iiinova — where your digital self keeps evolving

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Simon Cook @drsimoncook.bsky.social · 01/05/2026

I am pleased to share a link to the latest paper from the Cook lab. www.biorxiv.org/content/10.6... The DYRK protein kinases, near neighbours to the MAPKs in the CMGC arm of the human kinome, control critical cell fate decisions and are deregulated in disease, much like the MAPKs and CDKs.

biorxiv.org

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Alessandro Esposito 👨‍🔬🔬🧬👨‍👩‍👧🇪🇺🏳️‍🌈 @aesposito1975.bsky.social · 07/04/2026

Confused about Fisher Information and optimisation of Fluorescence Microscopy, #FLIM specifically? I have just completed a tutorial for you hilight-horizon.github.io/HILIGTHer_FL... @hilighthorizon.bsky.social

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Alessandro Esposito 👨‍🔬🔬🧬👨‍👩‍👧🇪🇺🏳️‍🌈 @aesposito1975.bsky.social · 02/04/2026

How many photons do you need to measure a fluorescence lifetime? We are proud to release HILIGTHer, a #FLIM #DigitalTwin designed to simulate most features of time-domain FLIM systems, just announced at #FOM2026 and incredibly well-received. Beta release now available: github.com/HiLIGHT-HORI...

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Alessandro Esposito 👨‍🔬🔬🧬👨‍👩‍👧🇪🇺🏳️‍🌈 @aesposito1975.bsky.social · 02/04/2026

What is Focus on Microscopy for me? A scientific family, friends and amazing innovation. We often see, even 10 years in advance, the techniques that will eventually disrupt biology, biomedical research, and healthcare. Industry and academia, together. #FOM2026 #Microscopy #HILIGHT

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Department of Chemical Engineering and Biotechnology, Cambridge @ceb.cam.ac.uk · 21/03/2026

We’re open! Today’s your chance to get hands on with world-leading science 🔬 🧪⚙️🌱🔋 #CamFest

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Alessandro Esposito 👨‍🔬🔬🧬👨‍👩‍👧🇪🇺🏳️‍🌈 @aesposito1975.bsky.social · 20/03/2026

After four months of happy usage of Google Antigravity with Gemini, sadly, #Gemini became unusable. It was an opportunity to explore #CODEX after a while and discover how CODEX (GPT5.4) is extraordinarily good and fast. Preparing two major releases of software for #FLIM :)

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Alessandro Esposito 👨‍🔬🔬🧬👨‍👩‍👧🇪🇺🏳️‍🌈 @aesposito1975.bsky.social · 10/01/2026

I am honoured to be appointed as new Director for @cengem.bsky.social. With massive thanks for Prof Jo Bridger with whom I worked as deputy over the past few years, CHMLS senior leadership for entrusting me with CenGEM and my amazing colleagues for their support.

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HILIGHT - An EU HORIZON project @hilighthorizon.bsky.social · 01/12/2025

We are excited to announce HILIGHT 2026: FLIM & Photonics, a free two day technical meeting at Brunel University London on 4th–5th March 2026. The programme will include talks from leading experts, posters, flash talks, and dedicated industry exhibition. Register here: shorturl.at/AwEOv

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HILIGHT - An EU HORIZON project @hilighthorizon.bsky.social · 10/12/2025

🎄 FLIM Advent Calendar 🎄 This December we’re revealing speakers for HILIGHT 2026: FLIM & Photonics Day 1: Prof Ruslan Dmitriev on using FLIM to track nanoplastics in organoids. Free Event: lnkd.in/eGUXXzNe LinkedIn Event page: lnkd.in/eBTRJRhq HILIGHT website Event page : lnkd.in/ewRw4G4j

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HILIGHT - An EU HORIZON project @hilighthorizon.bsky.social · 15/12/2025

🎄 FLIM Advent Calendar 🎄 Here’s the next speaker in our HILIGHT 2026: FLIM & Photonics Day 3: Dr Conor Treacy @c-trass.bsky.social on multiphoton FLIM and DNA signatures in Pancreatic Cancer Spheroids . Free Event: lnkd.in/eGUXXzNe LinkedIn: lnkd.in/eBTRJRhq HILIGHT: lnkd.in/ewRw4G4j

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HILIGHT - An EU HORIZON project @hilighthorizon.bsky.social · 19/12/2025

🎄 FLIM Advent Calendar 🎄 The next speaker in our HILIGHT 2026: FLIM & Photonics event line-up. Day 8: Dr Sylvain Boust, from III-V Lab, on versatile laser diode for 2ph FLIM at 8 Mpx/s in HILIGHT project. Free Event: lnkd.in/eGUXXzNe LinkedIn: lnkd.in/eBTRJRhq HILIGHT: lnkd.in/ewRw4G4j

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HILIGHT - An EU HORIZON project @hilighthorizon.bsky.social · 20/12/2025

