iiinova — where your digital self keeps evolving

Reposted by Ed Chuong

Ivan Zanoni @lozanzi.bsky.social · 21/08/2025

#InterferonPower! Thrilled for our latest work @cp-cell.bsky.social! With @danielboehmer.bsky.social, we dug into tons of papers & created what we hope will be a go-to resource for immunologists & non-immunologist about type I, II, III (& IV😉) #interferons! Free👉 authors.elsevier.com/a/1leKGL7PXu...

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Ed Chuong @edchuong.bsky.social · 17/07/2025

Are you bravely deciding to do a postdoc in the US? And also interested in some combination of genomics, immunology, and transposons? If so, consider applying to my lab at the BioFrontiers Institute in Boulder, Colorado! jobs.colorado.edu/jobs/JobDeta... 🧪🧬 #TESky #interferosky

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Reposted by Ed Chuong

Julius Brennecke @juliusbrennecke.bsky.social · 16/07/2025

Pls. share widely Calling all transposon fans & lovers of genetic innovation MOBILE GENOME welcomes you in Heidelberg, Nov. 4–7 2025 → Vibrant & friendly community → Cutting-edge talks from mechanisms to physiology → Plenty of surprises (TEs never stop innovating) submit abstract by July 29

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Cedric Feschotte @cedricfeschotte.bsky.social · 30/04/2025

💥🥳 At long last, our latest paper is out! Gag proteins of endogenous retroviruses are required for zebrafish development www.pnas.org/doi/10.1073/... Led heroically by Sylvia Chang & @jonowells.bsky.social A study which has changed the way I think of #transposons! No less! 🧵 1/n

pnas.org

Gag proteins encoded by endogenous retroviruses are required for zebrafish development | PNAS

Transposable elements (TEs) make up the bulk of eukaryotic genomes and examples abound of TE-derived sequences repurposed for organismal function. ...

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Reposted by Ed Chuong

Clément Canonne @ccanonne.github.io · 20/03/2025

If no single piece of the original ship remains in the current ship, is the ship still the Ship of Theseus? And if one percent of all my body's cells get replaced every single day, is it really me who, two months ago, accepted your review request?

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Reposted by Ed Chuong

Annika Barber @annikabarber.bsky.social · 24/02/2025

Wondering if your study section cancelled? I update this sheet daily. As of today, 56/124 study sections that should have met since Jan 2, 2025 have "not met as scheduled." docs.google.com/spreadsheets...

docs.google.com

2025 Study section tracking

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Reposted by Ed Chuong

Carolyn Ibberson @cbibberson.bsky.social · 22/02/2025

I created a brief spreadsheet of reductions I've heard of so far. Any additions you know of (especially if you have the links/receipts) would be great: docs.google.com/spreadsheets...

docs.google.com

Graduate Reductions Across Biomedical Sciences (2025)

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Reposted by Ed Chuong

Patrick Murphy @pjmurphy249.bsky.social · 05/02/2025

PREPRINT! Park et al. makes the case that we may be misunderstanding heterochromatin for past 30 years due to ChIP-Seq biases... 1/n

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Reposted by Ed Chuong

Marlies Oomen @marliesoomen.bsky.social · 20/01/2025

Very excited to share our paper on Gene and Transposable Element expression in mammalian preimplantation development, online today! www.cell.com/cell/fulltex... A short thread to highlight some of our findings 🧵

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Reposted by Ed Chuong

Todd Macfarlan @toddmacfarlan.bsky.social · 08/01/2025

I'm looking for a postdoc to join my fantastic team at the NIH in Bethesda, MD. Great resources. Competitive salary. www.training.nih.gov/jobs/pdf-mb-...

training.nih.gov

Postdoc: Molecular Biology/Genetics/Developmental Biology/Evolution/Computational Biology

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Reposted by Ed Chuong

Aaron Whiteley @aaronwhiteley.bsky.social · 19/12/2024

Check out this thread on the latest work from our lab, led by @emilykibby.bsky.social ! Here we used the power of computationally predicting protein-protein interactions to understand how a bacterial antiphage system senses infection.

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Reposted by Ed Chuong

Miguel V. Almeida @migueldvalmeida.bsky.social · 19/12/2024

First #bluetorial. 🎉🎉 We’re very happy to share our latest biorxiv #preprint, just in time before the holiday season. We explored how transposable elements (TEs) diversify eukaryotic proteomes and found a cool case in nematode F-box genes. #TEsky #evosky #Celegans Short 🧵 with highlights.

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Reposted by Ed Chuong

Ivan Zanoni @lozanzi.bsky.social · 12/12/2024

#NotOnlyParasites! 2 Cell papers by @edchuong.bsky.social lab & Amigorena lab demonstrate that transposable elements #TEs can exonize giving rise to functional (often shorter) proteins with distinct functions: eg a decoy short IFNAR2 that inhibits #interferon signaling! www.cell.com/cell/fulltex...

cell.com

Transposable element exonization generates a reservoir of evolving and functional protein isoforms

Transposable element exonization by unannotated splicing events produces stable protein isoforms with acquired functions that are subject to evolutionary selection.

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Ed Chuong @edchuong.bsky.social · 12/12/2024

I’m excited to share our latest study led by @giuliapasquesi.bsky.social out today in @cellpress.bsky.social , uncovering a new way transposons have been repurposed for human interferon signaling! Read on for a thread on cryptic splice variants, decoy receptors, and viruses (1/N) 👇🧵 #TESky 🧪

cell.com

Regulation of human interferon signaling by transposon exonization

Transposable element exonization can yield functional protein isoforms as seen for primate-specific IFNAR2.

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Reposted by Ed Chuong

Cedric Feschotte @cedricfeschotte.bsky.social · 04/12/2024

What better place than the city of lights to make my transposition to 🦋. Look at all that blue sky!

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Reposted by Ed Chuong

Tony Heitkam🌱🔍💚 @toheitka.bsky.social · 10/11/2024

Scraping who is on the platform working on #TransposableElements or other types of #RepetitiveDNA Have fun! go.bsky.app/7t5GQAP

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Ed Chuong @edchuong.bsky.social · 15/09/2023

Excited to share our latest preprint on transposon exonization and human immune signaling! We found that an Alu element forms a cryptic but highly expressed splice variant of the interferon receptor IFNAR2, which functions as an interferon decoy receptor that regulates interferon signaling.

biorxiv.org

Regulation of interferon signaling by transposon exonization

bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution

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Ed Chuong @edchuong.bsky.social · 10/09/2023

Hi, I'm Ed 👋! I'm an Assistant Professor at CU Boulder, where I study how transposons influence immune function and evolution. Posts on science, DEI, and pics including my dog and the blue skies of the American southwest #AcademicSky #evosky

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