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anuobig

@anuobig.bsky.social
53 followers 112 following 13 posts

The Optical Biofluidic Imaging Group (oBIG@ANU) works at the nexus of advanced imaging and biological physics. We achieve this by applying and inventing new optical techniques to precisely quantify the fundamental functions of biological systems.

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Raphaël Clément @raphclement.bsky.social · 27/08/2026
A developmental biologist's guide to mechanics, just out in Development! In which we learn about the three pillars of any mechanical model: forces, mechanical properties, and boundary conditions. @pflenne.bsky.social @alessandrochppr.bsky.social @caojialing1002.bsky.social @dev-journal.bsky.social
journals.biologists.com
A developmental biologist's guide to mechanics
Summary: A guide to mechanics in development: unlock how forces, material properties and geometry shape the forms of life.
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Henry De Belly @henrydebelly.bsky.social · 10/06/2026
Very excited to be sharing our new paper, just out in Nature Cell Biology! The big question we investigate: How do migrating cells put their front 🔴 and back 🔵 in the right place?
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Dr Zeinab Rekad 🔬🧬🧪 @zeinabrekad.bsky.social · 05/06/2026
Alright, I am pausing my social media break to share with you the final review of my PhD erra (times fly by 🥲). Featuring 2 of my favorite science fields: #RNAbiology and #celladhesion 😍. Also a fantastic collab with one of my top #women_in_sci role models: Stavroula Mili 💙
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FocalPlane @focalplane.bsky.social · 03/06/2026
ICYMI - we're hosting a new quarterly webinar series on cell migration! In our first webinar on Thursday 11 June at 15:00 BST (UTC+1), we'll hear talks from @juanmagararc.bsky.social, @kyohalie.bsky.social & @djcohen.bsky.social. focalplane.biologists.com/2026/05/29/n...
FocalPlane features... emergent models and quantitative analysis of cell migration

Thursday 11 June, 15:00-16:30 BST (UTC+1)

Organised by Pablo J. Sáez and Valeria Venturini

FocalPlane logo

Picture of Juan Manuel García-Arcos  (EPFL, Swiss Institute for Experimental Cancer Research)
‘Mapping live membrane tension during cell migration using Flipper-TR FLIM’

Picture of Yohalie Kalukula (Max-Planck-Zentrum für Physik und Medizin)
‘The actin cortex acts as Mechanical Memory of past confinements’

Picture of Daniel J. Cohen (Princeton University)
‘What sheepherding can teach us about cell migration’