🎄 FLIM Advent Calendar 🎄 The next speaker in our HILIGHT 2026: FLIM & Photonics event line-up. Day 9: Prof Gail Mcconnell @gailmcconnell.bsky.social on Multiphoton mesoscale imaging with the Mesolens. Free Event: lnkd.in/eGUXXzNe LinkedIn: lnkd.in/eBTRJRhq HILIGHT: lnkd.in/ewRw4G4j

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HILIGHT - An EU HORIZON project @hilighthorizon.bsky.social · 17/12/2025

🎄 FLIM Advent Calendar 🎄 The next speaker in our HILIGHT 2026: FLIM & Photonics event line-up. Day 4: Professor Edoardo Charbon on Picosecond Image Sensors: From FLIM to Quantum Imaging. Free Event: lnkd.in/eGUXXzNe LinkedIn: lnkd.in/eBTRJRhq HILIGHT: lnkd.in/ewRw4G4j

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HILIGHT - An EU HORIZON project @hilighthorizon.bsky.social · 18/12/2025

🎄 FLIM Advent Calendar 🎄 The next speaker in our HILIGHT 2026: FLIM & Photonics event line-up. Day 5: Dr Falk Schneider @faldalf.bsky.social on Navigating Cross-Excitation Challenges in Multiplexed NADH FLIM. Free Event: lnkd.in/eGUXXzNe LinkedIn: lnkd.in/eBTRJRhq HILIGHT: lnkd.in/ewRw4G4j

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HILIGHT - An EU HORIZON project @hilighthorizon.bsky.social · 19/12/2025

🎄 FLIM Advent Calendar 🎄 The next speaker in our HILIGHT 2026: FLIM & Photonics event line-up. Day 7: Dr Gunnar Blume on short-pulse semiconductor lasers for fluorescence lifetime imaging and spectroscopy at FBH. Free Event: lnkd.in/eGUXXzNe LinkedIn: lnkd.in/eBTRJRhq HILIGHT: lnkd.in/ewRw4G4j

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HILIGHT - An EU HORIZON project @hilighthorizon.bsky.social · 19/12/2025

🎄 FLIM Advent Calendar 🎄 The next speaker in our HILIGHT 2026: FLIM & Photonics event line-up. Day 6: Dr Sara Pellegrini on Pixels for FLIM: SPADs in monolithic and 3D stacked technology. Free Event: lnkd.in/eGUXXzNe LinkedIn: lnkd.in/eBTRJRhq HILIGHT: lnkd.in/ewRw4G4j

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HILIGHT - An EU HORIZON project @hilighthorizon.bsky.social · 10/12/2025

🎄 FLIM Advent Calendar 🎄 Here’s the next speaker in our HILIGHT 2026: FLIM & Photonics Day 2: Prof Marina Kuimova on measuring cellular viscosity with molecular rotors and FLIM. Free Event: lnkd.in/eGUXXzNe LinkedIn Event page: lnkd.in/eBTRJRhq HILIGHT website Event page : lnkd.in/ewRw4G4j

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Alessandro Esposito 👨‍🔬🔬🧬👨‍👩‍👧🇪🇺🏳️‍🌈 @aesposito1975.bsky.social · 01/12/2025

If you want to know why all biological models are wrong, you will be interested in our latest virtual debate. open.spotify.com/episode/6Usp... #biology #model #science

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Centre for Genome Engineering and Maintainance @cengem.bsky.social · 28/11/2025

When is a #modelsystem relevant? Interesting reflections by Dr Christian Rudolph rudolphlab.com/blog/on-narr...

rudolphlab.com

Rudolph BLOG

Pages of the Rudolph laboratory at Brunel University London.

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Alessandro Esposito 👨‍🔬🔬🧬👨‍👩‍👧🇪🇺🏳️‍🌈 @aesposito1975.bsky.social · 26/11/2025

I use #NotebookLM quite a bit for work. Useful for converting your content (in this case, our latest paper) into different formats. Here a #mindmap of "FOXO1 links #KRAS G12D and G12V alleles to glutamine and nitrogen #metabolism in #colorectalcancer" doi.org/10.1038/s443...

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Simon Cook @drsimoncook.bsky.social · 26/11/2025

www.embopress.org/doi/full/10.... Congratulations to Dilem Shakir, Michael Batie, Chun-Sui Kwok, Niall Kenneth and @srochaliv.bsky.social on their their lovely study describing NF-κB’s central role in the hypoxia response - just out in EMBO Reports. A pleasure to collaborate with Team Rocha!!👏 🍾 👌

embopress.org

NF-κB is a central regulator of hypoxia-induced gene expression | EMBO reports

imageimageHypoxia induces a specific NF-κB-dependent gene signature across multiple cell systems. NF-κB is required for over 60% of gene repression occurring in response to hypoxia, controlling oxidat...

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Reposted by Alessandro Esposito 👨‍🔬🔬🧬👨‍👩‍👧🇪🇺🏳️‍🌈

Simon Cook @drsimoncook.bsky.social · 21/11/2025

www.embopress.org/doi/full/10.... Congratulations to Suzan Ber and @aesposito1975.bsky.social on their lovely study of KRAS alleles on glutamine and nitrogen metablism and signalling - just out in EMBO Reports. Such a pleasure to collaborate on this fascinating project! 👏

embopress.org

FOXO1 links KRAS G12D and G12V alleles to glutamine and nitrogen metabolism in colorectal cancer | EMBO reports

imageimageKRAS mutations at codon 12 induce profound metabolic changes in colorectal cancer cells. These oncogenic mutations promote FOXO1-dependent glutamine and nitrogen recycling, uncovering a vuln...

