Technological advances over the past decade have enabled genome-wide mapping of chromatin organization across diverse organisms at unprecedented resolution. These studies have uncovered both conserve…

Nature Genetics - Pierre Chambon (1931–2026)

DNA methylation is an important epigenetic mechanism involved in gene regulation. Most methods focus on analysing DNA methylation averaged from multiple reads, yet these average methylation profiles o...

Nature Reviews Molecular Cell Biology - Single-molecule genomics methods are used to study the activity of regulatory factors on individual DNA molecules genome-wide, thereby enabling...

The Dorrity group at EMBL Heidelberg is seeking a motivated and skilled molecular biologist to join as a Laboratory Officer. Our group uses cutting-edge single-cell genomic techniques to study how cel...

Using rapid SPT5 depletion, Dulja et al. uncover different molecular phenotypes at different embryonic stages. In early embryos, SPT5 depletion shifts Pol II from the pausing site to the +1 nucleosome...

Transcription factors (TFs) are central to gene regulation and play critical roles in development, cellular homeostasis and disease. The ability to accurately measure TF activity is essential to under...

Researchers use synthetic biology approaches to test hundreds of DNA sequences for their effect on regulating gene expression

AbstractSummary. Single molecule footprinting profiles the heterogeneity of TF occupancy at cis-regulatory elements across cell populations at unprecedente

Researchers are rewriting the chemical tags on DNA and chromatin to tune gene expression.

This study uses single-molecule footprinting to quantify chromatin accessibility at enhancers and promoters in mouse embryonic stem cells and to dissect the contributions of transcription factor bindi...

The Helsen lab at the University of Geneva explores how centromeres and chromosomes evolve, diversify, and function across eukaryotes. Discover our latest publications, research team, and open positio...

The EMBO Journal -

Elimination of all spliceosomal introns reveals a spliceosome-independent eukaryote.

This study uses a precise and efficient clustered regularly interspaced short palindromic repeats (CRISPR) prime editing system to substitute lysine residues in histone H3, individually or in combinat...

The genetic program of animal development is conserved, but its rate of execution varies across species. Heterochrony, shifts in the relative timing of developmental events, generates phenotypic varia...

Nucleosome spacing influences higher-order chromatin fiber organization in vitro but how this relates to cellular chromosome structure remains contentious. To address this, we developed Ligation Analy...

Cis-regulatory elements, such as enhancers, play an essential role in coordinating gene expression programs during cellular transitions. As such, substantial efforts have been made to characterize enh...