#FocalPlaneFeatures focalplane@biologists.com

Image of time-coded tracks of migrating cells
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Journal of Cell Science @jcellsci.bsky.social · 15/05/2026
That’s a wrap for #JCSimaging, organised by @franbottanelli.bsky.social, @guijacquemet.bsky.social, @drmichaelway.bsky.social & Giulia Zanetti. Thanks to everyone who joined us and made the conference such a wonderful community event. journals.biologists.com/jcs
A large group of people standing on grass looking up to the photographer. At the top of the picture: Imaging Cell Dynamics 11-14 May 2026, Montanyà Hotel, Catalonia, Spain and the logo from Journal of Cell Science.
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Science & Medicine at ANU @scienceanu.bsky.social · 15/05/2026
A new label-free nanoscale imaging technique has revealed intricate cellular behaviours previously invisible to conventional microscopes. science.anu.edu.au/news-events/...
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anuobig @anuobig.bsky.social · 15/05/2026
Thrilled to share that our team’s latest work is now live in @natcomms.nature.com ! 🔬, we established RO-iSCAT (speckle-free iSCAT) and use it to track membrane protrusions in 3D. *Online* www.nature.com/articles/s41... *PDF* rdcu.be/fiFM3 *Press* www.eurekalert.org/news-release...
nature.com
Using rotational integration of oblique interferometric scattering to track axial spatiotemporal responses of tubular membrane protrusions - Nature Communications
The authors develop RO-iSCAT, which uses rotational integration of off-axis oblique-illuminated interference scattering signals to remove speckle noise in real time. It enables fast, label-free imagin...
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Alfonso Martinez Arias @amartinezarias.bsky.social · 02/05/2026
A clear/significant finding derived from the single cell (sc) analysis of biological systems has been the realization that phenotypically homogeneous populations are heterogeneous at the level of gene expression (GE). www.cell.com/fulltext/S00... 🧵
cell.com
Nature, Nurture, or Chance: Stochastic Gene Expression and Its Consequences
Gene expression is a fundamentally stochastic process, with randomness in transcription and translation leading to cell-to-cell variations in mRNA and protein levels. This variation appears in organis...
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paveltomancak.bsky.social @paveltomancak.bsky.social · 04/09/2025
We are all super happy and proud to see our work on the function and evolution of the #cephalic #furrow published in @nature.com. Let me say a few things about the background and history of this work on the #Evolution_of_Morphogenesis (1/12)
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Andrew G. York @andrewgyork.bsky.social · 29/04/2026
Meet MagLuc: a magnetically-controlled luminescent protein. This is a foundational tool for remote control of biological processes, also known as "magnetogenetics". Can you tell when the magnetic field turns on and off? From @mariaingaramo.bsky.social and the team at @nonfictionlabs.bsky.social
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Melanie D. White @melaniedwhite.bsky.social · 27/04/2026
I'm SO excited to see this new paper from our lab's first PhD graduate @wangjianxiong.bsky.social. An outstanding student with a promising career ahead! A PCP-independent role for Prickle1 in junctional neural tube formation. 🧪🐣 Check it out: www.nature.com/articles/s41...
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James Gagnon @james-gagnon.bsky.social · 28/04/2026
Using light-activated CRISPR in zebrafish, we triggered synchronized DNA breaks and track the repair process. ⚡🐟⚡ 

