling from Hryckowian Lab! #MDTP #UWMadison
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Drew Hryckowian @a-hryckowian.bsky.social · 06/02/2026
Postdoc position available in my lab! Project will focus on how the microbiome-derived metabolite butyrate shapes C. difficile fitness and pathogenesis & will build on our previous/ongoing work in this space. Apply here: hr.wisc.edu/postdoc-and-...
hr.wisc.edu
Postdoc, Postgrad, and Research Intern Vacancies
Browse Postoc and Research Intern vacancies at UW–Madison.
01414
Drew Hryckowian @a-hryckowian.bsky.social · 31/01/2026
New Infection and Immunity paper led by @uwmadisonmdtp.bsky.social student Joie Ling on GI colonization by Group B Streptococcus! It describes an adult mouse model of GBS GI colonization & uncovers strain-specific fitness and the role of capsule in persistence. journals.asm.org/doi/10.1128/...
journals.asm.org
A murine model of adult gastrointestinal colonization by Group B Streptococcus | Infection and Immunity
Group B Streptococcus (Streptococcus agalactiae, GBS) is a disease-causing gram-positive bacterial species. Found asymptomatically in the adult gastrointestinal (GI) tract and the female reproductive ...
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Reposted by Drew Hryckowian
UW Madison Microbiology Doctoral Training Program @uwmadisonmdtp.bsky.social · 02/12/2025
Next Monday, December 8th, Anna Gregory from the Hryckowian Lab will be giving her dissertation defense seminar!
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Drew Hryckowian @a-hryckowian.bsky.social · 29/09/2025
Excited to see Joie Ling's new preprint out! Adult mouse model shows robust GI colonization by Group B Strep without antibiotics. Capsule emerges as a persistence factor in the adult GI. www.biorxiv.org/content/10.1...
biorxiv.org
A murine model of adult gastrointestinal colonization by Group B Streptococcus
Group B Streptococcus (Streptococcus agalactiae, GBS) is a leading cause of invasive infections in neonates and adults. The adult gastrointestinal (GI) tract represents an understudied site of asympto...
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Drew Hryckowian @a-hryckowian.bsky.social · 24/09/2025
Thrilled to share @alex-dobrila.bsky.social’s new review in Infection & Immunity on how butyrate shapes C. difficile pathogenesis. A must-read for those interested in microbiome–pathogen interactions. 👉 journals.asm.org/doi/10.1128/...
journals.asm.org
The emerging view on the roles of butyrate in Clostridioides difficile pathogenesis | Infection and Immunity
The Centers for Disease Control and Prevention classifies Clostridioides difficile as an urgent threat to the nation’s health, as it causes 450,000 infections, 15,000 deaths, and 1 billion dollars in excess healthcare costs per year in the United States (1, 2). Most C. difficile infections (CDIs) occur in healthcare settings, where CDI is the most common cause of infectious diarrhea (3). Known and suspected risk factors for CDI include antibiotics, proton pump inhibitors, impaired immune function, advanced age, and diet, all of which are associated with dysbiotic gastrointestinal (GI) microbiomes (4–6). Though most CDIs are associated with antibiotic treatment, 22% of individuals with community-acquired CDI have no recent history of antibiotic use. Factors affecting persistent and recurrent CDIs remain poorly defined (7, 8). Despite the morbidity and mortality caused by C. difficile, up to 15% of healthy adults are asymptomatic carriers of toxigenic C. difficile (9), highlighting the gaps in our understanding of C. difficile.
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Drew Hryckowian @a-hryckowian.bsky.social · 07/02/2025
Check out Anna Gregory's great work, recently published in Journal of Bacteriology. Thanks for the shout out, @smitslab.bsky.social 👍
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