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HILIGHT - An EU HORIZON project @hilighthorizon.bsky.social · 27/10/2025

Another key milestone in the #HILIGHTProject development roadmap 📈 Our first multi-section 905 nm laser purpose-built for #2phFLIM is fabricated! 🔬 🧪 Next: characterisation at #III-VLab. @csem.ch , #BrunelUniversityLondon, @aesposito1975.bsky.social, #FBK, #VivaScope hilighthorizon.eu/blog/

Alessandro Esposito 👨‍🔬🔬🧬👨‍👩‍👧🇪🇺🏳️‍🌈 @aesposito1975.bsky.social · 08/09/2025

New Microscopills episode! We explore optogenetics: the science of using light to control living cells. From mapping brain circuits to controlling biochemical reactions, a 5-minute guide to optogenetics. open.spotify.com/episode/4e7j... #Microscopills #Optogenetics #SciencePodcast

lnkd.in

This link will take you to a page that’s not on LinkedIn

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Alessandro Esposito 👨‍🔬🔬🧬👨‍👩‍👧🇪🇺🏳️‍🌈 @aesposito1975.bsky.social · 22/08/2025

Amazing news! Looking forward to this new sensor. FBK is doing an amazing job as always!!!

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Alessandro Esposito 👨‍🔬🔬🧬👨‍👩‍👧🇪🇺🏳️‍🌈 @aesposito1975.bsky.social · 07/08/2025

#GPT5 is out. Superslow but the level of detail that gives is impressive at least as judged from initial accidental (I had not noticed it was rolled out as I was working on custom GPTs) use!

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Centre for Genome Engineering and Maintainance @cengem.bsky.social · 03/07/2025

We now have the audio summary of "#BMP antagonist #CHRDL2 enhances the #cancer #stemcell phenotype and increases #chemotherapy resistance in #colorectal cancer" by Eloise Clarkson and Annabelle Lewis published in Molecular Oncology open.spotify.com/episode/3vv8...

open.spotify.com

E03 - CHRDL2 in Colorectal Cancer [New paper from Lewis Lab]

CenGEM | Centre for Genome Engineering and Maintenance · Episode

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HILIGHT - An EU HORIZON project @hilighthorizon.bsky.social · 01/07/2025

🚀 Discover the future of diagnostics! The Hilight Project is revolutionising biomedical research with cutting-edge laser technology 🔬. #HighlightProject #DigitalDiagnostics #BiomedicalResearch #LaserTechnology #FLIMImaging #Innovation #MedicalTech See the video presentation at hilighthorizon.eu

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HILIGHT - An EU HORIZON project @hilighthorizon.bsky.social · 21/05/2025

Hard-working and smart, nothing else defines a #scientist or an #engineer. A scientist, an engineer, is someone like you. If you are considering a path in science or technology, know this: your ideas belong here because our #superpower is you! #oursuperpowerisyou hilighthorizon.eu/edi/

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Simon Cook @drsimoncook.bsky.social · 15/05/2025

Another reason to like MEKI!

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HILIGHT - An EU HORIZON project @hilighthorizon.bsky.social · 15/05/2025

We are releasing our EDI campaign material. Help us by using/reusing/altering our work and distributing it to schools, Universities and events. Just a small action, part of a larger commitment and ongoing conversation. hilighthorizon.eu/edi/ #EDI #WomenInSTEM

Engineering a better future with you - EDI campaign

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Christian Frezza @frezzalab.bsky.social · 13/11/2024

This is an old post, but I would like to propose it again as I am new here. This is a topic I am very passionate about. I hope you will enjoy the read, and you will find it useful. Happy to hear your views about the topic. The mindful scientist network.febs.org/posts/the-mi... #FEBSnet

network.febs.org

The mindful scientist

A more mindful approach to science can help scientists to handle negative and positive emotions better.

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Alessandro Esposito 👨‍🔬🔬🧬👨‍👩‍👧🇪🇺🏳️‍🌈 @aesposito1975.bsky.social · 10/05/2025

Hear the #women shaping #stemcell science! Discover the resilience, breakthroughs, and essential insights of female pioneers driving innovation in the field. open.spotify.com/episode/1lY9... This podcast explores their challenges, triumphs, and vital perspectives.

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Alessandro Esposito 👨‍🔬🔬🧬👨‍👩‍👧🇪🇺🏳️‍🌈 @aesposito1975.bsky.social · 05/05/2025

An introduction to #genes and #genomes, MSc #lecture I gave a couple of years ago, now on Spotify in the form of a conversational podcast. Next up: the central 'dogma' of molecular biology. open.spotify.com/episode/3t2e...

open.spotify.com

BB5708 - Genes and Genomes

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