 Well ... DNA repair is very different in embryos compared to tissue culture cells. Embryos repair DNA breaks incredibly fast - within minutes! www.biorxiv.org/content/10.6...
A cartoon showing how a caged guide RNA poises CRISPR cleavage until release by light. Below, a cartoon of injection of "light-activated CRISPR" into the embryo, followed by activation.
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Cell Biology J-Club @cellclub.bsky.social · 24/11/2025
Optogenetic control of mechanotransduction based on light-induced homodimerization of talin url: journals.biologists.com/jcs/article-...
journals.biologists.com
Optogenetic control of mechanotransduction based on light-induced homodimerization of talin
Integrin-based adhesion complexes serve as primary sites for actomyosin force transmission to the extracellular matrix, providing traction that drives cell mechanical responses including adhesion, mig...
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anuobig @anuobig.bsky.social · 10/10/2025
We've integrated FRAP, HILO, and TIRF microscopy into a single setup, driven entirely by a single SLM. Check out the details! #Microscopy #CellBiology #OpticsExpress opg.optica.org/oe/fulltext....
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Mark Peifer (He, him) @peiferlabunc.bsky.social · 20/08/2025
This blowing my mind 🧪
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Izzy Jayasinghe @ijayas.bsky.social · 30/07/2025
🚨Job Alert: My department in UNSW Sydney is recruiting a teaching-only Lecturer in Biophysics. The lecturer will play a key role in the pedagogical development and delivery of courses and practicals in the new undergraduate (BSc) major in #Biophysics that we are launching from 2026. #AcademicBsky 🧪
external-careers.jobs.unsw.edu.au
Lecturer in Biophysics, Education Focused
The incumbent will contribute to undergraduate teaching in Biophysics and across related disciplines within the School of Biomedical Sciences. Some responsibilities include preparing and delivering le...
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anuobig @anuobig.bsky.social · 19/08/2025
Pleased to share that a SLM can achieve multiple FRAP to HILO to TIRF. biorxiv.org/content/10.1... (to appear in Opt Exp opg.optica.org/oe/home.cfm). Great work done by Avinash www.linkedin.com/in/avinash-u... and Daniel linkedin.com/in/daniel-li... from the team.
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Martin J Booth @profmartinjbooth.bsky.social · 07/08/2025
We are recruiting for an academic position (Assoc Prof/Prof) in Optical and Photonic Engineering in Oxford. Please share. Closing date 9 September 2025. my.corehr.com/pls/uoxrecru...
my.corehr.com
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Journal of Cell Biology @jcb.org · 23/07/2025
WAVE complex forms linear arrays at negative membrane curvature to instruct #lamellipodia formation, say Muziyue Wu, Orion Weiner @oweinerlab.bsky.social and colleagues: rupress.org/jcb/article/... #Biophysics #Cytoskeleton #Migration #Motility #Actin
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Mark Peifer (He, him) @peiferlabunc.bsky.social · 14/07/2025
Publishing scientific papers is an obstacle course. There are many aspects to this but lengthy review times are one. That's why I am very excited about the new initiative @biologyopen.bsky.social, @biologists.bsky.social open access journal: Fast & Fair 1/n 🧪 journals.biologists.com/bio/pages/fa...
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Tsuyoshi Hirashima @hirashima0203.bsky.social · 04/07/2025
Excited to share our new review with Emmanuel on tissue patterning in organ morphogenesis! We explore how repetitive patterns form, starting with the concept of L-systems and highlighting an ERK-mediated curvature feedback. Please check it out! sciencedirect.com/science/arti...
sciencedirect.com
Curvature feedback for repetitive tissue morphogenesis – Bridging algorithmic principles and self-regulatory systems
Tissue patterning during organ development consists of intricate morphogenetic processes, driven by the interplay of physical and genetic cues among c…
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natalieadye.bsky.social @natalieadye.bsky.social · 13/05/2025
Join us in Singapore in September for the "Mechanobiology in Time and Space" meeting hosted by the Mechanobiology Institute at NUS @mbisg.bsky.social and Max Planck Society @maxplanck.de. Abstracts due soon! www.mbi.nus.edu.sg/events/mbico...
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bioRxiv Biophysics @biorxiv-biophys.bsky.social · 18/04/2025
Combining Multi-site FRAP and HILO-TIRF microscopy using a Spatial Light Modulator www.biorxiv.org/content/10.1101/202…
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Martin J Booth @profmartinjbooth.bsky.social · 09/04/2025
Adaptive Optics summer school - early registration deadline coming up on 14 April. Register soon to get reduced price.
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Oliver Drozdowski @omdrozdowski.bsky.social · 09/04/2025
📝 New preprint! 📝 Happy to share a new preprint from @kimboonekamp.bsky.social and me: We developed a 3D force inference method for budding organoids! biorxiv.org/content/10.1... From the labs of @ulrichschwarz.bsky.social and @michaelboutros.bsky.social with help from U. Engel. Here the details.
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Betzlab @betzlab.bsky.social · 22/02/2025
Getting tissue stress from images is tough, and elastic tension sensors are a way to solve this. Still, the analysis is complex. Try our GUI gitlab.gwdg.de/betzlab_publ... implementing analytical solutions to obtain surface stresses AND shape parameters of beads and nuclei.
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adamezracohen.bsky.social @adamezracohen.bsky.social · 31/03/2025
Also check out the related work led by Boaz Mohar. Pulse-chase labeling with permeable HaloLigand dyes probes protein turnover. www.nature.com/articles/s41...
nature.com
DELTA: a method for brain-wide measurement of synaptic protein turnover reveals localized plasticity during learning - Nature Neuroscience
Researchers developed DELTA, a method for brain-wide measurement of synaptic protein turnover with single-synapse resolution, providing a powerful tool to localize and study mechanisms underlying syna...
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anuobig @anuobig.bsky.social · 27/03/2025
Imaging throughput of compact handheld microscopes for quantitative single cell studies www.biorxiv.org/content/10.1... Using rotational integration of oblique interferometric scattering (RO-iSCAT) to track axial spatiotemporal responses of membrane protrusions www.biorxiv.org/content/10.1...
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Carmelo Ferrai @carmeloferrai.bsky.social · 23/03/2025
Great to be part of a fantastic community event with so much more to discover! Great science and fun Thanks to Leslie Yeo, Dario Carugo, Jessie Jeon, Christoph Westerhausen & @dfrivas.bsky.social for putting together such a wonderful meeting on high frequency mechanostimulation #sonomechanobiology
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bioRxiv Biophysics @biorxiv-biophys.bsky.social · 26/03/2025
Imaging throughput of compact handheld microscopes for quantitative single cell studies www.biorxiv.org/content/10.1101/202…
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bioRxiv Biophysics @biorxiv-biophys.bsky.social · 25/03/2025
Using rotational integration of oblique interferometric scattering (RO-iSCAT) to track axial spatiotemporal responses of membrane protrusions www.biorxiv.org/content/10.1101/202…
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Alfred Millett-Sikking @amsikking.bsky.social · 21/02/2025
Just a start! Who's missing? go.bsky.app/LAA7Sdx
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anuobig @anuobig.bsky.social · 04/03/2025
Thanks! Calo @jcsmr.bsky.social for highlighting this exciting venture bit.ly/AOaccel 🎉
jcsmr.anu.edu.au
Ability Optics lights up a faster, clearer future for biotech
ANU spinoff company Ability Optics Pty Ltd is accelerating to revolutionise biotechnology with an aim to speed up early lead drug screening by 100-fold.
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James Manton @jamesdmanton.bsky.social · 12/02/2025
In our work, we just put the camera directly into the remote refocus volume to detect the oblique plane directly, without the need for a tertiary microscope system!
Our new OPM system, in which the camera is placed directly after the secondary objective to directly detect the oblique plane.
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Mark Peifer (He, him) @peiferlabunc.bsky.social · 20/01/2025
I have seen this change the lives of many students and postdocs--if you are interested in cell biology, biophysics, microscopy or more: check this out! The Embryology course is also similarly life-changing
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Julia Eckert @juliaeckert.bsky.social · 13/01/2025
Interesting findings by Jacob Notbohm's group. Nematic defects may form as a result of spatially coordinated patterns in cell forces and motion. 👉 arxiv.org/abs/2501.04827
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Prisca Liberali @priscaliberali.bsky.social · 15/01/2025
A perfect start in the new year! 🌱 Regenerating tissues are just an amazing spatio temporal controlled process! Our new manuscript explores how cell heterogeneity and bistability orchestrate intestinal regeneration. 🧵 biorxiv.org/cgi/content/...
biorxiv.org
Cell heterogeneity and fate bistability drive tissue patterning during intestinal regeneration
Tissue regeneration relies on the ability of cells to undergo de novo patterning. While tissue patterning has been viewed as the transition from initially identical un-patterned cells to an arrangemen...
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Jennifer Waters @jencwaters.bsky.social · 13/01/2025
Hey PIs, do your trainees need to learn light microscopy and image analysis? Send them to us! Financial aid is available. meetings.cshl.edu/coursesinten...
meetings.cshl.edu
Courses Intent to Apply Form
Cold Spring Harbor Laboratory Meetings & Courses -- a private, non-profit institution with research programs in cancer, neuroscience, plant biology, genomics, bioinformatics.
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Prof. Andrea Armani @drarmani.bsky.social · 25/10/2023
Photonics Online Meetup (POM23) is a little over a wk away! Don't forget to register (for free!) to join on Gathertown for live streaming, posters, & more. Optica student chapters: apply for funding to support a Hub! #OpenAccess #free #SciSky #Acadsky photonicsonlinemeetup.org/registration/ 🧪 💡
Flyer about POM: no fees for registration
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